Inhibitors of extracellular proteases

ABSTRACT

Provided is a plant derived extract including inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a process and demonstrate the ability to inhibit one or more extracellular proteases which degrade human tissue matrix. Libraries of extracts can be prepared from stressed and non-stressed plants, where each of the extracts demonstrate inhibitory activity against on or more extracellular protease inhibitors. Alternatively, semi-purified and purified inhibitory compounds can be isolated from the extracts. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize degradation due to extracellular proteases.

CROSS REFERENCES TO RELATED APPLICATIONS

This is a Divisional application of U.S. patent application Ser. No. 12/871,097, filed Aug. 30, 2010, now abandoned, which was a Continuation application of U.S. patent application Ser. No. 11/878,978, filed Jul. 30, 2007, now abandoned, which was a Continuation application of U.S. patent application Ser. No. 10/469,402, filed Mar. 25, 2004, now abandoned, and which is a National Stage Entry Under USC 371 of International Application No. PCT/CA02/00285 filed Mar. 4, 2002, claims benefit of Canadian Application No. 2339081, filed Mar. 2, 2001, the contents of each of which are hereby incorporated by reference in their entirety.

FIELD OF INVENTION

The invention pertains to the field of protease inhibitors, specifically inhibitors of extracellular proteases.

BACKGROUND OF THE INVENTION

The cells of tissues are generally in contact with a network of large extracellular macromolecules that occupies the spaces in a tissue between the component cells and also occupies the space between adjacent tissues. This extracellular matrix functions as a scaffolding on which the cells and tissue are supported and is involved actively in regulating interaction of the cells that contact it. The principal macromolecules of the extracellular matrix include the collagens (the most abundant proteins in the body) and glycosaminoglycans (complex polysaccharides which are usually bonded also to protein and then termed proteoglycans). The macromolecules that comprise the extracellular matrix are produced typically by the cells in contact therewith, for example, epithelial cells in contact with a basement membrane and fibroblasts embedded in connective tissue.

The glycosaminoglycan (proteoglycan) molecules form a highly hydrated matrix (a gel) in which elastic or fibrous proteins (such as collagen fibers) are embedded. The aqueous nature of the gel permits diffusion of metabolically required substances between the cells of a tissue and between tissues. Additional proteins that may be found in extracellular matrix include elastin, fibronectin and laminin.

The term “connective tissue” refers to extracellular matrix plus specialised cells such as, for example, fibroblasts, chondrocytes, osteoblasts, macrophages and mast cells found therein. The term “interstitial tissue” is best reserved for an extracellular matrix that stabilizes a tissue internally, filling the gaps between the cells thereof. There are also specialized forms of extracellular matrix (connective tissue) that have additional functional roles—cornea, cartilage and tendon, and when calcified, the bones and teeth.

A structural form of extracellular matrix is the basal lamina (basement membrane). Basal laminae are thin zones of extracellular matrix that are found under epithelium or surrounding, for example, muscle cells or the cells that electrically insulate nerve fibres. Generally speaking, basal laminae separate cell layers from underlying zones of connective tissue or serve as a boundary between two cell layers wherein a basal lamina can serve as a pathway for invading cells associated with pathologic processes, or for structural organisation associated with tissue repair (i.e. as a blueprint from which to regenerate original tissue architecture and morphology).

The regulated turnover of extracellular matrix macromolecules is critical to a variety of important biological processes. Localised degradation of matrix components is required when cells migrate through a basal lamina, as when white blood cells migrate across the vascular basal lamina into tissues in response to infection or injury, or when cancer cells migrate from their site of origin to distant organs via the bloodstream or lymphatic vessels, during metastasis. In normal tissues, the activity of extracellular proteases is tightly regulated and the breakdown/production of connective tissue is in dynamic equilibrium, such that there is a slow and continual turnover due to degradation and resynthesis in the extracellular matrix of adult animals.

In each of these cases, matrix components are degraded by extracellular proteolytic enzymes that are secreted locally by cells. These proteases belong to one of four general classes: many are metalloproteinases, which depend on bound Ca.sup.2+ or Zn.sup.2+ for activity, while the others are serine, aspartic and cysteine proteases, which have a highly reactive serine, aspartate or cysteine residue in their respective active site (Vincenti et al., (1994) Arthritis and Rheumatism, 37: 1115-1126). Together, metalloproteinases, serine, aspartate and cysteine proteases cooperate to degrade matrix proteins such as collagen, laminin, and fibronectin.

Several mechanisms operate to ensure that the degradation of matrix components is tightly controlled. First, many proteases are secreted as inactive precursors that can be activated locally. Second, the action of proteases is confined to specific areas by various secreted protease inhibitors, such as the tissue inhibitors of metalloproteases and the serine protease inhibitors known as serpins. These inhibitors are specific for particular proteases and bind tightly to the activated enzyme to block its activity. Third, many cells have receptors on their surface that bind proteases, thereby confining the enzyme to where it is needed.

Many pathogenic bacteria produce extracellular metalloproteases, of which many are zinc containing proteases that can be classified into two families, the thermolysin (neutral) proteases and the serralysin (alkaline) proteases.

A number of patents and publications report the inhibition of one or more extracellular proteases by compounds extracted from plants. For example, Sun et al., (1996) Phytotherapy Res., 10: 194-197, reports the inhibition in vitro of stromelysin (MMP-3) and collagenase by betulinic acid extracted from Doliocarpus verruculosis. Sazuka et al, (1997).

Biosci. Biotechnol. Biochem., 61: 1504-1506, reports the inhibition of gelatinases (MMP-2 and MMP-9) and metastasis by compounds isolated from green and black teas. Kumagai et al, JP 08104628 A2, Apr. 1, 1996 (CA 125: 67741) reports the use of flavones and anthocyanines isolated from Scutellaris baicanlensis roots to inhibit collagenase. Gervasi et al., (1996) Biochem. Biophys. Res. Comm., 228: 530-538, reports the regulation of MMP-2 by some plant lectins and other saccharides. Dubois et al., (1998) FEBS Lett., 427: 275-278, reports the increased secretion of deletorious gelatinase-B (MMP-9) by some plant lectins. Nagase et al., (1998) Planta Med., 64: 216-219, reports the weak inhibition of collagenase (MMPs) by delphinidin, a flavonoid isolated from Solanum melongena.

Other reports discuss the use of extracts to inhibit extracellular proteases. For example, Asano et al., (1998) Immunopharmacology, 39: 117-126, reports the inhibition of TNF-a production using Tripteggium wilfordii Hook F. extracts. Maheu et al., (1998) Arthritis Rheumatol., 41: 81-91, reports the use of avocado/soy bean non-saponifiable extracts in the treatment of arthritis. Makimura et al., (1993). J. Periodontol., 64: 630-636, also reports the use of green tea extracts to inhibit collagenases in vitro. Obayashi et al., (1998) Nippon Keshonin Gijutsusha Kaishi, 32: 272-279 (CA 130: 92196) reports the inhibition of collagenase-I (MMP-1) from human fibroblast and neutrophil elastase by plant extract from Eucalyptus and Elder.

When a plant is stressed, several biochemical processes are activated and many new chemicals, in addition to those constitutively expressed, are synthesised as a response. These chemicals include enzymes, enzyme inhibitors (especially protease inhibitors), lectins, alkaloids, terpenes, oligosaccharides, and antibiotics. The biosynthesis of these defense chemicals and secondary metabolites is not yet fully understood. The most studied system is the production of protease inhibitors following pest attack or mechanical wounding. On the other hand, several inducible chemicals are the products of complex biochemical pathways which require several biosynthetic enzymes to be activated.

It has been shown that many chemicals can be used to “stress” plants and to artificially stimulate biosynthesis of several new and constitutive defense chemicals. Also, different types of stress can activate distinct metabolic defense pathways, thereby leading to production of a variety of chemicals. Although the various biosynthetic defense pathways share some similarities, these pathways are characteristic of specific plant species. Therefore, treating many plants with many types of stress can lead to a vast number of collections of diverse chemicals from plant origin.

In addition to pests, fungi, and other pathogenic attacks, stressors include drought, heat, water and mechanical wounding. Furthermore, many chemicals can act as stressors that activate gene expression; these include: hydrogen peroxide, ozone, sodium chloride, jasmonic acid and derivatives, .alpha.-linoleic acid, ‘.gamma.-linoleic acid, salicylic acid, abscesic acid, volicitin, small oligopeptides, among others.

The use of abiotic stressors on plants has been the focus of intense studies in plant science. Artificial stresses have been used to stimulate the production of natural plant protease inhibitors for insect digestive proteases, in order to enhance crop protection against certain pests and herbivores. They have proven useful in combination with plants genetically modified to express other protease inhibitor genes. Finally, in the area of molecular farming, stresses have been used to stimulate gene expression in plants genetically modified to include an inducible coding sequence for a protein of nutraceutical and/or medicinal interest (Ryan and Farmer, U.S. Pat. No. 5,935,809).

Likewise, the use of gene activators or elicitors have been described to enhance the production of volatile chemicals in plant cell cultures. These elicitors have been demonstrated to induce the activity of several enzymes such as for example phenylalanine ammonia lyase, therefore leading to an increase in the production of plant volatile components.

No one has used stress to improve or modify plants human protease inhibitor content.

BRIEF DESCRIPTION OF THE FIGURES AND TABLES

FIG. 1 presents an overview of one standard procedure that is followed in order to generate the extracts of the invention each of which is derived from the solid plant material. Solvent A, B and C generally represent separate classes of solvents, for example, aqueous, alcoholic and organic. They are generally applied in a polar to non-polar order. They can be applied in a non-polar to polar order, however, in each case the solid matter must be dried prior to contacting the solid matter with the subsequent solvent.

FIG. 2 describes in further detail, one standard procedure that is followed in order to generate the extracts of the invention.

FIG. 3 presents an overview of one example of a commercial procedure that could be followed to prepare extracts of the invention.

Table 1 reports the inhibition of human MMP-1 by aqueous (A), ethanolic (R) and organic (S) 25 extracts for exemplary stressed and non-stressed plant sources.

Table 2 reports the inhibition of human MMP-2 by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 4 reports the inhibition of human MMP-9 by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 5 reports the inhibition of human Cathepsin B by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 6 reports the inhibition of human Cathepsin D by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 7 reports the inhibition of human Cathepsin G by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 8 reports the inhibition of human Cathepsin L by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 9 reports the inhibition of human Cathepsin K by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 10 reports the inhibition of FILE by aqueous (A), ethanolic (R) and organic (S) extracts for 20 exemplary stressed and non-stressed plant sources.

Table 11 reports the inhibition of bacteria Clostripain by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

Table 12 reports the inhibition of bacteria subtilisin by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed and non-stressed plant sources.

SUMMARY OF THE INVENTION

In one aspect the invention provides n extract from a plant, which inhibits the activity of one or more extracellular proteases, wherein the extract has been prepared by the steps of harvesting plant material, treating plant material with a solvent, separating the resulting extract from the solid material. testing an aliquot of the extract against a panel of extracellular proteases, and retaining the extract if it inhibits the activity of one or more extracellular proteases an extract.

In one aspect the invention provides a library of extracts from plants wherein each extract inhibits the activity of one or more extracellular proteases.

In another aspect the invention provides a library of plant extracts formed by a process comprising: contacting plant material with either an aqueous, ethanolic, or an organic solvent; isolating an extract from said plant material; analysing said extract for the presence of one or more inhibitory activities against an extracellular protease; and collected together, so as to form a library of plant extracts wherein each extract inhibits one or more extracellular proteases.

In one aspect the invention provides an extract from a plant, which inhibits the activity of one or more extracellular proteases, wherein said plant has been stressed prior to generating the extract.

In a further aspect the invention provides a library of extracts derived from plants wherein each extract inhibits the activity of one or more extracellular proteases and wherein said 20 plants have been stressed prior to generating the extract.

In yet a further aspect provides an extracellular protease inhibitor derived from a plant comprising the steps of: contacting plant material with either an aqueous, ethanolic, or an organic solvent; isolating an extract from said plant material; analysing said extract for the presence of one or more inhibitory activities against a panel of extracellular proteases; further purifying a compound from said extract if said extract demonstrates the inhibition of one or more extracellular proteases greater than about 20%.

In another aspect the invention provides a method for increasing the levels of extracellular 30 protease inhibitors in plants comprising the step of stressing the plant prior to forming a plant extract.

In another aspect the invention provides for the use of such extracts during protein purification to minimize the degradation due to extracellular proteases.

DETAILED DESCRIPTION OF THE INVENTION Definitions

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

“Extracellular protease” means enzymes which degrade proteins (proteases) secreted outside the cell. Included MMPs, cathepsins, elastase, plasmin, TPA, uPA, kallikrein, ADAMS family members, neprilysin, gingipain, clostripain, thermolysin, serralysin, and other bacterial and viral enzymes.

“Extract of the invention,” means a composition prepared by contacting a solvent with plant material, produced following the procedures of the invention, which demonstrates inhibitory activity against one or more extracellular proteases. In one embodiment an extract of the invention demonstrates inhibitory activity against two or more extracellular proteases. In one embodiment an extract of the invention demonstrates inhibitory activity against three or more extracellular proteases. In one embodiment, an extract of the invention demonstrates inhibitory activity against four or more extracellular proteases. The solvent may be evaporated leaving a solid embodiment of the extract. In one embodiment, the inhibitory activity is greater than about 20% when measured according to one of the assays as described herein. In one embodiment a panel of extracellular proteases can be used to test the inhibitory activity of the extract.

“Panel of Extracellular Proteases” means the array of distinct extracellular proteases that are used to perform routine assays to monitor the presence or absence of inhibitory activity throughout the extraction process of the invention. In one embodiment, inhibitory activity against one or more extracellular proteases is monitored; in one embodiment, inhibitory activity against two or more extracellular proteases is monitored; in one embodiment inhibitory activity against three or more extracellular proteases is monitored; in one embodiment inhibitory activity against four or more extracellular proteases is monitored; in one embodiment inhibitory activity against five or more extracellular proteases is monitored. One skilled in the art would appreciate that as high throughput screening techniques develop, one could routinely assay the fractions of the extracts with as many extracellular proteases as the technology permits. In general, the more enzymes that can be routinely tested the more information that can be generated during this process that will be useful for defining extracts useful to inhibit extracellular proteases.

“Potential plants” includes all species of the Kingdom Plantae, including plants under the Division Chlorophyta, Division Rhodophora, Division Paeophyta, Division Bryophyta and Division Tracheophyta; Subdivision Lycopsida, Subdivision Sphenopsida, Subdivision Pteropsida and Subdivision Spermopsida; Class Gymnospermae, Class Angiospermae, Subclass Dicotyledonidae and Subclass Monocotyledonidae. In general terms, all plants, herbs, and lower plants such as fungi and algae. Potential plants are those plants that can be subjected to the methodology of the invention in order to generate an extract which can then be tested against a panel of extracellular proteases. Those plants which yield an extract demonstrating inhibitory activity against an extracellular protease are considered to be plants and extracts comprising the subject matter of the invention.

“Potential Pre-Extract” means an extract which has not yet been determined to possess inhibitory activity against one or more extracellular proteases.

“Plant material” means any part of a plant taken individually or in group, could include but not restricted to leafs, flowers, roots, seeds, stems, and other part of a plant, wherein a plant may be terrestrial, aquatic or other.

“Protease inhibitor” as used herein, refers to any compound that attenuates the proteolytic activity of proteases. “Protease inhibitor” may or may not be proteinaceous.

“Stressor” as used herein, refers to any physical stress, chemical compound, or a biological agent used to elicit production of extracellular protease inhibitors as a result of activation of a defence response in a plant. Elicitors and inducers are also considered to be stressors. Any material of a plant may be contacted with a stressor, elicitor, or inducer, which is a chemical compound, for example organic and inorganic acids, fatty acids, glycerides, phospholipids, glycolipids, organic solvents, amino acids, and peptides, monosaccharides, oligosaccharides, polysaccharides and lipopolysaccharides, phenolics, alkaloids, terpenes and terpenoids, antibiotics, detergents, polyamines, peroxides, ionophores, etc., or subjected to a physical treatment, such as ultraviolet radiation, low and high temperature stress, osmotic stress induced by salt or sugars, nutritional stress defined as depriving the plant of essential nutrients (N, P, or K), in order to induce or elicit increased production of one or more chemicals. Such chemical compound or physical treatment may be applied continuously or intermittently to the plant or plant part. In one embodiment, such treatment may be accomplished by contacting the plant material with a solution containing the elicitor or by irradiating the plant material or exposing the plant material to other environmental stresses such as temperature stresses.

The term “substantially purified” or “substantially pure” or “isolated,” when used in reference to a molecule having protease inhibitor activity, means that the molecule is in a form that is relatively free of proteins, nucleic acids, lipids, carbohydrates or other materials with which it is naturally associated in a plant. As disclosed herein, a plant extract of the invention is considered to be substantially purified. In addition, the molecules having protease inhibitor activity can be further purified using routine and well known methods as provided herein. As such, a substantially pure protease inhibitor of the invention can constitute at least about one or a few percent of a sample, for example, at least about five percent of a sample, generally at least about twenty percent of a sample, and can be further purified to constitute at least about fifty percent of a sample, generally at least about eighty percent of a sample, and particularly about ninety percent or ninety-five percent or more of a sample. A determination that a protease inhibitor of the invention is substantially pure can be made using methods as disclosed herein or otherwise known in the art, for example, by performing electrophoresis and identifying the particular molecule as a relatively discrete band.

Other chemistry terms herein are used according to conventional usage in the art, as exemplified by The McGraw-Hill Dictionary of Chemical Terms (ed. Parker, S., 1985), 30 McGraw-Hill, San Francisco, incorporated herein by reference).

The subject invention involves extracts from the tissues of plant species which provide inhibitory activity against extracellular proteases. In one embodiment, the present invention relates to the use of plants to produce extracts or semi-purified/purified compounds, compositions and formulations demonstrating an inhibitory activity against one or more proteases involved in the proteolytic degradation of human extracellular matrix. Such extracts, compounds, compositions and formulations derived from plant sources, optionally from water, ethanol or organic extracts prepared from said plant tissues, and fractions separable from said extracts by chromatography or centrifugal ultra-filtration or other means. In one aspect, these extracts with inhibitory activity can be used during protein purification to minimize the degradation due to extracellular proteases.

With reference to FIG. 1, the process for producing an extract of the invention begins with choosing a plant species. Then a pre-harvest treatment is selected, wherein either treatment with water, or water in addition to any combination of a stress, wherein the stress can be applied separately from the water (if the stress is drought, then the water would not be provided for the period in which the plant is to be stressed); followed by choosing whether the treated plant will be treated for storage and stored prior to contacting plant material with the first solvent. The plant material is treated with the first solvent and then the liquid is separated from the solid material (solid S2), wherein the liquid becomes Fraction F1 or Pre-Extract A. The solid S2 is treated with the second solvent and then the liquid is separated from the solid material (Solid S3), wherein the liquid becomes Fraction F2 or Pre-Extract B. The solid S3 is treated with the third solvent and then the liquid is separated from the solid material (Solid S4).

Plant Material

In one embodiment, plants that may be employed in the invention comprise: Abelmoschus esculentus; Abies balsamea; Abies lasiocarpa; Achillea millefolium; Achillea tomentosa; Aconitum napellus; Aconitum spp.; Acorus calamus; Actaea racemosa; Actinidia arguta; Actinidia chinensis; Adiantum pedatum; Adiantum tenerum; Aesculus hippocastanum; Aframomum melegueta; Agaricus bisporus; Agastache foeniculum; Ageratum conyzoides; Agrimonia eupatoria; Agropyron cristatum; Agropyron repens; Agrostis alba; Agrostis stolonifera; Alcea rosea; Alchemilla twills; Alkanna tinctoria; Allium ampeloprasum; Allium cepa; Allium fistulosum; Allium grande; Allium porrum; Allium sativum; Allium schoenoprasum; Allium tuberosum; Allium victorialis; Aloe vera; Alpinia officinarum; Althaea officinalis; Amaranthus caudatus; Amaranthus retroflexus; Amaranthus tricolor; Ambrosia artemisiifolia; Amelanchier alnifolia; Amelanchier canadensis; Amelanchier sanguinea; Amelanchier sanguinea.times.A. laevis; Amsonia tabemaemontana; Ananas comosus; Anaphalis margaritacea; Anethum graveolens; Angelica archangelica; Angelica dahurica; Angelica sinensis; Anthemis tinctoria; Anthoxanthum odoratum; Anthriscus cerefolium; Anthurium guildingii; Apium graveolens; Apocynum cannabinum; Arachis hypogaea; Aralia cordata; Aralia nudicaulis; Arctium lappa; Arctium minus; Arctostaphylos uva-ursi; Armoracia rusticana; Aronia melanocarpa; Aronia.times.prunifolia; Arrhenatherum elatius; Artemisia abrotanum; Artemisia absinthium; Artemisia dracunculus; Artemisia ludoviciana; Artemisia vulgaris; Asarum europaeum; Asclepias incarnata; Asclepias tuberosa; Asparagus officinalis; Aster spp.; Astilbe.times.arendsii; Astilboides tabularis; Athyrium asperum; Atriplex hortensis; Atropa belladonna; Avena sativa; Averrhoa carambola; Baptisia tinctoria; Beckmannia eruciformis; Begonia convolvulacea; Begonia eminii; Begonia glabra; Begonia mannii; Begonia polygonoides; Bellis perennis; Berberis vulgaris; Beta vulgaris; Betula alleghaniensis; Betula glandulosa; Boesenbergia rotunda; Boletus edulis; Borago officinalis; Brassica cepticepa; Brassica juncea; Brassica napus; Brassica nigra; Brassica oleracea; Brassica rapa; Bromus inermis; Buddleja davidii; Bupleurum falcatum; Butomus umbellatus; Caladium spp.; Calamagrostis arundiflora; Calamintha nepeta; Calendula officinalis; Camellia sinensis; Campanula rapunculus; Canna indica; Cantharellus cibarius; Capsella bursa-pastoris; Capsicum annuum; Capsicum frutescens; Carex morrowii; Carica papaya; Carthamus tinctorius; Carum carvi; Carya cordiformis; Castanea spp.; Centaurea solstitialis; Cerastium tomentosum; Chaerophyllum bulbosum; Chamaemelum nobile; Chelidonium majus; Chenopodium album; Chenopodium bonus-henricus; Chenopodium quinoa; Chrysanthemum coronarium; Cicer arietinum; Cichorium endivia subsp. endivia; Cichorium intybus; Cinnamomum verum; Cirsium arvense; Cissus discolor; Citrullus colocynthis; Citrullus lanatus; Citrus limettoides; Citrus limon; Citrus reticulata; Citrus sinensis; Citrus.times.paradisi; Clematis armandii; Clematis chiisanensis; Coccoloba caracasana; Cocos nucifera; Coix lacrymajobi; Colocasia spp.; Convallaria majalis; Conyza canadensis; Corchorus olitorius; Coriandrum sativum; Cornus canadensis; Cornus mas; Cosmos sulphureus; Cotinus coggygria; Crataegus sanguinea; Crataegus spp.; Crataegus submollis; Crithmum maritimum; Cryptotaenia canadensis; Cucumis anguria; Cucumis melo; Cucumis metuliferus; Cucumis sativus; Cucurbita maxima; Cucurbita moschata; Cucurbita pepo; Cullen corylifolium; Cuminum cyminum; Curcuma longa; Curcuma zedoaria; Cydonia oblonga; Cymbopogon citratus; Cymbopogon martinii; Cynara cardunculus subsp. cardunculus; Cyperus esculentus; Dactylis glomerata; Datisca cannabina; Datura metel; Datura stramonium; Daucus carota; Digitalis purpurea; Dimocarpus longan; Dioscorea batatas; Diospyros kaki; Dipsacus sativus; Dirca palustris; Dolichos lablab; Dryopteris filix-mas; Echinacea purpurea; Echinochloa frumentacea; Eleusine coracana; Equisetum hyemale; Erigeron speciosus; Eriobotrya japonica; Eruca vesicaria; Erysimum perofskianum; Eschscholzia californica; Fagopyrum esculentum; Fagopyrum tataricum; Festuca rubra; Filipendula rubra; Filipendula ulmaria; Filipendula vulgaris; Foeniculum vulgare; Forsythia.times.intermedia; Fortunella spp.; Fragaria.times.ananassa; Frangula alnus; Fucus vesiculosus; Fumaria officinalis; Galinsoga quadriradiata; Galium odoratum; Gaultheria hispidula; Gaultheria procumbens; Genista multibracteata; Gentiana lutea; Gentiana macrophylla; Geum rivale; Ginkgo biloba; Glechoma hederacea; Glyceria maxima; Glycine max; Glycyrrhiza glabra; Gossypium herbaceum; Guizotia abyssinica; Hamamelis virginiana; Hedeoma pulegioides; Hedychium spp.; Helianthus annuus; Helianthus strumosus; Helianthus tuberosus; Helichrysum angustifolium; Helichrysum thianschanicum; Heliotropium arborescens; Helleborus niger; Herba schizonepetae; Hibiscus cannabinus; Hordeum hexastichon; Hordeum vulgare; Hordeum vulgare subsp. vulgare; Houttuynia cordata; Humulus lupulus; Hydrastis canadensis; Hylotelephium spp.; Hymenoxys hoopesii; Hyoscyamus niger; Hypericum henryi; Hypericum perforatum; Hypericum spp.; Hypomyces lactifluorum; Hyssopus officinalis; Iberis amara; Iberis sempervirens; Inula helenium; Ipomoea batatas; Iris versicolor; Isatis tinctoria; Jeffersonia diphylla; Juglans nigra; Juniperus communis; Kochia scoparia; Koeleria glauca; Kolkwitzia amabilis; Krameria lappacea; Lactuca sativa; Lactuca serriola; Laportea canadensis; Laserpitium latifolium; Lathyrus sativus; Lathyrus sylvestris; Laurus nobilis; Lavandula angustifolia; Lavandula latifolia; Ledum groenlandicum; Lens culinaris subsp. culinaris; Lentinus edodes; Leonurus cardiaca; Lepidium sativum; Leucanthemum vulgare; Levisticum officinale; Ligularia dentata; Ligustrum vulgare; Linaria vulgaris; Lindera benzoin; Linum usitatissimum; Litchi chinensis; Lolium multiflorum; Lolium perenne; Lonicera ramosissima; Lonicera syringantha; Lotus corniculatus; Lotus tetragonolobus; Lunaria annua; Lupinus polyphyllus; Luzula sylvatica; Lychnis chalcedonica; Lycopersicon esculentum; Lycopersicon pimpinellifolium; Lysimachia clethroides; Lythrum salicaria; Madia sativa; Magnolia stellata; Malus hupehensis; Malus prunifolia; Malus spp.; Malva moschata; Malva sylvestris; Mangifera indica; Manihot esculenta; Marrubium vulare; Matricaria recutita; Matricaria spp.; Medicago sativa; Melaleuca alternifolia; Melilotus albus; Melilotus officinalis; Melissa officinalis; Mentha arvensis; Mentha pulegium; Mentha spicata; Mentha suaveolens; Mentha.times.piperita; Menyanthes trifoliata; Microlepia platyphylla; Miscanthus sacchariflorus; Miscanthus sinensis; Momordica charantia; Monarda didyma; Monarda fistulosa; Monarda spp.; Musa.times.paradisiaca; Myrica pensylvanica; Nasturtium officinale; Nepeta cataria; Nicotiana rustica; Nicotiana tabacum; Nigella sativa; Ocimum Basilicum; Oenothera biennis; Onobrychis viciifolia; Ophiopogon japonicus; Opuntia spp.; Origanum majorana; Origanum vulgare; Oryza sativa; Oxalis deppei; Oxyria digyna; Paeonia rubra; Paeonia spp.; Panax quinquefolius; Panicum miliaceum; Passiflora caerulea; Passiflora spp.; Pastinaca sativa; Pennisetum alopecuroides; Perilla frutescens; Persea americana; Petasites japonicus; Petroselinum crispum; Peucedanum cervaria; Peucedanum oreaselinum; Pfaffia paniculata; Phacelia tanacetifolia; Phalaris arundinacea; Phalaris canariensis; Phaseolus acutifolius; Phaseolus coccineus; Phaseolus vulgaris; Philadelphus coronarius; Phleum pratense; Phlox paniculata; Phoenix dactylifera; Physalis grisea; Physalis philadelphica; Physalis spp.; Physostegia virginiana; Phytolacca americana; Pimpinella anisum; Pisum sativum; Plantago coronopus; Plantago major; Plectranthus fruticosus; Plectranthus spp.; Pleurotus spp.; Plumbago zeylanica; Poa compressa; Poa pratensis; Podophyllum peltatum; Polygonatum odoratum; Polygonum aviculare; Polygonum chinense; Polygonum pensylvanicum; Polygonum persicaria; Pongamia pinnata; Pontederia cordata; Populus incrassata; Populus tremula; Populus.times.petrowskyana; Portulaca oleracea; Potentilla anserina; Poterium sanguisorba; Primula veris; Prunella vulgaris; Prunus armeniaca; Prunus cerasus; Prunus persica; Prunus spp.; Prunus tomentosa; Psathyrostachys juncea; Psidium guajava; Psidium spp.; Pteridium aquilinum; Pulmonaria officinalis; Pulmonaria saccharata; Punica granatum; Pyrus communis; Pyrus pyrifolia; Raphanus raphanistrum; Raphanus sativus; Rehmannia glutinosa; Reseda luteola; Reseda odorata; Rheum officinale; Rheum palmatum; Rheum.times.hybridum; Rhus aromatica; Rhus trilobata; Ribes grossularia; Ribes nigrum; Ribes rubrum; Ribes sylvestre; Ribes uva-crispa; Ribes.times.nidigrolaria; Ricinus communis; Rosa rugosa; Rosmarinus officinalis; Rubus allegheniensis; Rubus canadensis; Rubus idaeus; Rubus occidentalis; Rubus thibetanus; Rumex acetosa; Rumex acetosella; Rumex crispus; Rumex patientia; Rumex scutatus; Ruta graveolens; Saccharum officinarum; Salix purpurea; Salvia elegans; Salvia officinalis; Salvia sclarea; Salvia sylvestris; Sambucus canadensis; Sambucus ebulus; Sambucus nigra; Sanguisorba minor; Sanguisorba officinalis; Santolina chamaecyparissus; Saponaria officinalis; Satureja hortensis; Satureja montana; Satureja repandra; Scolymus hispanicus; Scorzonera hispanica; Scrophularia nodosa; Scutellaria lateriflora; Secale cereale; Sechium edule; Senecio vulgaris; Serenoa repens; Serratula tinctoria; Sesamum indicum; Setaria italica; Sidalcea spp.; Silene vulgaris; Silybum marianum; Sinapis alba subsp. alba; Sium sisarum; Solanum dulcamara; Solanum melongena; Solanum scabrum; Solanum tuberosum; Solidago canadensis; Solidago spp.; Solidago virgaurea; Solidago.times.hybrida; Sonchus oleraceus; Sorghum bicolor; Sorghum.times.drummondii; Spinacia oleracea; Stachys affinis; Stachys byzantina; Stachys macrantha; Stellaria graminea; Stellaria media; Stipa capillata; Symphytum officinale; Tamarindus indica; Tanacetum balsamita; Tanacetum balsamita subsp. balsamita; Tanacetum cinerariifolium; Tanacetum parthenium; Tanacetum vulgare; Taraxacum officinale; Tetradenia riparia; Teucrium chamaedrys; Thalictrum aquilegiifolium; Thlaspi arvense; Thuja occidentalis; Thymus fragantissimus; Thymus herba-barona; Thymus praecox subsp. arcticus; Thymus pseudolanuginosus; Thymus serpyllum; Thymus vulgaris; Thymus.times.citriodorus; Tiarella cordifolia; Tiarella spp.; Tragopogon porrifolius; Tragopogon spp.; Trichosanthes kirilowii; Trifolium hybridum; Trifolium incamatum; Trifolium pannonicum; Trifolium pratense; Trifolium repens; Trigonella foenum-graecum; Triticum aestivum; Triticum aestivum subsp. spelta; Triticum turgidum; Trollius.times.cultorum; Tropaeolum majus; Tsuga canadensis; Tsuga diversifolia; Tsuga mertensiana; Tussilago farfara; Typha latifolia; Ulmus americana; Urtica dioica; Uvularia perfoliata; Vaccinium angustifolium; Vaccinium corymbosum; Vaccinium macrocarpon; Valeriana officinalis; Valerianella locusta; Veratrum viride; Verbascum thapsus; Verbena officinalis; Veronica officinalis; Viburnum opulus; Vicia faba; Vicia sativa; Vicia villosa; Vigna angularis; Vigna mungo; Vigna unguiculata; Vinca minor; Vitis spp.; Weigela coraeensis; Weigela hortensis; Withania somnifera; .times.Triticosecale spp.; Xanthium sibiricum; Xanthium strumarium; Yucca filamentosa; Zea mays; Zingiber officinale; Achillea ptarmica; Ajuga reptans; Aster spp; Astilbe chinensis; Bergenia.times.schmidtii; Brassica chinensis; Butomus umbellatus; Buxus microphylla; Carpinus caroliniana; Centaurea dealbata; Chaenomeles.times.superba; Clematis alpina; Coreopsis verticillata; Corpus alba; Corpus sericea; Corylus maxima; Crambe cordifolia; Cyperus alternifolius; Dahlia spp.; Euphorbia amygdaloides; Fuchsia spp.; Fuchsia magellanica; Galium aparine; Geranium sanguineum; Geranium phaeum; Geranium pratense; Geranium sanguineum; Geranium.times.cantabrigiense; Glaux Maritima; Hamamelis mollis; Hedychium coronarium; Helenium spp.; Herba Schizonepetae; Hosta sieboldiana; Hydrangea quercifolia; Ipomoea aquatica; Lamiastrum galeobdolon; Magnolia.times.loebneri; Malva verticillata; Matteuccia pensylvanica; Microbiata decussata; Montia perfoliata; Ocimum tenuiflorum; Oenothera fruticosa subsp fruticosa; Onoclea sensibilis; paeonia suffruticosa; Penstemon digitalis; Petasites japonicus; Physalis alkekengi; Pinus cembra; Pinus mugo; Potentilla fruticosa; Rhododendron spp.; ribes americanum; Rodgersia spp.; Rodgersia podophylla; Rubus arcticus; Rubus phoenicolasius; Rubus pubescens; Rudbeckia maxima; Sempervivum tectorum; Soleirolia soleirolii; Solidago caesia; Staphylea trifolia; Stephanandra incisa; Stewartia pseudocamellia; Strelitzia reginae; Symphoricarpos orbiculatus; Symphoricarpos albus; Taxus.times.media; Vernonia gigantea; Veronica austriaca ssp teucrium; Veronica beccabunga; Viburnum plicatum.

It is further contemplated by this invention that any plant may be employed in the method as a potential plant. For example, plants belonging to the following classifications may optionally be employed in order to prepare an extract of the invention when such extracts are demonstrated to possess inhibitory activities against extracellular proteases: Superdivision Spermatophyta—Seed plants Division Coniferophyta—Conifers Class Pinopsida Order Finales Family Araucariaceae Araucaria family Family Cephalotaxaceae—Plum Yew family Family Cupressaceae—Cypress family Family Pinaceae—Pine family Family Podocarpaceae Podocarpus family Family Taxodiaceae—Redwood family Order Taxales Family Taxaceae—Yew family Division Cycadophyta Cycads Class Cycadopsida Order Cycadales Family Cycadaceae Cycad family Family Zamiaceae Sago-palm family Division Ginkgophyta—Ginkgo Class Ginkgoopsida Order Ginkgoales Family Ginkgoaceae—Ginkgo family Division Gnetophyta—Mormon tea and other gnetophytes Class Gnetopsida Order Ephedrales Family Ephedraceae—Mormon-tea family Order Gnetales Family Gnetaceae Gnetum family Division Magnoliophyta—Flowering plants Class Liliopsida—Monocotyledons Subclass Alismatidae Order Alismatales Family Alismataceae—Water-plantain family Family Butomaceae—Flowering Rush family Family Limnocharitaceae—Water-poppy family Order Hydrocharitales Family Hydrocharitaceae—Tape-grass family Order Najadales Family Aponogetonaceae—Cape-pondweed family Family Cymodoceaceae—Manatee-grass family Family Juncaginaceae—Arrow-grass family Family Najadaceae—Water-nymph family Family Posidoniaceae—Posidonia family Family Potamogetonaceae—Pondweed family Family Ruppiaceae—Ditch-grass family Family Scheuchzeriaceae—Scheuchzeria family Family Zannichelliaceae—Horned pondweed family Family Zosteraceae—Eel-grass family Subclass Arecidae Order Arales Family Acoraceae—Calamus family Family Araceae—Arum family Family Lemnaceae—Duckweed family Order Arecales Family Arecaceae—Palm family Order Cyclanthales Family Cyclanthaceae—Panama Hat family Order Pandanales Family Pandanaceae—Screw-pine family Subclass Commelimidae Order Commelinales Family Commelinaceae—Spiderwort family Family Mayacaceae—Mayaca family Family Xyridaceae—Yellow-eyed Grass family Order Cyperales Family Cyperaceae—Sedge family Family Poaceae—Grass family Order Eriocaulales Family Eriocaulaceae—Pipewort family Order Juncales Family Juncaceae—Rush family Order Restionales Family Joinvilleaceae—Joinvillea family Order Typhales Family Sparganiaceae—Bur-reed family Family Typhaceae—Cat-tail family Subclass Liliidae Order Liliales Family Agavaceae—Century-plant family Family Aloeaceae—Aloe family Family Dioscoreaceae—Yam family Family Haemodoraceae—Bloodwort family Family Hanguanaceae—Hanguana family Family Iridaceae—Iris family Family Liliaceae—Lily family Family Philydraceae—Philydraceae family Family Pontederiaceae—Water-Hyacinth family Family Smilacaceae—Catbrier family Family Stemonaceae—Stemona family Family Taccaceae—Tacca family Order Orchidales Family Burmanniaceae—Burmannia family Family Orchidaceae—Orchid family Subclass Zingiberidae Order Bromeliales Family Bromeliaceae—Bromeliad family Order Zingiberales Family Cannaceae—Canna family Family Costaceae—Costus family Family Heliconiaceae—Heliconia family Family Marantaceae—Prayer-Plant family Family Musaceae—Banana family Family Zingiberaceae—Ginger family Class Magnoliopsida—Dicotyledons Subclass Asteridae Order Asterales Family Asteraceae—Aster family Order Callitrichales Family Callitrichaceae—Water-starwort family Family Hippuridaceae—Mare's-tail family Order Calycerales Family Calyceraceae—Calycera family Order Campanulales Family Campanulaceae—Bellflower family Family Goodeniaceae—Goodenia family Family Sphenocleaceae—Spenoclea family Order Dipsacales Family Adoxaceae—Moschatel family Family Caprifoliaceae—Honeysuckle family Family Dipsacaceae—Teasel family Family Valerianaceae—Valerian family Order Gentianales Family Apocynaceae—Dogbane family Family Asclepiadaceae—Milkweed family Family Gentianaceae—Gentian family Family Loganiaceae—Logania family Order Lamiales Family Boraginaceae—Borage family Family Lamiaceae—Mint family Family Lennoaceae—Lennoa family Family Verbenaceae—Verbena family Order Plantaginales Family Plantaginaceae—Plantain family Order Rubiales Family Rubiaceae—Madder family Order Scrophulariales Family Acanthaceae—Acanthus family Family Bignoniaceae—Trumpet-creeper family Family Buddlejaceae—Butterfly-bush family Family Gesneriaceae—Gesneriad family Family Lentibulariaceae—Bladderwort family Family Myoporaceae—Myoporum family Family Oleaceae—Olive family Family Orobanchaceae—Broom-rape family Family Pedaliaceae—Sesame family Family Scrophulariaceae—Figwort family Order Solanales Family Convolvulaceae—Morning-glory family Family Cuscutaceae—Dodder family Family Fouquieriaceae—Ocotillo family Family Hydrophyllaceae—Waterleaf family Family Menyanthaceae—Buckbean family Family Polemoniaceae—Phlox family Family Solanaceae—Potato family Subclass Caryophyllidae Order Caryophyllales Family Achatocarpaceae—Achatocarpus family Family Aizoaceae—Fig-marigold family Family Amaranthaceae—Amaranth family Family Basellaceae—Basella family Family Cactaceae—Cactus family Family Caryophyllaceae—Pink family Family Chenopodiaceae—Goosefoot family Family Molluginaceae—Carpet-weed family Family Nyctaginaceae—Four o'clock family Family Phytolaccaceae—Pokeweed family Family Portulacaceae—Purslane family Order Plumbaginales Family Plumbaginaceae—Leadwort family Order Polygonales Family Polygonaceae—Buckwheat family Subclass Dilleniidae Order Batales Family Bataceae—Saltwort family Order Capparales Family Brassicaceae—Mustard family Family Capparaceae—Caper family Family Moringaceae—Horse-radish tree family Family Resedaceae—Mignonette family Order Diapensiales Family Diapensiaceae—Diapensia family Order Dilleniales Family Dilleniaceae—Dillenia family Family Paeoniaceae—Peony family Order Ebenales Family Ebenaceae—Ebony family Family Sapotaceae—Sapodilla family Family Styracaceae—Storax family Family Symplocaceae—Sweetleaf family Order Ericales Family Clethraceae—Clethra family Family Cyrillaceae—Cyrilla family Family Empetraceae—Crowberry family Family Epacridaceae—Epacris family Family Ericaceae—Heath family Family Monotropaceae—Indian Pipe family Family Pyrolaceae—Shinleaf family Order Lecythidales Family Lecythidaceae—Brazil-nut family Order Malvales Family Bombacaceae—Kapok-tree family Family Elaeocarpaceae—Elaeocarpus family Family Malvaceae—Mallow family Family Sterculiaceae—Cacao family Family Tiliaceae—Linden family Order Nepenthales Family Droseraceae—Sundew family Family Nepenthaceae—East Indian Pitcher-plant family Family Sarraceniaceae—Pitcher-plant family Order Primulales Family Myrsinaceae—Myrsine family Family Primulaceae—Primrose family Family Theophrastaceae—Theophrasta family Order Salicales Family Salicaceae—Willow family Order Theales Family Actinidiaceae—Chinese Gooseberry family Family Caryocaraceae—Souari family Family Clusiaceae—Mangosteen family Family Dipterocarpaceae—Meranti family Family Elatinaceae—Waterwort family Family Marcgraviaceae—Shingle Plant family Family Ochnaceae—Ochna family Family Theaceae—Tea family Order Violales Family Begoniaceae—Begonia family Family Bixaceae—Lipstick-tree family Family Caricaceae—Papaya family Family Cistaceae—Rock-rose family Family Cucurbitaceae—Cucumber family Family Datiscaceae—Datisca family Family Flacourtiaceae—Flacourtia family Family Frankeniaceae—Frankenia family Family Loasaceae—Loasa family Family Passifloraceae—Passion-flower family Family Tamaricaceae—Tamarix family Family Tumeraceae—Turnera family Family Violaceae—Violet family Subclass Hamamelidae Order Casuarinales Family Casuarinaceae—She-oak family Order Fagales Family Betulaceae—Birch family Family Fagaceae—Beech family Order Hamamelidales Family Cercidiphyllaceae—Katsura-tree family Family Hamamelidaceae—Witch-hazel family Family Platanaceae—Plane-tree family Order Juglandales Family Juglandaceae—Walnut family Order Leitneriales Family Leitneriaceae—Corkwood family Order Myricales Family Myricaceae—Bayberry family Order Urticales Family Cannabaceae—Hemp family Family Cecropiaceae—Cecropia family Family Moraceae—Mulberry family Family Ulmaceae—Elm family Family Urticaceae—Nettle family Subclass Magnoliidae Order Aristolochiales Family Aristolochiaceae—Birthwort family Order Illiciales Family Illiciaceae—Star-anise family Family Schisandraceae—Schisandra family Order Laurales Family Calycanthaceae—Strawberry-shrub family Family Hernandiaceae—Hernandia family Family Lauraceae—Laurel family Family Monimiaceae—Monimia family Order Magnoliales Family Annonaceae—Custard-apple family Family Canellaceae—Canella family Family Magnoliaceae—Magnolia family Family Myristicaceae—Nutmeg family Family Sonneratiaceae—Sonneratia family Family Winteraceae—Wintera family Order Nymphaeales Family Cabombaceae—Water-shield family Family Ceratophyllaceae—Homwort family Family Nelumbonaceae—Lotus-lily family Family Nymphaeaceae—Water-lily family Order Papaverales Family Fumariaceae—Fumitory family Family Papaveraceae—Poppy family Order Piperales Family Chloranthaceae—Chloranthus family Family Piperaceae—Pepper family Family Saururaceae—Lizard's-tail family Order Ranunculales Family Berberidaceae—Barberry family Family Lardizabalaceae—Lardizabala family Family Menispermaceae—Moonseed family Family Ranunculaceae—Buttercup family Family Sabiaceae—Sabia family Subclass Rosidae Order Apiales Family Apiaceae—Carrot family Family Araliaceae—Ginseng family Order Celastrales Family Aquifoliaceae—Holly family Family Celastraceae—Bittersweet family Family Corynocarpaceae—Karaka family Family Hippocrateaceae—Hippocratea family Family Icacinaceae—Icacina family Family Stackhousiaceae—Stackhousia family Order Comales Family Cornaceae—Dogwood family Family Garryaceae—Silk Tassel family Family Nyssaceae—Sour Gum family Order Euphorbiales Family Buxaceae—Boxwood family Family Euphorbiaceae—Spurge family Family Simmondsiaceae—Jojoba family Order Fabales Family Fabaceae—Pea family Order Geraniales Family Balsaminaceae—Touch-me-not family Family Geraniaceae—Geranium family Family Limnanthaceae—Meadow-Foam family Family Oxalidaceae—Wood-Sorrel family Family Tropaeolaceae—Nasturtium family Order Haloragales Family Gunneraceae—Gunnera family Family Haloragaceae—Water Milfoil family Order Linales Family Erythroxylaceae—Coca family Family Linaceae—Flax family Order Myrtales Family Combretaceae—Indian Almond family Family Lythraceae—Loosestrife family Family Melastomataceae—Melastome family Family Myrtaceae—Myrtle family Family Onagraceae—Evening Primrose family Family Punicaceae—Pomegranate family Family Thymelaeaceae—Mezereum family Family Trapaceae—Water Chestnut family Order Podostemales Family Podostemaceae—River-weed family Order Polygalales Family Krameriaceae—Krameria family Family Malpighiaceae—Barbados Cherry family Family Polygalaceae—Milkwort family Order Proteales Family Proteaceae—Protea family Order Rafflesiales Family Rafflesiaceae—Rafflesia family Order Rhamnales Family Elaeagnaceae—Oleaster family Family Rhamnaceae—Buckthorn family Family Vitaceae—Grape family Order Rhizophorales Family Rhizophoraceae—Red Mangrove family Order Rosales Family Brunelliaceae—Bruneilia family Family Chrysobalanaceae—Cocoa-plum family Family Connaraceae—Cannarus family Family Crassulaceae—Stonecrop family Family Crossosomataceae—Crossosoma family Family Cunoniaceae—Cunonia family Family Gros sulariaceae—Currant family Family Hydrangeaceae—Hydrangea family Family Pittosporaceae—Pittosporum family Family Rosaceae—Rose family Family Saxifragaceae—Saxifrage family Family Surianaceae—Suriana family Order Santalales Family Balanophoraceae—Balanophora family Family Eremolepidaceae—Catkin-mistletoe family Family Loranthaceae—Showy Mistletoe family Family Olacaceae—Olax family Family Santalaceae—Sandalwood family Family Viscaceae—Christmas Mistletoe family Order Sapindales Family Aceraceae—Maple family Family Anacardiaceae—Sumac family Family Burseraceae—Frankincense family Family Hippocastanaceae—Horse-chestnut family Family Meliaceae—Mahogany family Family Rutaceae—Rue family Family Sapindaceae—Soapberry family Family Simaroubaceae—Quassia family Family Staphyleaceae—Bladdernut family Family Zygophyllaceae—Creosote-bush family.

In one embodiment, potential plants comprise: Atropa Belladonna, Erythrinia glabeliferus, Ipomea tricolor, Erythrinia crista, Celosia cristata, Gallium sporium, Laurus nobilis, Vitis labrissa, Gratiola officinalis, Symphitium officinalis, Hosta fortuna, Casia hebecarpa, Thalictum flavum, Scutellarian altissima, Portulaca oleacea, Scutellaria certicola, Physalis creticola, Geum fanieri, Gentiana tibetica, Linium hirsutum, Aconitum napellus, Podophyllum amodii, Thymus cretaceus, Hosta fortunaea, Carlina acaulis, Charnaechrista fasciculata, Pinus pinea, Pegamun hamalis, Tamarindus india, Carica papaya, Cistus incanus, Capparis spinosa inemis, Cupress lusitanica, Diopiros kaka, Erungium campestre, Aesculus woerlitzenis, Aesculus hippocastanum, Cupressus sempervirens, Celtis occidentalis, Polygonum cuspidatum, Eleagnus angustifolia, Eleagnus cemutata, Gentiana macrophilla, Brassica napa, Sesbania exaltata, Sesbania speciosa, Spartina potentiflora, Brassica juncea, Helianthus annus, Puansetia sp., Pelargonium zonale, Sundapsis spp., Leontopodium alpinum, Lupinus luteaus, Buxus microphilla “japonica”, Liatris spinata, Rimula japonica, Betula nigra, Filipendula vulgrais, Lobelia siphitica, Gravilia robusta, Reseda luteola, Gentiana littorala, Campanula carpatica, Aesculus hypocastanum, Aesculus waertilensis, Ageratum conizoides, Psidium guajava, Ailantus altissima, Buxus microphylla “japonica”, Hydrocotile asiatica, Gravilea robusta, Brugmansia suaveolens, Thymus puliglodes, Thymus lemabarona, Thymus serphylum (wild), Gaultheria procumbens, Thymus serphylum, Thymus camosus, Thymus thrasicus, Calicatus floridus, Zingiber officinalis, Lapia dulcis, Thymus vulgaris “argenteus”, Thymus praecox “arcticus”, Thymus puleglodes “lemons”, Thymus speciosa, Thymus camosus, Thymus pseudolamginosus, Thymus praecox, Thymus vulgaris “oregano”, Ficus religiosa, Forsithsia suspensa, Chelidonium majus, Thymus wooly, Thymus portugalense, Nicotiana tabacum, Thymus cytridorus “aureus”, Thymus vulgaris, Cactus officinalis, Lal lab purpurea, Juglands regia, Actinidia chinensis, Hernerocalis spp., Betula pendula, Gardenia jasminoides, Taxodium dixticum, Magnolia loebheril, Crataegus praegophyrum, Larix dedidua, Tuja orientalis “eligantissima”, Tula ocidentalis “columbia”, Xeupressocyparis deylandii, Pseudotsuga menzisia, Abies firma, Fautenousus qualiqualia, Alium cernum (wild), Juniperus “blue pacific”, Taraxacum officinalis, Juca sp., Ilex agnifolium, Tsuga canadensis “penola”, Ilex cornuta, Taxus hiksii, Taxus media, Metasequoia glyptotrobioldes, Pinus bungiana, Boxus sempervirens, Stevartia coreana, Prunus xocane, Betula daurica, Plantago minor, Acer palmatum “burgundy”, Acer campestre, Cotynus cogygria, Quercus robur “fastigiate”, Acer truncatum, Archirantus bidentata, Alum japonica, Carum capsicum, Agastache mexuicana, Prunella vulgaris, Tagetes minuta, Nepeta cataria, Ratibiunda columnus-Fera, Aster-Nova anglicae, Mirica certifera, Pittisporum tibica, Taxodium dixticum (H.sub.20), Taxodium dixticum (Acetic acid), Plantago major, Scotch pine, Asorum canadensis, Pieras japonica, Pinus sirtrobus, Trifolium pratense, Prunus serotica, Darura stramonium, Geranium maculata, Hydrocotile asiatica, Astragulus sinicus, Centauria maculata, Ruschia indurata, Myrthus comunis, Platanus acidentalis, Liclum barbatum, Lavandula officinalis, Gravilea robusta, Hyppoach rhamnoides, Filipendula ulmaria, Betula pendula, Polygonium odoratum, Brugmansi graveolens (calf), Rhus toxicodenta, Armoraica ristica, Ficus benjaminii, Sluffera sp., Pelagonium zonale, Allium sp., Asimina triloba, Lippa dulcis, Epilobium augustifolium, Brugmansia suaveolens (old), Brugmansia suaveolens (young), Xanthosoma sagittifolium (leaf), Xanthosoma sagittifolium (stem), Monstera deliciosa, Aglaonema commutatus, Dieffenbachia leopoldii, Anthurium andreanum, Syngoniurn podophyllum, Dracaena fragrans, Ananas comosus, Strelitzia reglinae, Dieffenbachia segiunae, Syngoniurn aurutum, Dracaena sp., Haemanthus katharina, Anthurium altersianum, Spathiphyllum grandiflorum, Spathiphyllum cochlearispaturn, Monstera pertusa, Anthurium magnificurn, Anthurium hookeri, Anthurium elegans, Calathea zebrina, Yucca elephantipes, Bromelia balansae, Musa textilis (Leaf), Musa textilis (Stem), Myrthus communis, Olea olcaster, Olea europaea, Verium oleander, Cocculus laurifolius, Microsorium punctatum, Ficus sp., Senseviera sp., Adansonia digitata, Boechimeria boloba, Piper nigrum, Phymatosorus scolopendria, Tumera ulmifolia, Nicodemia diversifolia, Tapeinochilos spectabilis, Rauwolfia tetraphylla, Ficus elastica, Cycas cirinalis, Caryota ureus, Cynnamonum zeylonicum, Aechmea luddemoniana, Foenix zeulonica, Ficus benjamina, Ficus pumila, Murraya exotica, Trevesia sungaica, Clerodendrurn speciossicum, Actinidi colonicta, Paeonia lactiflora, Paeonia suffructicisa, Quercus imbricaria, Iris alida, Portulaca olleracea, Poligonum aviculare, Iris pseudocarpus, Allium nutans, Allium fistulosum, Antericum ramosum, Veratrum nigrum, Poligornun latifolia, Hosta lancefolia, Hosta zibalda, Echinops sphae, Paeonia daurica, Inula hilenium, Trambe pontica, Digitalis lutea, Bactisia australis, Austolachia australis, Hissopus zeraucharicus, Feucrium hamedris, Sedum album, Heraclelum pubescens, Origanurn vulgare, Cachris alpina, Haser trilobum, Matteucia strutiontoris, Sedum telchium, Bocconia cordata, Hiuga rentans, Talictrum minus, Anemona japonica, Clematis rectae, Talictrum sp., Alchemilla sp., Potentilla alba, Poterium sangiusorba, Minispermum dauricum, Oxobachus nictogenea, Armoracea rusticana, Cramble cardifolia, Agrimonia eupatora, Uschusa sp., Polymonium ceruleum, Valeriana officinalis, Pulmonaria molissima, Stachis lanata, Coronolla varia, Platicada grandiflora, Lavandula officinalis, Vincetocsicum officinalis, Acolypha hispida, Gnetum guemon, Psychotria nigropunctata, Psychotria metbacteriodomasica, Cobiaeum varilarturn, Phyllanthus grandifolium, Pterigota alata, Pachyra affinis, Sterulia data, Phylidendron speciosus, Pithecelobium unguis, Sanchezia nobilis, Oreopanax capitata, Ficus triangularis, Pigelia pennata, Piper chaba, Laurus nobilis, Erythrinia caffra, Metrosideros excelsa, Osmanthus spp., Cupressus sempervirens, Jacobinia sp., Senecio platifilla, Livistona fragrans, Tetraclinis articulata hinensis, Eucaliptus rudis, Podocarpus spinulosus, Eriobotria japonica, Gingko biloba, Rhododendron spp., Thuja occidentalis, Fagopyrum suffruticosum, Geum macrophyllum, Magnolia cobus, Vinca minor, Convalaria majalis, Corylus avelana, Barbaric sp., Rosa multiflora, Ostrea carpinifolia, Ostrea connote, Quercus rubra, Tulip tree, Sorbus aucuparia, Betula nigra (leaf), Betula nigra (flower), Castanea sativa, Bergenia crassifolia, Artemisia dracunculus, Ruta graveolens, Quercus nigra, Schisandra chinensis, Betula alba, Sambucus niora, Gentiana cruciata, Encephalaris horridum, Phebodium aureum, Microlepia platphylla, Ceratoramia mexicana, Stepochlaena tenuifolia, Adianthum trapezieformis, Adianthum radiatum, Lycodium japonicum, Aessopteria crasifolia, Asplenium australasicum, Agatis robusta, Osmunda regalis, Osmundastrum claytonionum, Phyllitis scolopendrium, Polyschium braunii, Crytomium fortunei, Dryopteris filis-max, Equisetum variegatum, Anthyrium nopponicum, Anthyrium filis-femina, Parthenosicus tricuspidata, Ligustum vulgare, Charnaeciparis pisifera, Rosa cocanica, Citinis coggriaria, Pinus strobus, Celtis occidentalis, Picea schrenkiana, Cydonia oblonga, Ulmus pumila, Euonomus verrucosa, Deutria scabra, Mespilus germanica, Quercus castanufolia, Euonomus europea, Seruginea suffruticisa, Keyleiteria paniculata, Sering a josiceae, Zelcova, carpinifolia, Abies cephalonica, Taccus bacata, Taxus cuspidata, Salis babilonics, Thuja occidentalis, Actinidia colomicta, Magonia agrifolia, Aralis mandshurica, Luglands nigra, Euonimus elata, Princepia sp., Forsitsia europea, Sorbocotoneaster sp., Morus alba, Crategus macrophyllum, Eucomia ulurifolia, Sorbus cominicta, Philodendron amurense, Comus mass, Korria japonica, Parrotia persica, Jasminum frutocarus, Sulda sanganea, Pentaphylloides fruticosa, Sibirea altaiensis, Cerasus japonica, Kolkwitzia amabilis, Amigdalus nana, Acer mandshurica, Salix tamarisifolia, Amelanchier spicata, Cerasus maghabab, Prunus cerasifera. Coryllus ayelana, Acer tataricum, Viburnum opulus, Siringa vulgaris, Fraxinus exelsior, Quercus trojana, Chaernomelis superba, Pinus salinifolia, Berberis vulgaris, Cotoneaster horisontalis, Cotoneaster fangianus, Fagus silvatica, Pinus pumila, Pinus silvestris and Berberis thungergi.

Another interesting group of plants that can be considered as plants and/or potential plants of the invention comprise the plants that are indigenous to arid regions, for example, those located between 35° north latitude and 35° south latitude. In accordance with the present invention potential extracts and extracts of the invention can be obtained from plants selected from the group comprising: the agave, Agavaceae, family including such members as: Yucca elata, Y. breviflora, Agave deserti, A. chrysantha, Dasylirion wheeleri; the buckwheat, Polygonaceae, family, such as Eriogonum fasciculatum; the crowfoot, Ranunculaceae, family, such as Delphinium scaposum, Anemone tuberosa and D. parishii; the poppy, Papaveraceae, family, including Platystemon californicus, Argemone pleiacantha, Corydalis aurea, Eschschoizia californica and Ar. corymbosa; members of the mustard, Cruciferae, family, such as Dithyrea californica, Streptanthus carinatus and Lesquerella gordoni; members of the legume, Leguminosae, family, such as Acacia greggii, Prosopis velutina, A. constrica, Senna covesii, Cercidium floridum, C. microphyllum, Lotus huminstratus, Krameria parvifolia, Parkinsonia aculeata, Calliendia eriophylla, Lupinus arizonicus, Olyneya tesota, Astragalus lentiginosus, Psorothamunus spinosus and Lupinus sparsiflorus; members of the loasa family, Loasaceae, including Mentzelia involucrata, M. pumila and Mohavea Confertiflora; members of the cactus, Cactaceae, family, such as Carnegiea gigantia, Opuntia leptocaulis, Ferocactus wislizenii, 0. bigelovii, 0. pheacantha, 0. versicolor, 0. fulgida, Echinocereus engelmannii, Mammillaria microcarpa, 0. basilaris, Stenocereins thurberi, 0. violacea, M. tetrancistra, 0. ramosissima, 0. acanthocarpa, E. pectinatins and 0. arbuscula; members of the evening primrose, Onagraceae, family, such as Oenothera deltoides, Camissonia claviformis and Oe. primiveris; members of the milkweed, Asclepiadaceae, family, including Asclepias erosa, A. sublata and Sarcostemma cynanchoides; members of the borage, Boraginaceae, family, such as Cryptantha augusti folia and Amsinckia intermedia; members of the sunflower, Compositae, family, including Baccharis sarothroides, Monoptiilon belloides, Erieron divergens, Zinnia acerosa, Melampodium leucanthan, Chaenactis fremontii, Calycoseris wrightii, Malacothrix californica, Helianthus annus, H. niveus, Geraea canescens, Hymenothrix wislizenii, Encelia farinosa Psilostrophe cooperi, Baileva multiradiata, Bebbia iuncea, Senecio douglasii, Trixis californica, Machaeranthera tephrodes, Xylorhiza tortifolia, Cirsiinm neomexicanum, Antennaria parviflora and Ch. douglasii; members of the caltrop, Zygophyllaceae, family, including Lama tridentata and Kallstroemia grandiflora; members of the mallow, Malvaceae, family, including Hibiscus coulteri, H. denudatus and Sphaeralcea ambigua; members of the phlox, Polemoniaceae, family, such as Luanthus aureus; members of the unicorn plant, Martyniac eae, family, such as Proboscidiea altheaefolia; members of the gourd, Cucurbitaceae, family, such as Cucurbita digitata; members of the lily, Lilaceae, family, including Calochortus kennedyi, Dichelostemma pulchellum, Allium macropetalum and Hesperocallis indulata; members of the ocotillo, Fouquieriaceae, family, including Fouquieria splendens; members of the figwort, Scrophulariaceae, family, such as Castilleja sp., Penstemon parryi and Orthocarpus purpurascens; members of the acanthus, Acanthaceae, family, including Anisacanthus thurberi, Justicia californica and Ruellia nudiflora; members of the four o'clock, Nyctaginaceae, family, such as Allionia incarnate, Abronia villosa and Mirabilis multiflora; members of the geranium, Geraniaceae, family, including Erodium cicutarium; members of the waterleaf, Hydrophyllaceae, family, such as Nama demissum, Phacelia bombycina and Ph. distans; members of the bignonia, Bignoniaceae, family, such as Chilopsis linearis; members of the vervain, Verbenaceae, family, including Glandularia gooddugii and Verbena neomexicana; members of the mint, Labiatae, family, such as Hyptis emoryi and Salvia columbariae; members of the broomrape, Orobanchaceae, family, such as Orobanche cooperi; members of the portulaca, Portulaceae, family, such as Talinum auriantiacum; members of the carpet-weed, Aizoaceae, family, such as Sesuvium verrucosum; members of the flax, Linaceae, family, such as Linum lewisii; members of the potato, Solanaceae, family, including Nicotiana trigonophylla and Physalis lobata; and members of the cochlospermum, Cochlospermaceae, family, such as Amoreuxia palmatifida.

Pre-Harvest Treatment

Once a potential plant is selected, a pre-harvest treatment is selected, wherein the treatment can be water or water in combination with a stressor, elicitor, or inducor. One skilled in the art would appreciate to perform the procedure with water and then with a series of stressors in order to determine whether the potential plant becomes an extract of the invention which demonstrates inhibitory activity against one or more extracellular proteases.

In one embodiment, this invention relates to altering the amount and/or composition of extracellular protease inhibitory activity by stressing a plant by chemical elicitors which act as stressor agent and activated defence plants pathways as mechanical wounding, drought, heat, or cold before tissue collection and extraction.

In one embodiment, stress involves exposing plants to a solution of one or more chemical elicitors to induce defense metabolic pathways and secondary metabolites prior to collection of plant tissues. Known chemical elicitors reported in the literature include ozone, hydrogen peroxide, jasmonic acid and its derivatives, arachidonic acid, salicylic acid and ester derivatives, alpha- and gamma-linoleic acids, volicitin, peptides, oligopeptides, saccharides, oligosaccharides such as chitosan, and synthetic chemicals such as Benzo-1,2,3-thiadiazole-7-carbathioic acid S-methyl ester (BTH).

A stressor may be one or more organic compounds. Some exemplary compounds that may be used as a stressor include Jasmonic acid, Jamonic acid lower alkyl esters, .alpha.-linoleic acid, .alpha.-linoleic acid lower alkyl esters, .gamma.-linoleic acid, .gamma.-linoleic acid lower alkyl esters, Arachidonic acid, Arachidonic acid lower alkyl esters, salicylic acid.

A stressor may be able to induce abiotic stresses in plants. Thus, for example, plants can be treated with one or more chemical or mechanical stresses prior to tissue collection. Mechanical stress can be performed twelve hours to ten days prior to tissue collection. In one embodiment, mechanical stress can be performed one day to three days prior to tissue collection. In one embodiment, mechanical stress can be performed three to six days prior to tissue collection. In one embodiment, mechanical stress can be performed four to eight days prior to tissue collection. In one embodiment, mechanical stress can be performed six to ten days prior to tissue collection.

Chemical stress can be induced by spraying plant material once or more than once with an aqueous or alcoholic solution of the chemical elicitor one hour to 10 days prior to tissue collection. In one embodiment, chemical stress can be induced one day to three days prior to harvesting the plant tissue; in one embodiment, chemical stress can be induced two to four days prior to harvesting the plant tissue; in one embodiment, chemical stress can be induced five to ten days prior to harvesting the plant tissue.

A chemical stress can be added by feeding a plant with an aqueous or alcoholic solution of the chemical. Likewise, the plants can be stressed by airborne transport of the chemical agents one hour to ten days prior tissue collection. In one embodiment, plants can be treated by spray one day before collection. In one embodiment, such chemical stress can be induced one hour to three days prior to harvesting the plant tissue; in one embodiment, such chemical stress can be induced two to eight days prior to harvesting the plant tissue; in one embodiment, such chemical stress can be induced five to ten days prior to harvesting the plant tissue.

Any combination of the above-mentioned stressors and treatment regiemes can be employed to induce the production or enhanced production of one or more extracellular proteases. One skilled in the art would be able to determine from the results of the assay against the panel of extracellular proteases whether it is desirable to follow one or more of the stressor regiemes.

Harvesting the Plant Material for Extraction and Optional Storage Treatment

The plant material may be used immediately after pre-harvest treatment, or it may be desirable to store the plant material for a period of time, prior to performing the extraction procedure(s). In one embodiment, the plant material could be treated prior to storage. In such cases, the treatment could include drying, freezing, lyophilisizing, or some combination thereof.

Following treatment to prepare the plant material for storage, the plant material may be stored for an extended period of time, prior to contacting the plant material with the first solvent. In one embodiment the plant material is stored less than one week. In one embodiment the plant material is stored from one week to one month. In one embodiment the plant material is stored from one month to six months. In one embodiment the plant material is stored from four months to one year. In one embodiment the plant material is stored longer than one year.

The Extraction Process

As depicted in FIG. 1, there are generally three basic extraction processes which can be performed in sequence to generate potential pre-extracts. The procedure for each Extraction process entails contacting the solid plant material with a solvent with adequate mixing and for an amount of time to ensure adequate exposure of the solid material to the solvent to enable inhibitory activity to be taken up by the solvent. Solvent A, B and C generally represent separate classes of solvents, for example, aqueous, alcoholic and organic. They are generally applied in a polar to non-polar order. They can be applied in a non-polar to polar order, however, in each case the solid matter must be dried prior to contacting the solid matter with the subsequent solvent. The liquid is then separated from the solid (insoluble) matter by a process known to those skilled in the art, to generate two fractions: the liquid fraction which is a potential pre-extract and a solid fraction.

The term “liquid” is used to denote a distinction from the solid, insoluble matter. Thus, a liquid, which may be converted to a gas or function in a gaseous form, as in the case with steam, for example can serve as a solvent. Likewise, other non-solid solvents may be used such as highly viscous liquids or other gaseous solvents, some of which can then be converted into a liquid phase.

A liquid solvent may also indicate a composition or a mixture of solvents. Common examples include a buffered aqueous solution, such as a TRIS-HCl buffer, or an ethanol/methanol combination.

In one embodiment, selected parts of a plant (which can be fresh, dried or frozen) can be crushed either mechanically, using a grinder or any device to break plant parts into small particles, or by freezing them in liquid nitrogen. In another embodiment, plant particles can be extracted with an aqueous TRIS-HCl buffer at pH 6-8, in one embodiment pH 7, from 30 minutes to 8 hours, in one embodiment 30 min to 2 hours, at a temperature between 4 to 50° C., in one embodiment 4 to 25° C.; in one embodiment, 4-10° C. In one embodiment, extraction can be performed at 4° C. for 30 minutes.

The solid material can be separated from the solvent by centrifugation, filtration or any other means known to those of skill in the art to separate solids from a solution, to yield aqueous, alcoholic or organic extract, a potential pre-extract. These potential pre-extracts can be tested directly by a panel of extracellular proteases for the ability to inhibit extracellular protease activity, and/or subjected to further separation procedures to generate a potential extract as

The remaining solid can be contacted with a second solvent, such as an alcoholic solvent and a cosolvent, methanol or water In one embodiment, ethanol is used as alcoholic solvent, wherein the range of ethanol:methanol, ranges from 50:50 to 85:15, and 10 minute to one hour, in one embodiment 15 to 30 minute extraction time, at a temperature range of 4 to 25° C. in one embodiment, 4 to 10° C. in one embodiment, and 4° C. in another embodiment. Adequate contact of the solvent with the plant material can be encouraged by shaking the solid suspension for 15 min to 24 hour at a temperature ranging from 4 to 50° C.

The alcoholic extract is recovered and separated from the solids by centrifugation (the material which is insoluble in alcohol is used for organic extraction(s)). The potential pre-extract can be dried using a lyophilizer, a speed vac, a rotary evaporator, or a vacuum pump and dried under vacuum in order to remove the solvent. The dried extract can be dissolved in Tris-HCl buffer wherein the pH is between pH 6 to pH 8, in one embodiment and at pH 7 in one embodiment, and assayed against the panel of extracellular proteases for its bioactivity or, as in the case of the aqueous extract, the alcoholic extract can be treated to obtain purified extracts, as described below.

The organic extract can be obtained by shaking the residual solid for one to twenty-four hours in one embodiment, for one to fifteen hours in one embodiment, one to eight in one embodiment, one to four in one embodiment, with an organic solvent such as diethylether, hexane, dichloromethane, or ethylacetate. The solid can be separated by centrifugation or by filtration (regular or suction) and the organic solvent removed by distillation or by using a rotating evaporator. The organic extract can be dissolved in an aqueous buffer, or a mixture of an aqueous buffer and a suitable solvent (such as dimethylsulfoxide), to evaluate its bioactivity. In one embodiment the organic extracts are prepared using dichloromethane as the solvent of extraction, and the extraction is performed at room temperature for 2 hours.

Are included in the invention extracts prepared by all known large, medium and small-scale 30 methods to prepare extracts.

Determination of Extracellular Protease Inhibitory Activity in an Extract

In order to prepare various embodiments of the invention, (i.e., extracts, compositions and formulations with extracellular protease inhibitory activity) one requires techniques for measuring qualitatively and/or quantitatively the presence of such inhibitory activity. One skilled in the art would appreciate that there are numerous methods and techniques for measuring such activity, that can be used to determine, for example, which extracts are of interest and to follow the processing of the active ingredient(s) giving rise to such activity.

Currently, there are several assays to measure MMP, elastase andcathepsins activity (for a review of these methods, see Murphy and Crabbe, In Barrett (ed.) Methods in Enzymology. Proteolytic Enzymes: Aspartic Acid and Metallopeptidases (New York: Academic Press, 1995)-248: 470. One method, the gelatinolytic assay, is based on the degradation of radio-labelled type I collagen. Although this method is relatively sensitive, it requires the use of radio-labelled specific substrates.

Another widely-used technique is the zymography assay. In this assay, MMP, elastase and cathepsins activity is detected by the presence of negatively-stained bands following electrophoresis in substrate-impregnated SDS polyacrylamide gels. The zymography assay is a sensitive and quantitative method for the detection of various MMPs, elastase, cathepsins and TACE in biological samples; nonetheless, it is labour intensive and has a low dynamic range. Zymography, moreover, is not suitable to measure the intrinsic net activity in biological samples: SDS dissociates MMP-TIMP complexes and activates latent enzyme forms. This is particularly important since matrix degradation ultimately depends on the ratio of free active gelatinase to latent proenzyme or TIMP-complexed forms.

A microtitreplate assay has been developed recently (Pacmen et al., (1996) Biochem. Pharm. 52: 105-111). This assay provides measurement of net biological enzymatic activity of MMP, does not require a radioisotope safety environment, and could be used efficiently for routine measurement of inhibitory activity of MMP; however, it is not likely to be highly efficient as a diagnostic test since the incubation times are long and the sensitivity is much lower than that obtained by standard zymography and radio-labelled substrate assays.

Other methods used auto-quenched fluorogenic substrates. Many fluorogenic substrates have been designed for the quantification of MMPs, elastase, and cathepsins activity throught fluorescent level variation measuring (reviewed by Nagase and Fields (1996) Biopolymers 40: 399-416).

Fluorescence polarization assays were based on the principle that when fluorescent molecules are excited with plane polarized light, they will emit light in the same polarized plane provided that the molecule remains stationary throughout the excited state. However, if the excited molecule rotates or tumbles during the excited state, then light is emitted in a plane different from the excitation plane. If vertically polarized light is used to excite the fluorophore, the emission light intensity can be monitored in both the original vertical plane and also the horizontal plane. The degree to which the emission intensity moves from the vertical to horizontal plane is related to the mobility of the fluorescently labeled molecule. If fluorescently labeled molecules are very large, they move very little during the excited state interval, and the emitted light remains highly polarized with respect to the excitation plane. If fluorescently labeled molecules are small, they rotate or tumble faster, and the resulting emitted light is depolarized relative to the excitation plane. Therefore, FP can be used to follow any biochemical reaction which results in a change in molecular size of a fluorescently labeled molecule (e.g. protein-DNA interactions; immunoassays; receptor-ligand interactions; degradation reactions). (Adapted from Bolger R, Checovich W. (1994) Biotechniques 17(3):585-9).

Another method uses the fluorescent activated substrate conversion (FASO) assay described in Canadian Patent No. 2,189,486 (1996) and in St-Pierre et al., (1996) Cytometry 25: 374-380.

The Commercial Process for Preparing Extracts of the Invention

Extracts of the invention can be prepared on a commercial scale by repeating the extraction process that results in an optimal composition of extracts demonstrating an inhibitory activity of interest. As demonstrated in FIG. 3, one would simply scale-up the procedure and include steps of quality control to ensure reproducible results for the resulting extracts.

Methods of Purifting or Fractionating Active Ingredients from Plant Extracts

There are a number of techniques well known in the art for isolating protease inhibitors from natural sources. For example, For example, purifications can be performed using centrifugation, ultracentrifugation, filtration, liquid or gas phase chromatography (including size exclusion, affinity, etc.) with or without high pressure, lyophylisation, evaporation, precipitation with various “carriers” (PVPP, carbon, antibody, etc.), or any combination thereof. One skilled in the art, would appreciate how to use the following options, in a sequential fashion, in order to enrich each successive fraction in the activity of interest by following its activity throughout the purification procedure, using one of the assays for the inhibitory activity against an extracellular protease of interest, as defined above.

The present invention also includes compounds, chemicals, active principles, and purified or concentrated extracts that could be obtained by purification, partial purification, and/or fractionation of plant extracts that are subject of the invention. Purification, partial purification, and/or fractionation can be achieved by any methods known by those skilled in the art. These methods include, but are not limited to: solid-liquid extraction, liquid-liquid extraction, solid-phase extraction (SPE), membrane and ultrafiltration, dialysis, chromatography, selective precipitation, electrophoresis, and solvent concentration.

Solid-liquid extraction means include the use of all possible solvents known from those in the art, and covers the use of supercritical solvents, soxhlet extractors, vortex shaker, ultrasounds and any other means to enhance extraction, as well as recovery by filtration, centrifugation and any related methods as described in the literature (R. J. P. Carmen, Natural Products Isolation, Humana Press, 1998). The solvent is selected from the group consisting of, but not limited to, hydrocarbon, chlorinated solvents, organic esters, organic ethers, alcohols, water, and mixtures thereof. In the case of supercritical fluid extraction, the invention also covers the use of modifiers as described in V. H. Bright, Ee Pe McNally, Supercritical Fluid Technology, ACS Symp. Ser. Vol. 488, ch. 22, 1999.

Liquid-liquid extraction means include the use of any mixture of solvents known from those in the art, including solvents under supercritical conditions. Typical solvents include, but are not limited to, hydrocarbon, chlorinated solvents, organic esters, organic ethers, alcohols, water, and all possible aqueous solutions. The liquid-liquid extraction can be effected manually, semi-automated or completely automated, and the solvent can be removed or concentrated by any usual techniques known from those in the art (S. Ahuja. Handbook of Bioseparations, Academic Press, 2000).

Solid-phase extraction (SPE) means include techniques using cartridges, columns or any other devices used in this technique and known in the art. The sorbents that may be used with this method include but are not limited to silica gel (normal phase), reverse phase silica gel (modified silica gel), ion-exchange resins, and fluorisil. The invention also includes the use of scavenger resins or any others trapping reagents attached to solid supports derived from organic or inorganic macromolecular materials to remove selectively active ingredients or any constituents from said extracts.

Membrane, reverse osmosis and ultrafiltration means include the use of all types of membranes known from those in the art, as well as the use of pressure, vacuum, centrifugal force, and/or any other means that can be utilized in membrane and ultrafiltration processes (S. Ahuja, Handbook of Bioseparations, Academic Press, 2000).

Dialysis means include membranes having molecular weight cut-offs varying from less than 0.5 KDa to larger than 50 KDa. The invention also covers the recovery of purified and/or fractionated extracts from either the dialysate or the retentate by any means known in the art including but not limited to evaporation, reduced pressure evaporation, distillation, vacuum distillation, and lyophilization.

Chromatographic means include all means of carrying out chromatography known by those skilled in the art and described in G. Sofer, L. Hagel, Handbook of Process Chromatography, Academic Press, 1997. Fractionation, partial purification, and/or purification can be carried out by but not limited to regular column chromatography, flash chromatography, high performance liquid chromatography (HPLC), medium pressure liquid chromatography (MPLC), supercritical fluid chromatography (SFC), countercurrent chromatography (CCC), moving bed chromatography, simulated moving bed chromatography, expanded bed chromatography, and planar chromatography. With every chromatographic methods, sorbents that may be used include but is not limited to silica gel, alumina, fluorisil, cellulose and modified celluloses, all possible modified silica gels, all types of ion-exchange resins, all types of size exclusion gels and any other sorbents known from those skilled in the art and described in T. Hanai. HPLC: A Practical Guide. RSC Press, U K 1999. The present invention also includes the use of two or more solvent gradients to effect the fractionation, partial purification, and/or purification of said active extracts in any chromatographic methods. The solvents that may be utilized include but are not limited to hexanes, pentane, petroleum ethers, cyclohexane, heptane, diethyl ether, methanol, ethanol, isopropanol, propanol, butanol, isobutanol, tert-butanol, water, dichloromethane, dichloroethane, ethyl acetate, tetrahydrofurane, dioxane, tert-butyl methyl ether, acetone, and 2-butanone. When water or and aqueous phase is used, it may contains certain amounts of iorganic or organic salts and the pH may be adjusted to different values with an acid or a base to enhance fractionation and/or purification.

In the case of planar chromatography, the present invention includes the use of all variants of this type of chromatography including but not limited to one- and two dimension thin-layer chromatography (1D- and 2D-TLC), high performance thin-layer chromatography (HPTLC), and centrifugal thin-layer chromatography (centrifugal TLC).

In the case of countercurrent chromatography (CCC), the present invention includes the use of manual, semi-automated, and automated systems, and the use of all possible solvents and solvent combinations necessary to effect fractionation and/or purification of said active extracts as described in W. D. Conway, R. J. Petroski, Modem Countercurrent Chromatography, ACS Symp. Ser. Vol. 593, 1995. Solvent removal and/or concentration can be effected by any means known by those skilled in the art, including but not limited to reduced pressure evaporation, evaporation, reduced pressure distillation, distillation, and lyophilization.

The present invention includes the fractionation, partial purification, and purification of said active plant extracts by expanded bed chromatography, moving and simulated moving bed chromatography, and any other related methods known by those skilled in the art and described in G. Sofer, L. Hagel, Handbook of Process Chromatography, Academic Press, 1997 and S. Ahuja, Handbook of Bioseparations, Academic Press, 2000.

Selective precipitation means includes the use of all possible solvents and solvent combinations, the use of temperature changes, the addition of precipitent and/or modifiers, and/or modifying the pH by adding a base or an acid to effect a selective preceipation of active principles or any other constituents.

Further, the present invention covers the fractionation, partial purification, and purification of said active plant extracts by electrophoresis and other related techniques known to those skilled in the art.

The invention also includes the fractionation, partial purification, and/or purification of said active plant extracts by steam distillation, hydrodistillation, or any other related methods of distillation known from those in the art (L. M. Harwood, C. J. Moody, Experimental Organic Chemistry, Blackwell Scientific Publications, U K, 1989).

The process of purifying the active component(s) also includes the concentration of purified or partially purified chemicals, active ingredients, active principles by solvent removal of said plant extracts and/or fractionated plant extracts, and/or purified plant extracts. The techniques of solvent removal are known to those skilled in the art and include but are not limited to rotary evaporation, distillation (normal and reduced pressure), centrifugal vacuum evaporation (speed-vac), and lyophilization.

One embodiment of the invention includes the concentration of chemicals, active ingredients, active principles by solvent removal of said plant extracts and/or fractionated plant extracts, and/or purified plant extracts. The techniques of solvent removal are known to those skilled in the art and include but are not limited to rotary evaporation, distillation (normal and reduced pressure), centrifugal vacuum evaporation (speed-vac), and lyophilization.

To get a better understanding of the invention described herein, the following examples are set forth. It should be understood that these examples are for illustrative purposes only. Therefore, they should not limit the scope of this invention in any way.

EXAMPLES Example I Preparation of Stressed and Non-Stressed Plant Extracts

Pre-Harvest Treatment Aerian parts of a living plant are sprayed with an aqueous solution of gamma linolenic acid (6,9,12-Octadecatrienoic acid, Sigma L-2378) (stress G) or arachidonic acid (5,8,11,14-Eicosatetraenoic acid, Sigma A-3925) (stress A) (400. mu.M in water with 0.125% (v/v) Triton X-100) to completely cover the leaves.

Harvest Solid SI and Optional Storage Treatment

Twenty to twenty-four hours after the stress, more than 4 grams of leaves, stems, fruit, flowers, seeds or other plant parts are harvested and frozen immediately in dry ice, then transferred as soon as possible to a −20° C. freezer until use. Plant materials may be stored at −20° C. for a long period of time, more than a year, without losing inhibitory activity.

Temperature is Monitored to Ensure a Constant Condition.

Stressed and non-stressed plant specimens are collected as wet samples and stored at −20° C. for various periods of time, and are submitted to a process which generats 3 subfractions: aqueous, ethanolic and organic fractions. Complete extraction process are performed in a continuous cycle using the following steps. An initial 5 g of plant specimen is homogenized in liquid nitrogen with a blender. The resulting powder is weighed.

Extraction Process I: Aqueous Extraction

To each 4.5 grams of plant powder, 12 ml of a cold solution of 100 mM Tris, pH 7.0 is added. The mixture is thoroughly vortexed for 2 minutes. The mixture is kept on ice for 30 minutes and vortexed after each 10 minute period of time. The sample is centrifuged in a Corex™ 30 ml tube for 5 minutes at 4500 rpm. The resulting supernatant is decanted in a 15 ml tube after filtration with a Miracloth™ filter. This extract is therefore referred as the Potential Pre-Extract A. The pellet, referred as Solid S2, is kept for ethanolic extraction.

The aqueous extract (Potential Pre-Extract A) is further purified in order to determine its extracellular protease inhibition capability. The Potential Pre-Extract A is purified by size-exclusion chromatography, wherein the aqueous extract is chromatographed on a calibrated Sephadex G-25 column (1.times.10 cm) using a 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 buffer as eluant. Fractions corresponding to compounds that seem to have molecular weight (MW) less than 1500 daltons (D) are pooled to constitute the purified aqueous extract that is tested for inhibitory activity in an assay as described in Example II.

Prior to this analysis, the extract is treated with 10% gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw.) in order to remove unspecific enzyme ligands. To 1 mL of extract, 100 .mu.L of gelatin-Sepharose resin is added in a microassay tube, the solution in the tube is mixed, kept on ice for 30 minutes, and then centrifuged 5 minutes at 5,000 rpm. The supernatant is removed and used directly for assays.

Extraction Process II: Alcoholic Extraction

To the pellet, Solid S2, collected from the previous aqueous extraction, 12 ml of cold ethanol:methanol (85:15) is added and the mixture is thoroughly vortexed for 2 minutes. The mixture is kept on ice for 30 minutes and vortexed every 10 minutes. The sample is centrifuged in a Corex™ 30 ml tube for 5 minutes at 4,500 rpm. The resulting supernatant is decanted in a 15 ml tube after filtration with a Miracloth™ filter. The pellet, referred as Solid S3 is kept for the subsequent organic extraction. This extract is therefore referred as the Potential Pre-Extract B.

The ethanolic extract, Potential Pre-Extract B, is purified by liquid/liquid extraction prior to analysis by enzymatic assay. For this purpose, 1 ml of ethanolic extract is evaporated under vacuum, dissolved in 150 .mu.l of dimethylsulfoxide (DMSO), and completed to a final volume of 1.5 ml with Tris buffer (final concentration: Tris-HCl 20 mM; pH 7.5). Four ml of hexane is added to the Tris phase in a glass tube and the tube is thoroughly vortexed, then allowed to form a biphasic liquid. The organic phase is removed and the extract is submitted to a second round of liquid/liquid extraction. The aqueous phase is removed and treated with 10% gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw.) to remove unspecific enzyme ligands prior to conducting subsequent assays. To 1 ml of extract, 100 .mu.l of gelatin-Sepharose resin is added in a microassay tube, the tube is mixed, kept on ice for 30 minutes, and then centrifuged 5 minutes at 5,000 rpm. Supernatant is removed and used directly for assays as described in Example II.

Extraction Process III: Organic Extraction

To the pellet, Solid S3, collected from previous ethanolic extraction, 12 ml of cold dichloromethane is added and the mixture is thoroughly vortexed for 2 minutes. The mixture is kept on ice for 30 minutes and vortexed after each 10 minutes period. The sample is centrifuged in a Corex™ 30 ml tube for 5 minutes at 4,500 rpm. The resulting supernatant is decanted in a 15 ml glass tube after filtration with a Miracloth™ filter. The final pellet is discarded. The organic solvent is evaporated under vacuum and the phase is dissolved with dimethylsulfoxide (DMSO). This extract is therefore referred as the Potential Pre-Extract C, which was further purified by solid phase extraction prior to analysis by enzymatic assay.

In order to assay the Potential Pre-Extract C, the organic extract is diluted 1:10 in a solution of DMSO:Methanol:Tris (20 mM, pH 7.5) (10:50:40) (Solution A), ie, 220 of extract is added to 2.0 ml of solution A. After 10 seconds of vigorous vortex, the mix is sonicated for 10 seconds. Dissolved extracts are subsequently applied to a solid phase extraction plate (Discovery SPE-96, Sigma Chemical Co, St-Louis, Mo.). After initial conditioning of the columns with 1 ml of methanol, columns are equilibrated with solution A, and extract samples are deposited on the columns. Elution is completed with solution A (final volume of 2 ml) and this fraction is used directly in assays as described in Example II.

Example II In Vitro Enzyme Inhibition Assays

The inhibitory activity of sample compositions towards human MMP-1, human MMP-2, human MMP-3, human MMP-9, human cathepsin-B, human cathepsin-D, human cathepsin-G, human cathepsin-L, human cathepsin-K, human leukocyte elastase (HLE), bacteria clostripain and bacteria subtilisin can be determined using either fluorogenic substrates or the FASC assay.

Measurement of Human MMP-1, -2, -3 and -9 Activity with Fluorogenic Peptidic Substrates

MMP-1, -2, -9 are purified from natural sources (human immortalized cell lines: 8505C (Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH) for MMP-1, HT-1080 (ATCC, Manassas, Va.) for MMP-2 and THP-1 (ATCC, Manassas, Va.) for MMP-9) as described in literature and based on protocols found in I. M. Clark: <<Matrix metalloproteinases protocols>>, Humana Press (2001). Recombinant human MMP-3 is overexpressed in E. Coli and purified according to Windsor L J, Steele D L (2001), Methods Mol Biol 151:191-205. Proteolytic activity of these proteases is evaluated with the assay based on the cleavage of auto-quenched peptide substrate: (MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. sub.2. TFA [Dpa=N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]) for MMP-1, -2, and -9; and, MCA-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys (DNP)-NH. sub.2 (DNP=2,4-dinitrophenyl; Nva=L-norvaline) for MMP-3 (Calbiochem, San Diego, Calif.). In the intact peptide, Dpa or DNP quenches the MCA fluorescence. Cleavage of the peptide causes release of the fluorescent MCA group which is then quantitated on a fluorometer (Gemini XS, Molecular Devices, Sunnyvale, Calif.). The assay is performed in TNCZ assay buffer (20 mM Tris-HCl; NaCl 150 mM; CaCL.sub.2 5 mM; ZnCl.sub.2 0.5 mM; pH 7.5) with human purified proteases (I. M. Clark: <<Matrix metalloproteinases protocols>>, Humana Press (2001). The substrate, primarily dissolved in DMSO is then redissolved in TNCZ buffer for the assay. In a typical assay, 10 .mu.l of purified enzyme (1-50 ng) and 5 .mu.l of dissolved substrate (final concentration of 10 .mu.M) is mixed in a final volume of 75 .mu.l (completed with TNCZ). All assays were performed in 96 well plate and the reaction is started by the addition of substrate. Assays are measured (excitation 325 nm, emission 392 nm) for 20, 40 and 60 minutes.

Measurement of Human Cathepsin L and K Activity with Fluorogenic Peptidic Substrate.

Human recombinant cathepsins L and K are overexpressed in P. Pastoris according to Krupa J C, Mort J S. (2000), Anal Biochem 283(1):99-103. The assay is similar to the previous except for the auto-quenched peptidic substrate: Z-Arg-Phe-AMC, 2HCl (Bachem California, Torrance, Calif.) and reaction buffer. Assays for Cathepsin L are performed in 20 mM acetate pH 5.5, 1 mM EDTA buffer and assays for Cathepsin K in 20 mM acetate pH 4.2, 1 mM EDTA. Assays are monitored with fluorometer settled at excitation 380 nm/emission 460 nm wavelengths (Krupa J C, Mort J S. (2000), Anal Biochem 283(1):99-103).

Measurement of Human MMP-9, Cathepsin B, Cathepsin G, and Human Leukocyte Elastase (HLE) Activity Using the FASC Assay

Human Cathepsin B and G and human leukocyte elastase are obtained from Calbiochem (San Diego, Calif.). Human MMP-9 is purified as previously described. The assay is based on the method described in Canadian Patent No. 2,189,486 (1996) and in St-Pierre et al., (1996) Cytometry 25:374-380. For the assay, 5 .mu.l of the purified enzyme (1-100 ng), 5 .mu.l of concentrated buffer solution (20 mM Tris-HCl; NaCl 150 mM; CaCL.sub.2 5 mM; ZnCl.sub.2 0.5 mM; pH 7.5), and 5 .mu.l of gelatin-FITC beads are typically used in a final volume of 100 .mu.l. The assay is performed by incubation of the reaction mixture for 90 minutes at 37° C. The reaction is stopped by the transfer of the mix in 0.5 ml of 20 mM Tris, 150 mM NaCl; pH 9.5 buffer. This tube is analyzed in a flow cytometer (Epics MCL, Beckman Coulter, Mississauga, Ontario) as described in Canadian Patent No. 2,189,486 (1996).

Measurement of Human Cathepsin D, Cathepsin B, Cathepsin G and HLE Activity with a Fluorogenic Proteic Substrate

Cathepsin D is purified from human MCF-7 cells according to Stewart A J, Piggott N H, May F E, Westley B R. (1994), Int J Cancer 57(5):715-8. Cathepsin B, Cathepsin G and HLE are obtained as previously described. The activities of Cathepsin D, Cathepsin B, Cathepsin G and HLE are measured by an assay based on the increase of fluorescence of a proteic substrate (Haemoglobin in the case of Cathepsin D and B and beta-casein in the case of Cathepsin G and HLE) heavily labelled with Alexa-488 dye (Molecular Probes, Eugene, Or). The substrate, when highly labelled with the dye, will almost quench the dye fluorescence. Cleavage of the substrate will result in an increase of the fluorescence which can be measured with a spectrofluorometer, and which is proportional to protease activity. Typically, 10 .mu.l of purified human Cathepsin D, Cathepsin B, Cathepsin G or HLE (10-50 ng) and 10 .mu.l of Hemoglobin-Alexa488 or beta-casein-Alexa488 (100 ng) are assayed in final volume of 75 .mu.l adjusted with 20 mM citrate pH 3.3 buffer in the case of Cathepsins D and B or TNCZ buffer in the case of Cathepsin G and HLE. The reaction is performed as already described except that the fluorescence is read at excitation 488 nm/emission 525 nm wavelengths.

Subtilisin Assay

Subtilisin (isolated from B. Subtilisis) is purchased from Fluka. Assays are performed with a fluorogenic peptide (Z-Gly-Gly-Leu-AMC, Bachem California, Torrance, Calif.) as already described for MMPs with the following modification: the assay is buffered with 20 mM Tris, 150 mM NaCl; pH 7.5 and the results are read at excitation 380 nrn/emission 460 nm wavelengths.

Clostripain Assay

Clostripain from Clostridium histolyticum (Worthington Lakewood, N.J.) is prepared and activated as described by manufacturer's protocol. The activity is determined by using Z-Arg-Arg-AMC, 2HCl (Calbiochem, San Diego, Calif.) as a fluorogenic peptidic substrate and the incubation buffer is 75 mM phosphate, pH 7.6. The reaction is performed as already described except that the fluorescence is read at excitation 380 nm/emission 460 nm wavelengths.

Extract Inhibition Assay

Before a typical assay, aqueous extracts prepared extracts prepared as described in Example I are preincubated with 1:10 of gelatin-Sepharose 4B™ for 30 minutes to remove fluorescence quenching. For the ethanolic extract, an initial hexane extraction is performed and samples are treated with 1:10 of gelatin-Sepharose 4B™ to remove quenching.

In a typical fluorescent assay, 10 .mu.l of purified enzyme at concentrations previously mentioned for the enzymatic assay, 5 .mu.l of dissolved fluorogenic peptide or 10 .mu.l of dissolved fluorescent proteic substrate (final concentration of 10 pM) and 40 .mu.L, of the aqueous, ethanolic or organic extract to be tested and prepared as described in Example I are mixed in a final volume of 75 .mu.l (completed with TNCZ for fluorogenic peptide substrate assay or 20 mM citrate pH 3.3 buffer for fluorescent protein substrate assay). All assays are performed in 96 well plate and the reaction is started by the addition of substrate. Assays are measured (excitation 325 nm, emission 392 nm for peptide and excitation 488 nm/emission 525 nm wavelengths for protein) for 20, 40 and 60 minutes. Activity and inhibition values are determined from the increase in fluorescence.

For the FASC assay, 35 .mu.l of the treated extract prepared as described in Example I, 5 .mu.l of the purified enzyme prepared as described previously, 5 .mu.l of concentrated buffer solution (TNCZ), and 5 .mu.l of gelatin-FITC beads are typically used. The initial step of the assay is the incubation of the reaction without beads for a 30 minutes period on ice to allow the binding of inhibitors to enzyme. Fluorescent beads are added and the reaction mix is incubated for 90 minutes at 37° C. The reaction is stopped is stopped by transfer of the mix in 0.5 ml of 20 mM Tris, 150 mM NaCl; pH 9.5 buffer. This tube is analyzed in the flow cytometer (Epics MCL, Beckman Coulter, Mississauga, Ontario) as described in Canadian Patent Application No. 2,189,486 (1996).

Results of the inhibition studies are shown in Tables 1-12. Table 1 reports the inhibition of human MMP-1 by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 2 reports the inhibition of human MMP-2 by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 3 reports the inhibition of human MMP-3 by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 4 reports the inhibition of human MMP-9 by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 5 reports the inhibition of human Cathepsin B by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 6 reports the inhibition of human Cathepsin D by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 7 reports the inhibition of human Cathepsin G by aqueous (A), ethanolic (D) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 8 reports the inhibition of human Cathepsin L by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 9 reports the inhibition of human Cathepsin K by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 10 reports the inhibition of HLE by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 12 reports the inhibition of bacteria subtilisin by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. Table 11 reports the inhibition of bacterial clostripain by aqueous (A), ethanolic (R) and organic (S) extracts for exemplary stressed (A and G) and non-stressed (T) plant sources. The inhibition is reported as percentage (%) of inhibition of substrate degradation as compared with the degradation without extract.

Example III Exemplary Purification of Inhibitory Activity Found in an Extract

Extracts were separated by HPLC on an Agilent 1100 system (San Fernando, Calif.). Briefly, 100 .mu.l of a crude extract prepared as described in Example I was applied on a C18 reverse-phase column (Purospher RP-18 5 .mu.m, 4.0.times.125 mm (HP), Agilent, San Fernando, Calif.). Elution of compounds was achieved with a linear gradient of 10-85% acetonitrile. Fractions were collected, evaporated, resuspended in aqueous buffer and then reanalysed for their inhibition activity on specific enzymes as already described. Fractions of interest (demonstrating a biological activity) where then reisolated at a larger scale for further analysis and characterization.

The invention being thus described, it will be obvious that the same may be varied in many ways. Such variations are not to be regarded as a departure from the spirit and scope of the invention, and all such modifications as would be obvious to one skilled in the art are intended to be included within the scope of the following claims.

TABLE 1 MMP-1 Inhibition Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achillea A O 22.2 Filipendula A O 51.7 millefolium rubra Acorus calamus A O 100.0 Foeniculum A O 86.2 vulgare Actinidia arguta A O 56.4 Fragaria x A O 23.7 ananassa Agastache A S 30.4 Fragaria x A S 40.6 foeniculum ananassa Alchemilla mollis A 4 36.4 Fragaria x A R 28.3 ananassa Allium cepa A O 61.4 Galinsoga A R 29.7 ciliata Allium grande A R 46.5 Gallium A 6 48.8 odoratum Allium porrum A R 25.0 Gaultheria A R 23.9 hispidula Allium porrum A O 98.9 Glycine max A R 24.7 Allium sativum A O 42.5 Glycine max A S 29.6 Allium sativum A R 98.7 Glycine max A O 100.0 Allium A R 22.3 Guizotia A S 39.4 schoenoprasum abyssinica Allium Tuberosum A R 29.9 Hamamelis A R 49.1 virginiana Allium Tuberosum A O 100.0 Helianthus A O 95.9 Tuberosus Althaea officinalis A S 21.6 Heliotropium A R 25.0 arborescens Angelica A S 45.9 Hordeum A O 100.0 archangelica hexastichon Anthemis nobilis A R 34.5 Hordeum A O 46.2 vulgare Aralia nudicaulis A O 100.0 Vulgare A O 43.8 Armoracia A O 31.2 Inula helenium A O 25.8 rusticana Armoracia A S 39.7 Lathyrus sativus A O 27.1 rusticana Aronia A R 39.8 Leonurus A O 34.4 melanocarpa cardiaca Aster sp A O 67.6 Levisticum A R 31.7 officinale Beckmannia A O 24.1 Lolium A O 39.0 eruciformis multiflorum Beta vulgaris A R 41.2 Lotus A O 100.0 corniculatus Beta vulgaris spp. A O 44.1 Malva sylvestris A R 22.8 Maritima Brassica napus A O 26.3 Matricaria A O 25.1 recutita Brassica oleracea A S 28.6 Matteucia A R 48.1 pensylvanica Brassica oleracea A R 33.8 Medicago sativa A R 25.1 Brassica Oleracea A O 100.0 Melissa A O 100.0 officinalis Brassica rapa A R 61.4 Mentha piperita A O 60.1 Calamintha nepeta A R 40.2 Mentha A O 35.1 suaveolens Camellia sinensis A O 39.3 Nepeta cataria A O 100.0 Capsicum annuum A R 34.3 Nicotiana A R 20.7 rustica Capsicum annuum A O 88.3 Origanum A R 60.5 vulgare Capsicum A R 39.4 Origanum A O 73.2 frutescens vulgare Chenopodium A O 100.0 Perilla A R 74.4 bonus-henricus frutescens Chenopodium A R 37.3 Perilla A O 92.4 bonus-henricus frutescens Chenopodium A O 66.3 Petroselinum A R 77.4 quinoa crispum Chrysanthenum A R 37.4 Phacelia A R 52.8 coronarium tanacetifolia Cichorium intybus A R 22.0 Phaseolus A R 20.9 coccineus Cichorium intybus A S 66.9 Phaseolus A S 34.2 coccineus Citrullus lanatus A O 41.9 Phaseolus A S 29.2 Vulgaris Comus canadensis A S 73.0 Phaseolus A R 56.1 vulgaris Crataegus sp A O 100.0 Phaseolus A R 60.0 Vulgaris Cucumis Anguria A S 34.2 Phaseolus A O 100.0 Vulgaris Cucurbita A O 27.3 Phlox paniculata A O 100.0 moschata Cucurbita pepo A O 84.9 Pimpinella A S 100.0 anisum Cymbopogn A O 100.0 Pimpinella A R 72.2 citratus anisum Cymbopogon A R 22.1 Plantago A R 23.7 citratus coronopus Cyperus esculentus A R 25.8 Plectranthus sp. A O 25.0 Cyperus esculentus A O 28.1 Poa compressa A O 31.5 Dactylis glomerata A O 25.5 Potentilla A R 71.2 anserina Daucus carota A O 43.4 Pysalis ixocarpa A R 32.1 Daucus carota A R 100.0 Raphanus A O 31.5 raphanistrum Dipsacus sativus A O 35.3 Raphanus A O 100.0 sativus Dirca palustris A S 47.9 Raphanus A O 30.2 sativus Eruca vesicaria A R 33.7 Rheum officinale A O 79.1 Eschscholzia A O 61.1 Rheum A R 22.9 californica rhabarbarum Eschscholzia A R 74.1 Rheum A R 32.8 californica rhabarbarum Ribes nigrum A O 100.0 Ribes nigrum A R 100.0 Ribes salivum A R 48.6 Ribes sylvestre A S 26.5 Ribes uva-crispa A R 100.0 Rubus A R 46.1 canadensis Rubus A R 53.1 canadensis Rubus idaeus A R 100.0 Salvia A O 100.0 officianalis Salvia sclarea A S 43.8 Satureja A R 100.0 montana Solanum A S 43.8 dulcamara Solanum A R 37.2 melanocerasum Solatium A R 100.0 tuberosum Cucurbita Pepo G O 40.2 Cuminum G R 25.5 Sorghum dochna A O 100.0 cyminum Stachys byzantina A S 28.9 Cymbopogon G R 33.7 citratus Stellaria media A S 33.1 Datura G O 73.5 stramonium Tanacetum A O 28.9 Daucus carota G O 86.0 parthenium Tanacetum vulgare A R 76.0 Daucus carota G O 27.9 Taraxacum A O 65.7 Diyopteris filix- G O 21.9 officinale mas Thymus praecox A O 64.2 Erysimum G O 24.4 subsp arcticus perofskianum Thymus praecox A R 88.2 Fagopyrum G O 100.0 subsp arcticus esculentum Thymus vulgaris A R 42.7 Foeniculum G O 28.0 vulgare Thymus x A O 34.7 Foeniculum G R 57.3 citriodorus vulgare Trichosanthes A R 31.8 Gaultheria G O 44.2 kirilowii hispidula Trifolium A R 96.0 Gaultheria G R 94.8 hybridum procumbens Trifolium A R 100.0 Glechoma G O 25.5 incamatum hederacea Trifolium A R 27.7 Glycine max G S 100.0 pannonicum Trifolium repens A R 79.5 Glycyrrhiza G O 24.9 glabra Vaccinum A R 52.5 Guizotia G R 30.3 augustifolium abyssinica Vaccinum A O 64.5 Helenium G O 28.6 macrocarpon hoopesii Vicia sativa A O 60.8 Helianthus G O 33.6 annuus Helianthus G O 54.4 Vicia sativa A R 28.6 tuberosus Hordeum G O 28.8 Vicia villosa A R 64.7 vulgare Vicia villosa A O 57.3 Vulgare G R 28.1 Vigna A O 33.0 Hypericum G R 80.0 sesquipedalis henryl Vigna A R 24.4 Iberis amara G O 44.6 sesquipedalis Vigna unguiculata A R 20.6 Lactuca sativa G R 25.3 Vitia spp A R 72.6 Lathyrus G O 90.2 sylvestris Vitia spp A O 100.0 Lavandula G R 22.5 angustifolia Zea Mays A R 99.2 Lepidium G S 29.5 Sativum Zea Mays A O 100.0 Levisticum G O 100.0 officinale Abelmochus G R 37.6 Lolium G O 24.9 esculentus multiflorum Aconitum napellus G O 100.0 Lolium G R 27.1 multiflorum Allium G R 33.4 Lotus G O 52.2 ampeloprasum corniculatus Allium G R 31.5 Lycopersicon G R 24.4 ascalonicum esculentum Allium cepa G O 34.4 Lycopersicon G R 30.3 pimpinellifolium Allium cepa G R 36.4 Malus G R 65.8 hupehensis Allium sativum G R 53.2 Malva G R 43.1 verticillata Matricaria G S 100.0 Allium tuberosum G R 68.3 recutita Althaea G O 47.7 Matteucia G R 57.5 officianalis pensylvanica Althaea officinalis G S 30.7 Melissa G O 28.5 officinalis Althaea officinalis G S 44.3 Mentha piperita G O 36.0 Althea officinalis G R 83.6 Mentha spicata G S 20.3 Anethum G S 44.3 Mentha spicata G S 26.0 graveolens Apium graveolens G R 27.7 Mentha G O 60.5 suaveolens Armoracia G O 51.8 Nepeta cataria G O 24.1 rusticana Armoracia G S 47.1 Nicotiana rusticana rustica G R 28.1 Aronia G S 66.5 Nicotiana G R 40.6 melanocarpa tabacum Artemisia G S 79.0 Oenothera G R 28.4 dracunculus biennis Artemisia G R 50.3 Oenothera G O 100.0 dracunculus biennis Asparagus Origanum officinalis G O 96.4 vulgare G S 100.0 Beilis perennis G R 44.1 Origanum G O vulgare 20.1 Beta vulgaris spp. G R 43.7 Origanum G O 85.4 Maritima vulgare Beta vulgaris spp. G O 34.9 Oryza Sativa G R 53.3 Maritima Betula glandulosa G S 40.8 Panax G S quinquefolius 100.0 Borago officinalis G O 30.3 Panicum G S miliaceum 100.0 Borago officinalis G R 29.7 Passiflora G O 20.9 caerula Brassica cepticepa G R 21.9 Pastinaca sativa G R 68.4 Brassica oleracea G O 33.6 Pastinaca sativa G O 100.0 Pennisetum G R 100.0 Brassica oleracea G O 100.0 alopecuroides Petroselinum G R 73.0 Brassica rapa G O 42.5 crispum Brassica rapa G R 40.2 Phalaris G O 100.0 canariensis Phaseolus G R 29.9 Calamintha nepeta G O 28.7 coccineus Calendula Phaseolus G R 67.6 officinalis L. G O 100.0 coccineus Phaseolus G O 32.4 Camellia sinensis G O 46.4 coccineus Campanula G R 27.2 Phaseolus G R 33.4 rapunculus vulgaris Capsella bursa- G R 24.1 Phaseolus G R 60.2 pastoris vulgaris Capsicum annum G O 36.0 Phaseolus G R 22.3 vulgaris Chaerophyllum G R 38.9 Phaseolus G O 87.7 bulbosum vulgaris Chenopodium G O 100.0 Phlox G O 89.3 quinoa paniculata Cichorium intybus G S 44.6 Physalis G O 37.0 pruinosa Circium arvense G R 30.3 Plantago G R 48.1 coronopus Citrullus lanatus G R 21.2 Plantago major G O 47.0 Cucurbita pepo G O 59.5 Plectranthus sp. G O 97.2 Potentilla anserina G R 22.0 Ananas comosus T O 100.0 Prunella vulgaris G O 21.2 Anthemis nobilis T O 22.7 Raphanus G O 95.9 Anthriscus T O 56.8 Raphanistrum cerefolium Raphanus sativus G O 67.7 Apium T R 29.8 graveolens Reseda odorata G O 40.6 Aralia T O 100.0 nudicaulis Armoracia T O 58.9 Rheum officinale G O 82.1 rusticana Rheum G R 48.1 Artemisia T O 100.0 rhabarbarum dracunculus Asparagus T R 25.2 Ribes Nigrum G R 100.0 officinalis Ribes Sylvestre G O 42.9 Atriplex T R 44.7 hortensis Ricinus communis G O 73.5 Beilis perennis T R 58.1 Rubus G R 31.4 Beta vulgaris T R 37.3 Phoenicalasius Ruta graveolens G R 100.0 Betula T O 23.5 glandulosa Salvia officinalis G R 100.0 Boletus edulis T S 64.2 Santolina G R 28.1 Brassica juncea T R 35.6 Satureja hortensis G R 100.0 Brassica napus T O 100.0 Satureja repandra G O 57.1 Brassica T R 33.2 oleracea Scrophularia G R 41.6 Brassica T O 49.7 nodosa oleracea Scutelaria G S 72.1 Camellia T O 24.7 lateriflora sinensis Slum sisarum G O 99.7 Camellia T R 45.7 sinensis Solanum G R 65.4 Canna edulis T R 26.2 dulcamara Solanum G R 32.4 melanocerasum Carum carvi T O 100.0 Solanum G O 100.0 Chaerophyllum T R 40.9 melorgena bulbosum Solanum G S 46.4 Chrysanthemun T R 48.1 tuberosum coronarium (Chp suey) Sorghum G R 100.0 Chrysanthenum T R 29.9 caffrorum coronarium Sorghum dochna G R 51.4 Chrysanthenum T R 100.0 coronarium Sorghum dochna G R 39.6 Cichorium T R 20.5 endivia Sorghum G O 97.4 Cichorium T R 21.9 sudanense endivia Cichorium T S 50.6 Stachys byzantina G O 41.4 intybus Stellaria media G O 33.8 Cichorium T R 31.7 intybus Symphytum G O 52.0 Cichorium T R 52.9 officinale intybus Tanacetum G O 79.1 Citrullus T O 100.0 parthenium lanatus Tanacetum vulgare G O 100.0 Citrus paradisi T O 40.6 Taraxacum G S 25.9 Cocos nucifera T O 27.2 officinale Teucrium G O 100.0 Comus T S 44.9 chamaedrys canadensis Teucrium G R 48.0 Crithmum T R 32.3 chamaedrys maritimum Cucumis T O 22.6 arcticus G R 73.1 anguria Thymus x G O 52.2 Cucurbita T O 33.5 citriodorus moschata Cucurbita T R 32.3 Trichosanthes G O 35.9 moschata (Early kirilowil Butternut) Trifolium G R 76.0 Cucurbita pepo T O 89.0 hybridum Trifolium G R 73.4 Cuminum T R 54.3 incarnatum cyminum Trifolium G R 24.8 Curcuma T S pannonicum zedoaria 100.0 Trifolium repens G R 48.5 Cymbopogon T O 42.6 citratus Triticosecale spp. G R 48.5 Datura metel T O 24.8 Triticum spelta G R 22.9 Datura metel T R 25.5 Tropaeolum majus G S 23.4 Dioscorea T R 100.0 batatas Urtica dioica G O 96.4 Dipsacus T O 85.0 sativus Vaccinium G S 60.7 Diyopteris filix- T O 46.4 corymbosum mas Vaccinium G R 61.4 Erigeron T O 100.0 corymbosum canadensis Vaccinum G R 54.7 Eruca vesicaria T R 30.9 angustifolium Vicia sativa G R 68.8 Erysimum T O 23.0 perofskianum Vicia sativa G O 31.5 Eschscholzia T O 37.8 califomica Eschscholzia T R 20.8 Vicia villosa G O 100.0 califomica Fagopyrum T O 100.0 Vicia villosa G R 35.5 esculentum Vigna G R 23.0 Fagopyrum T R 78.5 sesquipedalis tartaricum Foeniculum T O 63.4 Vitia spp G R 36.9 vulgare Withanla Foeniculum T O 27.2 somnifera G O 44.0 vulgare Xanthium G R 37.6 Forsythia x T S 32.0 strumarium intermedia Zea mays G O 100.0 Fragaria x T S 33.0 ananassa Aconitum napellus T R 100.0 Galinsoga T R 25.8 ciliata Agaricus bisporus T R 58.9 Gaultheria T O 46.8 procumbens Agaricus bisporus T O 100.0 Hedeoma T O 73.6 pulegioides Allium T R 43.3 Helianthus T O 39.3 ampeloprasum tuberosus Allium Hordeum ascalonicum T R 34.5 vulgare T O 32.4 Allium cepa T R 53.5 Humulus T O 21.1 lupulus Allium cepa T O 45.8 Hypericum T R 29.3 henryi Allium grande T R 43.2 Hypericum T R 42.7 perforatum Allium T R 47.1 Iberis amara T O 29.5 schoenoprasum Allium tuberosum T R 74.6 Ipomea T R 22.9 aquatica Allium tuberosum T O 33.6 Lathyrus Sativus T R 69.4 Aloe vera T R 34.1 Taurus nobilis T O 70.2 Lavandula T O 100.0 Althaea officinalis T S 47.8 latifolia Amelanchier T R 59.1 alnitolia Culinaris T O 70.2 Lepidium sativum T O 100.0 Ribes nigrum T R 30.0 Levisticum T O Ribes Sativum T R 61.7 officinale 100.0 Lolium multiflorum T O 35.1 Ribes Sylvestre T R 75.4 Lunaria annua T O 100.0 Ricinus T S 100.0 communis Rosmarinus T R 29.0 pimpinellifolium T R 24.4 officinalis Malus hupehensis T R 73.1 Rubus T R 86.1 canadensis Malus sp. T R 80.9 Sabal serrulata T R 100.0 Malva sylvestris T R 34.7 Salvia T O 100.0 officinalis Malva sylvestris T O 100.0 Sambuous T O 24.8 canadensis Satureja T R 100.0 Manihot esculenta T R 33.0 montana Melissa officinalis T O 100.0 Satureja T S 27.2 repandra Melissa officinalis T O 100.0 Satureja T O 36.4 repandra Mentha suaveolens T S 39.7 Satureja T R 42.0 repandra Nigella sativa T R 58.9 Scrophularia T R 68.8 nodosa Nigella sativa T R 100.0 Secale cereale T O 100.0 Ocimum Basilicum T R 100.0 Setaria italica T R 23.2 Origanum T O 41.5 Silybum majorana marianum T O 73.5 Origanum vulgare T O 29.8 Solanum T R 20.1 melongena Origanum vulgare T R 33.1 Solanum T S 24.4 tuberosum Panax T R 75.2 Solidago T R 71.4 quinquefolius virgaurea Passiflora spp. T S 32.0 Sorghum T O 22.5 dochna Pastinaca sativa T R 20.8 Stachys T O 39.2 byzantina Perroselinum T R 55.4 Stellaria media T O 43.3 crispum Petroselinum T R 76.1 Symphytum T O 58.7 crispum officinale Petroselinum T O 24.1 Tanacetum T O 100.0 crispum parthenium Peucedanum T O 21.0 Tanacetum T O 32.5 oreaselinum vulgare Phacelia T R 48.6 Taraxacum T S 27.8 tanacetifolia officinale Phalaris T O 56.4 Teucrium T R 62.9 canariensis chamaedrys Phaseolus T R 22.7 Teucrium T O 100.0 coccineus chamaedrys Phaseolus mungo T R 47.4 Thalpsi arvense T O 21.2 Phaseolus vulgaris T R 40.0 Thymus praecox T R 60.9 subsp arcticus Phaseolus vulgaris T O 29.4 Tragopogon T R 24.6 porrifolium Phoenix T R 46.3 Trifolium T R 33.7 dactylifera incarnatum pourpre T R 28.9 Trifolium T R 72.4 pannonicum Phytolacca T O 100.0 Trifolium repens T R 72.4 americana Triticosecale T R 33.7 Plectranthus sp. T O 73.8 spp. Tropaeolum T R 100.0 Pleurotus spp. T O 100.0 majus Poa compressa T O 22.3 Tropaeolum T O 31.5 majus Vaccinium T O 100.0 Poa pratensis T O 73.1 angustifolium Vaccinium T S 42.1 Populus Tremula T O 100.0 angustifolium Prunella vulgaris T O 38.0 Vaccinium T S 30.9 Psoralea T S 96.4 macrocarpon corylifolia T R 100.0 Vicia villosa T R 35.5 Raphanus T O 100.0 sesquipedalis raphanistrum Raphanus sativus T R 33.7 Vigna T R 31.6 unguiculata Raphanus sativus T R 28.0 Vinca minor T O 28.7 Raphanus sativus T O 100.0 Withania T O 26.9 somnifera Reseda luteola T S 69.6 Xanthium T O 30.9 strumarium Reseda odorata T O 51.8 Zea mays T R 20.1 Rheum officinale T O 46.7 Zea mays T O 32.2 Rheum officinale T S 100.0

TABLE 2 MMP-2 Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achillea millefolium A S 21.9 Capsicum annuum A R 100.0 Achillea millefolium A O 63.0 Capsicum frutescens A S 66.6 Achillea millefolium A R 100.0 Capsicum frutescens A R 100.0 Aconitum napellus A R 71.0 Carthamus tinctorius A R 21.3 Alcea rosea A R 67.9 Carthamus tinctorius A R 21.5 Alchemilla mollis A O 64.4 Chaerophyllum bulbosom A R 57.2 Allium ascalonicum A R 20.9 Chelidonium majus A S 34.4 Allium cepa A R 84.3 Chenopodium bonus-henricus A R 43.5 Allium grande A R 36.7 Chenopodium bonus-henricus A O 100.0 Allium porrum A O 100.0 Chenopodium bonus-henricus A R 76.4 Allium porum A S 51.9 Chenopodium quinoa A O 92.0 Allium porum A R 66.7 Chrysanthemum coronarium A R 48.6 Allium sativum A R 100.0 Chrysanthemum coronarium A O 49.7 Allium schoenoprasum A R 73.5 Chrysanthemun coronarium A R 47.3 Allium Tuberosum A S 24.3 Chrysanthenum coronarium A R 26.7 Allium Tuberosum A O 83.6 Cicer arietinum A S 22.0 Allium Tuberosum A R 89.3 Cicer arietinum A O 23.6 Aloe vera A R 69.7 Cichorium intybus A S 21.1 Althaea officinalis A S 27.6 Cichorium intybus A R 100.0 Althaea officinalis A R 64.7 Citrullus lanatus A S 65.5 Amaranthus gangeticus A S 29.4 Citrullus lanatus A R 96.3 Anethum graveolens A O 100.0 Citrullus lanatus A O 100.0 Apium graveolens A S 25.1 Coix Lacryma-Jobi A O 32.2 Apium graveolens A R 52.1 Cornus canadensis A S 52.8 Aralia cordata A S 66.4 Cosmos sulphureus A R 72.5 Aralia cordata A R 92.2 Crataegus spp A O 100.0 Aralia nudicaulis A O 29.4 Cryptotaenia canadensis A R 50.6 Arctium minus A S 28.4 Cryptotaenia canadensis A O 51.3 Armoracia rusticana A S 20.2 Cucumis anguria A S 53.4 Armoracia rusticana A O 55.0 Cucumis Anguria A R 84.9 Arrhenatherum elatius A S 40.2 Cucumis melo A R 91.7 Artemisia dracunculus A S 39.7 Cucurbita Maxima A S 34.9 Asparagus officinalis A S 29.3 Cucurbita Maxima A R 41.7 Atnpiex hortensis A R 33.6 Cucurbita moschata A R 36.8 Avena sativa A R 37.2 Cucurbita moschata A S 37.4 Beta vulgaris A S 45.4 Cucurbita pepo A S 48.1 Beta vulgaris A R 95.9 Cucurbita pepo A R 85.7 Beta vulgaris spp. Maritima A R 100.0 Curcuma zedoaria A S 21.0 Brassica chinensis A R 49.6 Curcuma zedoaria A R 32.1 Brassica napus A O 28.5 Curcurbita maxima A S 27.0 Brassica Napus A S 52.4 Cymbopogon citratus A R 34.5 Brassica Napus A R 82.4 Cymbopogon citratus A O 100.0 Brassica nigra A O 29.2 Cymbopogon martinii A S 47.4 Brassica oleracea A R 31.2 Dactylis glomerata A S 20.6 Brassica Oleracea A R 31.4 Dactylis glomerata A O 75.0 Brassica oleracea A R 64.0 Daucus carota A S 44.5 Brassica oleracea A S 68.7 Daucus carota A R 70.5 Brassica oleracea A R 75.3 Dipsacus sativus A O 40.4 Brassica oleracea A O 100.0 Dirca palustris A S 27.2 Brassica rapa A S 27.6 Dolichos Lablab A S 54.2 Brassica rapa A R 33.4 Dryopteris filix-mas A R 76.3 Brassica rapa A O 57.6 Echinacea purpurea A R 42.9 Brassica rapa A R 58.1 Eleusine coracana A S 37.5 Brassica rapa A R 84.5 Eleusine coracana A O 100.0 Calamintba nepeta A O 65.0 Erigeron canadensis A O 45.7 Camellia sinensis A S 21.9 Eruca vesicaria A R 80.2 Camellia sinensis A R 26.5 Eschscholzia californica A S 42.4 Camellia sinensis A O 79.0 Eschscholzia californica A O 75.0 Cana edulis A R 45.5 Eschscholzia californica A R 88.8 Canna edulis A S 20.2 Fagopyrum esculentum A O 100.0 Capsella bursa-pastoris A S 35.5 Fagopyrum tartaricum A R 38.6 capsicum annuum A S 61.5 Fagopyrum tartaricum A S 40.3 Capsicum annuum A O 89.8 Nicotiana tabacum A S 42.5 Fagopyrum tartaricum A O 71.0 Nicotiana tabacum A R 61.1 Filipendula rubra A R 36.3 Nigella sativa A R 81.7 Foeniculum vulgare A R 41.6 Ocimum tenuiflorum A R 23.1 Foeniculum vulgare A S 84.4 Oenothera biennis A R 28.6 Foeniculum vulgare A O 100.0 Origanum majorana A O 52.9 Forsythia intermedia A R 35.8 Origanum majorana A R 100.0 Fragaria x ananassa A R 97.2 Origanum vulgare A O 66.8 Galinsoga ciliata A R 54.0 Panax quinquefolius A S 31.8 Galium odoratum A O 34.3 Pastinaca sativa A S 27.7 Galium odoratum A O 100.0 Pastinaca sativa A R 33.8 Gaultheria hispidula A S 35.8 Petasites japonicus A S 26.2 Gaultheria hispidula A R 100.0 Petroselinum crispum A R 69.1 Glaux maritima A R 46.5 Phalaris canariensis A S 28.4 Glycine max A S 27.0 Phalaris canariensis A R 29.7 Glycine Max A R 43.1 Phalaris canariensis A O 94.3 Glycine max A O 100.0 Phaseolus coccineus A S 30.8 Guizotia abyssinica A S 29.8 Phaseolus coccineus A R 79.5 Guizotia abyssinica A R 32.5 Phaseolus coccineus A O 80.9 Hamamelis virginiana A R 75.7 Phaseolus mungo A R 59.8 Helianthus annuus A R 69.0 Phaseolus vulgaris A S 47.3 Helianthus Tuberosus A R 22.2 Phaseolus Vulgaris A R 74.4 Helianthus tuberosus A R 69.7 Phaseolus vulgaris A R 83.2 Heliantbus Tuberosus A O 100.0 Phaseolus Vulgaris A O 100.0 Hordeum hexastichon A R 22.3 Phlox paniculata A O 23.7 Hordeum hexastichon A R 34.9 Phlox paniculata A R 81.7 Hordeum hexastichon A O 86.9 Physalis alkekengi A R 23.5 Hordeum vulgare A O 74.8 Physalis Ixocarpa A O 85.8 Hordeum vulgare subsp. Vulgare A S 34.5 Physalis ixocarpa A R 91.5 Hordeum vulgare subsp. Vulgare A O 74.2 Physalis Pruinosa A R 25.7 Hyssopus officinalis A O 57.5 Physalis Pruinosa A O 83.5 Inula helenium A S 26.8 Phytolacca decandra A O 31.5 Ipomoea Batatas A S 20.1 Phytolacca decandra A S 38.5 Lathyrus sativus A S 28.7 Pimpinella anisum A S 100.0 Lathyrus sativus A O 100.0 Pimpinella anisum A R 100.0 Lathyrus sylvestris A R 42.4 Plantago coronopus A R 36.0 Lavandula latifolia A O 39.1 Plantago coronopus A R 38.4 Lepidium sativum A O 20.1 Plantago coronopus A O 53.6 Lepidium sativum A S 49.0 Plantago major A R 65.3 Levisticum officinale A S 23.0 Plectranthus sp. A O 74.2 Levisticum officinale A O 29.8 Poa compressa A S 37.3 Linum usitatissimum A R 56.9 Poa compressa A R 49.8 Lolium multiflorum A S 41.5 Poa compressa A O 100.0 Lolium multiflorum A O 92.3 Polygonum pensylvanicum A R 63.5 Lotus comiculatus A O 95.5 Polygonum pensylvanicum A O 72.9 Lotus tetragonolobus A R 76.7 Polygonum persicaria A S 27.5 Lycopersicon esculentum A S 35.3 Polygonum persicaria A O 43.0 Lycopersicon esculentum A R 78.1 Poterium sanguisorba A R 100.0 Lycopersicon esculentum A R 85.6 Poterium Sanquisorba A O 84.2 Lycopersicon pimpinollifolium A R 74.9 Pteridium aquilinum A O 45.1 Malva moschata A S 21.5 Pteridium aquilinum A R 100.0 Malva moschata A O 44.5 Pysalis ixocarpa A R 87.3 Malva verticillata A R 22.0 Raphanus raphanistrum A S 32.2 Matricaria recutita A S 40.9 Raphanus sativus A R 25.3 Matricaria recutita A O 67.3 Raphanus sativus A S 47.5 Melaleuca alternifolia A O 65.0 Raphanus sativus A R 83.5 Melilotus albus A S 50.7 Raphanus sativus A R 84.7 Melilotus albus A O 100.0 Raphanus Sativus A O 100.0 Melissa officinalis A O 42.4 Rheum officinale A O 44.0 Mentha pulegium A O 88.3 Ribes nigrum A O 100.0 Mentha spicata A O 94.8 Ribes nigrum A R 100.0 Mentha suaveotens A O 82.9 Ricinus communis A O 100.0 Nepeta cataria A O 100.0 Rosa rugosa A R 25.2 Nicotiana rustica A S 24.0 Rosa rugosa A S 26.6 Nicotiana rustica A R 100.0 Triticum spelta A R 26.4 Rosa rugosa A O 83.2 Triticum spelta A S 36.7 Rosmarinus officinalis A R 68.2 Triticum spelta A O 51.9 Rubus idaeus A O 81.9 Tropaeolum majus A R 25.8 Rubus ideaus A R 73.4 Urtica dioica A O 22.9 Rumex Acetosa A S 24.2 Urtica dioica A S 30.6 Rumex Acetosa A R 85.5 Vaccinium Corymbosum A R 100.0 Rumex Acetosa A O 100.0 Veratrum viride A R 33.2 Rumex crispus A O 46.7 Verbascum thapsus A S 22.9 Rumex crispus A R 100.0 Veronica beccabunga A R 52.8 Ruta graveolens A O 100.0 Veronica officinalis A R 84.2 Saccharum officinarum A R 80.8 Vicia sativa A R 100.0 Salix purpurea A S 56.7 Vicia villosa A S 32.9 Salvia officinalis A S 24.1 Vicia villosa A R 100.0 Salvia officinalis A O 91.8 Vigna angularis A R 54.0 Salvia sclarea A O 99.7 Vigna sesquipedalis A S 48.3 Santolina chamaecyparissus A O 83.8 Vigna sesquipedalis A R 73.0 Satureja hortensis A O 79.1 Vigna sesquipedalis A O 96.6 Satureja hortensis A R 100.0 Vigna unguiculata A R 70.7 Satureja montana A R 60.4 Vinca minor A S 22.1 Satureja montana A O 76.1 Vinca minor A R 88.4 Scorzonera hispanica A S 22.1 Vitis sp. A S 20.9 Secale cereale A R 47.2 Vitis sp. A R 30.4 Secale cereale A O 67.2 Xanthium sibiricum A S 39.2 Senecio vulgaris A S 23.2 Xanthium sibiricum A R 47.8 Senecio vulgaris A R 76.6 Xanthium sibiricum A O 70.1 Sesamum indicum A R 100.0 Zea mays A R 100.0 Sesamum indicum A S 100.0 Zea Mays A O 100.0 Solanum dulcamara A R 54.5 Abelmochus esculentus G S 21.6 Solanum melanocerasum A S 45.4 Abelmochus esculentus G R 79.3 Solanum melanocerasum A R 85.2 Achillea millefolium G O 62.7 Solanum melanocerasum A O 88.7 Aconitum napellus G O 82.0 Soianum melongena A S 42.5 Acorus calamus G S 100.0 Solanum melongena A R 85.9 Ageratum conyzoides G S 49.3 Sonchus oleraceus A R 25.6 Alcea rosea G R 64.4 Sorghum caffrorum A R 39.6 Alchemilla mollis G S 21.5 Sorghum dochna A S 30.0 Alchemilla mollis G R 30.2 Sorghum dochna A R 48.0 Alchemilla mollis G O 55.7 Sorghum dochna A O 62.0 Allium ampeloprasum G O 36.1 Sorghum durra A R 72.1 Allium ampeloprasum G R 52.8 Sorghum durra A O 94.6 Allium ascalonicum G O 68.9 Sorghum sudanense A O 100.0 Allium cepa G S 40.2 Spinacia oleracea A S 23.6 Allium cepa G R 66.4 Stachys affinis A R 74.4 Allium cepa G O 100.0 Stachys byzantina A R 48.4 Allium grande G R 36.4 Stachys byzantina A O 100.0 Allium sativum G S 29.5 Stellaria graminea A S 20.8 Allium sativum G R 68.4 Stellaria graminea A R 37.5 Allium sativum G O 100.0 Stellaria media A R 49.0 Allium schoenoprasum G S 47.1 Stellaria media A S 50.7 Allium schoenoprasum G R 61.7 Symphytum officinale A R 44.2 Allium tuberosum G S 23.8 Tanacetum cinerariifolium A R 100.0 Allium tuberosum G O 54.5 Tanacetum parthenium A S 30.4 Allium tuberosum G R 85.9 Tanacetum vulgare A S 28.6 Aloe vera G R 53.6 Tanacetum vulgare A R 100.0 Althaea officinalis G S 37.4 Taraxacum officinale A R 59.1 Althaea officinalis G S 42.4 Thymus praecox subsp arcticus A R 43.5 Amaranthus caudathus G S 30.9 Thymus vulgaris A S 30.1 Amaranthus caudathus G O 56.7 Thymus x citriodorus A R 100.0 Amaranthus gangeticus G S 23.1 Trichosanthes kirilowii A S 29.2 Anethum graveolens G S 23.9 Trichosanthes kirilowii A O 42.1 Angelica archangelica G S 22.0 Thgonetta foenumgraecum A O 53.4 Angelica archangelica G S 24.9 Triticosecal spp. A R 44.8 Apium graveolens G O 33.0 Triticum aestivum A R 65.5 Apium graveolens G R 44.8 Triticum durum A O 53.9 Cosmos sulphureus G S 79.4 Apium graveolens G S 54.1 Cucumis sativus G S 39.9 Apium graveolens G R 84.1 Cucumis sativus G S 39.9 Aralia nudicaulis G R 51.8 Cucurbita maxima G S 33.9 Arctium minus G S 25.4 Cucurbita maxima G R 43.4 Armoracia rusticana G O 52.1 Cucurbita maxima G O 100.0 Aronia melanocarpa G S 22.5 Cucurbita moschata G S 41.3 Aronia melanocarpa G R 82.3 Cucurbita pepo G S 42.8 Artemisia dracunculus G R 53.6 Cucurbita pepo G S 45.4 Artemisia dracunculus G R 58.8 Cucurbita Pepo G R 83.0 Artemisia dracunculus G S 100.0 Cuminum cyminum G O 66.2 Artemisia dracunculus G O 100.0 Curcuma zedoaria G R 33.9 Asclepias incarnata G S 26.9 Cymbopogon citratus G R 65.8 Asparagus officinalis G S 24.0 Cymbopogon martinii motia G S 41.4 Asparagus officinalis G R 65.9 Cymbopogon martinii motia G O 60.5 Asparagus officinalis G O 95.0 Dactylis glomerata G S 21.9 Aster spp G O 48.4 Dactylis glomerata G O 61.2 Beckmannia eruciformis G O 24.8 Datura stramonium G S 27.0 Bellis perennis G O 52.6 Daucus carota G O 21.3 Beta vulgaris G S 45.3 Daucus carota G S 31.0 Beta vulgaris G R 100.0 Daucus carota G R 100.0 Beta vulgaris spp. Maritima G R 100.0 Digitalis purpurea G S 30.9 Brassica cepticepa G R 52.9 Dipsacus sativus G O 63.6 Brassica chinensis G R 41.9 Dirca palustris G O 23.1 Brassica juncea G R 22.8 Dolichos Lablab G S 33.0 Brassica Napus G S 22.9 Dryopteris filix-mas G R 100.0 Brassica oleracea G R 45.5 Echinacea purpurea G R 93.4 Brassica oleracea G R 47.1 Eleusine coracana G S 30.0 Brassica oleracea G S 62.9 Erigeron speciosus G S 28.9 Brassica oleracea G R 77.9 Errhenatherum elatius G S 55.6 Brassica oleracea G O 100.0 Eruca vesicaria G R 54.7 Brassica rapa G S 26.5 Eschscholzia carlifornica G S 47.9 Brassica rapa G R 38.9 Eschscholzia californica G O 75.9 Brassica Rapa G R 53.6 Fagopyrum tartaricum G O 41.1 Calamintba nepeta G S 20.4 Filipendula rubra G R 38.5 Calamintba nepeta G O 78.0 Foeniculum vulgare G R 70.0 Cameilia sinensis G O 100.0 Foeniculum Vulgare G S 100.0 Campanula rapunculus G R 60.6 Galinsoga ciliata G S 34.6 Canna edutis G O 78.1 Galinsoga ciliata G R 48.2 Capsella bursa-pastoris G S 30.7 Gaultheria hispidula G R 60.5 Capsella bursa-pastoris G R 60.6 Gaultheria hispidula G 0 100.0 Capsicum annuum G S 70.8 Gaultheria hispidula G S 100.0 Capsicum annuum G O 80.0 Glaux maritima G R 59.3 Capsicum annuum G R 100.0 Glycine max G R 21.1 Capsicum frutescens G S 63.2 Glycine max G S 24.4 Capsicum frutescens G R 100.0 Glycine max G O 28.1 Carthamus tinctorius G R 100.0 Guizotia abyssinica G S 26.0 Centaurea solstilialis G S 46.4 Guizotia abyssinica G R 36.8 Cerastium tomentosum G R 52.3 Guizotia abyssinica G O 100.0 Chenopodium bonus-benricus G S 22.0 Hedeoma pulegioides G O 94.6 Chenopodium quinoa G S 31.0 Helianthus annuus G S 35.5 Chenopodium quinoa G O 53.4 Helianthus annuus G O 75.0 Chrysanthemun coronarium G R 76.2 Helianthus annuus G R 79.9 Chrysanthenum coronarium G R 54.2 Helianthus strumosus G O 100.0 Cicer arietinum G S 23.1 Helianthus tuberosus G R 64.2 Cichorium endivia subsp endivia G S 28.7 Helichrysum thianschanicum G O 61.1 Cichorium endivia subsp endivia G O 68.7 Helleborus niger G R 48.0 Cichorium intybus G S 41.4 Hordeum hexastichon G S 26.8 Cichorium intybus G O 62.1 Hordeum vulgare G O 65.4 Circium arvense G S 25.3 Hordeum vulgare subsp. Vulgare G O 75.8 Circium arvense G R 59.3 Humulus lupulus G S 26.0 Citrullus lanatus G S 24.8 Hypericum henryi G R 20.2 Citrullus lanatus G R 41.1 Hypericum henryi G O 71.1 Citrullus lanatus G R 100.0 Hyssopus officinalis G O 100.0 Cosmos sulphureus G R 77.9 Pastinaca sativa G S 24.3 Ibens amara G S 21.2 Pastinaca sativa G R 90.2 Inula helenium G S 24.3 Petroselinum crispum G R 87.6 Lactuca sativa G R 100.0 Petroselinum crispum G O 100.0 Lactuca serriola G R 69.3 Phalaris canariensis G R 100.0 Laportea canadensis G R 100.0 Phalaris canariensis G O 100.0 Latbyrus sylvestris G O 39.6 Phaseolus acutifolius G R 79.6 Lavandula angustifolia G O 70.0 Phaseolus coccineus G S 28.3 Lavandula latifolia G S 22.7 Phaseolus coccineus G R 80.4 Lepidium Sativum G R 30.6 Phaseolus mungo G R 37.2 Lepidium sativum G S 53.3 Phaseolus vulgaris G R 54.3 Levisticum officinale G O 80.7 Phaseolus vulgaris G S 59.0 Lolium multiflorum G O 34.5 Phaseolus vulgaris G O 73.7 Lotus comiculatus G S 32.9 Phaseolus vulgaris G R 100.0 Lotus comiculatus G O 100.0 Phlox paniculata G R 37.7 Lotus tetragonolobus G R 79.9 Phlox paniculata G O 77.0 Lycopersicon esculentum G S 28.2 Phlox paniculata G R 80.8 Lycopersicon esculentum G R 75.4 Physalis ixocarpa G S 30.5 Lycopersicon pimpinellifolium G R 81.4 Physalis ixocarpa G R 78.3 Malus hupehensis G R 32.5 Physalis ixocarpa G R 80.9 Malus hupehensis G S 41.2 Physalis pruinosa G O 63.2 Malva moschata G O 47.1 Phytolacca americana G S 36.1 Malva sylvestris G S 23.1 Phytolacca americana G O 100.0 Malva verticillata G R 39.9 Pimpinella anisum G S 26.1 Matricaria recutita G O 30.0 Pimpinella anisum G R 30.0 Matricaria recutita G S 71.3 Pisum sativum G S 28.4 Melaleuca alternifolia G O 58.3 Plantago coronopus G R 27.8 Melilotus alba G S 41.1 Plantago coronopus G O 51.1 Melilotus albus G O 88.8 Plantago coronopus G R 67.5 Melilotus albus G R 100.0 Plantago major G S 30.3 Melissa officinalis G O 47.8 Plantago major G O 64.6 Mentha arvensis G R 33.9 Poa compressa G O 63.0 Mentha arvensis G O 63.3 Poa compressa G S 67.4 Mentha piperita G S 32.3 Poa compressa G R 89.0 Mentha piperita G O 85.9 Poa pratensis G S 28.2 Mentha piperita G R 100.0 Polygonum aviculare G R 100.0 Mentha spicata G S 28.9 Polygonum pensylvanicum G S 27.7 Mentha spicata G R 37.5 Polygonum pensylvanicum G O 54.1 Mentha suaveotens G R 25.6 Polygonum persicaria G S 32.0 Mentha suaveotens G O 70.3 Polygonum persicaria G O 35.7 Momordica charantia G R 52.9 Polygonum persicaria G R 100.0 Monarda didyma G S 22.0 Portulaca oleracera G R 51.5 Monarda didyma G O 100.0 Poterium sanguisorba G O 89.9 Monarda fistulosa G O 26.0 Poterium sanguisorba G R 100.0 Nepeta cataria G S 23.4 Poterium sanquisorba G S 23.7 Nicotiana tabacum G S 45.2 Prunella vulgaris G S 26.7 Nigella sativa G R 94.7 Prunus cerasifera G R 95.3 Ocimum basilicum G S 23.0 Raphanus Raphanistrum G R 41.7 Ocimum basilicum G O 100.0 Raphanus Raphanistrum G S 43.5 Ocimum tenuifiorum G R 45.3 Raphanus sativus G R 41.0 Oerothera biennis G R 54.3 Raphanus sativus G S 44.6 Origanum majorana G O 100.0 Raphanus sativus G R 50.5 Origanum majorana G R 100.0 Raphanus sativus G R 86.1 Origanum vulgare G R 93.3 Raphanus sativus G O 100.0 Origanum vulgare G O 93.5 Reseda odorata G O 58.3 Origanum vulgare G S 97.4 Rheum officinale G O 30.7 Oxalis Deppei G S 28.7 Ribes nigrum G O 54.3 Oxalis Deppei G R 87.2 Ribes nigrum G R 63.8 Oxalis Deppei G O 100.0 Ribes Sylvestre G R 100.0 Oxyria digyna G R 54.5 Ricinus communis G R 41.5 Panicum miliaceum G O 71.1 Ricinus communis G O 100.0 Panicum miliaceum G R 100.0 Rosmarinus officinalis G R 90.0 Panicum miliaceum G S 100.0 Rubus idaeus G S 37.1 Passiflora caerula G S 26.3 Rubus ideaus G R 26.6 Passiflora caerula G R 72.1 Thymus vulgaris G S 23.3 Rubus occidentalis G R 35.1 Thymus vulgaris G R 86.4 Rumex crispus G R 30.3 Thymus x citriodorus G R 97.6 Rumex crispus G S 100.0 Tragopogon porrifolius G R 76.2 Rumex patientia G R 41.0 Trichosanthes kirilowii G O 87.7 Rumex patientia G S 41.9 Trigonella foenumgraecum G S 31.0 Ruta graveolens G S 47.9 Trigonella foenumgraecum G O 84.0 Ruta graveolens G R 82.1 Triticosecale spp G S 26.5 Saccharum officinarum G R 100.0 Triticosecale spp G O 73.5 Salvia elegens G O 100.0 Triticum aestivum G R 62.4 Salvia officinalis G S 35.3 Triticum durum G O 51.9 Salvia officinalis G O 100.0 Triticum spelta G S 24.5 Salvia officinalis G R 100.0 Triticum spelta G O 32.9 Sambucus ebulus G R 53.9 Triticum turgidum G O 25.1 Santolina chamaecyparissus G S 36.4 Tropaeolum majus G S 21.3 Santolina chamaecyparissus G O 69.5 Tropaeolum majus G R 45.6 Santolina chamaecyparissus G R 100.0 Urtica dioica G S 21.3 Saponaria officinalis G S 29.8 Urtica dioica G O 100.0 Satureja hortensis G O 97.4 Valerianella locusta G O 32.2 Satureja hortensis G R 100.0 Veratrum viride G R 77.7 Satureja montana G O 59.2 Verbascum thapsus G S 34.0 Satureja repandra G S 35.3 Veronica beccabunga G R 44.1 Satureja repandra G O 66.2 Veronica officinalis G S 38.8 Scorzonera hispanica G S 24.5 Veronica officinalis G R 87.5 Scrophularia nodosa G S 24.5 Viburnum trilobum G O 62.6 Scrophularia nodosa G O 30.0 Vicia faba G S 22.2 Scrophularia nodosa G R 55.6 Vicia sativa G 0 74.8 Scutellaria lateriflora G S 20.3 Vicia sativa G R 100.0 Scutellaria lateriflora G R 83.1 Vicia villosa G R 100.0 Secale cereale G O 51.1 Vigna angularis G R 65.2 Senecio vulgaris G R 42.5 Vigna sesquipedalis G S 35.1 Sesamum indicum G S 34.3 Vigna sesquipedalis G R 73.8 Sesamum indicum G R 44.5 Vigna sesquipedalis G O 100.0 Silene vulgaris G S 34.1 Vigna unguiculata G S 65.9 Sium sisarum G O 100.0 Vigna unguiculata G R 84.5 Solanum melanocerasum G S 40.6 Vinca minor G S 22.1 Solanum melanocerasum G R 85.4 Vitis sp. G R 40.1 solanum melongena G S 58.2 Vitis sp. G O 74.7 solanum melongena G O 83.0 Withania somnifera G S 37.3 solanum melongena G R 85.6 Withania somnifera G O 91.0 Solanum tuberosum G O 40.2 Xanthium sibiricum G S 38.4 Sonchus oleraceus G R 41.1 Xanthium sibiricum G O 100.0 Sorghum dochna G S 25.0 Xanthium strumarium G S 37.7 Sorghum dochna G O 64.3 Xanthium strumarium G O 39.6 Sorghum dochna G R 100.0 Xanthium strumarium G R 40.0 sorghum durra G R 60.1 Zea mays G S 43.3 Sorghum durra G O 100.0 Zea mays G O 64.4 Sorghum sudanense G O 98.0 Zea mays G R 68.3 Spinacia oleracea G S 24.9 Perilla frutescens T R 100.0 Spinacia oleracea G O 100.0 Abies lasiocarpa T S 20.2 Stachys byzantina G R 78.8 Abies lasiocarpa T R 59.1 Stellaria graminea G S 29.3 Achillea millefollum T O 84.7 Stellaria media G S 33.4 Aconitum napellus T O 22.0 Stellaria media G R 45.4 Aconitum napellus T R 100.0 Symphytum officinale G O 57.5 Adiantum pedatum T R 100.0 Tanacetum cinerariifolium G R 100.0 Agaricus bisporus T R 52.1 Tanacetum parthenium G R 28.2 Agaricus bisporus T R 65.6 Tanacetum vulgare G S 25.2 Ageratum conyzoides T S 26.7 Tanacetum vulgare G R 39.3 Agropyron repens T S 30.2 Tanacetum vulgare G O 81.2 Agrostis Stolonifera T O 100.0 Taraxacum officinale G R 51.1 Alces rosea T R 63.7 Thymus fragantissimus G S 29.9 Alchemilla mollis T R 28.6 Thymus fragantissimus G O 55.3 Allium ampeloprasum T R 55.9 Thymus praecox subsp arcticus G S 27.7 Allium ampeloprasum T O 60.4 Thymus serpyllum G R 74.9 Camellia sinensis T R 43.8 Allium ascalonicum T S 20.4 Camellia sinensis T O 66.2 Allium ascalonicum T O 73.4 Canna edulis T O 100.0 Allium cepa T S 33.8 Cantharellus cibarias T S 26.0 Allium cepa T S 35.6 Capsicum annuum T S 54.6 Allium cepa T R 48.0 Capsicum annuum T R 100.0 Allium cepa T R 78.6 Capsicum frutescens T S 60.9 Allium grande T R 32.4 Capsicum frutescens T R 100.0 Allium schoenoprasum T R 67.7 Carex morrowii T R 24.4 Allium tuberosum T S 38.8 Carica papaya T S 20.8 Allium tuberosum T O 82.5 Carthamus tinctorius T R 39.6 Allium tuberosum T R 85.2 Carya cordiformis T R 100.0 Aloe vera T R 74.6 Cerastium tomentosum T R 54.8 Althaea officianalis T S 37.7 Chaerophyllum bulbosum T S 42.2 Althaea officinalis T O 55.3 Chaerophyllum bulbosum T R 74.3 Althaea officinalis T R 72.3 Chelidonium majus T S 20.3 Amaranthus caudathus T O 53.5 Chenopodium quinoa T O 76.0 Amaranthus gangeticus T S 28.1 Chrysanthemum coronarium T S 30.6 Ananas comosus T R 37.9 Chrysanthemum parthenium T R 57.2 Ananas comosus T O 100.0 chrysanthemun coronarium T R 56.5 angelica archangelica T R 41.3 Chrysanthenum coronarium T R 81.6 Anthemis nobilis T O 100.0 Cicer arietinum T O 32.2 Anthemis nobilis T R 100.0 Cichorium endivia subsp endivia T R 27.1 Anthriscus cerefolium T S 21.9 Cichorium endivia subsp. Endivia T S 26.9 Anthriscus cerefolium T O 67.1 Cichorium endivia subsp. Endivia T O 64.5 Apium graveolens T R 35.5 Cichorium intybus T S 22.7 Apium graveolens T R 52.1 Cichorium intybus T R 53.5 Aralia cordata T R 100.0 Cimicifuga racemosa T S 41.1 Aralia nudicaulis T R 31.2 Cimicifuga racemosa T R 68.4 Arctium minus T S 31.3 Circium arvense T S 42.5 Arctium minus T O 73.7 Circium arvense T R 64.5 Armoracia rusticana T O 49.9 Citrullus lanatus T S 72.4 Arrhenatherum elatius T O 100.0 Citrullus lanatus T O 92.2 Artemisia dracunlus T S 100.0 Citrullus lanatus T R 100.0 Asclepias incarnata T S 32.3 Citrus limettoides T O 77.1 Asparagus officinalis T S 48.2 Citrus limon T R 43.6 Atriplex hortensis T R 28.4 Citrus paradisi T S 21.8 Avena sativa T R 31.3 Citrus paradisi T R 90.9 Avena sativa T O 70.6 Citrus sinensis T R 46.7 Avena sativa T R 100.0 Colocasia sp T R 43.4 Averrhoa carambola T R 44.0 Colocasia sp T O 84.3 Bellis perennis T R 82.0 Corchorus olitorius T R 22.7 Beta vulgaris T S 33.7 Corlandrum sativum T S 20.4 Beta vulgaris T R 100.0 Comus canadensis T S 66.0 Betula glandulosa T O 53.5 Cosmos sulphureus T R 47.1 Boletus edulis T S 21.8 Crataegus submollis T S 21.2 Borago officinalis T S 42.3 Crataegus submollis T O 94.3 Borago officinalis T R 78.5 Cucumis anguria T S 49.4 Brassica hirta T R 53.1 Cucumis anguria T R 84.1 Brassica hirta T O 68.9 Cucumis melo T S 56.6 Brassica Napus T S 45.1 Cucumis melo T R 92.4 Brassica Napus T R 82.9 Cucumis melo T O 100.0 Brassica oleracea T R 38.8 Cucumis metuliferus T S 29.5 Brassica oleracea T R 49.7 Cucumis sativus T S 28.3 Brassica oleracea T O 75.5 Cucurbita maxima T S 26.7 Brassica oleracea T R 77.0 Cucurbita maxima T O 34.7 Brassica oleracea T S 77.2 Cucurbita maxima T R 62.1 Brassica rapa T R 25.4 Cucurbita moschata T R 30.7 Brassica rapa T O 37.9 Cucurbita moschata T S 33.4 Brassica rapa T S 47.7 Cucurbita moschata T S 48.3 Brassica rapa T R 64.7 Cucurbita moschata T R 98.8 Brassica rapa T R 81.8 Cucurbita moschata T O 100.0 Calamintba nepeta T O 57.6 Cucurbita pepo T S 45.8 Calendula officinalis T S 32.6 Cucurbita pepo T R 80.2 Camellia sinensis T S 21.0 Helleborus niger T R 23.0 Cucurbita pepo T O 98.9 Hibiscus cannabinus T R 37.9 Cuminum cyminum T O 54.0 Hordeum vulgare T O 75.9 Curcuma zedoaria T S 100.0 Hordeum vulgare supsp vulgare T S 20.5 Cymbopogon citratus T S 21.0 Hordeum vulgare supsp vulgare T O 62.3 Cymbopogon martinii motia T S 27.5 Humulus lupulus T S 44.7 Cynara scoiymus T S 23.1 Humulus lupulus T O 70.6 Cynara scoiymus T O 83.4 Hypericum henryl T O 76.8 Cyperus esculentus T R 100.0 Hypericum henryl T R 99.8 Dactilis Glomerata T S 30.8 Hypericum perforatum T R 38.8 Dactilis Glomerata T O 34.5 Hyssopus officinalis T O 100.0 Daucus carota T S 27.1 Iberis amara T O 100.0 Daucus carota T R 56.8 Juniperus communis T S 100.0 Daucus Carota T O 100.0 Kochia scoparia T S 25.2 Digitalis purpurea T S 38.4 Koeleria glauca T S 23.1 Dirca palustris T S 45.9 Lactuca sativa T R 70.5 Dolichos lablab T S 46.6 Lactuca serriola T R 34.1 Dryopteris filix-mas T O 29.5 Laportea canadensis T R 61.3 Dryopteris filix-mas T R 100.0 Lathyrus sylvestris T R 48.6 Echinacea purpurea T R 59.3 Laurus nobilis T O 73.6 Echinacea purpurea T O 87.8 Lavandula angustifolia T R 35.0 Eleusine coracana T S 28.6 Lavandula angustifolia T O 100.0 Eleusine coracana T R 80.0 Lavandula latifolia T O 77.1 Erigeron canadensis T O 100.0 Lepidium sativum T S 35.2 Eruca vesicaria T R 60.5 Lepidium sativum T R 48.1 Erysimum perofskianum T S 28.2 Lepidium sativum T O 72.9 Erysimum perofskianum T R 85.2 Levisticum officinale T S 38.7 Eschscholzia califomica T S 49.9 Levisticum officinale T O 60.3 Eschscholzia califomica T O 74.5 Linum usitatissimum T R 24.7 Fagopyrum esculentum T O 52.9 Lolium multiflorum T S 39.8 Fagopyrum tartaricum T S 25.6 Lolium multiflorum T O 74.1 Fagopyrum tartaricum T R 68.4 Lonicera ramosissima T S 34.4 Fagopyrum tartaricum T O 100.0 Lonicera ramosissima T O 80.5 Festuca rubra T O 51.6 Lonicera syringantha T R 58.4 Festuca rubra T S 56.6 Lotus cornioulatus T S 36.0 Festuca rubra T R 71.7 Lotus corniculatus T O 100.0 Foeniculum vulgare T S 36.5 Lotus tetragonolobus T R 76.1 Foeniculum vulgare T R 41.4 Lunaria annua T R 47.4 Foeniculum vulgare T O 100.0 Lycopersicon esculentum T R 69.7 Fortunella spp T R 53.9 Lycopersicon pimpinellifolium T R 58.7 Fragaria xananassa T R 28.1 Malus hupehensis T R 53.1 Galinsoga ciliata T S 43.2 Malus hupehensis T S 100.0 Galinsoga ciliata T R 73.3 Malus sp. T R 72.6 Galium odoratum T S 42.0 Malva moschata T O 96.7 Galium odoratum T O 94.2 Malva verticilata T R 35.8 Glaux Maritima T R 24.8 Manihot esculenta T R 53.7 Glycine max T R 37.2 Melaleuca altemifolia T S 21.5 Glycine max T O 100.0 Melaleuca altemifolia T O 78.7 Glycine max T R 100.0 Melilotus albus T R 79.7 Glycine max T S 100.0 Melilotus officinalis T S 34.6 Gossypium herbaceum T R 48.7 Melilotus officinalis T R 100.0 Guizotia abyssinica T S 26.8 Melissa officinalis T O 100.0 Guizotia abyssinica T R 100.0 Mentha piperita T S 24.5 Hedeoma pulegioides T R 20.3 Mentha pulegium T O 100 Hedeoma pulegioides T O 72.7 Mentha suaveolens T O 20.9 Heliantbus annuus T R 56.1 Miscanthus sinensis Andress T S 69.1 Heliantbus strumosus T O 100.0 Momordica charantia T R 54.9 Heliantbus tuberosus T S 25.3 Monarda didyma T S 31.3 Heliantbus tuberosus T R 28.1 Monarda fistulosa T S 21.3 Heliantbus tuberosus T O 78.6 Monarda fistulosa T O 100.0 Heliantbus tuberosus T R 91.5 Montia perfoliata T R 67.2 Helichrysum angustifolium T R 83.4 Musa paradisiaca T R 47.3 Helichrysum angustifolium T S 88.3 nasturtium officinale T S 55.7 Helichrysum thianschanicum T O 26.0 Nepeta cataria T S 20.7 Heliotropium arborescens T R 100.0 Plantago major T S 22.3 Nepeta cataria T S 69.0 Plectranthus sp. T S 59.2 Nepeta cataria T O 100.0 Pleurotus spp T R 26.6 Nicotiana rustica T S 52.8 Poa compressa T S 33.4 Nicotiana rustica T R 88.1 Poa compressa T R 75.7 Nicotiana tabacum T S 50.3 Poa compressa T O 100.0 Nicotians tabacum T R 91.5 Poa pratensis T S 25.4 Nigella sativa T R 34.2 Polygonum pensylvanicum T O 66.8 Nigella sativa T R 90.3 Polygonum pensylvanicum T R 73.3 Nigella sativa T R 100.0 Polygonum persicaria T S 27.1 Ocimum Basilicum T S 21.6 Polygonum persicaria T O 50.8 Ocimum Basilicum T O 100.0 Populus inerassata T O 74.3 Ocimum tenuiflorum T R 44.5 Populus incrassata T S 100.0 Oenothera biennis T R 48.2 Prunus armeniaca T R 55.0 Onobrychis vicHfolia T S 34.4 Prunus cerasus T O 100.0 Onobrychis vicHfolia T O 35.6 Prunus persica T S 26.0 Opunlia sp. T S 23.5 Prunus persica T R 46.2 Origanum vulgare T S 20.7 Psoralea corylifolia T S 47.4 Origanum vulgare T R 76.7 Pteridium aquilnum T R 100.0 Origanum vulgare T O 100.0 Pyrus communis T R 42.9 Oryza sativa T R 60.8 Raphanus raphanistrum T S 24.4 Oxalis Deppei T S 22.2 Raphanus raphanistrum T R 56.9 Oxalis Deppei T R 81.4 Raphanus raphanistrum T O 62.1 Passiflora caerulea T S 36.9 Raphanus raphanistrum T O 100.0 Passiflora caerulea T R 87.0 Raphanus sativus T R 48.9 Passiflora spp T R 54.6 Raphanus sativus T S 59.8 Pastinaca sativa T S 24.8 Raphanus sativus T R 81.6 Pastinaca sativa T R 74.7 Reseda odorata T O 71.3 Perroselinum crispum T R 85.2 Rhamnus frangula T O 44.6 Perroselinum crispum T O 100.0 Rhamnus frangula T R 74.4 Persea americana T R 43.1 Rheum officinale T O 73.9 Petasites Japonious T S 21.9 Rheum officinale T S 100.0 Petroselinum crispum T R 52.8 Ricinus communis T O 100.0 Peucedanum oreaselinum T R 41.9 Rosmarinus officinalis T O 100.0 Phalaris canariensis T R 41.1 Rosmarinus officinalis T R 100.0 Phalaris canariensis T O 100.0 Rubus ideaus T R 78.1 Phaseotus acutifollus T R 88.2 Rumex acetosella T R 42.2 Phaseolus coccineus T S 22.2 Rumex crispus T 0 73.1 Phaseolus coccineus T R 36.4 Rumex patientia T S 52.0 Phaseolus coccineus T R 86.7 Ruta graveolens T S 34.7 Phaseolus coccineus T O 100.0 Ruta graveolens T 0 100.0 Phaseolus mungo T S 43.0 Saccharum officinarum T S 59.6 Phaseolus vulgaris T S 62.9 Saccharum officinarum T R 66.1 Phaseolus vulgaris T R 71.9 Salvia elegans T S 36.3 Phaseolus vulgaris T R 73.0 Salvia elegans T O 44.3 Phaseolus vulgaris T O 100.0 Salvia officinalis T S 28.2 Phlox paniculata T R 23.1 Salvia officinalis T O 100.0 Phlox paniculata T R 92.8 Salvia sclarea T R 38.6 Physalis alkekengi T R 39.5 Sambucus canadensis T S 36.3 Physalis ixocarpa T R 36.7 Sambucus canadensis T R 64.5 Physalis ixocarpa T R 75.9 Sambucus canadensis T O 100.0 Physalis pruinosa T R 65.6 Sanguisorba minor T O 73.1 Physalis pruinosa T R 71.0 Sanguisorba minor T R 100.0 Physalis pruinosa T O 100.0 Santolina chamaecyparissus T 0 27.7 Physalis pruinosa T O 100.0 Santolina chamaecyparissus T R 100.0 Phytolacca decandra T S 39.3 Saponaria officinalis T R 100.0 Phytolacca decandra T O 42.0 Satureja hortensis T O 62.2 Pimpinella anisum T S 27.9 Satureja hortensis T R 100.0 Pimpinella anisum T R 35.8 Satureja montana T S 34.7 Pimpinella anisum T O 49.9 Satureja montana T O 36.3 Pimpinella anisum T R 55.5 Satureja montana T R 100.0 Pisum sativum T S 22.3 Satureja repandra T O 47.0 Plantago coronopus T R 35.2 Satureja repandra T S 47.6 Plantago coronopus T R 46.0 Satureja repandra T R 84.6 Plantago coronopus T O 73.5 Typha latifolia T S 29.2 Scolymus hispanicus T R 35.8 Urtica diolca T S 29.5 Scorzorera hipanica T R 99.4 Vaccinium angustifolium T R 59.4 Scrophularia nodosa T S 29.1 Vaccinium angustifolium T R 100.0 Scrophularia nodosa T R 90.1 Vaccinium macrocarpon T S 51.1 Scrophularia nodosa T O 100.0 Vaccinium macrocarpon T O 64.7 Scutellaria lateriflora T S 30.9 Valerianella locusta T S 22.7 Scutellaria lateriflora T R 63.9 Valerianella locusta T O 24.8 Secaie cereale T O 100.0 Veronica beccabunga T R 33.3 Senecio vulgaris T S 24.7 Veronica officinalis T R 59.2 Senecio vulgaris T R 32.2 Veronica officinalis T O 100.0 Sesamum indicum T R 100.0 Vibumum trilobum T O 71.2 Silene vulgaris T S 25.6 Vicia faba T S 25.5 Sium sisarum T O 81.4 Vicia faba T R 27.0 Sium sisarum T O 100.0 Vicia sativa T O 56.6 Solanum melanocerasum T s 28.0 Vicia villosa T R 100.0 Solanum melanocerasum T R 78.8 Vigna angularis T R 49.2 Solanum melanocerasum T R 99.6 Vigna sesquipedalis T R 77.4 Solanum melongena T S 70.5 Vigna sesquipedalis T O 100.0 Sorghum caffrorum T S 28.1 Vigna unguiculata T S 27.2 Sorghum dochna T R 40.6 Vigna unguiculata T R 59.0 Sorghum dochna T O 100.0 Vinca minor T R 39.2 Sorghum durra T R 29.7 Vitis sp. T R 31.9 Sorghum durra T O 78.9 Vitis sp. T S 36.3 Sorghum sudanense T R 74.6 Vitis sp. T O 72.2 Sorghum sudanense T O 100.0 Weigela coraeensis T S 32.9 Spinacia oleracea T S 28.5 Weigela coraeensis T R 61.5 Spinacia oleracea T O 62.7 Withania somnifera T S 36.1 Stachys byzantina T R 66.9 Withania somnifera T O 83.3 Stachys byzantina T O 100.0 Xanthium sibiricum T S 32.1 Stellaria media T S 21.4 Xanthium sibiricum T R 33.2 Stellaria media T R 87.1 Xanthium sibiricum T O 62.4 Stipa capillata T R 37.5 Xanthium strumarium T S 47.2 Symphytum officinale T O 58.5 Xanthium strumarium T O 74.3 Tanacetum cinerariifolium T O 100.0 Zea mays T R 55.7 Tanacetum cinerariifolium T R 100.0 Zea mays T O 100.0 Tanacetum parthenium T R 100.0 Zingiber officinale T R 79.0 Tanacetum vulgare T R 20.8 Taraxacum officinale T R 76.3 Teucrium chamaedrys T O 75.6 Thalpsi arvense T O 64.1 Thymus fragantissimus T S 21.4 Thymus praecox subsp arcticus T S 36.4 Thymus pseudolanuginosus T S 21.1 Thymus pseudolanuginosus T O 75.4 Thymus serpyllum T O 64.2 Thymus vulgaris T R 71.5 Thymus x citriodorus T S 27.6 Tragopogon porrifolium T S 44.8 Tragopogon porrifolius T O 39.1 Tragopogon porrifolius T R 57.9 Tragopogon sp. T R 20.0 Trifolium repens T R 79.7 Trigonella foenum graecum T O 28.4 Trigonella foenum graecum T S 34.8 Triticosecale spp T S 28.5 Triticosecale spp T O 100.0 Triticum aestivum T R 32.9 Triticum aestivum T O 67.7 Triticum durum T O 47.7 Triticum spelta T O 37.1 Triticum turgidumm T O 41.2 Tropaeolum majus T S 42.7 Tropaeolum majus T R 77.6 Tsuga diversifolia T R 53.4

TABLE 3 MMP-3 Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achillea millefolium A O 21.4 Hypericum perforatum A R 31.7 Allium Tuberosum A S 32.5 Hyssopus officinalis A R 21.6 Anethum graveolens A S 26.0 Iris versicolor A R 53.6 Anthemis nobilis A R 20.3 Isatis tinctoria A S 32.9 Anthemis tinctoria A R 58.0 Levisticum officinale A O 46.7 Apium graveolens A R 34.1 Lotus tetragonolobus A R 26.2 Arctium minus A R 53.9 Matricaria recutita A S 43.5 Arctium minus A O 100.0 Matteucia pensylvanica A R 24.7 Arctostaphylos uva-ursi A S 58.6 Melissa officinalis A S 30.3 Aronia melanocarpa A R 32.2 Mentha suaveolens A R 91.7 Artemisia Absinthium A O 100.0 Nepeta cataria A S 30.3 Artemisia dracunculus A R 23.4 Nigella sativa A O 26.0 Artemisia dracunculus A S 63.0 Ocinum tenuiflorum A O 33.0 Aster sp A O 42.4 Ocinum tenuiflorum A R 49.8 Atropa belladonna A O 23.8 Perilla frutescens A R 34.8 Beta vulgaris A S 24.1 Petasites japonicus A R 38.0 Beta vulgaris A O 42.9 Phaseolus mungo A O 62.6 Beta vulgaris A O 94.3 Phaseolus vulgaris A S 21.2 Beta vulgaris A R 97.9 Phaseolus vulgaris A O 50.6 Beta vulgaris var. condivata A O 21.2 Phaseolus Vulgaris A R 100.0 Brassica napus A S 25.0 Phlox paniculata A S 46.4 Brassica napus A O 100.0 Physalis alkekengi A O 37.5 Brassica oleracea A S 39.9 Plantago major A O 27.3 Canna edulis A S 39.6 Polygonum aviculare linne A S 24.8 Capsicum annuum A S 35.4 Polygonum persicaria A S 59.1 Capsicum frutesoens A S 27.2 Potentilla anserina A R 40.1 Cichorium intybus A O 20.2 Poterium sanguisorba A R 75.7 Cichorium intybus A R 26.5 Prunus cerasifera A R 80.0 Cichorium intybus A S 28.2 Ptaridium aquilinus A R 39.6 Citrullus lanatus A S 21.7 Raphanus raphanistrum A S 28.2 Citrullus lanatus A O 27.8 Raphanus sativus A S 64.4 Citrullus lanatus A R 34.4 Ribes nigrum A O 47.6 Coix Lacryma-Jobi A S 37.3 ribes uva-crispa A R 21.0 Coix Lacryma-Jobi A O 78.1 ribes uva-crispa A O 100.0 Cosmos sulphureus A R 26.8 Rosa rugosa A S 21.4 Crataegus submollis A S 22.3 Rosmarinus officinalis A R 27.3 Crataegus submollis A R 61.6 Rubus allegheniensis A R 81.0 Cucumis anguria A S 27.8 Rubus arcticus A R 51.0 Cucurbita Maxima A S 28.9 Rubus canadensis A R 48.8 Cucurbita moschata A S 32.9 Rubus idaeus A S 28.5 Cucurbita pepo A S 50.9 Rubus idaeus A R 35.1 Datisca cannabina A R 43.3 Rubus pubescens A O 50.4 Datisca cannabina A S 100.0 Rubus thibetanus A O 39.1 Digitalis purpurea A R 20.0 Rumex patientia A S 24.8 Dipsacus sativus A R 64.8 Ruta graveolens A O 56.1 Dirca palustris A S 29.6 Salvia officinalis A R 43.2 Diyopteris filix-mas A R 22.0 Santolina chamaecyparissus A R 27.0 Diyopteris filix-mas A O 32.8 Scutellaria lateriflora A R 53.5 Echinacea purpurea A O 100.0 Solanum melongena A S 21.8 Fagopyrum tataricum A R 28.3 Solidago canadensis A S 27.4 Fagopyrum tataricum A O 29.7 Stachys affinis A S 100.0 Filipendula rubra A S 43.7 Stellaria media A O 24.4 Filipendula rubra A R 63.2 Tanacetum vulgare A R 62.1 Fragaria x A R 41.5 Thymus praecox A S 28.4 ananassa subsp arcticus Fragaria x A S 67.1 Thymus praecox A O 31.8 ananassa subsp arcticus Fragaria x ananassa A O 99.6 Trichosanthes kirilowii A S 23.2 Fragaria x ananassa A R 31.7 Vaccinium Corymbosum A R 100.0 Gaultheria hispidula A R 50.5 Vaccinium macrocarpon A S 48.6 Glycyrrhiza glabra A R 56.2 Vaccinum augustifolium A R 56.6 Hedeoma pulegioides A O 51.7 Vigna angularia A O 23.1 Helianthus tuberosus A O 22.9 Vigna sesquipedalis A O 37.8 Hordeum vulgare subsp vulgare A S 36.0 Vigna unguiculata A S 52.5 Hyperioum henryi A R 67.2 Vinca minor A O 23.2 Vitis sp. A S 20.8 Iris versicolor G R 47.0 Vitis sp. A O 21.5 Isatis tinctoria G S 32.1 Vitis sp. A R 33.6 Lavandula angustifolia G S 43.9 Xanthium sibiricum A S 27.3 Levisticum officinale G O 51.4 Aconitum napellus G O 59.0 Malus hupehensis G S 24.2 Agropyron repens G O 69.4 Malus hupehensis G R 37.2 Alchemilla mollis G S 30.6 Malva sylvestris G O 73.7 Alchemilla mollis G O 73.3 Matricaria recutita G S 31.5 Allium grande G O 33.4 Melaleuca alternifolia G S 21.5 Anethum graveolens G S 40.5 Melissa officinalis G S 32.8 Aronia melanocarpa G O 100.0 Melissa officinalis G R 44.8 Artemisia absinthium G S 31.3 Melissa officinalis G O 82.4 Artemisia absinthium G O 67.9 Mentha piperita G F 77.3 Artemisia dracunculus G S 100.0 Mentha pulegium G R 41.1 Atropa belladonna G S 41.2 Monarda didyma G S 31.8 Bellis perennis G S 48.4 Nepeta cataria G R 25.8 Brassica oleracea G S 26.4 Nepeta cataria G O 84.9 Brassica oleracea G O 40.6 Nigella sativa G O 44.9 Brassica rapa G S 21.4 Ocinum tenuiflorum G R 23.7 Capsicum annuum G S 35.0 Oenothera biennis G S 25.6 Capsicum annuum G S 35.7 Origanum vulgare G S 28.6 Capsicum frutescens G S 27.5 Origanum vulgare G R 31.2 Chelidonium majus G O 34.7 Pennisetum alopecuroides G S 49.9 Cichorium intybus G R 34.4 Petroselinum crispum G S 31.5 Coix Lacryma-Jobi G S 20.2 Peucedanum oreaselinum G R 68.3 Cosmos sulphureus G O 32.9 Phaseolus acutifolius G R 25.4 Crataegus submollis G S 25.6 Phaseolus acutifolius G O 61.8 Crataegus submollis G R 28.6 Phaseolus vulgaris G O 24.4 Cucumis anguria G S 33.6 Phaseolus vulgaris G S 35.6 Cucurbita maxima G S 44.6 Phiox paniculata G S 27.2 Cucurbita moschata G S 33.4 Physalis alkekengi G R 26.1 Cucurbita pepo G S 25.3 Physalis alkekengi G O 54.9 Cymbopogon citratus G S 30.3 Plantago major G O 55.9 Cymbopogon martinii G S 61.1 Plectranthus sp. G R 23.0 Daucus carota G O 30.0 Polygonum persicaria G S 41.1 Diyopteris filix-mas G S 26.0 Potentilla anserina G R 55.4 Diyopteris filix-mas G R 45.3 Poterium sanguisorba G R 76.4 Echinacea purpurea G O 51.8 Prunus cerasifera G R 55.3 Echinochloa frumentacea G S 30.3 Ptaridium aquilinus G R 44.5 Fagopyrum esculentum G R 50.9 Rhaphanus sativus G O 98.1 Fagopyrum tartaricum G O 44.0 Rheum x cultorum G R 27.0 Fagopyrum tartaricum G R 46.0 Ribes nidigrolaria G R 22.0 Filipendula rubra G S 53.1 Ribes Silvestris G R 88.8 Filipendula rubra G R 58.7 Rosmarinus officinalis G R 39.4 Forsythi aintermedia G O 52.9 Rubus idaeus G S 100.0 Fragaria x ananassa G R 40.7 Rubus ideaus G O 37.0 Fragaria x ananassa G R 28.1 Rubus Phoenicalasius G R 24.9 Gaultheria hispidula G R 72.8 Rubus pubescens G O 23.0 Gaultheria hispidula G O 100.0 Rubus thibetanus G O 41.2 Gaultheria procumbens G R 24.1 Rumex patientia G S 36.2 Glycine max G S 31.2 Salvia officinalis G O 34.5 Glycyrrhiza glabra G R 37.1 Salvia officinalis G R 89.5 Gulzotia abyssinica G R 35.4 Sanguisorba officinalis G S 48.8 Hamamelis virginiana G S 29.1 Santolina chamaecyparissus G R 33.7 Hamamelis virginiana G R 67.1 Secale cereals G S 24.4 Helenium hoopesii G R 39.8 Senecio vulgaris G R 37.6 Helianthus tuberosus G O 32.8 Solanum melongena G S 21.1 Hordeum hexastichon G S 60.9 Solanum tuberosum G S 27.6 Humulus lupulus G R 61.2 Sorghum dochna G S 23.7 Humulus lupulus G S 90.5 Sorghum dochna G R 56.3 Hypericum henryi G R 100.0 Symphytum officinale G S 25.2 Hypericum perforalum G R 43.4 Teucrium chamaedrys G S 75.4 Hyssopus officinalis G S 25.1 Thymus praecox subsp arcticus G S 28.4 Hyssopus officinalis G O 48.2 Thymus praecox subsp arcticus G O 52.1 Thymus x citriodorus G R 25.3 Carya cordiformis T R 27.5 Triticum durum G S 21.9 Chaerophyllum bulbosum T S 27.1 Triticum turgidum G O 80.2 Chaerophyllum bulbosum T O 100.0 Vaccinium angustifolium G R 47.6 Chelidonium majus T O 54.0 Vaccinium angustifolium G R 48.1 Chrysanthemum parthenium T S 50.4 Vaccinium angustifolium G R 71.0 Chrysanthemum coronarium T S 25.8 Vaccinium corymbosum G R 60.6 Cichorium intybus T R 23.9 Vaccinium corymbosum G R 61.7 Citrullus lanatus T S 33.2 Vaccinium corymbosum G O 99.4 Citrullus lanatus (Garden baby) T S 21.4 Vaccinium macrocarpon G R 100.0 Citrus limettoides T O 39.2 Vaccinum angustifolium G O 24.4 Citrus limon T O 60.4 Vaccinum angustifolium G R 41.5 Corchorus olitorius T S 28.6 Valeriana officinalis G R 33.5 Comus canadensis L. T O 50.0 Veronica officinalis G S 27.0 Comus canadensis L. T R 80.6 Vicia faba G O 31.2 Cosmos sulphureus T R 20.6 Vicia faba G R 44.7 Cosmos sulphureus T S 27.0 Vigna angularia G O 40.8 Crataegus sp T S 43.9 Vigna angularis G S 39.4 Crataegus submollis T O 24.2 Vigna unguiculata G O 26.1 Crataegus submollis T R 55.1 Vitis sp. G R 62.4 Cucumis anguria T S 33.2 Vitis sp. G S 63.3 Cucumis sativus Fanfare T S 35.4 Vitis sp. G O 82.0 Cucurbita moschata T S 30.4 Withania somnifera G S 22.4 Cucurbita pepo T R 23.8 Xanthium strumarium G S 20.7 Cucurbita pepo T S 46.6 Zea mays G S 26.1 Cuminum cyminum T S 23.1 Zea mays G R 67.5 Curcuma zedoaria T S 20.8 Abies lasiocarpa T R 46.2 Cymbopogon citratus T S 39.7 Acorus calamus T R 21.8 Dolichus lablab T S 25.8 Actinidia arguta T R 64.6 Diyopteris filix-mas T O 54.0 Agropyron repens T O 48.3 Echinacea purpurea T S 20.4 Alchemilla mollis T R 100.0 Eriobotrya japonica T O 34.8 Alchemilla mollis T O 100.0 Eriobotrya japonica T S 42.9 Allium cepa T R 39.8 Foericulum vulgare T O 33.1 Allium cepa T O 45.2 Fragaria x ananassa T S 20.3 Allium tuberosum T R 28.2 Fragaria x ananassa T R 42.8 Allium tuberosum T S 28.8 Glycine max T O 26.3 Alpinia officinarum T S 26.4 Glycine max T O 30.5 Amelanchier alnitolia T R 78.3 Gossypium herbaceum T R 22.5 Amelanchier sanguinea xA. laevis T R 66.5 Guizotia abyssinica T R 46.6 angelica archangelica T S 25.2 Hamamelis virginiana T S 33.1 Apium graveolens T R 43.3 Hamamelis virginiana T S 33.1 Aralia cordata T S 31.5 Hamamelis virginiana T R 44.8 Aralia nudicaulis T S 37.7 Hedeoma pulegiodes T O 46.8 Aralia nudicaulis T R 48.5 Helenium hoopesii T R 27.9 Aronia melanocarpa T S 26.0 Helianthus annus T S 22.7 Aronia melanocarpa T O 53.3 Helianthus strumosus T O 30.0 Aronia prunifolia T R 79.2 Heliotropium arborescens T O 53.7 Artemisia absinthium T O 100.0 Helleborus niger T S 40.5 Artemisia dracunlus T S 42.0 Hibiscus cannabinus T O 34.0 Ayperus esculentus T O 67.8 Hordeum vulgare subsp. Vulgare T O 100.0 Beta vulgaris T R 27.9 Humulus lupulus T S 24.9 Beta vulgaris T S 33.2 Humulus lupulus T R 55.1 Beta vulgaris T O 53.0 Humulus lupulus T R 77.6 Borago officinalis T O 55.7 Humulus lupulus T S 79.1 Brassica Napus T O 71.9 Humulus lupulus T S 100.0 Brassica oleracea T O 37.0 Humulus lupulus T R 100.0 Brassica oleracea T S 46.9 Humulus lupulus T S 100.0 Brassica rapa T S 36.7 Hypericum henryl T R 100.0 Bromus inermis T R 42.8 Hypericum perforatum T O 99.3 Calendula officinalis L. T S 28.4 Hypomyces lactillorum T O 20.5 Camellia sinensis syn. Thea sinensis T R 86.4 Iris versicolor T R 48.5 Capsicum annus T S 29.7 Juniperus communis T R 33.8 Capsicum annus T R 43.7 Lactuca serriola T R 21.5 Capsicum frutescens (tabasco) T S 22.0 Laportea canadensis T S 37.7 Lavendula angustifolia T S 91.7 Rosmarinum officinalis T R 48.2 Lepidium sativum T R 24.7 Rubus arotious T R 59.1 Levisticum officinale T O 24.9 Rubus ideaus T O 21.5 Lolium perenne T S 22.3 Rubus pubescens T O 51.8 Lonicera ramosissima T R 42.5 Rubus thibetanus T O 33.7 Lonicera syringantha T R 21.1 Rumex patientia T S 34.4 Malus T O 53.1 Ruta graveolens T O 24.3 Malus hupehensis (Pamp.) Rehd. T R 76.5 Salvia (elegens) T O 37.2 Malus sp. T R 39.8 Salvia (elegens) T R 42.9 Malus sp. T R 45.7 Salvia officinalis T R 67.3 Malva moschata T S 22.8 Sambucus canadensis T S 30.2 Malva sylvestris T O 57.6 Sanguisorba minor T R 21.0 Matteucia pensylvanica T R 20.1 Sanguisorba minor T R 29.9 Melissa officinalis T O 55.0 Sanguisorba minor T R 30.8 Mentha piperita T R 35.5 Sanguisorba minor T R 44.5 Mentha piperita T 0 43.9 Santolina T R 43.8 Mentha piperita T R 56.6 Sarratula tinctoria T S 37.7 Mentha pulegium T O 33.3 Satureja montana T R 45.0 Mentha pulegium T R 56.2 Satureja repandra T S 46.3 Mentha spicata hipanica T O 43.4 Scorzorera T R 25.7 Mentha spicata T O 58.0 Scuttellaria lateriflora T S 41.2 Nicotiana tabacum T R 27.3 Setaria italica T S 33.4 Nigella sativa T R 25.1 Solidago canadensis T S 78.5 Ocimum Basilicum T R 20.2 Stachys affinis T S 100.0 Oenothera bienris T S 37.8 Stachys byzantina T O 100.0 Origanum marjonara T R 45.2 Stellaria media (linne) Cyrillo T O 51.2 Origanum vulgare T S 21.3 Tanacetum vulgare T R 30.5 Origanum vulgare T O 23.3 Tepary T R 31.7 Origanum vulgare T R 23.6 Tepary T O 39.7 Origanum vulgare T O 37.2 Thymus serpyllum T O 29.9 Panicum miliaceum T S 20.6 Thymus serpyllum T R 32.6 Panicum miliaceum T S 30.7 Thymus x citriodorus T S 22.1 Pastinaca saliva T R 26.1 Tiarella cordifolia T R 46.8 Pastinaca sativa T O 100.0 Tragopogon porrifolium T R 26.3 Peucedanum oreaselinum T S 39.6 Tragopogon porrifolium T R 29.8 Peucedanum oreaselinum T R 53.4 Tragopogon porrifolium T O 58.0 Phaseolus vulgaris T S 21.8 Triticale sp. T O 25.3 Phaseolus vulgaris T O 23.6 Tropaeolum majus T O 46.9 Phaseolus vulgaris T O 59.8 Tropaeolum majus T O 55.8 Physalis alkekengi T O 55.5 Tropaeolum majus T R 64.7 Physalis pruinosa T S 24.8 Tsuga canOadensis T R 39.2 Plantago major T O 77.1 Vaccinium angustifolium T R 28.0 Poa compressa T R 54.4 Vaccinium angustifolium T S 29.6 Polygonium chinense T O 36.3 Vaccinium angustifolium T R 33.3 Polygonium chinense T R 61.4 Vaccinium angustifolium Ait. T R 100.0 Polygonium persicaria T S 21.3 Vaccinium macrocarpon T S 25.1 Populus incrassata T S 50.7 Vaccinium macrocarpon T R 27.4 Populus incrassata T S 50.7 Vaccinium macrocarpon T O 35.4 Populus x petrowskyana T R 66.7 Vaccinium macrocarpon T R 80.5 Prunus cerasifera T O 26.1 Vaccinium macrocarpon T O 90.5 Prunus cerasifera T R 64.2 Valeriana officinalis T 0 33.0 Psidium guajaba T S 22.9 Veratrum viride T S 46.8 Ptaridium aquilinus T R 43.0 Verbascum thapsus T O 33.4 Pyrus pyrifolia T S 28.2 Vicia faba T R 26.6 Rahmnus frangula T R 25.9 Vicia faba T O 35.8 Raphanus sativus T R 21.4 Vigna angularia T S 29.3 Raphanus sativus T O 36.9 Vigna angularia T O 54.0 Rhamnus frangula T O 43.2 Vigna sesquipedalis T O 100.0 Rheum rhabarbarum T O 28.5 Vigna ungulculata T S 49.5 Rheum x cultorum T R 28.2 Vitia sp. T O 99.6 Rianus communis T S 32.4 Vitis sp T R 50.9 Ribes nidigrolaria T S 28.5 Vitis sp. T R 75.8 Ribes nigrum T R 49.9 Weigela coracensis T S 22.8 Rosa rugosa T S 29.1 Weigela coracensis T S 22.8 Weigela hortensis T R 54.9 Zea mays T O 74.3

TABLE 4 MMP-9 Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Abelmochus esculentus A S 26.8 Brassica napus A R 53.1 Achillea millefolium A S 41.6 Brassica napus A O 100.0 Aconitum napellus A O 47.7 Brassica nigra A S 24.2 Acorus calamus A O 83.2 Brassica oleracea A R 33.0 Actinidia arguta A S 26.8 Brassica oleracea A R 36.0 Adiantum pedatum A O 20.7 Brassica oleracea A W 36.2 Agastache foeniculum A S 100.0 Brassica oleracea A S 73.1 Agrimonia eupatoria A W 21.4 Brassica Oleracea A O 100.0 Agropyron cristatum A R 51.4 Brassica rapa A R 31.0 Agropyron repens A S 27.3 Brassica rapa A W 38.6 Agrostis alba A R 40.6 Brassica rapa A V 42.8 Agrostis Stofonifera A R 35.4 Brassica rapa A R 48.8 Alcea rosea A S 45.8 Brassica rapa A S 68.2 Alkanna tinctoria A S 42.5 Brassica rapa A O 89.2 Allium cepa A O 49.7 Bromus inermis A R 51.4 Allium grande A R 71.4 Campanula rapunculus A O 25.1 Allium porrum A S 28.0 Canna edulis A S 31.1 Allium porrum A O 82.0 Canna edulis A O 47.6 Allium sativum A S 23.7 Canna edulis A R 68.9 Allium schoenoprasum A O 45.5 Capsella bursa-pastoris A R 32.5 Allium tuberosum A V 20.1 Capsicum annuum A O 22.0 Allium Tuberosum A O 91.5 Capsicum annuum A R 24.0 Althaea officinalis A S 29.6 capsicum annuum A S 55.7 Amaranthus gangeticus A O 25.1 Capsicum frutescens A S 30.3 Amaranthus gangeticus A R 31.1 Capsicum frutescens A O 34.7 Amaranthus gangeticus A S 73.2 Carthamus tinctorius A R 28.5 Amaranthus retroflexus A S 20.4 Carum carvi A S 38.6 Ambrosia artemisiifolia A R 50.1 Chelidonium majus A O 27.9 Amelanchier sanguinea A W 37.6 Chenopodium bonus-henricus A R 47.4 Anthemis nobilis A O 40.4 Chenopodium bonus-henricus A O 20.7 Anthemis nobilis A R 66.7 Chenopodium bonus-henricus A W 23.2 Anthemis tinctorium A S 30.3 chenopodium bonus-henricus A S 62.8 Apium graveolens A R 71.2 Chenopodium quinoa A V 23.1 Arachis hypogaea A V 23.5 Chenopodium quinoa A W 34.7 Aralia cordata A S 21.2 Chrysanthemum leucanthemum A O 20.6 Aralia cordata A S 56.3 Chrysanthemum leucanthemum A R 30.9 Arctium minus A R 31.1 Chrysanthemun coronarium (Chp Suey) A R 26.4 Arctostaphylos uva-ursi A S 31.2 Chrysanthemum coronarium A S 66.6 Arctostaphylos uva-ursi A O 31.2 Cichorium intybus A S 44.7 Arctostaphylos uva-ursi A R 59.7 Citrullus lanatus A S 62.1 Armoracia rusticana A W 25.1 Citrullus lanatus A O 70.6 Armoracia A S 56.2 Cornus A S 48.5 rusticana canadensis Aronia melanocarpa A S 26.8 Cosmos sulphureus A S 23.4 Aronia melanocarpa A S 41.3 Cosmos sulphureus A O 37.0 Aronia melanocarpa A O 44.8 Crataegus sp A V 32.4 Aronia melanocarpa A W 47.7 Crataegus sp A S 45.5 Aronia melanocarpa A R 55.7 Crataegus sp A R 100.0 Aronia melanocarpa A V 100.0 Crataegus submollis A S 45.5 Arrhenatherum elatius A R 40.4 Cryptotaenia canadensis A W 26.4 Artemisia dracunculus A S 51.1 Cucumis Anguria A R 27.2 Asparagus officinalis A S 20.9 Cucumis anguria A S 36.6 Asparagus officinalis A S 32.6 Cucumis anguria A O 38.5 Aster sp A O 29.5 Cucumis melo A O 59.2 Aster sp A R 80.0 Cucumis sativus A R 39.8 Atropa belladonna A S 47.4 Cucumis sativus A O 49.4 Beta vulgaris A S 25.3 Cucumis sativus A S 54.4 Beta vulgaris A R 26.6 Cucurbita Maxima A O 46.7 Beta vulgaris A W 34.0 Cucurbita moschata A S 32.1 Beta vulgaris A O 42.0 Cucurbita pepo A O 37.0 Beta vulgaris A V 44.0 Curburbita pepo A R 41.0 Beta vulgaris spp. A R 44.0 Curburbita A S 43.9 Maritima pepo Beta vulgaris var. A R 35.4 Curcuma A S 67.6 condivata zedoaria Brassica napus A S 24.6 Levisticum officinale A O 44.9 Curcurbita maxima A S 25.8 Linaria vulgaris miller A O 23.6 Cymbopogon citratus A O 26.7 Linum usitatissimum A R 33.3 Dactylis glomerata A R 27.2 Lolium multiflorum A S 29.0 Datisca cannabina A S 26.9 Lolium perenne A R 52.0 Datisca cannabina A O 38.0 Lotus comiculatus A R 62.9 Daucus carota A R 30.8 Lotus tetragonolobus A S 62.9 Daucus carota A O 31.9 Lycopersicon esculentum A S 26.1 Dirca palustris A O 27.3 Lycopersicon esculentum A W 33.0 Dirca palustris A S 34.2 Malva moschata A S 31.8 Dolicos Lablab A S 22.0 Malva sylvestris A S 21.4 Dolicos Lablab A R 25.3 Malva verticillata A R 43.4 Diyopteris filix-mas A S 24.9 Matteucia pensylvanica A R 26.9 Diyopteris filix-mas A R 40.6 Medicago sativa A V 20.4 Eleusine coracana A S 20.2 Melilotus albus A R 53.9 Eleusine coracana A R 20.9 Melissa officinalis A S 21.4 Eleusine coracana A O 71.1 Melissa officinalis A O 36.8 Elymus junceus A R 45.4 Melissa officinalis A R 53.7 Erigeron canadensis A S 35.7 Mentha piperita A S 57.7 Eruca vesicaria A R 59.9 Mentha pulegium A S 66.1 Fagopyrum esculentum A V 20.7 Mentha spicata A S 67.7 Fagopyrum tartaricum A W 30.3 Mentha suaveolens A S 51.8 Fagopyrum tartaricum A O 33.2 Momordica charantia A R 29.7 Festuca rubra A R 31.8 Momordica charantia A S 72.1 Foeniculum Vulgare A W 27.4 Nicotiana rustica A O 30.3 Foeniculum vulgare A O 50.6 Nicotiana rustica A S 59.1 Forsythia intermedia A O 100.0 Nicotiana tabacum A S 39.0 Fragaria x ananassa A V 30.0 Nicotiana tabacum A W 47.6 Fragaria x ananassa A S 36.3 Nicotiana tabacum A O 100.0 Galium odoratum A R 26.9 Nigella sativa A R 59.4 Gaultheria hispidula A R 28.4 Oenothera biennis A O 21.3 Gaultheria hispidula A S 40.7 Oenothera biennis A O 36.7 Gentiana lutea A R 34.7 Origanum vulgare A W 21.3 Glechoma hederacea A S 37.6 Origanum vulgare A V 42.7 Glycine max A R 38.1 Oryza sativa A W 56.5 Glycine Max A O 56.4 Oxyria digyna A W 35.1 Glycine max A S 71.4 Oxyria digyna A V 76.4 Glycyrrhiza glabra A S 62.6 Pastinaca sativa A V 20.3 Glycyrrhiza glabra A W 100.0 Pastinaca sativa A W 23.2 Guizotia abyssinica A R 91.9 Pastinaca sativa A O 42.1 Hamamelis virginiana A S 41.0 Pastinaca sativa A R 46.9 Hamamelis virginiana A R 74.6 Phalaris canariensis A R 20.3 Hedeoma pulegioides A O 22.0 Phalaris canariensis A O 80.5 Helianthus tuberosus A W 21.2 Phaseolus mungo A O 51.3 Helianthus tuberosus A W 51.5 Phaseolus mungo A S 74.1 Helichrysum A V 21.0 Phaseolus A V 23.0 angustifolium vulgaris Heliotropium arborescens A S 54.1 Phaseolus vulgaris A O 51.4 Helleborus niger A S 37.8 Phaseolus vulgaris A S 62.6 Hordeum hexastichon A W 38.0 Phlox paniculata A O 41.0 Hyssopus officinalis A O 25.1 Physalis alkekengi A R 31.6 Inula helenium A S 29.7 Physalis ixocarpa A S 45.2 Isatis tinctoria A S 41.5 Physalis ixocarpa A O 65.3 Lactuca serrila A R 41.3 Physalis Pruinosa A O 87.3 Lactuca serriola A S 46.6 Phytolacca americana A S 49.6 Laportea Canadensis A S 26.3 Phytolacca americana A O 89.8 Lathyrus sativus A O 22.2 Pimpinella anisum A S 100.0 Lathyrus sativus A R 50.2 Plantago coronopus A S 48.3 Lathyrus sylvestris A V 31.3 Plantago coronopus A O 89.3 Lathyrus sylvestris A W 31.8 Plantago major A S 21.8 Laurus nobilis A S 25.7 Poa compressa A R 22.4 Laurus nobilis A V 30.0 Poa compressa A S 49.3 Lavandula latifolia A S 40.3 Poa pratensis A R 22.4 Leonurus cardiac A R 27.0 Polygonum pensylvanicum A S 43.3 Lepidium sativum A S 41.8 Polygonum persicaria A O 21.6 Levisticum officinale A S 29.0 Sium Sisarum A R 32.6 Polygonum persicaria A S 38.5 Sium Sisarum A O 42.7 Potentilla anserine A S 26.3 Solanum dulcamara A S 43.3 Potentilla anserine A O 31.2 Solanum dulcamara A O 48.6 Poterium Sanquisorba A S 29.2 Solanum melanocerasum A O 21.3 Pteridium aquilinum A S 27.3 Solanum melongena A R 20.5 Raphanus sativus A W 22.7 Solanum melongena A V 35.6 Raphanus sativus A R 30.8 Solanum melongena A O 49.4 Raphanus sativus A R 40.2 Solanum melongena A S 65.2 Raphanus sativus A S 71.5 Solidago sp A R 32.7 Raphanus sativus A O 100.0 Spinacia oleracea A S 41.0 Rheum rhabarbarum A S 21.3 Stachys affinis A R 22.5 Rheum rhabarbarum A V 67.9 Stachys affinis A S 43.9 Rheum rhabarbarum A W 72.4 Stachys affinis A O 92.0 Ribes nidigrolaria A W 32.6 Symphytum officinale A S 28.0 Ribes nidigrolaria A V 64.6 Tanacetum cinerariifolium A O 20.3 Ribes nigrum A W 23.6 Tanacetum cinerariifolium A R 69.7 Ribes nigrum A V 27.2 Tanacetum vulgare A O 20.2 Ribes nigrum A S 41.0 Tanacetum vulgare A S 84.2 Ribes nigrum A O 65.8 Teucrium chamaedrys A O 20.4 Ribes Nigrum A W 100.0 Teucrium chamaedrys A R 20.4 Ribes Salivum A R 75.4 Thymus serpyllum A W 24.3 Ribes Sylvestre A V 27.7 Thymus vulgaris A S 42.5 Ribes Sylvestre A W 100.0 Thymus x citriodorus A W 27.4 ribes uva-crispa A S 24.4 Tragopogon porrifolius A W 21.9 Ribes Uva-crispa A W 36.6 Tragopogon porrifolius A V 26.2 Ricinus communis A R 21.6 Trifolium hybridum A R 30.9 Rosa rugose A V 30.6 Trifolium pannonicum A R 41.0 Rosa rugose A S 36.2 Trifolium repens A R 51.3 Rosa rugose A W 39.3 Trigonella foenum graecum A S 44.2 Rosmarinus officinalis A W 27.2 Triticum spelta A S 30.0 Rosmarinus officinalis A R 45.7 Triticum turgidum A S 31.3 Rubus allegheniensis A S 53.7 Typha latifolia A S 57.7 Rubus Canadensis A V 27.0 Urtica dioica A O 26.5 Rubus Canadensis A S 41.0 Urtica dioica A S 50.2 Rubus Canadensis A W 41.2 Vaccinium Corymbosum A W 39.9 Rubus Canadensis A S 45.1 Vaccinium Corymbosum A S 64.8 Rubus idaeus A V 24.3 Vaccinum augustifolium A R 44.8 Rubus idaeus A S 39.7 Vaccinum macrocarpon A S 100.0 Rubus idaeus A W 62.2 Veratrum virid A S 29.1 Rubus ideaus A R 37.0 Veratrum viride A O 31.8 Rumex acetosella A V 75.8 Verbascum thapsus A S 42.6 Rumex acotosa A W 25.5 Verbascum thapsus A O 75.2 Rumex crispus A R 73.3 Viburnum trilobum A V 97.4 Rumex crispus A O 60.5 Vicia sativa A R 53.3 Rumex patientia A O 49.4 Vicia villosa A R 48.9 Rumex patientia A S 65.8 Vigna unguiculata A R 27.0 Rumex Scutatus A W 25.5 Vigna unguiculata A O 44.8 Rumex Scutatus A V 61.9 Vigna unguiculata A S 55.5 Rumex Scutatus A O 93.8 Vinca minor A S 35.1 Ruta graveolens A S 25.8 Vitis sp. A V 52.2 Ruta graveolens A W 27.1 Vitis sp. A S 59.6 Salix purpurea A S 22.1 Vitis sp. A R 87.8 Salix purpurea A R 33.8 Xanthium sibiricum A S 57.1 Salvia elegans A W 23.7 Zea mays A V 26.1 Salvia officinalis A V 20.8 Zea mays A W 32.1 Salvia officinalis A S 31.4 Zea Mays A O 38.7 Salvia sclarea A S 28.0 Achillea millefolium G S 45.5 Satureja montana A W 21.7 Aconitum napellus G S 24.0 Scuttellaria lateriflora A S 54.1 Aconitum napellus G O 53.9 Secale cereale A V 22.6 Acorus calamus G O 87.6 Secale cereale A S 22.9 Acorus calamus G S 100.0 Secale cereale A W 26.9 Actinidia arguta G S 33.8 Sesamum indicum A O 21.2 Adiantum pedatum G R 31.6 Setaria italica A O 27.0 Brassica oleracea G S 76.1 Adiantum pedatum G S 31.7 Brassica oleracea G O 100.0 Ageratum conyzoides G S 23.1 Brassica rapa G R 21.1 Agropyron cristatum G R 64.1 Brassica rapa G S 64.0 Agropyron repens G S 29.2 Brassica rapa G O 100.0 Agropyron repens G O 32.6 Bromus inermis G R 36.7 Agrostis Stolonifera G R 34.4 Campanula rapunculus G O 59.9 Alcea rosea G S 22.7 Canna edulis G O 20.8 Alchemilla mollis G S 30.5 Canna edulis G O 83.1 Alchemilla mollis G W 33.2 Capsicum annuum G R 20.2 Allium ampeloprasum G O 53.4 Capsicum annuum G S 29.6 Allium cepa G S 22.5 Capsicum annuum G O 51.5 Allium cepa G O 60.7 Capsicum annuum G S 60.8 Allium schoenoprasum G S 21.1 Capsicum frutescens G S 32.8 Allium schoenoprasum G O 60.4 Carthamus tinctorius G R 29.8 Allium tuberosum G S 38.8 Carum carvi G S 30.4 Allium tuberosum G O 74.4 Chelidonium majus G O 39.9 Althaea officianalis G S 54.9 Chenopodium bonus-henricus G O 63.0 Amaranthus candathus G O 42.6 Chenopodium quinoa G O 34.1 Amaranthus caudathus G W 27.1 Chenopodium quinoa G W 42.8 Amaranthus gangeticus G S 56.8 Chenopodium quinoa G V 46.1 Amaranthus gangeticus G S 74.4 Chichorium endivia subsp endivia G W 22.0 Ambrosia artemisiifolia G R 49.0 Chichorium endivia subsp endivia G S 22.9 Amelanchier sanguinea G W 45.2 Chrysanthemum coronarium G R 23.2 Angelica archangelica G S 20.9 Chrysanthemum coronarium G S 68.4 Anthemis nobilis G R 58.9 Chrysanthemum leucanthemum G R 20.5 Apium graveolens G O 30.4 Cicer arietinum G S 25.7 Apium graveolens G S 36.4 Cichorium intybus G W 51.1 Apium graveolens G R 60.6 Cichorium intybus G S 53.4 Arachis hypogaea G W 26.0 Citrullus lanatus G S 36.5 Aralia cordata G S 66.0 Citrullus lanatus G O 71.5 Arctium minus G O 26.6 Coix Lacryma-Jobi G O 21.0 Arctium minus G R 30.8 Cornus canadensis G S 34.8 Arctostaphylos uva-ursi G S 29.3 Crataegus sp G W 54.0 Arctostaphylos uva-ursi G 0 38.8 Crataegus submollis G S 31.3 Arctostaphylos uva-ursi G R 80.2 Cryptotaenia canadensis G W 32.1 Armoracia rusticana G S 62.7 Cucumis anguria G S 27.3 Aronia melanocarpa G O 26.7 Cucumis anguria G O 32.5 Aronia melanocarpa G V 100.0 Cucumis sativus G O 39.4 Aronia melanocarpa G R 100.0 Cucumis sativus G S 69.4 Aronia melanocarpa G W 39.1 Cucurbita G O 34.1 (Michx.) Ell. maxima Artemisia dracunculus G O 44.3 Cucurbita maxima G S 42.6 Artemisia dracunculus G S 65.4 Cucurbita moschata G S 32.0 Asclepias incarnata G R 20.3 Cucurbita moschata G O 39.2 Asparagus officinalis G O 22.3 Cucurbita pepo G S 28.8 Asparagus officinalis G S 26.6 Cucurbita pepo G O 32.6 Asparagus officinalis G W 28.7 Curcuma zedoaria G O 23.3 Aster sp G O 34.3 Curcuma zedoaria G S 57.6 Aster sp G R 62.6 Cymbopogon citratus G O 70.1 Atropa belladonna G S 34.9 Cynara scolymus G S 20.2 Beta vulgaris G R 28.3 Cynara scolymus G O 37.5 Beta vulgaris G R 42.2 Cynara scolymus G R 88.7 Beta vulgaris G O 47.0 Cyperus esculentus G S 66.7 Beta vulgaris spp. Maritima G O 46.7 Datura metel G S 29.2 Brassica cepticepa G R 26.7 Datura stramonium G O 27.6 Brassica cepticepa G S 68.3 Daucus carota G O 24.2 Brassica juncea G O 45.0 Daucus carota G R 29.3 Brassica juncea G S 66.1 Dipsacus sativus G S 48.7 Brassica Napus G S 27.5 Dirca palustris G O 29.9 Brassica Napus G R 37.6 Dirca palustris G S 36.4 Brassica napus G O 94.8 Dolichos Lablab G S 35.8 Brassica nigra G S 36.4 Dolichos Lablab G R 74.5 Brassica oleracea G R 38.7 Diyopteris filix-mas G S 27.9 Brassica oleracea G W 39.0 Diyopteris filix-mas G R 42.6 Brassica oleracea G R 49.4 Leonurus cardiaca G O 22.6 Echinochloa frumentacea G O 68.4 Lepidium sativum G S 23.3 Eleusine coracana G O 47.8 Levisticum officinale G S 23.1 Elymus junceus G R 42.7 Levisticum officinale G W 27.5 Erigeron canadensis G S 37.8 Levisticum officinale G O 41.3 Erigeron speciosus G R 34.6 Linum usitatissimum G R 21.4 Errhenatherum elatius G R 34.4 Lolium perenne G R 32.7 Fagopyrum tartaricum G W 31.4 Lotus comiculatus G R 54.2 Foeniculum vulgare G W 28.0 Malus hupehensis G R 26.4 Foeniculum vulgare G S 44.6 Malva verticillata G R 37.9 Foeniculum vulgare G O 68.9 Matricaria recutita G O 50.3 Foeniculum Vulgare G R 100.0 Medicago sativa G W 29.1 Forsythia intermedia G O 100.0 Melilotus albus G R 52.1 Forsythia x Intermedia G O 79.5 Melissa officinalis G O 22.7 Galium odoratum G S 32.4 Melissa officinalis G S 35.9 Galium odoratum G R 100.0 Melissa officinalis G R 38.6 Gaultheria hispidula G R 48.4 Mentha piperita G S 64.4 Gaultheria hispidula G S 80.4 Mentha suaveolens G W 22.5 Gaultheria hispidula G O 100.0 Momordica charantia G R 29.3 Gaultheria procumbens G S 26.9 Momordica charantia G S 90.6 Gaultheria procumbens G W 54.3 Nepeta cataria G R 50.5 Glechoma hederacea G S 26.6 Nicotiana rustica G O 35.3 Glycine max G R 52.5 Nicotiana rustica G S 100.0 Glycine max G O 67.9 Nicotiana tabacum G S 31.6 Glycine max G O 75.8 Nicotiana tabacum G O 100.0 Glycyrrhiza glabra G R 21.4 Nigella sativa G R 24.2 Glycyrrhiza glabra G V 21.6 Ocimum basilicum G S 30.6 Glycyrrhiza glabra G W 100.0 Oenothera biennis G O 48.0 Guizotia abyssinica G R 91.4 Oenothera biennis G R 76.6 Hamamelis virginiana G O 39.8 Origanum vulgare G V 41.3 Hamamelis virginiana G R 78.8 Oryza Saliva G O 22.1 Hamamelis virginiana G S 96.6 Oxyria digyna G O 26.5 Hedeoma pulegioides G S 45.4 Oxyria digyna G V 70.3 Helenium hoopesii G S 22.6 Panicum miliaceum G O 94.4 Helenium hoopesii G O 52.8 Pastinaca sativa G R 29.4 Helianthus annuus G R 22.0 Pastinaca sativa G S 79.2 Helianthus annuus G S 31.6 Pennisetum alopecuroides G O 22.0 Helianthus strumosus G R 30.5 Petasites japonicus G S 29.2 Helianthus strumosus G O 71.7 Peucedanum oreaselinum G O 21.3 Helianthus tuberosus G W 21.2 Phacelia tanacetifolia G R 23.5 Helianthus tuberosus G S 50.7 Phalaris arundinacea G R 47.5 Helianthus tuberosus L. G R 24.9 Phalaris canariensis G R 23.1 Heliotropium arborescens G S 40.0 Phalaris canariensis G O 100.0 Heliotropium arborescens G O 45.6 Phaseolus coccineus G O 37.0 Helleborus niger G S 38.0 Phaseolus coccineus G R 74.1 Hordeum vulgare G S 21.5 Phaseolus mungo G O 42.2 Humulus lupulus G O 35.1 Phaseolus mungo G S 52.2 Hypericum sp G W 26.1 Phaseolus vulgaris G V 35.5 Hyssopus officinalis G S 74.5 Phaseolus vulgaris G S 48.0 Iberis amara G O 20.9 Phaseolus vulgaris G O 58.1 Iberis amara G S 21.7 Phlox paniculata G S 32.2 Inula helenium G S 27.6 Phlox paniculata G O 40.1 Ipomoea batatas G S 37.5 Physalis ixocarpa G O 20.6 Isatis tinctoria G S 48.0 Physalis pruinosa G O 80.0 Lachica serrola G R 53.0 Phytolacca americana G S 62.0 Lactuca sativa G W 24.5 Phytolacca americana G O 100.0 Laportea canadensis G S 36.0 Pimpinella anisum G S 37.3 Laportea canadensis G O 81.7 Pisum sativum G W 34.4 Lathyrus sativus G W 37.8 Pisum sativum G O 63.3 Lathyrus sylvestris G R 40.7 Plantago coronopus G O 42.7 Lathyrus sylvestris G O 79.1 Plantago coronopus G S 46.4 Laurus nobilis G S 22.7 Plantago major G O 28.3 Lavandula angustifolia G S 31.7 Plantago major G S 41.4 Lavandula latifolia G O 27.2 Plectranthus sp. G S 29.3 Ledum groenlandicum G S 61.1 solanum melongena G S 36.6 Poa compressa G R 22.1 solanum melongena G O 40.1 Poa compressa G S 45.5 solanum melongena G V 50.0 Poa pratensis G R 35.7 solanum melongena G S 74.9 Polygonum pensylvanicum G S 38.3 Solanum tuberosum G S 39.1 Polygonum persicaria G S 31.0 Solanum tuberosum G O 39.2 Potentilla anserina G O 46.8 Solidago sp G R 30.7 Poterium sanquisorba G S 24.7 Sorghum caffrorum G O 87.9 Poterium sanquisorba G W 30.6 Sorghum dochna G W 20.6 Prunus cerasifera G R 45.9 Sorghum dochna G O 20.6 Pteridium aquilinum G S 22.4 Sorghum dochna G S 34.1 Raphanus Raphanistrum G S 36.5 Sorghum dochna G O 97.0 Raphanus Raphanistrum G O 75.0 Sorghum durra G O 30.6 Raphanus sativus G R 20.8 sorghum durra G S 30.6 Raphanus sativus G R 27.5 sorghum durra G O 48.0 Raphanus sativus G S 35.4 Sorghum sudanense G S 21.7 Rheum rhabarbarum G S 27.0 Sorghum sudanense G O 24.6 Ribes Grossularia G W 33.7 Sorghum sudanense G V 32.1 Ribes nidigrolaria G S 30.7 Spinacia oleracea G S 53.2 Ribes nidigrolaria G V 40.5 Stachys Affinis G S 25.0 Ribes nigrum G V 35.9 Stachys Affinis G R 27.8 Ribes nigrum G W 58.6 Stachys Affinis G O 100.0 Ribes Silvestris G V 26.9 Symphytum officinale G W 21.7 Ribes Silvestris G W 100.0 Symphytum officinale G O 25.2 Ricinus communis G R 21.8 Symphytum officinale G S 34.6 Rosmarinus officinalis G S 24.7 Tanacetum cinerariifolium G R 52.4 Rosmarinus officinalis G W 30.9 Tanacetum vulgare G R 27.1 Rosmarinus officinalis G R 60.3 Tanacetum vulgare G S 72.7 Rubus ideaus G O 32.5 Teucrium chamaedrys G R 24.6 Rubus ideaus G S 47.0 Teucrium chamaedrys G O 52.8 Rubus occidentalis G S 39.4 Thymus fragantissumus G R 100.0 Rubus occidentalis G R 74.1 Thymus vulgaris G V 24.2 Rumex acetosa G W 45.6 Thymus x citriodorus G S 23.7 Rumex acetosella G W 22.8 Tiarella cordifolia G S 20.8 Rumex acetosella G V 31.5 Tiarella cordifolia G O 30.8 Rumex crispus G O 25.9 Tragopogon porrifolius G O 22.8 Rumex crispus G R 70.3 Trifolium hybridum G R 24.7 Rumex patientia G O 39.8 Trifolium pannonicum G R 65.5 Rumex patientia G S 54.2 Trifolium repens G R 57.5 Rumex scutatus G W 23.8 Trigonella foenumgraecum G S 37.6 Rumex scutatus G V 69.9 Triticum furgidum G S 56.5 Rumex scutatus G O 78.8 Triticum spelta G S 40.8 Ruta graveolens G R 30.7 Tropaeolum majus G O 76.1 Ruta graveolens G S 61.5 Typha latifolia G S 43.3 Salvia elagens G W 25.4 Urtica dioica G S 40.3 Salvia elegans G S 31.1 Vaccinium angustifolium G S 42.4 Sambucus canadensis G W 80.6 Vaccinium corymbosum G S 61.5 Sambucus ebulus G W 26.1 Vaccinium macrocarpon G S 43.7 Sambucus ebulus G V 34.4 Vaccinum angustifolium G R 23.1 Sambucus ebulus G S 37.8 Veratrum viride G S 43.6 Sanguisorba officinalis G R 100.0 Verbascum thapsus G S 37.8 Santolina chamaecyparissus G R 21.7 Verbascum thapsus G O 87.0 Santolina chamaecyparissus G S 25.2 Veronica officinalis G S 30.5 Satureja montana G O 21.2 Viburnum trilobum G S 49.4 Scuttellaria lateriflora G S 37.0 Viburnum trilobum G R 100.0 Secale cereale G S 26.7 Viburnum trilobum G V 100.0 Secale cereale G W 27.3 Vicia faba G R 50.5 Serratula tinctoria G S 36.2 Vicia sativa G R 42.4 Serratula tinctoria G O 70.3 Vicia villosa G R 89.2 Sesamum indicum G O 27.6 Vigna angularia G R 28.1 Sesamum indicum G S 44.3 Vigna angularia G S 71.5 Silybum marianum G S 34.7 Vigna unguiculata G R 21.0 Sium sisarum G O 79.0 Vigna unguiculata G O 38.7 Solanum dulcamara G R 25.2 Vigna unguiculata G S 61.1 Solatium dulcamara G S 64.6 Apium graveolens T W 32.4 Vinca minor G O 33.6 Apium graveolens T R 56.6 Vinca minor G S 34.3 Aralia cordata T R 29.2 Vitis sp. G O 29.0 Aralia cordata T S 45.0 Vitis sp. G W 50.2 Arctium minus T R 25.8 Vitis sp. G S 53.3 Arctostaphylos uva-ursi T O 31.0 Vitis sp. G V 63.0 Arctostaphylos uva-ursi T S 35.2 Vitis sp. G R 86.6 Arctostaphylos uva-ursi T R 58.6 Withania somnifera G S 20.3 Armoracia rusticana T W 24.9 Xanthium sibiricum G S 34.7 Armoracia rusticana T S 52.9 Xanthium strumarium G S 23.2 Aronia melanocarpa T W 40.0 Zea mays G V 20.1 Aronia melanocarpa T V 91.9 Zea mays G S 45.9 Aronia prunifolia T W 100.0 Zea mays G O 97.5 Arrhenatherum elatius T R 22.8 Abelmochus esculentus T S 24.8 Artemisia draculus T S 74.9 Abies lasiocarpa T W 44.7 Artemisia dracunculus T S 47.8 Achillea millefolium T O 24.1 Asclepias incarnate T R 20.5 Achillea millefolium T S 59.2 Asctinidia chinensis T V 43.4 Aconitum napellus T S 40.6 Asctinidia chinensis T O 66.4 Aconitum napellus T O 41.6 Asparagus officinalis T O 91.3 Acorus calamus T O 47.1 Asparagus officiralis T R 23.3 Actinidia arguta T S 21.8 Asparagus officiralis T S 44.7 Adiantum pedatum T S 26.8 Aster Linne T S 47.5 Adiantum pedatum T O 45.8 Aster sp T R 62.0 Adiantum pedatum T R 86.0 Atriplex hortensis T R 54.6 Agaricus bisporus T S 26.3 Atropa belladonna T R 20.1 Agaricus bisporus T O 29.8 Atropa belladonna T S 51.0 Agaricus bisporus T W 36.9 Avena sativa T R 24.8 Agaricus bisporus T W 44.0 Avena sativa T W 26.4 Agaricus bisporus T S 46.0 Averrhoa carambola T W 23.4 Agastache foeniculum T S 70.0 Ayperus esculentus T S 46.2 Ageratum conyzoides T S 31.7 Beta vulgaris T R 28.2 Agropyron cristatum T R 86.9 Beta vulgaris T S 30.4 Agropyron repens T O 49.6 Beta vulgaris T O 56.8 Agrostis alba T R 21.9 Beta vulgaris spp. Maritima T R 23.6 Agrostis Stolonifera T R 35.8 Betula glandulosa T O 22.2 Alcea rosea T S 35.2 Betula glandulosa T V 22.2 Alchemilla mollis T S 37.9 Betula glandulosa T S 25.7 Allium ampeloprasum T O 48.0 Betula glandulosa T W 32.9 Allium ascalonicum T S 26.2 Boletus edulis T S 36.2 Allium ascalonicum T O 77.2 Boletus edulis T O 90.2 Allium cepa T O 92.6 Borago officinalis T S 27.9 Allium grande T R 60.4 Borago officinalis T O 76.1 Allium schoenoporasum T O 65.8 Brassica cepticepa T O 65.4 Allium schoenoprasum T W 31.0 Brassica cepticepa T S 71.5 Allium tuberosum T S 22.8 Brassica Chineusis T R 27.1 Allium tuberosum T O 99.7 Brassica juncea T O 51.0 Althaea officianalis T S 22.8 Brassica juncea T R 66.0 Althaea officinalis T O 22.1 Brassica juncea T S 74.1 Amaranthus candathus T W 43.9 Brassica Napus T S 22.0 Amaranthus gangeticus T O 30.3 Brassica Napus T R 34.0 Amaranthus gangeticus T S 66.0 Brassica Napus T O 100.0 Ambrosia artemisiifolia T R 58.7 Brassica nigra T S 26.7 Amelanchier alnitolia T R 70.5 Brassica nigra T O 27.4 Amelanchier sanguinea T W 37.3 Brassica nigra T R 82.5 Ananas comosus T W 23.8 Brassica oleracea T O 21.2 Ananas comosus T V 95.0 Brassica oleracea T S 22.1 Ananas comosus T O 99.6 Brassica oleracea T W 26.2 angelica archangelica T S 30.5 Brassica oleracea T R 27.2 angelica archangelica T R 38.9 Brassica oleracea T O 31.3 Anthemis nobilis T O 41.4 Brassica oleracea T W 46.5 Anthemis nobilis T R 72.8 Brassica oleracea T S 71.2 Anthemis tinctorium T S 27.3 Brassica oleracea T O 93.5 Anthriscus cerefolium T W 35.8 Brassica rapa T R 25.6 Apium graveolens T S 31.7 Cucumis melo T O 46.2 Brassica rapa T R 33.9 Cucumis metuliferus T W 32.0 Brassica rapa T R 56.0 Cucumis sativus Fanfare T O 40.3 Brassica rapa T S 69.7 Cucurbita maxima T S 23.6 Brassica rapa T O 100.0 Cucurbita maxima T S 33.1 Bromus inermis T R 57.3 Cucurbita maxima T O 55.2 Campanula rapunculus T O 77.5 Cucurbita moschata T S 20.1 Canna edulis T O 75.6 Cucurbita moschata T S 26.7 Cantharellus ciparium T O 52.5 Cucurbita moschata T O 41.7 Capsella bursa-pastoris T O 35.9 Cucurbita pepo T S 41.9 Capsicum annus T S 43.9 Cucurbita pepo T O 82.9 Capsicum annuum T S 50.1 Curcuma zedoaria T S 100.0 Capsicum frutescens T S 28.9 Cydonia oblonga T W 42.9 Carica papaya T W 31.1 Cynara scolymus T R 51.6 Carthamus tinctorius T R 37.3 Cynara scolymus T S 60.9 Carum carvi T S 30.1 Dactilis Glomerata T R 25.7 Castanea spp. T W 21.7 Datura stramonium T R 21.9 Chaerophyllum bulbosum T S 46.0 Daucus carota T R 25.9 Chamaemelum nobile T W 36.8 Dioscorea batatas T O 47.6 Chamaemelum nobile T W 48.4 Dioscorea batatas T O 83.1 Chelidonium majus T O 46.6 Diospiros Kaki T W 34.9 Chenapodium bonus-henricus T R 22.4 Dirca palustris T S 27.6 Chenopodium bonus-henricus T S 57.6 Dirca palustris T O 90.4 Chenopodium quinoa T V 35.5 Dolichus lablab T R 66.4 Chenopodium quinoa T W 54.4 Dolichus lablab T O 85.3 Chrysanthemum T R 26.5 Diyopteris filix- T S 21.9 leucanthemum mas Chrysanthemun T R 48.4 Diyopteris filix- T R 77.9 coronarium (Chp suey) mas Chrysanthemum coronarium T R 38.2 Echinacea purpurea T S 48.6 Chrysanthemum coronarium T S 63.9 Eleusine coracana T O 45.2 Cicer arietinum T S 20.0 Elymus junceus T R 41.0 Cichorium endivia T S 25.6 Erigeron canadensis T S 31.4 Cichorium endivia crispa T O 38.4 Eriobotrya japonica T W 28.3 Cichorium intybus T S 30.2 Eruca vesicaria T R 44.9 Cimicifuga racemosa T S 33.7 Fagopyrum esculentum T W 76.7 Citrullus colocynthus T S 20.4 Fagopyrum tartaricum T W 42.6 Citrullus lanatus T O 68.3 Festuca rubra T R 29.6 Citrullus lanatus T S 31.9 Festuca rubra T S 42.9 Citrus limettoides T W 20.4 Foeniculum vulgare T V 22.1 Citrus limettoides T V 37.5 Foericulum vulgare T S 21.6 Citrus limon T V 47.7 Foericulum vulgare T O 84.8 Citrus limon T O 72.4 Forsythia intermedia T O 70.8 Citrus paradisi T W 23.8 Forsythia x intermedia T O 60.2 Citrus paradisi T V 33.4 Fortunella spp T S 35.7 Citrus reticulata T V 20.4 Fortunella spp T W 50.7 Citrus reticulata T V 20.9 Fortunella spp T O 74.5 Citrus reticulata T W 26.0 Fragaria T W 24.8 Citrus reticulata T S 40.4 Fragaria T V 52.4 Citrus reticulata T O 50.0 Fragaria T O 100.0 Citrus reticulata T O 79.2 Fragaria x ananassa T S 29.3 Citrus sinensis T W 25.3 Galium odoratum T R 26.0 Citrus sinensis T V 59.8 Gaultheria hispidula T W 40.3 Coix Laciyma-Tobi T W 20.0 Ginkgo biloba T V 27.0 Corchorus olitorius T S 38.9 Ginkgo biloba T W 68.9 Cornus canadensis T S 35.6 Glechoma hederacea T R 20.4 Cosmos sulphureus T S 51.4 Glechoma hederacea T S 30.4 Crataegus sp T V 28.0 Glycine max T O 26.6 Crataegus sp T R 60.9 Glycine max T R 47.4 Crataegus submollis T O 25.5 Glycine max T S 82.0 Crithmum maritima T S 50.6 Glycyrrhiza glabra T S 35.4 Cryptotaenia canadensis T O 21.2 Glycyrrhiza glabra T O 40.5 Cryptotaenia canadensis T W 26.0 Glycyrrhiza glabra T W 100.0 Cryptotaenia canadensis T V 40.0 Gossypium herbaceum T S 36.1 Cucumis anguria T S 38.7 Guizotia abyssinica T R 28.9 Cucumis anguria T O 46.6 Guizotia abyssinica T S 40.4 Cucumis melo T S 30.3 Malus T V 44.4 Hamamelis virginiana T O 52.4 Malus hupehensis (Pamp.) Rehd. T R 26.3 Hamamelis virginiana T S 67.5 Malus hupehensis (Pamp.) Rehd. T S 67.0 Hamamelis virginiana T R 84.1 Malus sp. T R 65.3 Hedeoma pulegiodes T S 57.4 Malva moschata T S 41.1 Helenium hoopesii T O 33.7 Malva sylvestris T S 36.4 Helenium hoopesii T S 49.0 Malva sylvestris T O 47.4 Helianthus annus T S 53.4 Malva verticillata T R 42.7 Helianthus strumosus T R 20.3 Mangifera indica T O 30.5 Helianthus strumosus T O 71.7 Manihot esculenta syn. M. utilissima T W 38.3 Helianthus tuberosa T W 22.8 Manihot esculenta syn. M. utilissima T S 50.4 Helianthus tuberosus L. T V 22.6 Manihot esculenta syn. M. utilissima T O 86.5 Helianthus tuberosus L. T S 55.0 Melilotus alba T R 30.4 Helichrysum angustifolium T S 67.0 Melilotus officinalis T R 68.1 Heliotropium arborescens T S 58.9 Melissa officinalis T S 33.7 Helleborus niger T S 31.9 Melissa officinalis T O 34.7 Hibiscus cannabinus T S 48.9 mentha arvensis T R 53.7 Hordeum vulgare T S 29.2 Mentha suaveolens T S 26.8 Humulus lupulus T W 22.4 Menyanthes trifoliata T S 32.8 Humulus lupulus T R 39.1 Miscanthus sinensis Andress T R 22.7 Humulus lupulus T O 63.1 Momordica charantia T S 55.5 Humulus lupulus T S 100.0 Monarda didyma T S 26.8 Hydrastis canadensis T S 20.2 Monarda fistulosa T S 21.5 Hydrastis canadensis T W 31.0 Montia perfoliata T R 26.6 Hyoscyamus niger T O 56.8 Musa paradisiaca T W 29.0 Hypericum henryi T O 48.8 nasturtium officinale T S 35.4 Hypericum perforatum T S 48.1 Nepeta cataria T W 26.5 Hypericum perforatum T O 63.7 Nepeta cataria T O 27.5 Hypomyces lactiflorum T S 44.8 Nepeta cataria T S 41.9 Hypomyces T O 60.9 Nephelium longana ou T W 43.4 lactiflorum Euphoria longana Hyssops officinalis T W 22.9 Nicotiana rustica T O 26.0 Inula helenium T S 24.6 Nicotiana rustica T S 32.7 Juniperus communis T S 33.0 Nicotiana tabacum T S 25.1 Juniperus communis T O 38.2 Nicotiana tabacum T O 77.7 Lactuca sativa T S 44.5 Nigella sativa T R 59.3 Lactuca sativa T R 50.7 Nigella sativa T R 100.0 Laportea canadensis T S 30.2 Ocimum Basilicum T W 20.2 Lathyrus Sativus T O 20.4 Ocimum Basilicum T V 20.2 Lathyrus Sativus T R 52.5 Ocimum Basilicum T S 32.8 Lathyrus sylvestris T W 27.7 Oenothera biennis linne T R 100.0 Lathyrus sylvestris T O 36.8 Onobrychis viciafolia T R 45.0 Laurus nobilis T S 52.0 Optunia sp. T W 33.4 Lavendula angustifolia T W 26.4 Origanum marjonara T O 20.5 Lavendula angustifolia T S 53.2 Origanum vulgare T O 20.8 Lavendula latifolia T S 51.3 Origanum vulgare T W 21.6 Ledum groenlandicum T S 44.4 Oryza sativa T W 42.4 Lentinus edodes T W 42.1 oxyria digyna T O 57.0 Lentinus edodes T O 100.0 oxyria digyna T V 77.9 Lepidium sativum T S 44.2 Panax quinquefolius L. T O 23.5 Levisticum officinale T S 20.8 Panicum miliaceum T W 36.5 Levisticum officinale T O 39.4 Passiflora spp T S 35.8 Linum usitatissimum T R 42.3 Passiflora spp T V 38.3 Litchi chinensis T W 25.7 Passiflora spp T W 46.2 Lolium multiflorum T S 20.6 Passiflora spp T O 100.0 Lolium perenne T R 28.7 Pastinaca sativa T O 21.7 Lonicera ramosissima T S 26.3 Pastinaca sativa T R 38.6 Lonicera ramosissima T O 40.4 Pastinaca sativa T S 39.2 Lonicera ramosissima T W 53.2 Persea americana T V 32.5 Lonicera syringantha T W 95.8 Persea americana T O 38.6 Lotus comiculatus T R 100.0 Petasites Japonicus T S 26.2 Lotus tetragonolubus T S 65.4 Phalaris canariensis T O 80.0 Lunaria annua T O 55.7 Phaseolus coccineus T S 44.4 Lunaria annua T S 67.3 Phaseolus coccineus T R 79.1 Lycopersicon esculentum T R 37.6 Phaseolus mungo T S 27.0 Malus T W 31.8 Raphanus sativus T W 38.1 Phaseolus mungo T O 37.9 Raphanus sativus T S 63.6 Phaseolus vulgaris T R 20.1 Raphanus sativus T O 93.4 Phaseolus vulgaris T S 51.9 Reseda luteola T S 22.5 Phaseolus vulgaris T O 61.7 Rhamnus frangula T S 34.2 Phlox paniculata T S 22.9 Rhamnus frangula T R 39.5 Phlox paniculata T O 44.5 Rheum officinale T S 100.0 Phoenix dactylifera T O 29.6 Rheum palmatum T W 20.2 Physalis alkekengi T R 32.9 Rheum rhabarbarum T S 33.8 Physalis ixocarpa T R 26.6 Rianus communis T S 20.9 Physalis ixocarpa T O 28.3 Ribes nidigrolaria T W 44.5 Physalis pruinosa T S 27.3 Ribes nidigrolaria T V 53.1 Physalis pruinosa T R 47.8 Ribes nigrum T S 40.7 Physalis pruinosa T O 93.1 Ribes nigrum L. T W 50.0 Physalis sp T W 39.1 Ribes nigrum L. T V 60.1 Physalis sp T V 60.8 Ribes sativam syme T W 47.9 Phytolacca americana T S 41.8 Ribes Sativum T R 48.2 Phytolacca americana T O 100.0 Ribes Silvestre T V 26.3 Phytolacca decandra T O 85.9 Ribes T W 100.0 syn. P. americana Silvestre Pimpinella anisum T S 20.2 Ribes uva-crispa T O 57.5 Pimpinella anisum T O 68.4 Rosa rugosa T S 27.8 Pisum sativum T W 20.1 Rosa rugosa thunb. T W 37.5 Pisum sativum T S 25.8 Rosa rugosa thunb. T V 45.7 Pisum sativum T V 27.0 Rosmarinum officinalis T R 44.2 Pisum sativum T O 51.8 Rosmarinum officinalis T W 65.9 Plantago coronopus T R 21.9 Rubus canadensis T S 45.5 Plantago coronopus T O 48.6 Rubus idaeus T W 31.4 Plantago coronopus T S 66.8 Rubus idaeus T V 57.2 Plantago major T S 35.1 Rubus ideaus T S 28.5 Pleurotus spp T W 25.3 Rubus ideaus T O 38.0 Pleurotus spp T S 59.3 Rubus occidentalis T O 21.4 Pleurotus spp T O 85.2 Rubus occidentalis T S 36.5 Poa compressa T R 26.2 Rubus occidentalis T R 60.2 Poa pratensis T O 21.5 Rumes scutatus T O 84.5 Poa pratensis T R 30.0 Rumex crispus linne T O 52.5 Podophyllum peltatum T O 33.9 Rumex crispus linne T R 100.0 Podophyllum peltatum T S 50.2 Rumex patientia T O 23.1 Polygonum aviculare linne T R 31.0 Rumex patientia T S 65.8 Polygonum pennsylvanicum T S 56.6 Ruta graveolens T S 37.2 Polygonum persicaria T S 20.1 Sabal serrulata syn. Serenoa repens T V 34.4 Populus incrassata T W 54.9 Sabal serrulata syn. Serenoa repens T S 44.6 Populus Tremula T W 31.0 Salix purpurea T R 67.8 Populus x petrowskyana T W 100.0 Salvia (elegens) T O 51.1 Potentilla anserina T S 22.1 Sambucus canadensis T S 44.8 Potentilla anserina T O 41.1 Sambucus canadensis T O 72.4 Prunus cerasus T V 30.1 Sambucus canadensis L. T W 67.8 Prunus persica T W 26.6 Sambucus ebulus T V 44.3 Prunus persica T V 38.5 Sanguisorba officinalis T R 100.0 Prunus spp T S 24.0 Santolina T R 37.9 Prunus spp T V 49.1 Satureja montana T S 20.0 Psidium guajaba T V 22.5 Satureja montana T O 21.3 Psidium guajaba T W 44.3 Satureja repandra T S 36.3 Psidium guajaba T O 95.4 Scorzorera hipanica T R 27.1 Psidium spp T S 36.6 Scorzorera hipanica T S 31.7 Psidium spp T W 47.6 Scuttellaria lateriflora T S 44.3 Psidium spp T O 87.6 Secale cereale T S 24.2 Pteridium aquilinum T R 22.0 Secale cereale T W 31.1 Punica granatum T V 52.1 Sechium edule T S 37.8 Pyrus communis T V 39.5 Sesamum indicum T S 59.2 Pyrus pyrifolia T W 33.7 Setaria italica T W 33.0 Raphanus raphanistrum T O 24.5 Silybum marianum T O 92.4 Raphanus raphanistrum T S 44.8 Slum sisarum T O 32.7 Raphanus raphanistrum T S 46.1 Slum sisarum T S 33.1 Raphanus sativus T V 25.4 Sium sisarum T O 81.3 Raphanus T R 32.1 Vaccinium angustifolium T R 34.6 sativus Vaccinium angustifolium T O 59.6 Solanum melogena T O 21.9 Vaccinium angustifolium T R 65.7 solanum melogena T V 26.1 Vaccinium macrocarpon T O 30.2 Solanum melogena T R 34.0 Vaccinium macrocarpon T S 39.0 Solanum melogena T S 67.1 Vaccinium macrocarpon T S 56.9 Solanum Tuberosum T O 68.6 Vaccinum macrocarpon T V 39.2 Solidago canadensis T S 48.4 Vaccinum macrocarpon T W 42.3 Solidago sp T R 31.4 Veratrum viride T O 20.5 Solidago virgaurea T S 56.2 Veratrum viride T S 33.1 Sorghum caffrorum T O 23.3 Verbascum thapsus T S 43.1 Sorghum dochna T W 20.8 Verbascum T O 70.2 bicolor gr technicum thapsus Sorghum dochna Snowdrew T S 21.4 Veronica officinalis T O 20.5 Sorghum dochna Snowdrew T O 27.7 Viburnum trilobum Marsh. T S 40.6 Spinacia oleracea T V 25.0 Vicia faba T R 61.5 Spinacia oleracea T W 32.1 Vicia sativa T R 30.1 Spinacia oleracea T S 47.6 Vigna angularia T R 32.6 Spinacia oleracea T O 63.1 Vigna angularia T S 64.2 Stachys affinis T R 31.7 Vigna unguiculata T R 32.4 Stachys affinis T O 100.0 Vigna unguiculata T O 47.4 Stachys byzantina T W 30.9 Vigna unguiculata T S 51.0 Stipa capiliata L. T R 20.1 Vinca minor T S 21.3 Symphytum officinale T S 24.1 Vitis sp. T V 28.3 Tanacetum cinerarifolium T O 24.2 Vitis sp. T O 29.4 Tanacetum cinerarifolium T R 84.4 Vitis sp. T S 45.4 Tanacetum vulgare T R 25.7 Vitis sp. T V 50.7 Tanacetum vulgare T S 75.6 Vitis sp. T W 61.6 Taraxacum T S 21.1 Vitis sp. T R 100.0 officinale (Red ribe) Weigela coracensis T W 35.5 Tepary T R 56.7 Withania somnifera T S 35.5 Teucrium chamaedrys L. T R 27.3 Xanthium sibiricum T S 38.6 Thalpsi arvense T S 61.4 Xanthium strumarium T S 33.5 Thymus fragantissumus T R 100.0 Zea mays T S 37.1 Thymus herba-barona T W 22.0 Zea mays T O 65.5 Thymus pseudolanuginosus T R 36.8 Zingiber officinale T S 20.1 Thymus pseudolanuginosus T S 37.1 Zingiber officinale T W 58.9 Thymus serpyllum T S 26.0 Zingiber officinale T O 75.9 Thymus serpyllum T W 42.7 Thymus x citriodorus T O 22.7 Tiarella cordifolia T R 100.0 Tragopogon porrifolius T V 26.8 Tragopogon porrifolius T O 28.4 Tragopogon porrifolius T S 42.1 Tragopogon sp. T O 20.3 Tragopogon sp. T S 32.0 Tragopogon sp. T W 66.3 Trichosanthes kirilowii T O 66.5 Trifolium incarnatum T R 47.9 Trifolium repens T R 81.7 Trigonella foenum graecum T S 39.6 Triticale sp. T O 64.1 Triticum aestivum T W 24.5 Triticum aestivum T S 29.4 Triticum furgidumm T S 35.8 Triticum spelta T S 34.7 Tropaeolum majus T O 90.3 Tropaeolum malus T W 20.1 Tsuga canOadensis T O 21.5 Tsuga canOadensis T W 64.4 Tsuga diversifolia T O 45.9 Tsuga diversifolia T W 100.0 Tsuga F. macrophylla T W 28.1 Typha latifolia L. T S 30.6 Urtica dioica T O 31.4 Urtica dioica T R 36.9 Urtica dioica T S 41.7 Vaccinium angustifolium T V 25.2

TABLE 5 Cath B Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achillea A O 61.9 Cichorium A R 100.0 millefolium intybus Achillea tomentosa A O 60.8 Citrullus A O 24.4 Aconitum A O 38.6 lanatus Aconitum napellus A O 61.1 Convallaria A O 57.0 Alchemilla mollis A R 26.7 maialis Allium A R 43.0 Coriandrum A R 20.8 Allium cepa gr. A O 49.9 sativum Cepa Cryptotaenia A O 20.4 Allium cepa gr. A O 70.1 canadensis Cepa Cucumis A O 26.8 Allium cepa gr. A R 45.8 Anguria Cepa Cucumis sativus A R 45.6 Allium sativum A O 25.6 Curburbita A O 30.8 Allium Tuberosum A O 91.5 pepo Allium Tuberosum A O 75.0 Daucus carota A R 68.8 Allium victorialis A O 31.1 Daucus carota A O 20.3 Amaranthus A O 26.1 Daucus carota A R 72.5 gangeticus Daucus carota A O 22.6 Amaranthus A O 29.0 Daucus carota A O 25.6 gangeticus Daucus carota A R 65.9 Amelanchier A R 28.7 Daucus carota A R 77.3 canadensis Daucus carota A R 41.6 Anthemis tinctoria A O 26.8 Dirca palustris A R 100.0 Anthemis tinctoria A R 32.4 Eruca vesicaria A O 41.4 Anthoxanthum A O 24.9 Filipendula A R 65.0 odoratum rubra Apium graveolens A O 31.1 Forsythia A R 100.0 Apium graveolens A O 20.6 intermedia Aralia cordata A R 52.3 Forsythia x A R 100.0 Arctium lappa A O 33.7 intermedia Arctium lappa A R 33.0 Geum rivale A O 26.4 Aronia A R 41.2 Glycyrrhiza A R 86.8 melanocarpa glabra (Michx.) Ell. Heliotropium A O 29.5 Aronia A O 21.6 arborescens melanocarpa Humulus A O 65.4 (Michx.) Ell. Lupulus Asarum A O 24.9 Humulus A R 100.0 europaeum Lupulus Athaea officinalis A O 57.7 Hylotelephium A R 23.7 Athyrium asperum A O 27.3 Hypericum A R 44.4 Atropa belladonna A O 37.7 henryl Begonia A O 26.0 Iberis A O 84.6 convolvulacea sempervirens Begonia eminii A O 34.2 Jeffersonia A O 35.4 Begonia glabra A O 38.9 diphylla Begonia Hannii A O 52.9 Ligularia A O 30.3 Begonia A O 67.3 dentata polygonoides Lonicera A R 48.7 Berberis vulgaris A O 54.6 ramosissima Beta vulgaris A R 39.9 Miscanthus A O 50.9 Beta vulgaris A R 30.4 sacchariflorus Beta vulgaris A O 61.9 Nicotiana A O 40.0 Beta vulgaris A O 43.0 tabacum Beta vulgaris A R 91.0 Nicotiana A O 56.8 Beta vulgaris A O 46.7 tabacum Beta vulgaris A R 65.3 Nicotiana A O 55.2 Beta vulgaris A R 33.4 tabacum Beta vulgaris A O 54.3 Nigella sativa A O 40.3 Beta vulgaris A O 38.2 Origanum A O 49.7 Beta vulgaris A R 55.9 majorana Beta vulgaris A R 28.5 Origanum A O 67.0 Beta vulgaris A O 40.1 vulgare Beta vulgaris spp. A O 33.4 Origanum A O 39.9 Maritima vulgare Brassica juncea A O 21.3 Panax A O 24.0 Brassica Oleracea A O 27.5 quinquefolius L. Brassica Oleracea A O 48.2 Pastinaca A R 33.5 Brassica rapa A O 20.8 sativa Calendula A O 35.6 Petroselinum A O 70.2 officinalis crispum Camellia sinensis A R 24.4 Peucedanum A O 21.5 syn. Thea sinensis cervaria Cana edulis A R 100.0 Phaseolus A O 67.9 Capsicum annuum A O 25.0 Vulgaris Capsicum A O 29.6 Philadelphus A O 24.0 frutescens coronarius Chrysanthemum A O 89.3 Physostegia A O 56.9 balsamita virginiana Chrysanthemun A O 55.0 Phytolacca A O 100.0 balsamina Plantago major A O 31.2 Chrysanthemun A O 30.1 Plectranthus A O 32.1 coronarium (Chp fruticosus Suey) Polygonum A R 70.1 Chrysanthemun A O 36.4 pennsylvanicum coronarium (Chp Pulmonaria A O 31.1 Suey) saccharata Salvia sclarea A O 21.5 Raphanus A O 21.5 Saponaria A O 68.5 sativus officinalis Raphanus A O 50.5 Satureja montana A O 47.6 sativus Scorzonera A O 29.9 Raphanus A O 58.9 hispanica sativus Sesamum indicum A O 84.8 Ribes nigrum L. A O 53.1 Solanum A O 51.3 Rubus A O 56.7 dulcamara Allegheniensis Solidago A O 95.3 Rubus ideaus A R 89.0 canadensis Rumex crispus A R 65.2 Solidago hybrida A O 94.5 linn{acute over (e)} Solidago hybrida A O 99.5 Salvia elegens A O 32.6 Solidago sp ? A O 60.9 Salvia A O 26.2 Stellaria graminea A O 40.2 nemorosa linn{acute over (e)} Salvia A O 26.3 Tamarindus indica A O 59.2 officianalis Taraxacum A O 88.6 Salvia sclarea A R 51.6 officinale Daucus carota G O 27.2 Thalictrum A O 65.2 Dirca palustris G R 100.0 aquilegiifolium Echinacea G O 22.9 Thalictrum A O 44.5 purpurea Aquilegiifolium Equisetum G O 100.0 Thuja occidentalis A O 50.6 hyemale Thymus praecox A O 23.9 Erigeron G O 73.3 subsp arctitus canadensis Tiarella A R 34.4 Erigeron G O 22.9 Vaccinum A R 67.2 speciosus augustifolium (Lindl.) D.C. Vaccinum A R 37.1 Eruca vesicaria G O 29.2 macrocarpon Erysimum G O 89.8 Vitia sp. A R 93.7 perofskianum Xanthium A O 83.2 Fish. S. strumarium Fenouil bronze G R 23.7 Yucca filamentosa A O 34.5 Filipendula G R 93.2 Zea mays A O 29.7 rubra Zea mays A O 93.2 Filipendula G R 100.0 Achillea tomentosa G O 41.0 rubra Adiantum tenerum G R 30.2 Filipendula G O 20.5 Alcea rosea G O 37.7 ulmaria Alchemilla mollis G R 32.8 Filipendula G O 26.2 Allium G O 49.3 vulgaris schoenoporasum Forsythia G R 100.0 Allium tuberosum G O 79.1 intermedia Allium tuberosum G O 77.4 Forsythia x G R 100.0 Allium victorialis G O 45.5 intermedia Althaea officinalis G O 67.2 Galium G O 21.0 amaranthus G O 23.5 odoratum gangeticus Gaultheria G R 39.3 Anaphalis G R 34.7 hispidula (L.) margaritacea Muhl Angelica dahurica G R 27.9 Gaultheria G R 43.4 Anthemis nobilis G O 42.3 procumbens Apium graveolens G O 25.7 Geum rivale G O 21.7 Apium graveolens G O 27.4 Glycine max G O 64.2 Arctostaphylos G R 94.5 Glycyrrhiza G R 53.4 uva-ursi glabra Aronia G R 74.5 Hamamelis G R 88.4 melanocarpa virginiana Aronia G 0 21.3 Heliotropium G O 23.0 melanocarpa arborescens Aronia G R 79.9 Humulus G R 100.0 melanocarpa lupulus (Michx.) Ell. Humulus G O 90.2 Aronia G R 28.3 lupulus melanocarpa Hydrastis G O 30.9 (Michx.) Ell. canadensis Asarum G O 55.4 Hylotelephium G R 43.8 europaeum Hypericum G R 50.3 Atropa belladonna G O 58.9 henryi Begonia eminii G O 24.7 Iberis G O 87.7 Begonia glabra G O 42.9 sempervirens Begonia manii G O 32.1 Lathyrus G R 25.9 Begonia G O 38.2 sativus polygonoides Ligularia G O 31.5 Berberis vulgaris G O 42.3 dentata Beta vulgaris G R 75.3 Lunaria annua G O 59.7 Beta vulgaris G O 28.7 Lythrum G R 33.1 Beta vulgaris G O 21.7 salicaire Beta vulgaris G R 40.0 Melissa G O 27.6 Beta vulgaris spp. G O 31.4 officinalis Maritima Miscanthus G O 30.7 Betula glandulosa G R 38.5 sacchariflorus Calendula G O 36.2 Nicotiana G O 54.8 officinalis rustica Capsicum annus G O 49.9 Nicotiana G O 36.2 Chrysanthemum G O 100.0 tabacum balsamita Nigella sativa G O 40.3 Chrysanthemum G O 33.1 Origan G O 98.8 balsamina Origanum G O 48.9 Cynara scolymus G O 51.9 majorana Daucus carota G O 81.3 Panax G O 21.1 Silene vulgaris G O 35.5 quinquefolius L. Solanum G O 56.9 Panicum G R 100.0 dulcamara miliaceum Solidago G O 99.8 Passiflora G 66.2 canadensis caerula Solidago G O 100.0 Petroselinum G 65.0 canadensis crispum Solidago sp ? G O 71.8 Phaseolus G R 40.3 Sorghum G O 34.5 vulgaris caffrorum Physostegia G O 74.0 Tamarindus indica G O 65.4 virginiana Taraxacum G O 82.7 Phytolacca G O 100.0 officinale americana taraxacum G O 42.7 Plantago major G O 60.9 officinale Plectranthus G O 29.2 Tetradenia riparia G O 32.5 fruticosus Thalictrum G O 62.1 Polygonum G R 45.6 aquilegiifolium aviculare linn{acute over (e)} Thuja occidentalis G O 57.7 Pongamia G O 41.7 Thymus vulgaris G O 40.7 pinnata “Argenteus” Pulmonaria G O 36.9 Tiarella G R 39.0 officinalis Tropaeolum majus G O 36.6 Pulmonaria G O 24.7 Tussilago farfara G O 26.8 saccharata Vaccinium G R 26.4 Raphanus G O 38.9 angustifolium sativus Vaccinium G R 89.1 Raphanus G O 86.4 angustifolium sativus Vaccinum G R 33.9 Rhus aromatica G O 49.1 macrocarpon Ribes nigrum L. G O 20.6 Vitia sp. G R 100.0 Rubus ideaus G R 56.9 Vitia sp. G R 90.9 Rubus G R 61.3 Vitis sp. G O 37.1 occidentalis Achillea T O 44.1 Saponaria G O 48.3 millefolium officinalis Aconitum napelius T O 27.4 Sarriette vivace G O 44.6 Aesculus T R 84.2 Satureja G O 72.3 hippocastanum repandra Aesculus T O 47.3 Sesamum G O 46.8 hippocastanum indicum Alcea rosea T O 24.3 Sidalcea G O 55.2 “Nigra” Aubepine, T R 72.7 Alchemilla mollis T R 24.9 hawthorne Allium T O 31.1 Begonia T O 32.1 ascalonicum convolvulacea Allium cepa gr. T O 39.4 Begonia eminii T O 40.4 Cepa Begonia glabra T O 84.3 Allium cepa gr. T R 23.2 Begonia manii T O 64.2 Cepa Berberus T O 35.4 Allium cepa gr. T O 45.5 vulgaris Cepa Beta vulgaris T O 34.1 Allium fistulosum T O 21.9 Beta vulgaris T R 86.7 Allium grande T O 39.5 Beta vulgaris T O 23.8 Allium tuberosum T O 26.6 Beta vulgaris T R 79.4 Allium tuberosum T O 33.1 Beta vulgaris T O 34.2 Allium tuberosum T O 72.3 Beta vulgaris T R 20.8 Allium tuberosum T R 22.6 Beta vulgaris T R 37.0 Allium victorialis T O 42.3 Beta vulgaris T R 83.6 Alpinia oficinarum T O 57.4 spp. Maritima Alpinia oficinarum T R 88.9 Betula T R 62.5 Althacea T O 51.5 glandulosa officinalis Borago T O 23.5 Althaea T O 25.2 officinalis Amelanchier T O 20.8 Brassica Napus T O 27.6 canadensis Brassica T O 21.8 Amelanchier T R 42.1 oleracea canadensis Brassica T O 22.3 Amsonia oleracea tabernaemontana T O 30.2 Butomus T O 20.8 Ananas comosus T R 36.2 umbellatus Anaphalis T R 33.9 Canna edulis T R 100.0 margaritacea cannelle T R 99.5 Angelica dahurica T R 40.7 Carica papaya T R 100.0 Angelica sinensis T O 91.0 Chrysanthemum T O 89.3 syn. A. balsamita polymorpha Chrysanthemum T R 44.6 Anthriscus T R 23.3 parthenium cerefolium chrysanthemun T O 28.7 Anthriscus T O 21.7 coronarium cerefolium (Chp Suey) Aralia cordata T R 44.1 chrysanthemun T O 59.2 Aronia T R 33.1 coronarium melanocarpa (Chp Suey) Aronia T R 100.0 Citrus paradisi T R 100.0 melanocarpa Citrus sinensis T R 100.0 Aronia T R 35.0 Cocos nucifera T R 100.0 melanocarpa Cocos nucifera T O 71.9 (Michx.) Ell. Convallaria T O 67.1 Aronia prunifolia T R 50.4 majalis Artemisia draculus T O 42.5 Corchorus T R 26.0 Asarum T O 39.4 olitorius europaeum Crataegus T O 33.1 Asclepias T O 48.7 sanguinea incarnata L. Cryptotaenia T R 23.1 Asclepias tuberosa T O 21.5 canadensis Asctinidia T O 24.9 Cucumis T O 26.4 chinensis anguria Atriplex hortensis T O 22.4 Cucumis sativus T O 25.7 Atropa belladonna T O 94.1 (Fanfare) Iberis T O 90.8 Cydonia T R 23.6 sempervirens oblonga Jeffersonia T O 43.0 Datura T O 61.4 diphylla stramonium Juglans nigra T R 66.7 Daucus carota T R 21.1 Kochia scoparia T O 38.4 Diospiros Kaki T R 100.0 (L.) Schrad. Echinacea T O 27.8 Krameria T R 63.6 purpurea Triandra Eriobotrya T R 25.2 Lentinus edodes T R 100.0 japonica Lentinus edodes T R 26.2 Eruca vesicaria T O 34.5 Ligularia dentata T O 34.9 Erysimum T O 91.0 Ligustrum vulgare T O 29.5 perofskianum Lunaria annua T O 72.3 Fish. S. Lunaria annua T R 51.1 Fragaria x Lupinus T O 47.4 ananassa T R 37.5 polyphyllus lind L. Fucus T R 87.1 Lychnis T O 34.4 vesiculosis chalcedonica Fumaria T O 44.4 Lythrum salicaire T R 53.8 officianalis Mangifera indica T R 100.0 officinalis Mangifera indica T O 29.3 Gaultheria T R 74.8 Nigella sativa T O 26.1 procumbens Nil T O 73.6 Gentiana T O 44.5 Nil T R 25.4 macrophylla Nil T R 24.6 Glyceria T O 37.6 Nil T R 49.8 maxima Nil T O 43.6 Glycine max T O 40.3 Nil T R 28.4 Envy Optunia sp. T R 100.0 Glycyrrhiza T R 37.7 Panax T O 27.4 glabra quinquefolius L. Hamamelis T R 78.3 Passiflora caerula T O 39.8 virginiana Pastinaca sativa T O 20.5 Helichrysum T R 21.8 Perroselinum T O 60.9 angustifolium crispum Heliotropium T O 26.8 Phaseolus vulgaris T O 37.5 arborescens Physostegia T O 64.2 Humulus T R 84.7 virginiana lupulus Phytolacca T O 51.9 Humulus T O 39.2 americana lupulus Phytolacca T O 100.0 Humulus T O 100.0 americana lupulus Plectranthus T O 23.4 Humulus T R 100.0 fruticosus lupulus Polygonatum T O 100.0 Hydrastis T 1 42.7 odoratum canadensis Polygonium T R 33.6 Hypericum T R 51.8 chinense henryi Pontederia T O 26.2 Hypericum T O 52.3 cordata perforatum Portulacea T O 20.7 Hypomyces T O 30.1 oleracea lactiflorum Primula veris T O 58.2 Silene vulgaris T O 51.3 Prunus persica T R 100.0 Solidago T O 92.8 Prunus persica T R 100.0 hybrida (hybride de la Solidago T O 100.0 peche) Hybrida Pulmonaria T O 22.8 Solidago T R 100.0 officinalis Hybrida Punica granatum T R 100.0 Solidago sp ? T O 39.6 Pyrus pyrifolia T R 22.4 Tamarindus T O 64.2 Radix Paeonia T O 39.8 indica rubra Tanacetum T O 100.0 Rahmnus frangula T R 25.3 balsamila Raphanus sativus T O 45.8 Tanacetum T O 23.3 Rhus trilobata T O 20.2 vulgare Ribes uva-crispa T R 34.2 Taraxacum T O 90.9 Rosa Rugosa T O 45.4 officinale “Alba” Taraxacum T O 34.5 Rubus idaeus T R 31.2 officinale (Red Rubus idaeus L. T O 42.7 ribe) Rubus ideaus T R 74.2 Thuja T O 37.6 Rubus occidentalis T R 68.1 occidentalis Rumex crispus T R 37.9 Thymus T O 20.6 linn{acute over (e)} serpyllum Salvia nemorosa T O 38.2 Tiarella T R 35.6 Sambucus T O 27.5 Tragopogon sp. T R 21.1 canadensis Trigonella T R 97.3 Sambucus nigra T O 30.8 foenum Sanguisorba minor T R 78.3 graecum Saponaria T O 68.7 Tropaeolum T O 58.8 officinalis majus Saponaria T O 44.2 Tropaeolum T R 28.6 officinalis L. majus Satureja hortensis T O 62.1 Tropaeolum T O 36.7 Sechium edule T O 34.4 majus Sesamum indicum T O 78.6 Tsuga T R 64.0 Sidalcea T O 42.9 diversifolia Vaccinium T R 72.2 angustifolium Vaccinium T R 50.7 angustifolium Vaccinium T R 52.6 macrocarpon Vitia sp. T O 35.1 Vitia sp. T R 98.9 Vitis sp. T R 32.6 Weigela T R 24.6 coracensis Zea mays T R 100.0 Zea mays T R 48.1

TABLE 6 Cath D Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Agastache foeniculum A O 91.6 Citrullus lanatus A R 35.9 Agropyron cristatum A O 24.5 Citrullus lanatus A O 76.5 Agropyron repens A O 75.2 Coix Lacryma-Jobi A O 20.9 Agrostis Stofonifera A O 94.7 Coix Lacryma-Jobi A O 93.2 Alchemilla mollis A O 39.0 Cornus canadensis A O 30.9 Allium sativum A R 100.0 Cuburbita pepo A O 21.9 Allium schoenoprasum A R 40.0 Cucumis melo A O 44.1 Althaea officinalis A O 96.5 Cucumis sativus A O 21.3 Amaranthus gangeticus A R 67.4 Cucumis sativus A R 33.3 Amaranthus gangeticus A O 74.3 Cucurbita Maxima A R 100.0 Amaranthus retroflexus A O 100.0 Cucurbita moschata A R 20.5 Ambrosia artemisiifolia A O 75.4 Cucurbita pepo A O 31.9 Anethum graveolens A O 48.7 Cucurbita pepo A R 40.9 Angelica archangelica A O 27.6 Cucurbita pepo A O 41.2 Anthemis nobilis A O 56.2 Curcuma zedoaria A O 26.3 Anthemis tinctoria A S 42.3 Cymbopogon martinii A O 77.8 Aralia cordata A R 100.0 Daucus carota A O 55.1 Aralia nudicaulis A R 44.9 Daucus carota A R 100.0 Arctium minus A O 93.2 Dipsacus sativus A O 21.1 Arctium minus A O 100.0 Elymus junceus A O 27.7 Aronia melanocarpa A O 22.8 Eschscholzia califomica A O 44.4 Artemisia abrotanum A O 31.3 Foeniculum vulgare A O 81.8 Artemisia abrotanum A O 43.6 Forsythia intermedia A O 40.4 Artemisia absinthium A O 58.3 Forsythia intermedia A R 100.0 Artemisia Absinthium A O 71.4 Fragaria x ananassa A R 38.5 Artemisia dracunculus A O 70.5 Galinsoga ciliata A O 46.7 Artemisis Ludoviciana A O 74.4 Galium odoratum A O 21.6 Artemisis Ludoviciana A O 100.0 Galium odoratum A R 22.7 Asparagus officinalis A O 61.9 Gaultheria hispidula A R 71.9 Aster sp A O 100.0 Gaultheria hispidula A O 90.2 Aster sp A O 100.0 Gentiana lutea A R 100.0 Atropa belladonna A O 100.0 Glechoma hederacea A O 32.7 Beckmannia eruciformis A R 22.1 Glycine max A S 55.1 Beckmannia eruciformis A O 48.3 Glycine max A R 100.0 Beta vulgaris A R 21.2 Glycyrrhiza glabra A R 100.0 Beta vulgaris A R 100.0 Guizotia abyssinica A O 73.8 Beta vulgaris spp. Maritima A O 30.8 Hedeoma pulegioides A O 100.0 Betta vulgaris A O 100.0 Helianthus tuberosus A O 37.2 Brassica napus A R 63.6 Hordeum hexastichon A R 34.6 Brassica oleracea A R 33.3 Hordeum hexastichon A O 63.6 Brassica rapa A R 23.8 Hordeum vulgare A O 66.7 Brassica rapa A O 26.1 Hordeum vulgure subsp. Vulgare A O 33.3 Bromus inermis A O 59.6 Hypericum henryi A O 66.7 Calamintha nepeta A R 24.0 Hyssopus officinalis A O 100.0 Campanula rapunculus A O 41.6 Ipomoea Batatas A O 55.1 Canna edulis A O 100.0 Iris versicolor A R 24.1 Capsella bursa-pastoris A O 36.7 Iris versicolor A O 30.8 Capsicum annuum A R 25.8 Lathyrus sativus A O 20.6 Capsicum annuum A R 28.2 Laurus nobilis A O 33.3 Capsicum annuum A O 64.7 Levisticum officinale A O 87.6 Capsicum annuum A R 76.9 Linum usitatissimum A R 21.4 Capsicum frutescens A O 44.1 Linum usitatissimum A O 44.4 Carthamus tinctorius A O 42.9 Lolium perenne A O 30.9 Carum carvi A R 28.6 Lotus corniculatus A O 23.4 Chaerophyllum bulbosom A O 100.0 Lycopersicon esculentum A R 40.0 Chelidonium majus A R 100.0 Matricaria recutita A S 56.4 chenopodium bonus-henricus A O 54.3 Medicago sativa A R 20.5 Chenopodium quinoa A R 22.2 Melissa officinalis A O 100.0 Chrysanthemum coronarium A O 96.8 Mentha piperita A O 22.7 Cichorium endivia susp. Endivia A R 36.0 Mentha piperita A R 100.0 Cichorium endivia susp. Endivia A O 78.4 Mentha suaveolens A O 53.2 Cichorium intybus A O 100.0 Nepeta cataria A O 100.0 Citrullus lanatus A O 22.7 Nicotiana tabacum A O 37.7 Citrullus lanatus A R 26.7 Solanum melanocerasum A S 44.6 Nicotiana tabacum A R 44.3 Solanum melanocerasum A R 60.0 Oenothera biennis A O 23.8 Solanum tuberosum A O 29.2 Oenothera biennis A O 40.0 Solidago sp A O 98.4 Oenothera biennis A R 100.0 Spinacia oleracea A O 40.5 Origanum vulgare A O 94.7 Spinacia oleracea A S 57.7 Panax quinquefolius A O 29.8 Stachys affinis A O 23.8 Panax quinquefolius A O 35.1 Stachys byzantina A O 96.1 Panax quinquefolius A O 40.4 Stellaria graminea A O 34.4 Pastinaca sativa A O 74.4 Stellaria media A O 24.6 Perilla frutescens A O 86.7 Symphytum officinale A O 87.7 Perilla frutescens A R 100.0 Symphytum officinale A O 100.0 Petasites japonicus A O 43.5 Tanacetum cinerariifolium A O 70.7 Petroselinum crispum A O 100.0 Tanacetum parthenium A R 40.0 Phalaris arundinacea A O 21.3 Tanacetum parthenium A O 74.7 Phalaris canariensis A O 22.0 Tanacetum parthenium A R 100.0 Phaseolus coccineus A O 68.8 Tanacetum vulgare A O 26.7 Phaseolus mungo A S 58.5 Tanacetum vulgare A R 32.7 Phaseolus mungo A O 100.0 Tanacetum vulgare A O 98.4 Phaseolus vulgaris A O 33.3 Tanacetum vulgare A O 100.0 Phaseolus vulgaris A O 80.3 Taraxacum officinale A R 22.7 Phleum pratense A O 20.2 Taraxacum officinale A O 100.0 Physalis ixocarpa A R 100.0 Teucrium chamaedrys A O 100.0 Pimpinella anisum A O 86.7 Thymus praecox subsp arcticus A O 75.6 Plantago major A O 99.0 Thymus praecox subsp arcticus A O 100.0 Plectranthus sp. A R 50.0 Thymus serpyllum A O 78.1 Plectranthus sp. A O 64.0 Thymus vulgaris A O 90.9 Polygonum aviculare A O 55.7 Trichosanthes kirilowii A O 100.0 Poterium sanguisorba A R 100.0 Trifolium incarnatum A S 76.9 Poterium Sanquisorba A O 23.4 Trifolium pannonicum A O 72.6 Prunus Tomentosa A O 27.6 Trifolium pratense A O 100.0 Raphanus Sativus A O 36.8 Trifolium repens A O 100.0 Raphanus sativus A R 100.0 Triticum durum A R 22.7 Rheun rhabarbarum A R 33.0 Triticum spelta A R 24.0 Ribes nigrum A R 21.1 Triticum spelta A O 32.4 Ribes nigrum A O 32.6 Typha latifolia A O 52.1 Ribes rubrum A O 24.5 Vaccinium Corymbosum A R 53.3 Ribes Sylvestre A O 21.1 Vaccinium macrocarpon A R 44.3 Ribes Sylvestre A R 30.3 Valeriana officinalis A O 23.1 Rosa rugosa A R 21.1 Verbascum thapsus A O 65.6 Rosa rugosa A O 36.6 Vitis sp. A O 33.7 Rosa rugosa A O 40.2 Vitis sp. A R 93.3 Rosmarinus officinalis A O 95.7 Zea mays A R 25.0 Rubus canadensis A R 25.8 Zea mays A R 50.0 Rubus canadensis A O 31.7 Achillea millefolium G O 47.7 Rubus idaeus A O 85.9 Agropyron repens G O 93.3 Rubus ideaus A R 66.7 Alchemilla mollis G O 32.1 Rumex acetosella A O 27.4 Allium ascalonicum G O 29.7 Rumex crispus A O 25.0 Allium sativum G R 100.0 Rumex Scutatus A O 21.3 Allium schoenoprasum G R 100.0 Salvia officinalis A O 21.3 Allium tuberosum G R 100.0 Salvia officinalis A O 85.1 Althaea officinalis G O 95.6 Salvia officinalis A R 100.0 Amaranthus caudathus G O 95.3 Salvia sclarea A O 29.9 Amaranthus gangeticus G O 45.7 Sanguisorba officinalis A O 23.1 Amaranthus retroflexus G O 78.3 Sanguisorba officinalis A R 48.3 Ambrosia artemisiifolia G O 73.8 Santolina chamaecyparissus A O 52.9 Amelanchier alnifolius G O 50.5 Satureja montana A O 87.4 Anethum graveolens G O 100.0 Scorzonera hispanica A O 30.8 Anthemis nobilis G O 94.3 Secale cereale A R 21.2 Apium graveolens G O 21.9 Senecio vulgaris A O 42.6 Arctium minus G O 65.9 Sesamum indicum A O 27.3 Arctium minus G O 71.7 Silybum marianum A O 25.2 Arctostaphylos uva-ursi G O 84.8 Sium sisarum A O 34.4 Aronia melanocarpa G O 31.5 Solanum dulcamara A R 21.4 Foeniculum vulgare G O 100.0 Arrhenatherum elatius G S 50.8 Forsythia intermedia G R 100.0 Artemisia abrotanum G O 52.1 Forsythia x intermedia G O 42.1 Artemisia absinthium G O 59.7 Galium odoratum G R 63.6 Artemisia absinthium G O 72.9 Galium odoratum G O 64.7 Artemisia Ludoviciana G O 64.1 Gaultheria hispidula G R 63.4 Artemisia Ludoviciana G O 90.7 Gaultheria hispidula G O 69.6 Artemisia vulgaris G O 55.2 Glechoma hederacea G O 50.5 Artemisia vulgaris G O 83.3 Glechoma hederacea G R 100.0 Asclepias incarnata G O 38.9 Glycine max G O 27.9 Asclepias incarnata G O 75.6 Glycine max G R 100.0 Asparagus officinalis G R 27.8 Guizotia abyssinica G R 33.3 Aster sp G O 33.3 Guizotia abyssinica G O 83.6 Atropa belladonna G O 96.6 Helianthus annuus G R 100.0 Beta vulgaris G O 92.1 Helianthus strumosus G R 28.9 Beta vulgaris G R 100.0 Helianthus strumosus G O 52.2 Beta vulgaris spp. Maritima G R 100.0 Helianthus tuberosus G O 29.3 Borago officinalis G O 100.0 Helianthus tuberosus G O 54.9 Brassica napus G R 40.9 Helichrysum thianschanicum G O 30.5 Brassica oleracea G R 66.7 Heliotropium arborescens G R 29.1 Bromus inermis G O 38.3 Hysopus officinalis G O 100.0 Calamintha nepeta G R 25.3 Ipomoea batatas G O 45.8 Campanula rapunculus G S 50.8 Lactuca sativa G O 26.6 Campanula rapunculus G O 68.8 Lathyrus sativus G O 72.7 Campanula rapunculus G O 69.9 Lathyrus sylvestris G O 33.3 Canna edulis G S 50.8 Lathyrus sylvestris G R 56.8 Capsella bursa-pastoris G O 30.0 Lavandula angustifolia G R 100.0 Capsicum annuum G O 27.9 Lavandula angustifolia G O 100.0 Capsicum annuum G R 33.3 Lavandula latifolia G O 100.0 Capsicum annuum G R 35.9 Leonurus cardiaca G O 100.0 Capsicum annuum G R 41.0 Levisticum officinale G O 98.1 Capsicum annuum G S 43.1 Levisticum officinale G R 100.0 Capsicum annuum G O 56.9 Linum usitatissimum G O 42.9 Capsicum frutescens G O 60.8 Lolium perenne G O 25.5 Carthamus tinctorius G O 30.2 Lotus tetragonolobus G R 49.2 Carum carvi G O 28.6 Lupinus polyphyllus G O 33.3 Chaerophyllum bulbosum G O 88.9 Lycopersicon esculentum G O 29.5 Chrysanthemum coronarium G O 82.5 Lycopersicon esculentum G R 43.3 Cicer arietinum G R 31.8 Lycopersicon pimpinellifolium G R 100.0 Cichorium endivia subsp endivia G O 100.0 Malva moschata G O 100.0 Cichorium intybus G O 100.0 Medicago sativa G O 32.6 Circium arvense G S 53.8 Melissa officinalis G O 100.0 Circium arvense G O 63.3 Mentha piperita G O 40.3 Citrullus lanatus G O 40.9 Mentha suaveolens G O 79.2 Citrullus lanatus G O 56.9 Monarda didyma G R 100.0 Coix Lacryma-Jobi G O 100.0 Nepeta cataria G O 100.0 Cornus canadensis G O 20.2 Ocimum basilicum G O 80.5 Cornus canadensis G O 35.1 Oenothera biennis G O 41.7 Cucumis anguria G R 40.0 Oenothera biennis G R 100.0 Cucurbita maxima G O 31.4 Origanum majorana G O 67.4 Cucurbita maxima G R 40.9 Origanum vulgare G O 100.0 Cucurbita moschata G O 23.0 Oxalis Deppei G O 22.2 Cucurbita moschata G R 31.8 Oxalis Deppei G S 44.6 Cucurbita moschata G S 47.7 Oxyria digyna G O 21.3 Cucurbita pepo G O 29.8 Panax quinquefolius G O 25.5 Cucurbita pepo G R 53.3 Panax quinquefolius G O 38.3 Cymbopogon martinii G O 100.0 Panicum miliaceum G R 83.3 Cynara scolymus G O 27.3 Pennisetum alopecuroides G R 21.5 Datura metel G O 54.1 Petasites japonicus G O 40.6 Daucus carota G O 28.6 Petroselinum crispum G O 100.0 Daucus carota G R 100.0 Peucedanum cervaria G O 42.9 Digitalis purpurea G R 100.0 Phaseolus mungo G O 100.0 Dirca palustris G R 24.5 Phaseolus vulgaris G O 54.8 Elymus junceus G O 38.3 Phaseolus vulgaris G O 67.2 Erigeron speciosus G O 73.7 Thymus praecox subsp arcticus G O 100.0 Plantago major G O 95.2 Thymus serpyllum G O 100.0 Plectranthus sp. G R 100.0 Thymus vulgaris G O 64.4 Plectranthus sp. G O 100.0 Thymus x citriodorus G O 72.7 Poa compressa G O 20.2 Tiarella cordifolia G O 92.4 Portulaca oleracera G O 60.0 Trifolium hybridum G O 29.5 Potentilla anserina G R 100.0 Trifolium pannonicum G O 54.7 Poterium sanguisorba G O 21.3 Trifolium pratense G O 92.9 Poterium sanguisorba G R 100.0 Trifolium repens G O 100.0 Prunella vulgaris G O 70.3 Triticum spelta G R 37.3 Raphanus Raphanistrum G O 33.3 Triticum turgidum G O 59.5 Raphanus Raphanistrum G R 80.0 Typha latifolia G O 23.4 Raphanus sativus G O 52.6 Vaccinium corymbosum G O 26.5 Raphanus sativus G R 100.0 Vaccinum angustifolium G O 27.7 Ribes nigrum G O 42.1 Vaccinum macrocarpon G R 33.0 Ribes Sylvestre G R 32.0 Valeriana officinalis G R 27.6 Ricinus communis G R 100.0 Valeriana officinalis G O 51.3 Rosa rugosa G O 52.4 Verbascum thapsus G O 21.3 Rosa rugosa G O 90.2 Vinca minor G O 28.6 Rosmarinus officinalis G O 100.0 Vitis sp. G R 40.0 Rubus ideaus G O 34.8 Vitis sp. G O 42.6 Rubus occidentalis G R 60.0 Zea mays G R 26.9 Rubus occidentalis G O 65.3 Zea mays G R 100.0 Rumex crispus G O 43.3 Perilla frutescens T O 96.0 Ruta graveolens G O 23.0 Perilla frutescens T R 100.0 Salvia officinalis G O 100.0 Abies lasiocarpa T O 25.6 Salvia officinalis G R 100.0 Agastache foeniculum T O 100.0 Sambucus canadensis G O 80.6 Agropyron cristatum T O 20.2 Sambucus ebulus G R 21.1 Agrostis alba T O 24.5 Sambucus ebulus G O 36.8 Alchemilla mollis T O 33.3 Sanguisorba officinalis G O 43.6 Alchemilla mollis T S 49.2 Santolina chamaecyparissus G O 50.6 Alchemilla mollis T O 66.2 Saponaria officinalis G O 85.6 Allium ampeloprasum T O 100.0 Satureja hortensis G R 36.8 Allium ascalonicum T O 29.7 Satureja hortensis G O 68.4 Allium ascalonicum T R 38.7 Senecio vulgaris G O 31.1 Allium cepa T R 100.0 Sesamum indicum G O 27.3 Allium tuberosum T R 100.0 Sium sisarum G O 20.8 Alpinia officinarum T R 50.0 Sium sisarum G O 47.8 Althaea officinalis T O 58.6 Solanum melanocerasum G O 23.5 Amaranthus candathus T R 22.9 Solanum melongens G O 28.6 Amaranthus candatus T O 93.2 solanum melongens G R 41.2 Amaranthus caudathus T O 100.0 Solidago sp G O 72.1 Amaranthus gangeticus T O 57.1 Sonchus oleraceus G O 95.1 Amaranthus retroflexus T O 100.0 Stachys Affinis G O 38.1 Ambrosia artemisiifolia T O 86.9 Stachys byzantina G O 28.6 Amelanchier alnifolia T O 50.5 Stellaria graminea G O 39.3 Anthemis nobilis T O 100.0 Stellaria media G O 21.3 Anthriscus cerefolium T O 100.0 Symphytum officinale G R 37.8 Aralia cordata T R 100.0 Symphytum officinale G S 43.1 Arctium minus T O 68.3 Symphytum officinale G O 92.6 Aronia melanocarpa T O 50.0 Symphytum officinale G O 100.0 Aronia prunifolia T O 44.7 Tanacetum cinerariifolium G O 91.3 Arrhenatherum elatius T O 78.7 Tanacetum parthenium G R 60.0 Artemisia absinthium T O 58.4 Tanacetum parthenium G O 86.7 Artemisia dracunculus T R 28.6 Tanacetum vulgare G O 44.4 Artemisia dracunculus T O 86.3 Tanacetum vulgare G O 67.9 Artemisia Ludoviciana T O 48.8 Tanacetum vulgare G O 85.7 Artemisia vulgaris T O 50.0 taraxacum officinale G R 40.9 Artemisia vulgaris T O 82.8 taraxacum officinale G O 100.0 Asclepias incarnata T O 72.9 Teucrium chamaedrys G R 33.3 Asparagus officinalis T O 69.8 Teucrium chamaedrys G O 66.7 Aster sp T O 35.0 Thymus fragantissimus G O 24.1 Avena sativa T O 31.8 Thymus praecox subsp arcticus G R 25.0 Baptisia tinctoria T O 33.8 Thymus praecox subsp arcticus G O 92.7 Dioscorea batatas T S 41.5 Beta vulgaris T O 25.5 Dipsacus sativus T O 73.7 Beta vulgaris T O 28.6 Dirca palustris T O 88.5 Beta vulgaris T R 34.6 Eleusine coracana T S 49.2 Beta vulgaris T S 43.6 Elymus junceus T O 35.1 Beta vulgaris T O 54.5 Erigeron speciosus T O 67.8 Beta vulgaris T R 100.0 Fagopyrum esculentum T O 27.3 Beta vulgaris spp. Maritima T R 100.0 Foeniculum vulgare T R 80.0 Brassica nigra T R 45.5 Forsythia intermedia T O 50.9 Brassica oleracea T O 50.0 Forsythia x intermedia T O 57.9 Brassica oleracea T R 100.0 Fucus vesiculosus T O 83.7 Bromus inermis T O 30.9 Fucus vesiculosus T R 100.0 Calamagrostis arundiflora T O 85.6 Galinsoga ciliata T O 56.7 Calendula officinalis T O 23.7 Galium aparine T O 60.5 Campanula rapunculus T O 25.0 Galium odoratum T R 31.8 Canna edulis T O 26.3 Gaultheria hispidula T O 33.7 Capsella bursa-pastoris T O 21.7 Gaultheria procumbens T O 25.0 Capsicum annum T O 46.1 Gentiana lutea T O 98.1 Capsicum annuum T R 20.5 Gentiana macrophylla T O 100.0 Capsicum annuum T O 23.3 Glechoma hederacea T O 62.6 Capsicum annuum T R 41.0 Glycine max T O 26.2 Capsicum frutescens T O 58.8 Glycyrrhiza glabra T R 50.0 Carthamus tinctorius T O 36.5 Glycyrrhiza glabra T S 51.3 Carum carvi T O 88.6 Guizotia abyssinica T O 39.3 Chaerophyllum bulbosum T O 25.0 Guizotia abyssinica T R 100.0 Chaerophyllum bulbosum T O 95.2 Hedeoma pulegioides T O 100.0 Chelidonium majus T O 27.1 Helianthus annus T O 75.8 Chelidonium majus T R 50.0 Helianthus strumosus T R 55.6 Chenopodium bonus-henricus T O 60.0 Helianthus tuberosus T O 22.1 Chenopodium quinoa T R 31.5 Helichrysum angustifolium T O 96.1 Chenopodium quinoa T O 50.0 Helichrysum thianschanicum T O 70.5 Chrysanthemum coronarium T R 65.5 Heliotropium arborescens T O 83.2 Chrysanthemum coronarium T O 100.0 Helleborus niger T O 24.1 Cicer arietinum T R 27.3 Herba Schizonepetae T O 60.5 Cichorium endivia subsp endivia T R 27.3 Hibiscus cannabinus T S 52.6 Cichorium endivia subsp endivia T O 97.3 Hordeum vulgare T O 77.8 Cichorium intybus T O 100.0 Hydrastis canadensis T O 64.9 Cimicifuga racemosa T R 22.2 Hypericum henryl T O 100.0 Circium arvense T O 78.3 Hypericum perforatum T R 31.0 Citrullus lanatus T R 26.7 Hyssopus officinalis T O 100.0 Citrullus lanatus T O 45.5 Inula helenium T O 100.0 Citrullus lanatus T O 62.7 Ipomoea batalas T O 91.5 Coix Lacryma-Jobi T O 77.3 Iris versicolor T O 35.9 Coriandrum sativum T O 90.0 Juniperus communis T O 83.8 Cornus canadensis T O 29.3 Krameria Triandra T O 25.6 Cucumis anguria T R 50.0 Lactuca sativa T O 100.0 Cucumis anguria T O 70.1 Lathyrus Sativus T R 27.3 Cucumis melo T R 20.5 Lathyrus Sativus T O 33.3 Cucumis melo T O 51.0 Lathyrus sylvestris T O 20.3 Cucumis sativus T O 23.4 Lathyrus sylvestris T R 100.0 Cucurbita maxima T O 50.0 Laurus nobilis T R 23.8 Cucurbita moschata T O 84.9 Laurus nobilis T O 26.0 Cucurbita pepo T R 20.5 Lavandula latifolia T R 100.0 Cucurbita pepo T O 39.2 Lavandula latifolia T O 100.0 Cucurbita pepo T S 53.8 Lens culinaris subsp culinaris T O 21.3 Curcuma zedoaria T O 24.6 Leonorus cardiaca T O 57.9 Cymbopogon citratus T O 100.0 Lepidium sativum T O 31.6 Cynara scolymus T R 33.3 Levisticum officinale T O 90.5 Dactilis Glomerata T O 20.2 Levisticum officinale T R 100.0 Datura metel T O 37.8 Linum usitatissimum T O 23.8 Datura stramonium T R 50.0 Lonicera syringantha T O 79.5 Daucus carota T R 21.1 Lotus corniculatus T R 46.7 Daucus carota T O 30.3 Lupinus polyphyllus lindl. T O 36.6 Daucus carota T O 49.3 Lycopersicon esculentum T R 60.0 Daucus carota T S 52.3 Rumex scutatus T O 23.0 Lycopersicon pimpinellifollum T R 100.0 Ruta graveolens T O 62.1 Malus hupehensis T R 100.0 Saccharum officinarum T O 27.0 Malva sylvestris T O 100.0 Salvia officinalis T O 92.0 Matricaria spp. T O 100.0 Salvia officinalis T O 93.3 Medicago sativa T O 27.7 Sambucus canadensis T O 42.9 Melissa officinalis T O 100.0 Sanguisorba officinalis T O 68.6 Menyanthes trifoliata T O 44.9 Santolina chamaecyparissus T O 66.7 Menyanthes trifoliata T R 50.0 Saponaria officinalis T O 36.6 Miscanthus sinensis T R 23.5 Saponaria officinalis T O 84.7 Miscanthus sinensis T O 24.6 Satureja montana T O 80.5 Nepeta cataria T O 78.9 Satureja repandra T O 47.1 Ocimum Basilicum T R 35.7 Senecio vulgaris T O 44.3 Ocimum Basilicum T O 100.0 Setaria italica T O 27.9 Oenothera biennis T R 100.0 Silybum marianum T O 31.0 Origanum vulgare T O 94.7 Sium sisarum T O 24.8 Origanum vulgare T R 100.0 Sium sisarum T R 25.5 Oxalis Deppei T O 21.1 Solanum dulcamara T R 21.4 oxyria digyna T O 24.6 Solanum melongena T R 25.8 Panax quinquefolius T O 39.4 Solanum melongena T O 34.9 Panicum miliaceum T R 20.8 Solanum tuberosum T O 38.1 Pastinaca sativa T O 21.3 Solidago canadensis T O 100.0 Pastinaca sativa T R 25.0 Solidago sp T O 73.8 Pastinaca sativa T R 25.0 Sonchus oleraceus T O 100.0 Pastinaca sativa T O 79.4 Sorghum durra T O 23.8 Pastinaca sativa T O 100.0 Spinacia oleracea T R 29.3 Petasites Japonicus T O 29.0 Stachys affinis T R 23.6 Petroselinum crispum T R 40.0 Stachys affinis T O 23.9 Peucedanum oreaselinum T S 55.1 Stachys affinis T O 50.0 Pfaffia paniculata T R 100.0 Stachys byzantina T O 41.6 Phaseolus mungo T O 70.2 Stellaria graminea T O 62.3 Phaseolus vulgaris T O 71.4 Stipa capillata T O 27.1 Phaseolus vulgaris T O 100.0 Symphytum officinale T R 28.9 Phaseolus vulgaris T R 100.0 Symphytum officinale T O 87.7 Physalis ixocarpa T O 25.5 Symphytum officinale T O 97.8 Pimpinella anisum T R 100.0 Tanacetum cinerarlifolium T O 62.7 Pimpinella anisum T O 100.0 Tanacetum parthenium T O 94.7 Pisum sativum T O 37.5 Tanacetum vulgare T R 28.9 Plantago major T O 100.0 Tanacetum vulgare T S 47.7 Plectranthus sp. T O 36.0 Tanacetum vulgare T O 75.6 Plectranthus sp. T R 80.0 Tanacetum vulgare T O 95.2 Poa pratensis T O 38.3 Tanacetum vulgare T O 100.0 Populus x petrowskyana T O 25.5 Taraxacum officinale T O 95.3 Prunella vulgaris T O 23.3 Thymus praecox subsp arcticus T R 24.4 Prunella vulgaris T O 88.1 Thymus praecox subsp arcticus T O 60.0 Raphanus raphanistrum T O 73.7 Thymus praecox subsp arcticus T O 90.0 Raphanus raphanistrum T R 100.0 Thymus pseudolanuginosus T O 83.9 Raphanus sativus T S 60.3 Thymus serpyllum T O 100.0 Raphanus sativus T R 100.0 Tiarella cordifolia T O 93.3 Reseda luteola T O 100.0 Tragopogon porrifolius T O 34.4 Rheum officinale T O 36.8 Tragopogon porrifolius T O 58.0 Ribes sativum T O 20.4 Trichosanthes kirilowii T R 25.3 Ribes Sylvestre T R 44.3 Trifolium pannonicum T O 61.1 Ricinus communis T R 100.0 Trifolium pratense T O 92.9 Rosmarinus officinalis T R 60.0 Trifolium repens T O 100.0 Rosmarinus officinalis T O 100.0 Triticum aestivum T O 29.5 Rubus canadensis T R 32.0 Triticum durum T O 100.0 Rubus canadensis T O 34.7 Triticum turgidum T O 29.7 Rubus idaeus T O 93.5 Ulmus americana T O 76.9 Rubus ideaus T R 100.0 Ulmus americana T O 81.0 Rubus occidentalis T O 38.6 Urtica dioica T R 40.9 Rubus occidentalis T S 52.3 Vaccinium angustifolium T R 26.3 Rubus occidentalis T R 100.0 Vaccinium angustifolium T O 28.3 Rumex acetosella T O 26.3 Vaccinium angustifolium T O 47.6 Rumex crispus T O 30.0 Vaccinium angustifolium T R 100.0 Vaccinium corymbosum T O 21.4 Vaccinium macrocarpon T R 80.0 Valeriana officinalis T O 43.6 Vicia sativa T S 43.1 Vitiis sp. T O 26.7 Vitiis sp. T R 93.3 Zea mays T R 21.2 Zea mays T R 100.0

TABLE 7 Cath G Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achillea millefolium A V 40.1 Echinacea purpurea A W 100.0 Achillea millefolium A O 29.5 Filipendula rubra A O 20.2 Acorus calamus A R 68.6 Filipendula rubra A S 77.6 Adiantum pedatum A R 29.7 Foeniculum vulgare A R 23.3 Agastache foeniculum A O 36.8 Fragaria x ananassa A O 32.3 Agastache foeniculum A S 22.4 Fragaria x ananassa A W 100.0 Agropyron rupens A S 24.5 Fragaria x ananassa A S 100.0 Alchemilla mollis A W 100.0 Fragaria x ananassa A S 100.0 Alchemilla mollis A S 81.1 Frangoria x ananassa A W 100.0 Alchemilla mollis A O 51.5 Frangoria x ananassa A V 100.0 Alchemilla mollis A S 78.6 Galinsoga ciliata (Rofiresque) Blake A R 21.2 Alchemilla mollis A O 82.9 Gaultheria hispidula (L.) Muhl. A R 85.3 Alchemilla mollis A S 35.6 Gaultheria hispidula (L.) Muhl. A R 100.0 Alkanna tinctoria A O 51.6 Gaultheria procumbens A W 56.1 Alkanna tinctoria A R 100.0 Glycine Max A S 36.0 Allium Tuberosum A S 20.6 Glycine max A S 38.7 Althaea officinalis A R 21.6 Glycyrrhiza glabra A W 46.2 Althaea officinalis A S 39.6 Glycyrrhiza glabra A S 35.5 Ambrosia artemisiifolia linné A O 47.6 Glycyrrhiza glabra A R 100.0 Ambrosia artemisiifolia linné A R 38.2 Hamamelis virginiana A R 100.0 Amelanchier sanguinea (Pursh) DC. A W 29.7 Helianthus tuberosus A W 22.6 Angelica archangelica A S 68.1 Helichrysum angustifolium A V 82.6 Anthemis tinctoria A O 26.0 Heliotropium arborescens A O 57.3 Anthemis tinctoria A V 28.4 Heliotropium arborescens A R 57.2 Anthemis tinctorium A O 46.9 Hordeum vulgare A O 34.3 Arachis hypogaea A V 84.5 Hypericum henryi A O 30.4 Aralia nudicaulis A S 61.9 Hypericum perforatum A R 100.0 Arctostaphylos uva-ursi A O 25.0 Inula helenium A S 64.0 Arctostaphylos uva-ursi A R 100.0 Isatis tinctoria A O 94.0 Arctostaphylos uva-ursi A S 38.4 Laurus nobilis A S 49.9 Aronia melanocarpa (Michx.) Ell. A O 24.4 Lavendula latifolia A W 100.0 Aronia melanocarpa (Michx.) Ell. A R 27.3 Lavendula latifolia A V 48.7 Aronia melanocarpa (Michx.) Ell. A W 47.8 Leonorus cardiaca A R 100.0 Artemisia dracunculus sativa A W 32.2 Levisecum officinale A V 46.8 Artemisis Ludoviciana A O 88.8 Lolium multiflorum A O 34.1 Aster sp ? A O 47.2 Melissa officinalis A O 54.1 Aster sp ? A R 100.0 Melissa officinalis A W 100.0 Beta vulgaris A R 23.9 Melissa officinalis A V 80.7 Brassica napus A R 22.3 Melissa officinalis A O 100.0 Brassica napus A S 22.8 Mentha pulegium A O 29.1 Brassica nigra A S 47.2 Mentha spicata A V 47.0 Brassica rapa A S 46.0 Nepeta cataria A V 57.6 Capsella bursa-pastoris (linné) médicus A R 43.4 Ocrothera biennis A S 33.1 Chaerophyllum bulbosom A V 90.7 Oenothera biennis linné A O 47.4 Chaerophyllum bulbosom A W 57.4 Oenothera biennis linné A R 100.0 chenopodium bonus-henricus A R 23.7 Origanum majorana A S 34.6 Chichorium endivia A O 53.0 Origanum vulgare A V 65.9 Chrysanthemum leucanthemum linné A O 55.5 Origanum vulgare A W 48.2 Cicer arietinum A R 26.2 Origanum vulgare A V 70.0 Cichorium intybus A O 100.0 Origanum vulgare A W 62.9 Cichorium intybus A V 83.6 Origanum vulgare A O 68.4 Cichorium intybus A O 51.0 Origanum vulgare A V 81.9 Crataegus sp ? A O 100.0 Origanum vulgare A W 61.3 Crataegus sp ? A R 81.6 Origanum vulgare A S 21.7 Cymbopogan citratus A S 33.9 Oxyria digyna A V 40.1 Datisca cannabina A S 20.2 Perilla frutescens A V 65.0 Daucus carota A O 62.0 Perilla frutescens A W 51.9 Daucus carota A W 99.4 Peucedanum cervaria A R 28.3 Dirca palustris A R 24.9 Peucedanum cervaria A R 45.1 Dirca palustris A S 47.0 Phaseolus Vulgaris A S 38.4 Diyopteris filix-mas A O 24.1 Phaseolus Vulgaris A S 26.3 Diyopteris filix-mas A R 95.7 Tanacetum vulgare “Goldsticks” A V 51.9 Echinacea purpurea A V 80.7 Taraxacum officinale A W 28.5 Phytolacca americana A S 27.8 Taraxacum officinale A V 82.3 Plantago coronopus A O 22.7 Thymus praecox subsp arctitus A O 43.4 Polygonum aviculare linné A R 76.0 Thymus pseudolanuginosus A V 29.7 Poterium sanguisorba A O 20.1 Thymus serpyllum A O 100.0 Poterium sanguisorba A R 93.1 Thymus serpyllum A W 73.6 Poterium sanguisorba A V 47.7 Thymus serpyllum A V 74.9 Poterium sanguisorba A S 36.1 Thymus vulgaris A O 35.6 Pteridium aquilinum A O 25.7 Thymus vulgaris A R 66.5 Pteridium aquilinum A R 100.0 Thymus vulgaris “Argenteus” A V 73.9 Ribes nidigrolaria A W 51.8 Triticum furgidum?? A O 21.6 Ribes Nigrum A W 100.0 Vaccinum augustifolium A S 26.1 Ribes nigrum A S 33.6 Vaccinum Corymbosum A W 95.7 Ribes nigrum L. A W 58.8 Vaccinum macrocarpon A W 46.1 Ribes nigrum L. A O 21.5 Valerianella locusta A S 96.0 Ribes Salivum A R 21.4 Veronica officinalis A S 26.4 Ricinus communis A R 100.0 Viburnum trilobum Marsh. A W 25.0 Rosa rugosa thunb. A W 20.1 Vida sativa A O 28.2 Rosa rugosa thunb. A W 100.0 Vicia villosa A O 34.5 Rosa rugosa thunb. A R 100.0 Vitia sp. A W 26.0 Rosmarinus officinalis A O 100.0 Vitia sp. A S 41.6 Rosmarinus officinalis A R 64.0 Vitia sp. A W 100.0 Rosmarinus officinalis A W 55.6 Vitia sp. A S 30.8 Rosmarinus officinalis A V 76.7 Vitia sp. A O 22.3 Rubus allegheniensis A S 32.1 Vitia sp. A S 28.5 Rubus canadensis A W 94.5 Zea Mays A S 32.3 Rubus canadensis A S 64.2 Zea Mays A S 34.5 Rubus idaeus A S 86.0 Achillea millefolium G W 30.6 Rubus idaeus A O 29.5 Achillea millefolium G V 71.1 Rubus idaeus A W 38.7 Aconitum napellus G R 100.0 Rubus idaeus A S 41.0 Acorus calamus G R 27.8 Rubus idaeus A W 100.0 Adiantum pedatum G R 100.0 Rubus idaeus L. A V 30.2 Agastache toeniculum “Snow Pike” G V 46.9 Rubus idaeus L. A W 29.4 Agastache toeniculum “Snow Pike” G W 71.5 Rubus idaeus L. A S 100.0 Alchemilla mollis G W 100.0 Rubus ideaus A R 100.0 Alchemilla mollis G O 52.6 Rubus ideaus A S 67.1 Alchemilla mollis G S 80.7 Rubus occidentalis A S 100.0 Alchemilla mollis G O 33.4 Rumex crispus linné A R 100.0 Alchemilla mollis G S 38.7 Salvia elegens A W 69.7 althaea officinalis G R 27.5 Salvia officinalis A W 100.0 althaea officinalis G S 36.9 Salvia officinalis A V 58.0 Ambrosia artemisiifolia linné G O 48.4 Salvia officinalis A O 100.0 Ambrosia artemisiifolia linné G R 36.0 Salvia officinalis A R 39.9 Amelanchier sanguinea (Pursh) DC. G W 46.5 Salvia officinalis A V 45.7 Angelica archangelica G S 39.1 Salvia officinalis A W 65.4 Arachis hypogaea G V 81.8 Salvia sclarea A W 29.1 Aralia nudicaulis G S 44.9 Santolina A W 65.5 Arctium minus (Hill) Bernhardi G O 35.6 Satureja montana A V 72.2 Arctostaphylos uva-ursi G S 59.9 Satureja montana A W 100.0 Aronia melanocarpa (Michx.) Ell. G W 28.4 Satureja montana A O 90.5 Artemisia Ludoviciana G O 66.0 Satureja montana A V 28.9 Aster sp ? G O 51.8 Scuttellaria lateriflora A S 23.7 Aster sp ? G R 100.0 Sonchus oleraceus L. A O 25.9 Beta vulgaris G R 26.5 Sorghum dochna bicolor A O 25.6 Brassica napus G R 32.9 Sorghum durra (Stapif) A O 46.9 Brassica napus G S 33.5 Symphytum officinale A O 99.4 Brassica oleracea G S 100.0 Symphytum officinale A O 97.8 Calamintha nepeta G V 51.5 Tanacetum cinerarifolium A W 28.2 Calendula officinalis L. G O 26.7 Tanacetum parthenium A W 34.8 Canna edulis G O 20.6 Tanacetum vulgare A W 80.0 Chaerophyllum bulbosum G O 37.0 Tanacetum vulgare A V 53.8 Chaerophyllum bulbosum G V 88.6 Tanacetum vulgare A O 35.9 N G R 34.8 Tanacetum vulgare A R 68.8 Nepeta cataria G V 38.4 Chaerophyllum bulbosum G W 26.5 Ocimum basilicum G W 20.4 Chichorium endivia G S 25.2 Ocimum basilicum G O 89.9 Chrysanthemum leucanthemum linné G O 44.2 Ocimum basilicum G V 31.3 Cicer arietinum G R 26.1 Ocimum basilicum G W 82.3 Cichorium endivia G O 23.7 Oenothera biennis linné G O 62.8 Cichorium intybus G O 100.0 Oenothera biennis linné G R 100.0 Cichorium intybus G V 79.2 Oenothera biennis linné G R 100.0 Cichorium intybus G O 82.5 Oenothera biennis Linne G S 100.0 Crataegus sp ? G W 27.9 Origanum vulgare G V 67.1 Cynara scolymus G O 66.3 Origanum vulgare G V 65.5 Dirca palustris G R 28.8 Origanum vulgare G W 58.1 Dirca palustris G S 85.2 Origanum vulgare G V 70.5 Diyopteris filix-mas G R 100.0 Origanum vulgare G W 34.5 Echinacea purpurea G V 84.2 Origanum vulgare G V 60.1 Echinacea purpurea G O 83.2 Origanum vulgare G O 100.0 Erigeron speciosus (Lindl.) D.C. G O 46.1 Origanum vulgare G S 28.5 Fagopyrum esculentum G O 27.5 Origanum vulgare G O 83.7 Filipendula rubra G S 59.6 Origanum vulgare G S 22.1 Galinsoga ciliata (Rofiresque) Blake G R 20.5 Oxyria digyna G V 57.7 Galium odoratum G R 56.8 Perilla frutescens G V 75.8 Gaultheria hispidula (L.) Muhl G O 100.0 Peucedanum cervaria G R 37.5 Glycine max G O 22.8 Peucedanum cervaria G R 25.3 Glycyrrhiza glabra G S 28.4 Plantago major G O 31.7 Hamamelis virginiana G O 33.8 Plectranthus sp. G V 28.5 Hamamelis virginiana G R 100.0 Portulaca oleracera linné G O 37.8 Helianthus annus G R 26.5 Potentilla anserina G S 21.1 Helianthus strumosus G O 21.2 Poterium sanguisorba G V 72.1 Helianthus tuberosus L. G W 48.4 Poterium sanguisorba G S 65.9 Helichrysum angustifolium G W 38.1 Poterium sanquisorba G O 63.6 Helichrysum angustifolium G V 83.8 Poterium sanquisorba G W 28.7 Helichrysum thianschanicum Regel G O 61.3 Prunella vulgaris G O 40.7 Heliotropium arborescens G O 56.2 Pteridium aquilinum G O 25.7 Heliotropium arborescens G R 54.9 Pteridium aquilinum G R 100.0 Humulus lupulus G V 70.5 Raphanus Raphanistrum G R 42.7 Humulus lupulus G S 43.0 Ribes nidigrolaria G W 45.9 Hypericum henryi G O 31.0 Ribes nigrum G W 35.9 Hypericum perforatum G R 100.0 Ribes Silvestris G W 34.9 Inula helenium G W 85.3 Ribes Uva-crispa G S 30.5 Inula helenium G V 74.7 Ricinus communis G R 95.0 Inula helenium G S 37.4 Ricinus communis G S 48.3 Ipomea batatas G O 39.0 Rosa rugosa thunb. G W 40.3 Isatis tinctoria G O 100.0 Rosa rugosa thunb. G S 97.8 Laportea canadensis G O 26.9 Rosmarinus officinalis G O 100.0 Laurus nobilis G W 51.5 Rosmarinus officinalis G R 54.1 Laurus nobilis G S 100.0 Rosmarinus officinalis G W 77.7 Lavendula angustifolia G V 44.4 Rosmarinus officinalis G V 72.2 Lavendula latifolia G V 44.8 Rubus canadensis G S 25.3 Ledum groenlandicum G S 100.0 Rubus idaeus L. G W 31.1 Levistecum officinale G W 39.6 Rubus ideaus G S 100.0 Matricaria recutita G O 100.0 Rubus ideaus G R 37.6 Melissa officinalis G W 98.0 Rubus ideaus G O 34.8 Melissa officinalis G V 76.3 Rubus occidentalis G S 93.3 Melissa officinalis G R 36.6 Rubus occidentalis G O 22.7 Melissa officinalis G O 80.6 Rubus occidentalis G S 21.6 Mentha arvensis G O 83.5 Rumex crispus linné G R 100.0 Mentha piperita G O 79.0 Rumex crispus linné G R 100.0 Mentha piperita vulgaris G V 45.9 Salvia elegens G V 41.3 Mentha pulegium G O 47.0 Salvia elegens G W 62.9 Mentha spicata G V 73.9 Salvia officinalis G R 43.3 Mentha spicata G O 81.3 Salvia officinalis G O 55.1 Mentha spicata G O 93.0 Salvia officinalis G W 100.0 Monarda didyma G S 35.8 Alchemilla mollis T S 98.8 N G R 100.0 Alchemilla mollis T O 24.3 Salvia officinalis G V 52.5 Alchemilla mollis T S 83.7 Salvia officinalis G O 100.0 Alchemilla mollis T O 80.0 Salvia officinalis G R 38.8 Althaea officianalis T S 34.1 Salvia officinalis G V 49.5 Althaea officinalis T S 34.3 Salvia officinalis G W 95.3 Althaea officinalis T S 30.8 Salvia officinalis G W 41.3 Ambrosia artemisiifolia linné T O 61.6 Salvia sclarea G W 31.1 Ambrosia artemisiifolia linné T R 52.1 Sarriette commune G O 59.7 Amelanchier sanguinea x A. laevis T S 38.6 Sarriette vivace G O 72.3 angelica archangelica T S 54.8 Sarriette vivace G S 26.0 Anthemis tinctorium T O 67.7 Satureja montana G V 78.5 Arachis hypogaea T V 85.1 Satureja montana G W 100.0 Aralia nudicaulis T S 74.2 Solanum tuberosum G O 35.8 Arctostaphylos uva-ursi T R 98.8 Sonchus oleraceus L. G O 41.0 Arctostaphylos uva-ursi T S 82.4 Sorghum dochna G S 100.0 Aronia prunifolia T W 27.3 Sorghum sudanense G O 32.6 Artemisia draculus T S 20.2 Sorghum sudanense G W 39.7 Artemisia dracunlus T S 37.2 Symphytum officinale G V 79.4 Artemisia Ludoviciana T O 54.8 Symphytum officinale G O 74.6 Aster sp ? T O 43.4 Tanacetum parthenium G V 23.1 Aster sp ? T R 99.9 Tanacetum parthenium G W 24.3 Ayperus esculentus T W 46.9 Tanacetum vulgare G W 20.8 Beta vulgaris T R 81.4 Tanacetum vulgare G O 32.0 Beta vulgaris T O 30.6 Tanacetum vulgare G O 58.5 Betula glandulosa T W 58.2 Tanacetum vulgare “Goldsticks” G V 44.8 Borago officinalis T O 20.2 Taraxacum officinale G V 58.2 Brassica juncea T R 56.6 Thymus fragantissumus G R 39.9 Brassica napus T R 34.1 Thymus herba-barona G W 26.6 Brassica nigra T S 32.3 Thymus herba-barona G V 35.7 Brassica rapa T R 21.4 Thymus praecox subsp arctitus G O 78.0 Calamintha nepeta T V 71.4 Thymus serpyllum G V 47.4 Calamintha nepeta T W 30.3 Thymus serpyllum G O 100.0 Canna edulis T O 31.9 Thymus serpyllum G W 22.6 Canneberge T R 66.3 Thymus serpyllum G V 70.2 Capsella bursa-pastoris (linné) médicus T R 37.1 Thymus vulgaris G O 40.8 Carya cordiformis T W 100.0 Thymus vulgaris G W 37.3 Chaerophyllum bulbosum T V 86.0 Thymus vulgaris “Argenteus” G V 87.7 Chrysanthemum leucanthemum linné T O 45.4 Thymus x citriodorus G W 27.2 Cichorium intybus T V 74.8 Vaccinum angustifolium G S 41.7 Cichorium intybus T W 23.8 Vaccinum macrocarpon G W 63.5 Cichorium intybus T O 38.9 Viburnum trilobum Marsh. G R 67.7 Cimicifuga racemosa T W 65.1 Viburnum trilobum Marsh. G W 23.6 Citrullus colocynthus T S 50.2 Vica sativa G O 38.5 Citrus limettoides T O 45.1 Vica villosa G O 25.2 Citrus limettoides T V 28.9 Vitia sp. G S 24.8 Citrus limon T O 25.9 Vitia sp. G W 100.0 Citrus limon T V 43.3 Vitia sp. G R 100.0 Coix Laciyma-Jobi T O 22.1 Vitia sp. G S 20.8 Coriandrum sativum T W 62.0 Zea mays G O 53.7 Crataegus sp ? T R 44.0 Perilla frutescens T O 100.0 Crataegus submollis T S 40.7 Perilla frutescens T W 61.7 Crataegus submollis T S 29.3 Perilla frutescens T V 75.6 Curcuma longa syn. C. domestica T O 22.2 Achillea millefolium T W 41.8 Cynara scolymus T R 42.2 Achillea millefolium T V 31.5 Dioscorea batatas T O 29.1 Acorus calamus T R 68.4 Dioscorea batatas T O 28.9 Acorus calamus T S 39.2 Diospiros Kaki T V 57.8 Adiantum pedatum T R 100.0 Dirca palustris T S 39.2 Agastache foeniculum T O 78.0 Dolichus lablab T R 42.9 Agastache foeniculum “Snow Pike” T W 34.5 Dryopteris filix-mas T O 24.9 Agastache foeniculum “Snow Pike” T V 54.3 Dryopteris filix-mas T R 100.0 Agrimonia eupatoria T W 100.0 Echinacea purpurea T V 78.9 Alchemilla mollis T V 37.1 Melissa officinalis T V 36.0 Alchemilla mollis T W 100.0 Melissa officinalis T W 36.8 Echinacea purpurea T W 95.8 Melissa officinalis T O 100.0 Echinacea purpurea T O 53.7 Melissa officinalis T R 30.3 Erigeron speciosus (Lindl.) D.C. T O 96.2 mentha arvensis T R 67.2 Fragaria T O 42.7 Mentha piperita T S 20.8 Fragaria x ananassa T S 100.0 Mentha piperita T O 100.0 Fragaria x ananassa T S 100.0 Mentha piperita T S 26.9 Fruit de la passion T O 30.2 Mentha piperita T O 97.8 Fucus vesiculosis T O 93.3 Mentha piperita vulgaris T W 20.2 Galinsoga ciliata (Rofiresque) Blake. T R 33.0 Mentha piperita vulgaris T V 42.5 Galium odoratum T R 27.0 Mentha pulegium T O 100.0 Gaultheria hispidula (L.) Muhl T W 100.0 Mentha spicata T W 51.6 Gaultheria procumbens T W 30.0 Mentha spicata T V 81.8 Gaultheria procumbens T S 100.0 Mentha spicata T O 100.0 Glycine max Envy T O 20.1 Mentha spicata T O 100.0 Glycyrrhiza glabra T W 47.9 Mentha spicata T S 23.2 Guizotia abyssinica T R 74.1 Nepeta cataria T V 62.8 Guizotia abyssinica T S 22.7 Ocimum Basilicum T V 41.1 Hamamelis virginiana T O 100.0 Ocimum Basilicum T W 40.0 Hamamelis virginiana T R 100.0 Ocimum Basilicum T O 28.4 Helenium hoopesii T O 21.7 Oenothera biennis linné T O 67.3 Helenium hoopesii T S 24.6 Oenothera biennis linné T R 100.0 Helianthus annus T O 21.0 Onobrychis viciafolia T O 34.0 Helianthus strumosus T O 85.6 Origanum marjonara T O 29.5 Helianthus tuberosa T V 64.5 Origanum vulgare T V 55.5 Helianthus tuberosa T W 100.0 Origanum vulgare T W 67.7 Helichrysum angustifolium T O 100.0 Origanum vulgare T W 46.4 Helichrysum angustifolium T W 87.0 Origanum vulgare T V 68.6 Helichrysum angustifolium T V 84.4 Origanum vulgare T W 99.9 Helichrysum angustifolium T S 92.3 Origanum vulgare T V 42.0 Helichrysum thianschanicum Regel T O 59.5 Origanum Vulgare T V 28.8 Heliotropium arborescens T O 85.1 Origanum Vulgare T W 46.7 Hibiscus cannabinus T O 25.0 Origanum vulgare T O 100.0 Humulus lupulus T S 21.4 Origanum vulgare T W 51.7 Humulus lupulus T S 21.5 Origanum vulgare T S 30.8 Humulus lupulus T R 88.4 Origanum vulgare T O 25.4 Humulus lupulus T S 22.5 Origanum vulgare T S 38.2 Hypericum perforatum T R 100.0 oxyria digyna T V 23.1 Inula helenium T V 97.1 Pastinaca sativa T O 33.1 Inula helenium T W 69.0 Pastinaca sativa T R 22.2 Inula helenium T S 29.3 Petroselinum crispum Nyman ex. A. W Hill T W 24.8 Ipomea batalas T O 27.0 Peucedanum cervaria T R 53.0 Iris versicolor T R 22.9 Peucedanum cervaria T R 35.9 Juniperus communis T R 100.0 Plaffia paniculata T O 85.9 Krameria Triandra T O 52.6 Phaseolus vulgaris T O 35.7 Lathyrus sylvestris T R 32.5 Phytolacca americana T S 28.6 Laurus nobilis T S 100.0 Phytolacca decandra syn. P. americana T O 31.6 Lavendula angustifolia T V 74.8 Plectranthus sp. T V 66.0 Lavendula angustifolia T W 70.2 Polygonium chinense Polygonum T S 33.2 Lavendula latifolia T W 85.6 Polygonium aviculare linné T R 100.0 Lavendula latifolia T V 63.3 Populus x petrowskyana T O 25.4 Lavendula latifolia T O 20.2 Potentilla anserina T S 55.8 Ledum groenlandicum T R 100.0 Poterium sanguisorba T W 100.0 Ledum groenlandicum T S 94.1 Poterium sanguisorba T V 82.3 Lepidium sativum T O 20.5 Prunella vulgaris T O 52.6 Litchi chinensis T S 100.0 Psoralea corylifolia T O 21.3 Lolium multiflorum T O 22.7 Psoralea corylifolia T S 26.0 Lonicera ramosissima T S 30.9 Psoralea corylifolia T S 27.4 Lotus corniculatus T R 60.2 Pteridium aquilinum T R 100.0 Malus T V 23.1 Punica granatum T V 21.3 Malva moschata T S 31.4 Punica granatum T W 77.1 Melissa officinalis T V 81.4 Punica granatum T S 43.9 Melissa officinalis T W 87.5 Satureja repandra T R 35.8 Melissa officinalis T O 100.0 Satureja repandra T W 100.0 Radix Rehmannia T O 23.9 Satureja repandra T V 75.0 Raphanus raphanistrum T R 36.5 Solanum Tuberosum T O 30.9 Raphanus raphanistrum T R 30.5 Solidago canadensis T R 91.8 Rhamnus frangula T R 100.0 Sonchus oleraceus L. T O 45.9 Rheum palmatum T W 100.0 Sorghum dochna Snowdrew T O 31.5 Rianus communis T R 100.0 Sorghum sudanense T O 33.6 Rianus communis T S 100.0 Stipa capillata L. T O 33.0 Rianus communis T S 68.2 Symphytum officinale T O 94.1 Ribes Grossularia L. T W 61.1 Symphytum officinale T O 42.8 Ribes nidigrolaria T W 32.1 Tanacetum parthenium T W 40.1 Ribes nigrum T O 90.2 Tanacetum parthenium T V 33.6 Ribes nigrum T S 20.3 Tanacetum vulgare T V 36.5 Ribes nigrum L. T W 21.1 Tanacetum vulgare T W 51.2 Ribes nigrum L. T W 51.6 Tanacetum vulgare T O 95.6 Ribes sativam syme T W 20.9 Tanacetum vulgare T O 38.4 Ribes uva-crispa T S 41.8 Tanacetum vulgare T R 27.4 Rosa rugosa T S 100.0 Tanacetum vulgare “Goldsticks” T V 37.9 Rosa rugosa thumb. T W 94.1 Taraxacum officinale T V 57.8 Rosmarinum officinalis T O 100.0 Thymus fragantissumus T R 34.0 Rosmarinum officinalis T R 40.0 Thymus fragantissumus T W 72.7 Rosmarinum officinalis T V 76.9 Thymus fragantissumus T V 71.0 Rubus canadensis T S 31.3 Thymus praecox subsp arctitus T O 59.2 Rubus canadensis T V 22.8 Thymus pseudolanuginosus T O 85.7 Rubus canadensis T W 100.0 Thymus pseudolanuginosus T W 20.9 Rubus idaeus T V 25.0 Thymus serpyllum T O 94.8 Rubus idaeus L. T S 100.0 Thymus serpyllum T W 38.4 Rubus ideaus T S 46.1 Thymus vulgaris T O 100.0 Rubus ideaus T R 32.0 Thymus vulgaris “Argenteus” T V 80.4 Rubus ideaus T O 28.5 Thymus x citriodorus T O 100.0 Rubus occidentalis T R 100.0 Tiarella cordifolia T R 100.0 Rubus occidentalis T O 23.5 Trichosanthes kirilowii T O 100.0 Rumes scutatus T O 27.1 Triticale sp. T O 24.4 Rumex acetosella linné T O 23.0 Tropaeolum majus T O 20.6 Rumex crispus linné T R 100.0 Ulmus americana T O 43.7 Rumex crispus linné T R 100.0 Urtica dioica T R 28.9 Salvia (elegens) T O 100.0 Vaccinium angustifolium T S 43.2 Salvia elegens T W 63.5 Vaccinium angustifolium T S 42.4 Salvia officinalis T O 34.0 Vaccinium macrocarpon T W 59.2 Salvia officinalis T R 41.7 Vaccinium macrocarpon T S 27.2 Salvia officinalis T V 64.3 Vaccinium macrocarpon T S 21.6 Salvia officinalis T W 100.0 Vaccinum macrocarpon T V 62.6 Salvia officinalis T R 38.8 Veronica officinalis T S 52.6 Salvia officinalis T O 73.4 Viburnum trilobum Marsh. T R 100.0 Salvia officinalis T W 95.3 Vida villosa T O 36.6 Salvia officinalis T V 56.8 Vitia sp. T W 58.9 Salvia officinalis T W 25.1 Vitis sp T S 24.7 Salvia sclarea T W 28.6 Vitis sp. T S 22.8 Sambucus canadensis T S 40.1 Vitis sp. T S 21.7 Sambucus canadensis L. T O 50.2 Zea mays T S 20.5 Sambucus canadensis T S 29.7 Sanguisorba minor T V 32.0 Sanguisorba minor T W 59.5 Sanguisorba minor T S 58.5 Sanguisorba minor T S 68.5 Satureja hortensis T O 66.5 Satureja hortensis T S 20.1 Satureja montana T O 43.3 Satureja montana T R 36.7 Satureja montana T W 100.0 Satureja montana T V 81.1 Satureja montana T S 40.6 Satureja montana T V 54.0 Satureja montana T O 90.1

TABLE 8 Cath L Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Actinidia arguta A R 63.3 Capsella bursa- A O 47.0 pastoris Actinidia arguta A O 46.3 Capsicum annuum A R 29.1 Achillea A O 32.4 Carum carvi A O 60.4 millefolium Achillea A R 26.3 Chaerophyllum A O 48.6 millefolium bulbosum Aconitum napellus A O 30.0 Chaerophyllum A R 48.2 bulbosum Acorus calamus A R 25.9 Chelidonium majus A O 35.5 Adiantum pedatum A O 20.2 Chelidonium majus A R 23.1 Adiantum pedatum A R 22.2 Chenopodium A O 65.9 bonus-henricus Agropyron repens A O 98.6 Chenopodium A R 62.3 quinoa Agropyron repens A R 61.8 Chenopodium A O 90.0 quinoa Alchemilla mollis A O 75.7 Cicer arietinum A O 82.4 Alchemilla mollis A R 36.5 Cichorium intybus A R 58.0 Allium porrum A R 39.7 Cichorium intybus A O 81.7 Allium porrum A O 58.2 Coix Lacryma-Jobi A R 32.6 Allium cepa A O 51.0 Coix Lacryma-Jobi A O 43.4 Allium sativum A O 53.8 Coriandrum A R 26.9 sativum Allium A O 74.6 Coriandrum A O 65.0 schoenoprasum sativum Allium Tuberosum A O 69.5 Cornus canadensis A R 99.7 Aloe vera A R 44.7 Cornus canadensis A O 60.6 Aloe vera A O 55.6 Crataegus sp A R 25.9 Althaea officinalis A O 95.0 Crataegus sp A O 28.2 Althaea officinalis A R 33.4 Cryptotaenia A O 73.3 canadensis Amaranthus A R 74.5 Cryptotaenia A R 36.1 retroflexus canadensis Amaranthus A O 98.4 Cymbopogon A O 32.7 retroflexus citratus Anethum A R 37.4 Daucus carota A R 63.6 graveolens Anethum A O 58.7 Daucus carota A O 43.4 graveolens Angelica A O 79.1 Dirca palustris A O 61.1 archangelica Apium graveolens A R 27.9 Dirca palustris A R 46.6 Apium graveolens A O 46.5 Echinacea purpurea A O 54.8 Aralia nudicaulis A O 89.3 Eleusine coracana A O 36.4 Aralia nudicaulis A R 55.4 Fagopyrum A R 37.9 esculentum Arctium lappa A R 32.8 Fagopyrum A O 43.3 esculentum Arctium minus A R 72.5 Fagopyrum A R 28.4 tataricum Arctium minus A O 61.3 Fagopyrum A O 32.8 tataricum Armoracia A O 95.8 Foeniculum vulgare A O 48.8 rusticana Aronia A R 39.8 Fragaria x A R 46.3 melanocarpa ananassa Aronia A O 28.2 Fragaria x A O 78.8 melanocarpa ananassa Artemisia A R 51.7 Galinsoga ciliata A O 46.0 Absinthium Artemisia A O 63.7 Galium odoratum A R 59.8 Absinthium Artemisia A O 45.4 Galium odoratum A O 79.5 dracunculus Aster sp A R 41.8 Gaultheria A R 53.4 hispidula Aster sp A O 91.5 Gaultheria A O 54.3 hispidula Atropa belladonna A O 47.3 Glechoma A O 23.4 hederacea Atropa belladonna A R 31.7 Glechoma A R 26.9 hederacea Cyperus A R 41.3 Glycine max A R 20.5 esculentus Cyperus A O 33.8 Glycine max A O 73.8 esculentus Beckmannia A O 60.8 Glycyrrhiza glabra A O 57.7 eruciformis Beckmannia A O 60.8 Glycyrrhiza glabra A R 53.8 eruciformis Beta vulgaris A R 66.1 Guizotia abyssinica A R 29.6 Beta vulgaris A O 79.5 Guizotia abyssinica A O 78.6 Beta vulgaris spp. A O 63.3 Hamamelis A R 41.2 Maritima virginiana Beta vulgaris spp. A R 59.1 Hedeoma A O 26.3 Maritima pulegioides Borago officinalis A O 40.9 Helleborus niger A O 36.9 Brassica napus A O 64.6 Helleborus niger A R 35.4 Brassica napus A R 21.1 Hordeum A R 31.1 hexastichon Brassica oleracea A R 66.6 Hyssopus officinalis A R 84.8 Brassica oleracea A O 68.6 Hyssopus officinalis A O 85.8 Brassica rapa A O 99.0 Inula helenium A O 58.4 Brassica rapa A R 99.3 Inula helenium A R 32.7 Campanula A R 59.0 Ipomoea Batatas A O 29.6 rapunculus Campanula A O 50.6 Lathyrus sativus A R 31.7 rapunculus Canna edulis A O 23.9 Lathyrus sativus A O 71.1 Capsella bursa- A R 49.0 Lathyrus sylvestris A R 65.3 pastoris Lathyrus sylvestris A O 66.4 Rosa rugosa A O 35.9 Laurus nobilis A R 43.1 Rosmarinus A O 78.2 officinalis Laurus nobilis A O 46.1 Rubus A O 76.8 allegheniensis Leonurus cardiaca A O 63.3 Rubus canadensis A R 40.7 Leonurus cardiaca A R 24.5 Rubus canadensis A O 72.6 Levisticum A R 20.9 Rubus idaeus A R 35.5 officinale Levisticum A O 43.8 Rubus idaeus A O 97.9 officinale Lotus corniculatus A R 59.0 Rumex Acetosa A O 32.0 Lotus corniculatus A O 87.4 Rumex acetosella A R 73.2 Lycopersicon A R 28.0 Rumex acetosella A O 56.9 esculentum Malva sylvestris A O 23.1 Rumex crispus A R 49.7 Medicago sativa A R 63.8 Rumex crispus A O 37.5 Medicago sativa A O 53.6 Rumex Scutatus A O 53.1 Melilotus albus A O 93.7 Rumex Scutatus A R 25.9 Melilotus albus A R 80.1 Ruta graveolens A O 56.2 Melissa officinalis A R 40.8 Salix purpurea A R 71.4 Melissa officinalis A O 69.5 Salix purpurea A O 24.7 Mentha piperita A R 61.0 Salvia elegans A O 67.6 Mentha piperita A O 73.2 Salvia officinalis A O 70.5 Mentha pulegium A O 69.0 Salvia officinalis A R 56.6 Mentha spicata A O 94.6 Salvia sclarea A O 70.1 Mentha A O 55.2 Santolina A R 59.5 suaveolens chamaecyparissus Nepeta cataria A R 45.9 Santolina A O 59.2 chamaecyparissus Nepeta cataria A O 66.3 Satureja montana A O 71.7 Nicotiana tabacum A R 46.8 Scorzonera A O 21.9 hispanica Oenothera biennis A R 69.8 Secale cereale A R 33.3 Oenothera biennis A O 47.3 Senecio vulgaris A R 47.5 Origanum A O 38.5 Senecio vulgaris A O 20.8 majorana Origanum vulgare A R 43.3 Setaria italica A R 48.6 Origanum vulgare A O 68.2 Setaria italica A O 37.1 Panax A R 41.7 Sium Sisarum A O 33.8 quinquefolius Panax A O 83.7 Sium Sisarum A R 62.5 quinquefolius Pastinaca sativa A O 62.8 Solanum tuberosum A O 53.6 Pastinaca sativa A R 44.2 Solidago sp A R 54.0 Perilla frutescens A O 66.2 Solidago sp A O 95.1 Petasites A R 22.6 Sonchus oleraceus A R 59.4 japonicus Petasites A O 25.5 Sonchus oleraceus A O 69.2 japonicus Petroselinum A O 79.1 Sorghum dochna A R 33.9 crispum Petroselinum A R 32.3 Sorghum dochna A O 55.3 crispum Phalaris A R 45.4 Sorghum durra A R 61.3 canariensis Phaseolus vulgaris A R 31.0 Sorghum durra A O 83.9 Phaseolus A O 61.8 Stachys byzantina A R 61.6 Vulgaris Pimpinella anisum A O 38.1 Stachys byzantina A O 73.8 Plantago major A O 95.1 Stellaria graminea A R 40.1 Plectranthus sp. A R 76.9 Stellaria graminea A O 55.8 Plectranthus sp. A O 58.0 Stellaria media A R 70.9 Polygonum A R 28.0 Stellaria media A O 51.4 aviculare Polygonum A O 49.7 Tanacetum A O 67.7 aviculare cinerariifolium Potentilla A R 26.6 Tanacetum A R 50.8 anserina parthenium Poterium A O 58.0 Tanacetum A O 81.9 Sanquisorba parthenium Pteridium A R 32.9 Tanacetum vulgare A R 56.2 aquilinum Raphanus A R 70.7 Tanacetum vulgare A O 51.9 raphanistrum Raphanus A O 83.2 Taraxacum A O 98.7 raphanistrum officinale Raphanus salivus A R 90.9 Taraxacum A R 82.1 officinale Raphanus sativus A O 95.4 Teucrium A O 62.2 chamaedrys Rheum A R 26.0 Thymus praecox A R 42.0 rhabarbarum subsp arcticus Rheum A O 62.9 Thymus praecox A O 54.2 rhabarbarum subsp arcticus Ribes nigrum A O 62.9 Thymus serpyllum A O 93.4 Ribes Sylvestre A R 34.5 Thymus serpyllum A R 57.5 Ribes Sylvestre A O 80.3 Thymus vulgaris A R 68.7 Ricinus communis A R 89.9 Thymus vulgaris A O 55.8 Ricinus communis A O 81.0 Thymus x A O 72.8 citriodorus Rosa rugosa A R 32.9 Thymus x A R 31.9 citriodorus Tragopogon A O 67.2 Asparagus G O 86.3 porrifolius officinalis Tragopogon A R 37.0 Aster Linne G O 57.5 porrifolius Tropaeolum malus A O 62.8 Aster sp G R 48.7 Typha latifolia A R 77.5 Aster sp G O 94.5 Typha latifolia A O 70.6 Atropa belladonna G R 29.2 Vaccinium A O 74.7 Beckmannia G O 32.9 Corymbosum eruciformis Vaccinium A R 69.5 Beta vulgaris G R 47.9 Corymbosum Vaccinium A R 71.4 Beta vulgaris G O 61.9 macrocarpon Vaccinum A O 78.9 Borago officinalis G O 51.9 macrocarpon Verbascum A O 76.8 Brassica Napus G O 92.1 thapsus Verbascum A R 62.0 Brassica napus G R 30.2 thapsus Vicia sativa A R 79.2 Brassica oleracea G R 79.0 Vicia sativa A O 88.7 Brassica oleracea G O 85.4 Vicia villosa A O 74.5 Brassica rapa G O 81.7 Vicia villosa A R 61.0 Calamagrostis G R 59.7 arundiflora Vinca minor A O 46.7 Campanula G R 65.4 rapunculus Vinca minor A R 31.9 Campanula G O 54.8 rapunculus Vitiis sp. A R 89.5 Canna edulis G O 30.0 Vitiis sp. A O 54.6 Capsella bursa- G R 48.1 pastoris Zea mays A R 52.0 Capsella bursa- G O 50.9 pastoris Zea mays A O 93.8 Tropaeolum majus G R 22.2 Achillea G O 45.8 Tropaeolum majus G O 59.1 millefolium Achillea G R 24.6 Carum carvi G O 62.4 millefolium Aconitum napellus G R 28.7 Cerastium G R 45.1 tomentosum Acorus calamus G R 37.5 Chaerophyllum G O 30.0 bulbosum Acorus calamus G O 32.8 Chaerophyllum G R 54.5 bulbosum Actinidia arguta G R 47.8 Chelidonium majus G O 43.2 Actinidia arguta G O 78.4 Chelidonium majus G R 30.7 Adiantum pedatum G O 45.9 Chichorium endivia G O 64.2 Adiantum pedatum G R 27.0 Chichorium endivia G R 48.3 subsp endivia Agropyron repens G O 83.0 Chichorium endivia G O 67.0 subsp endivia Agropyron repens G R 31.9 Cichorium intybus G O 78.3 Alchemilla mollis G O 71.0 Cichorium intybus G R 87.8 Allium G R 36.8 Circium arvense G R 94.1 ampeloprasum Allium G O 62.2 Circium arvense G O 58.7 ampeloprasum Allium cepa G R 56.1 Coix Lamyma-Tobi G R 35.7 Allium cepa G O 64.4 Coix Lamyma-Tobi G O 31.4 Allium sativum G O 65.2 Cornus canadensis G R 61.3 Allium G O 78.4 Cornus canadensis G O 80.6 schoenoporasum Allium tuberosum G O 46.6 Crataegus G R 21.0 submollis Aloe vera G O 45.7 Crataegus G O 44.4 submollis Althaea G O 50.0 Cymbopogon G R 39.6 officianalis citratus althaea officinalis G R 42.2 Cyperus esculentus G R 62.4 Amaranthus G R 41.7 Cyperus esculentus G O 49.6 retroflexus Amaranthus G O 90.3 Daucus carota G O 36.3 retroflexus Anethum G R 31.3 Daucus carota G R 44.3 graveolens Anethum G O 60.5 Dirca palustris G O 85.1 graveolens Angelica G O 64.3 Dirca palustris G R 47.1 archangelica Angelica G R 63.3 Echinacea purpurea G O 36.4 archangelica Apium graveolens G O 57.0 Eleusine coracana G O 65.4 Apium graveolens G R 28.4 Eleusine coracana G R 36.8 Aralia nudicaulis G O 71.8 Erigeron speciosus G R 39.1 Aralia nudicaulis G R 38.2 Erysimum G R 58.7 perofskianum Arctium minus G R 42.4 Erysimum G O 93.1 perofskianum Arctium minus G O 41.5 Fagopyrum G R 36.4 esculentum Armoracia G O 67.1 Fagopyrum G O 41.0 rusticana esculentum Aronia G R 32.0 Fagopyrum G R 43.3 melanocarpa tataricum Aronia G O 70.0 Fagopyrum G O 29.1 melanocarpa tataricum Artemisia G R 63.1 Galinsoga ciliata G R 49.8 absinthium Artemisia G O 61.1 Galinsoga ciliata G O 58.0 absinthium Asclepias G R 58.4 Galium odoratum G R 65.1 incarnata Asclepias G O 63.3 Galium odoratum G O 94.2 incarnata Asparagus G R 61.2 Gaultheria G R 55.7 officinalis hispidula Gaultheria G O 50.6 Oenothera biennis G O 44.3 hispidula Gaultheria G R 53.3 Origanum G O 44.7 procumbens majorana Gaultheria G O 67.7 Origanum vulgare G O 58.1 procumbens Glechoma G O 70.9 Origanum vulgare G R 22.9 hederacea Glechoma G R 25.3 Oryza Sativa G R 71.8 hederacea Glycine max G R 78.6 Oryza Sativa G O 39.8 Glycine max G O 85.9 Oxalis Deppei G R 80.1 Glycyrrhiza G R 59.1 Oxalis Deppei G O 28.8 glabra Glycyrrhiza G O 60.6 Oxyria digyna G R 51.8 glabra Guizotia G R 41.8 Oxyria digyna G O 36.2 abyssinica Guizotia G O 74.3 Panax G R 72.1 abyssinica quinquefolius Hamamelis G R 44.2 Panax G O 81.6 virginiana quinquefolius Helianthus G O 40.6 Panicum miliaceum G O 93.4 strumosus Helianthus G R 61.4 Passiflora caerula G R 33.2 strumosus Helianthus G O 75.1 Passiflora caerula G O 63.2 tuberosus Helianthus G R 30.1 Pastinaca sativa G O 54.0 tuberosus Helichrysum G R 56.3 Pennisetum G R 61.0 thianschanicum alopecuroides Helichrysum G O 84.0 Petasites japonicus G O 50.0 thianschanicum Helleborus niger G O 38.8 Petroselinum G R 49.1 crispum Helleborus niger G R 25.9 Petroselinum G O 52.2 crispum Hordeum G O 62.3 Phalaris G O 72.1 hexastichon canariensis Hordeum G R 29.4 Phaseolus vulgaris G R 21.8 hexastichon Hyssopus G R 64.7 Pimpinella anisum G O 86.2 officinalis Hyssopus G O 71.9 Pisum sativum G O 61.6 officinalis Inula helenium G O 29.4 Pisum sativum G R 57.5 Inula helenium G R 25.7 Plantago major G O 91.9 Ipomoea batatas G O 36.9 Plectranthus sp. G R 53.0 Lactuca sativa G O 70.4 Plectranthus sp. G O 73.0 Lactuca sativa G R 49.9 Polygonum G R 32.2 aviculare Lathyrus sativus G O 62.8 Polygonum G O 36.4 aviculare Lathyrus sativus G R 29.0 Portulaca oleracea G R 82.1 Lathyrus sylvestris G R 52.1 Portulaca oleracea G O 63.3 Lathyrus sylvestris G O 52.5 Potentilla anserina G R 26.3 Laurus nobilis G R 27.1 Poterium G O 79.9 sanquisorba Laurus nobilis G O 61.0 Prunella vulgaris G R 68.8 Lavandula G R 51.9 Prunella vulgaris G O 57.4 angustifolia Lavandula G O 57.0 Raphanus G R 91.9 angustifolia Raphanistrum Ledum G O 73.4 Raphanus G O 55.2 groenlandicum Raphanistrum Ledum G R 52.6 Rhaphanus sativus G R 55.7 groenlandicum Leonurus cardiaca G O 88.8 Rhaphanus sativus G O 78.4 Leonurus cardiaca G R 38.5 Rheum G R 27.1 rhabarbarum Levistecum G R 51.2 Rheum G O 56.8 officinale rhabarbarum Levistecum G O 78.3 Ribes nidigrolaria G O 70.7 officinale Lotus comiculatus G O 86.8 Ribes nigrum G R 37.9 Lotus comiculatus G R 50.3 Ribes nigrum G O 98.9 Lupinus G R 78.9 Ribes Sylvestris G R 25.2 polyphyllus Lupinus G O 66.7 Ribes Sylvestris G O 65.7 polyphyllus Malus hupehensis G R 52.7 Ricinus communis G R 39.3 Malus hupehensis G O 64.1 Ricinus communis G O 84.3 Malva sylvestris G R 26.2 Rosmarinus G O 68.6 officinalis Medicago sativa G R 43.4 Rubus idaeus G O 26.3 Medicago sativa G O 92.5 Rumex crispus G R 54.2 Melilotus albus G R 75.5 Rumex crispus G O 62.0 Melilotus albus G O 70.0 Rumex scutatus G O 38.1 Melissa officinalis G O 81.1 Ruta graveolens G O 85.0 Mentha piperita G O 54.4 Salix purpurea G R 74.7 Mentha pulegium G O 59.4 Salix purpurea G O 38.5 Mentha spicata G R 38.8 Salvia elegans G O 54.8 Mentha spicata G O 83.0 Salvia officinalis G R 89.7 Mentha G O 56.5 Salvia officinalis G O 84.9 suaveolens Nepeta cataria G O 56.2 Salvia sclarea G O 61.8 Ocimum basilicum G O 60.3 Sambucus ebulus G R 48.2 Oenothera biennis G R 39.2 Sambucus ebulus G O 98.2 Santolina G R 61.3 Vaccinium G O 76.7 chamaecyparissus macrocarpon Santolina G O 88.2 Veratrum viride G O 35.4 chamaecyparissus Saponaria G R 52.9 Verbascum thapsus G O 72.9 officinalis Saponaria G O 71.8 Verbascum thapsus G R 60.5 officinalis Satureja hortensis G O 44.9 Viburnum trilobum G R 52.6 Satureja montana G O 76.8 Vicia sativa G R 36.6 Scorzonera G R 32.9 Vicia sativa G O 83.2 hispanica Scuttellaria G O 49.8 Vicia villosa G O 77.3 lateriflora Scuttellaria G R 39.6 Vicia villosa G R 46.8 lateriflora Secale cereale G R 37.0 Vinca minor G O 63.0 Senecio vulgaris G R 31.0 Vinca minor G R 30.8 Senecio vulgaris G O 47.0 Vitis sp. G R 52.7 Setaria italica G R 44.9 Vitis sp. G O 99.2 Setaria italica G O 42.0 Zea mays G R 45.1 Silene vulgaris G R 76.8 Zea mays G O 55.3 Silene vulgaris G O 92.2 Perilla frutescens T R 68.0 Sium sisarum G O 58.9 Perilla frutescens T O 74.4 Sium sisarum G R 66.6 Achillea millefolium T O 46.0 solanum G R 66.8 Achillea millefolium T R 32.9 melongena Solanum G O 47.4 Aconitum napellus T O 35.2 tuberosum Solidago sp G R 53.6 Aconitum napellus T R 31.9 Solidago sp G O 88.3 Acorus calamus T O 40.6 Sonchus oleraceus G R 62.5 Acorus calamus T R 26.9 Sonchus oleraceus G O 55.5 Actinidia arguta T R 80.0 Sorghum dochna G R 67.4 Actinidia arguta T O 66.3 Sorghum dochna G O 73.7 Adiantum pedatum T O 43.4 sorghum durra G R 24.8 Agrimonia T O 37.5 eupatoria sorghum durra G O 42.3 Agropyron repens T O 75.0 Sorghum G R 35.5 Agropyron repens T R 50.0 sudanense Sorghum G O 66.3 Alchemilla mollis T O 71.6 sudanense Stachys byzantina G R 75.5 Alchemilla mollis T R 81.1 Stachys byzantina G O 66.7 Allium T O 84.4 ampeloprasum Stellaria graminea G R 36.9 Allium cepa T O 49.2 Stellaria graminea G O 40.1 Allium cepa T R 30.1 Stellaria media G R 31.2 Allium sativum T O 63.8 Stellaria media G O 51.1 Allium T O 79.6 schoenoprasum Symphytum G R 90.2 Allium tuberosum T O 55.8 officinale Symphytum G O 90.8 Allium tuberosum T R 29.6 officinale Tanacetum G O 76.1 Aloe vera T R 30.3 cinerariifolium Tanacetum G R 70.1 Aloe vera T O 42.7 parthenium Tanacetum G O 62.4 Althaea officinalis T R 42.5 parthenium Tanacetum G R 36.2 Althaea officinalis T O 46.3 vulgare Tanacetum G O 72.5 Amaranthus T R 37.3 vulgare candatus Taraxacum G O 100.0 Amaranthus T O 60.0 officinale candatus Taraxacum G R 78.6 Amaranthus T R 33.2 officinale retroflexus Teucrium G O 50.5 Amaranthus T O 94.3 chamaedrys retroflexus Teucrium G R 40.1 angelica T O 37.4 chamaedrys archangelica Thymus G R 81.4 angelica T R 55.7 fragantissimus archangelica Thymus G O 58.4 Anthriscus T O 86.5 fragantissimus cerefolium Thymus praecox G R 49.2 Anthriscus T R 69.6 subsp arcticus cerefolium Thymus praecox G O 62.4 Apium graveolens T R 22.0 subsp arcticus Thymus serpyllum G O 70.4 Aralia nudicaulis T O 77.5 Thymus serpyllum G R 54.9 Aralia nudicaulis T R 28.4 Thymus vulgaris G R 55.1 Arctium minus T R 54.4 Thymus x G O 47.1 Arctium minus T O 89.5 citriodorus Tiarella cordifolia G O 52.8 Armoracia T O 84.9 rusticana Typha latifolia G R 65.1 Aronia T R 61.9 melanocarpa Typha latifolia G O 46.9 Aronia T O 84.5 melanocarpa Vaccinium G O 54.5 Artemisia T R 29.0 corymbosum absinthium Vaccinium G R 82.9 Artemisia T O 55.9 corymbosum absinthium Vaccinium G R 27.9 Artemisia T O 96.7 angustifolium dracunculus Vaccinium G O 66.8 Artium lappa T O 26.0 angustifolium Vaccinium G R 40.7 Asclepias incarnata T R 58.5 macrocarpon Asclepias T O 66.8 Fagopyrum T O 25.6 incarnata tataricum Aster spp T R 40.5 Foeniculum vulgare T O 79.0 Aster spp T O 86.7 Fragaria x T O 26.0 ananassa Atropa belladonna T O 61.4 Galinsoga ciliata T R 34.6 Atropa belladonna T R 30.4 Galinsoga ciliata T O 60.3 Avena sativa T R 38.0 Galium odoratum T R 98.8 Cyperus T O 47.6 Galium odoratum T O 96.1 esculentus Cyperus T R 49.5 Gaultheria T O 33.1 esculentus hispidula Beta vulgaris T O 62.2 Gaultheria T O 84.2 procumbens Borago officinalis T O 39.1 Glechoma T O 70.1 hederacea Brassica Napus T O 89.3 Glechoma T R 38.5 hederacea Brassica nigra T R 26.9 Glycine max T O 54.8 Brassica oleracea T O 63.9 Glycine max T R 38.0 Brassica oleracea T R 76.2 Glycine max T O 88.7 Brassica oleracea T O 69.9 Glycyrrhiza glabra T O 65.5 Bromus inermis T R 79.8 Glycyrrhiza glabra T R 40.5 Bromus inermis T O 88.1 Guizotia abyssinica T R 48.1 Calamagrostis T R 62.8 Guizotia abyssinica T O 84.1 arundifloram Calendula T R 64.6 Hamamelis T R 35.9 officinalis virginiana Canna edulis T O 47.5 Hedeoma T R 24.8 pulegioides Capsella bursa- T R 48.7 Helianthus T O 32.9 pastoris strumosus Capsella bursa- T O 40.9 Helianthus T R 31.0 pastoris strumosus Carex morrowii T R 45.7 Helianthus T R 42.8 tuberosus Carex morrowii T O 70.3 Helianthus T O 72.1 tuberosus Carum carvi T R 22.7 Helichrysum T R 69.6 angustifolium Cerastium T R 46.8 Helichrysum T O 84.9 tomentosum angustifolium Chaerophyllum T R 22.9 Helichrysum T R 96.2 bulbosum thianschanicum Chaerophyllum T O 40.9 Helichrysum T O 80.7 bulbosum thianschanicum Chelidonium T O 60.7 Humulus lupulus T O 71.3 majus Chelidonium T R 24.0 Humulus lupulus T R 60.6 majus Chenopodium T R 41.5 Hyoscyamus niger T O 68.0 quinoa Chenopodium T O 86.7 Hyssopus officinalis T R 73.3 quinoa Cicer arietinum T R 20.4 Hyssopus officinalis T O 76.9 Cicer arietinum T O 84.2 Inula helenium T O 93.3 Cichorium endivia T O 76.3 Inula helenium T R 63.5 Cichorium intybus T O 81.7 Ipomoea batalas T O 99.9 Cichorium intybus T R 73.3 Juniperus T R 26.9 communis Circium arvense T R 50.0 Kochia scoparia. T O 76.7 Circium arvense T O 74.8 Koeleria glauca T R 89.1 Citrullus T O 62.5 Koeleria glauca T O 67.7 colocynthus Citrullus T R 57.3 Lactuca sativa T O 75.2 colocynthis Coix Lacryma- T R 33.7 Lactuca sativa T R 55.3 Jobi Coriandrum T O 59.2 Lathyrus Sativus T R 23.3 sativum Coriandrum T R 37.1 Lathyrus Sativus T O 70.6 sativum Cornus canadensis T R 82.6 Lathyrus sylvestris T R 77.1 Cornus canadensis T O 47.7 Lathyrus sylvestris T O 53.0 Crataegus sp T O 33.9 Laurus nobilis T R 61.6 Crataegus T O 64.3 Laurus nobilis T O 92.7 submollis Cryptotaenia T O 60.9 Lavandula T R 54.1 canadensis angustifolia Cryptotaenia T R 41.5 Lavandula T O 84.4 canadensis angustifolia Cymbopogon T R 65.2 Lavandula latifolia T R 55.4 citratus Cymbopogon T O 65.6 Lavandula latifolia T O 82.9 citratus Daucus carota T R 27.5 Ledum T O 96.1 groenlandicum Dioscorea batatas T O 42.3 Ledum T R 74.0 groenlandicum Dirca palustris T O 57.4 Lens culinaris T R 36.4 subsp culinaris Dirca palustris T R 29.5 Lens culinaris T O 100.0 subsp culinaris Echinacea T O 83.0 Levisticum T R 38.8 purpurea officinale Eleusine coracana T O 70.3 Levisticum T O 73.4 officinale Erysimum T R 90.4 Lotus corniculatus T O 81.6 perofskianum Erysimum T O 92.2 Lotus corniculatus T R 52.0 perofskianum Fagopyrum T R 61.6 Lupinus polyphyllus T R 53.3 esculentum Fagopyrum T O 39.0 Lupinus polyphyllus T O 64.4 esculentum Fagopyrum T R 36.7 Luzula sylvatica T R 62.6 tataricum Malus T O 70.9 Ribes Sylvestre T O 87.9 Malus hupehensis T R 77.6 Ribes Siylvestre T R 40.2 Malus hupehensis T O 72.4 Ribes Siylvestre T O 45.2 Medicago sativa T R 41.0 Rosmarinus T O 69.6 officinalis Medicago sativa T O 94.1 Rubus canadensis T R 37.2 Melilotus T R 44.0 Rubus canadensis T O 57.9 officinalis Melilotus T O 90.8 Rubus idaeus T R 64.9 officinalis Mentha piperita T O 20.6 Rubus idaeus T O 94.9 Menyanthes T R 20.8 Rumes scutatus T O 74.9 trifoliata Miscanthus T R 89.0 Rumes scutatus T R 20.7 sinensis Miscanthus T O 73.7 Rumex acetosella T R 40.1 sinensis Nepeta cataria T R 25.3 Rumex acetosella T O 42.0 Ocimum Basilicum T O 65.7 Rumex crispus T R 40.7 Oenothera biennis T R 40.2 Rumex crispus T O 51.2 Oenothera biennis T O 49.2 Ruta graveolens T O 91.2 Onobrychis T R 53.2 Salix purpurea T R 55.5 viciiafolia Onobrychis T O 49.2 Salix purpurea T O 51.2 viciiafolia Origanum vulgare T R 50.6 Salvia officinalis T R 64.7 Origanum vulgare T O 45.1 Salvia officinalis T O 66.6 Oryza sativa T R 40.3 Sambucus T O 92.5 canadensis Oryza sativa T O 28.6 Sambucus T R 64.0 canadensis Oxalis Deppei T R 35.2 Sanguisorba minor T O 68.4 Oxalis Deppei T O 42.1 Santolina T R 84.4 chamaecyparissus oxyria digyna T R 42.8 Santolina T O 33.9 chamaecyparissus oxyria digyna T O 52.3 Saponaria T R 59.3 officinalis Panax T O 78.8 Saponaria T O 80.4 quinquefolius officinalis Panicum T R 52.6 Satureja hortensis T O 26.5 miliaceum Passiflora T O 77.5 Satureja hortensis T R 23.0 caerulea Pastinaca sativa T R 52.0 Satureja montana T R 57.2 Pastinaca sativa T O 31.8 Satureja montana T O 43.5 Pennisetum T O 73.4 Satureja repandra T R 47.1 alopecuroides Pertoselinum T R 65.2 Satureja repandra T O 66.3 crispum Petasites T R 31.3 Scuttellaria T O 20.3 Japonicus lateriflora Petasites T O 24.6 Scuttellaria T R 33.8 Japonicus lateriflora Pertoselinum T O 45.2 Secale cereale T R 28.5 crispum Phalaris T R 33.6 Senecio vulgaris T R 34.0 canariensis Phalaris T O 86.5 Setaria italica T R 40.7 canariensis Phaseolus vulgaris T O 57.0 Silene vulgaris T R 66.3 Physalis pruinosa T O 58.2 Silene vulgaris T O 99.7 Pimpinella anisum T O 95.9 Sium sisarum T O 90.7 Pimpinella anisum T R 91.7 Sium sisarum T R 39.6 Pisum sativum T R 30.5 Solidago sp T R 44.3 Pisum sativum T O 69.3 Solidago sp T O 73.6 Plantago major T O 93.8 Sonchus oleraceus T R 53.7 Plantago major T R 20.2 Sonchus oleraceus T O 36.9 Plectranthus sp. T R 44.4 Sorghum caffrorum T R 96.4 Plectranthus sp. T O 50.8 Sorghum caffrorum T O 80.1 Polygonum T R 47.9 Sorghum dochna T R 95.3 aviculare Polygonum T O 72.7 Sorghum dochna T O 70.3 aviculare Potentilla T R 21.8 Sorghum dochna T R 98.5 anserina Prunella vulgaris T R 84.3 Sorghum dochna T O 85.3 Prunella vulgaris T O 56.7 Sorghum durra T R 86.5 Pteridium T R 32.6 Sorghum durra T O 81.7 aquilinum Raphanus T R 68.6 Sorghum sudanense T R 34.7 raphanistrum Raphanus T O 77.0 Stachys affinis T O 75.7 raphanistrum Raphanus sativus T R 41.0 Stachys affinis T R 33.5 Raphanus sativus T O 63.1 Stachys byzantina T R 60.8 Frangula alnus T O 27.0 Stachys byzantina T O 77.5 Frangula alnus T R 45.3 Stellaria graminea T R 37.5 Ricinus communis T R 22.4 Stellaria graminea T O 54.7 Ricinus communis T O 72.0 Stellaria media T R 26.0 Ribes nigrum T R 50.5 Stellaria media T O 49.0 Ribes nigrum T O 70.1 Stipa capillata T R 43.4 Symphytum T R 55.1 Urtica dioica T R 77.8 officinale Symphytum T O 64.0 Urtica dioica T O 75.6 officinale Tanacetum T O 65.5 Vaccinium T O 58.6 cinerariifolium angustifolium Tanacetum T R 45.2 Vaccinium T R 20.1 parthenium macrocarpon Tanacetum T O 54.7 Vaccinium T O 41.7 parthenium macrocarpon Tanacetum T R 59.8 Veratrum viride T O 57.1 vulgare Tanacetum T O 86.0 Veratrum viride T R 26.6 vulgare Taraxacum T O 100.0 Verbascum thapsus T O 72.8 officinale Taraxacum T R 91.3 Verbascum thapsus T R 56.0 officinale Teucrium T O 60.8 Vibumum trilobum T R 49.5 chamaedrys Teucrium T R 69.2 Viburnum trilobum T O 56.8 chamaedrys L. Thymus T R 97.8 Vicia sativa T O 73.9 fragantissimus Thymus T O 81.7 Vicia villosa T R 79.2 fragantissimus Thymus praecox T R 36.1 Vicia villosa T O 70.9 subsp arcticus Thymus praecox T O 31.8 Vinca minor T O 21.5 subsp arcticus Thymus T R 33.9 Vitis sp. T R 79.7 pseudolanuginosus Thymus T O 43.7 Vitis sp. T O 97.4 pseudolanuginosus Thymus serpyllum T R 39.2 Zea mays T R 83.5 Thymus serpyllum T O 68.6 Zea mays T O 58.2 Thymus x T O 70.9 citriodorus Thymus x T R 46.1 citriodorus Tiarella cordifolia T O 72.0 Tragopogon T O 40.9 porrifolius Tragopogon T R 20.5 porrifolius Triticosecala spp. T O 38.2 Triticum aestivum T R 31.4 Triticum aestivum T O 33.8 Tropaeolum majus T R 29.2 Tropaeolum majus T O 20.9 Typha latifolia T R 67.0 Typha latifolia T O 56.0

TABLE 9 Cath K Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achillea A O 27.6 Allium A O 78.2 millefolium schoenoprasum Aconitum napellus A O 74.0 Allium Tuberosum A O 99.6 Acorus calamus A O 74.8 Aloe vera A R 60.0 Actinidia arguta A R 28.1 Aloe vera A O 78.4 Actinidia arguta A O 96.6 Althaea officinalis A O 98.1 Agropyron repens A O 98.0 Amaranthus A R 37.4 retroflexus Alchemilla mollis A O 61.3 Amaranthus A O 43.4 retroflexus Alchemilla mollis A R 95.8 Anethum graveolens A O 33.7 Allium cepa A O 80.6 Angelica A R 36.0 archangelica Allium porrum A R 30.9 Angelica A O 85.2 archangelica Allium porrum A O 87.5 Apium graveolens A R 46.7 Allium sativum A O 71.2 Apium graveolens A O 88.8 Aralia nudicaulis A R 79.0 Hordeum A R 26.9 hexastichon Aralia nudicaulis A O 98.5 Hyssopus officinalis A R 40.2 Arctium minus A R 24.6 Inula helenium A O 86.0 Arctium minus A O 67.9 Ipomoea Batatas A R 25.6 Arctostaphylos A R 75.1 Lathyrus sativus A R 26.9 uva-ursi Arctostaphylos A O 89.8 Lathyrus sativus A O 84.9 uva-ursi Armoracia A O 92.3 Lathyrus sylvestris A R 22.4 rusticana Aronia A O 60.1 Lathyrus sylvestris A O 93.4 melanocarpa Aronia A R 61.6 Laurus nobilis A O 64.2 melanocarpa Aronia A O 82.3 Laurus nobilis A R 64.6 melanocarpa Artemisia A R 88.6 Leonurus cardiaca A O 90.0 Absinthium Artemisia A O 55.6 Levisticum officinale A R 49.4 dracunculus Aster sp A R 50.7 Levisticum officinale A O 53.3 Atropa belladonna A O 89.4 Lotus corniculatus A R 67.4 Beckmannia A R 86.0 Lotus corniculatus A O 98.8 eruciformis Beckmannia A O 96.2 Lycopersicon A R 30.1 eruciformis esculentum Beta vulgaris A R 69.3 Malva sylvestris A O 82.3 Beta vulgaris A O 87.6 Medicago sativa A R 44.0 Beta vulgaris spp. A R 53.7 Medicago sativa A O 94.4 Maritima Beta vulgaris spp. A O 84.2 Melilotus albus A R 80.7 Maritima Borago officinalis A O 38.6 Chenopodium quinoa A O 84.3 Brassica napus A R 43.5 Cicer arietinum A O 91.1 Brassica napus A O 84.4 Cichorium intybus A R 21.0 Brassica oleracea A O 60.6 Cichorium intybus A O 94.8 Brassica rapa A R 62.1 Mentha piperita A R 60.8 Brassica rapa A O 98.9 Mentha pulegium A O 55.4 Campanula A O 77.0 Mentha spicata A O 97.0 rapunculus Canna edulis A R 32.0 Mentha suaveolens A O 46.8 Capsella bursa- A R 71.4 Nepeta cataria A R 32.6 pastoris Capsella bursa- A O 72.8 Nepeta cataria A O 67.2 pastoris Capsicum annuum A R 39.0 Nicotiana tabacum A R 34.1 Chaerophyllum A O 86.6 Oenothera biennis A R 48.5 bulbosum Chelidonium A O 90.3 Oenothera biennis A O 83.4 majus Chenopodium A O 38.8 Origanum majorana A O 63.2 bonus-henricus Chenopodium A R 42.3 Origanum vulgare A R 62.2 quinoa Coix Lacryma- A O 35.2 Origanum vulgare A O 90.0 Jobi Coriandrum A R 63.6 Panax quinquefolius A O 32.3 sativum Coriandrum A O 84.4 Panax quinquefolius A R 75.9 sativum Cornus canadensis A O 58.6 Panicum miliaceum A R 25.6 Cornus canadensis A R 99.4 Panicum miliaceum A O 45.1 Crataegus sp A R 22.7 Pastinaca sativa A O 100.0 Crataegus A O 45.4 Petasites japonicus A O 82.7 submollis Cryptotaenia A R 26.3 Petroselinum A R 50.2 canadensis crispum Cryptotaenia A O 29.1 Petroselinum A O 85.7 canadensis crispum Cymbopogon A O 45.2 Petroselinum A O 92.2 citratus crispum Cyperus A O 75.0 Phalaris canariensis A R 89.5 esculentus Daucus carota A O 92.9 Phaseolus vulgaris A R 22.1 Dirca palustris A O 84.7 Phaseolus Vulgaris A O 90.3 Dirca palustris A R 94.2 Pimpinella anisum A O 72.4 Diyopteris filix- A O 85.7 Plantago major A R 22.2 mas Echinacea A O 89.8 Plantago major A O 99.8 purpurea Eleusine coracana A R 50.6 Plectranthus sp. A R 73.5 Eleusine coracana A O 58.7 Potentilla anserina A O 92.9 Fagopyrum A O 68.0 Pteridium aquilinum A O 81.9 esculentum Fagopyrum A O 20.3 Raphanus A O 70.2 tataricum raphanistrum Fagopyrum A R 33.0 Raphanus sativus A R 28.4 tataricum Foeniculum A O 40.3 Raphanus sativus A O 99.0 vulgare Fragaria x A R 44.8 Rheum rhabarbarum A R 21.4 ananassa Fragaria x A O 92.3 Rheum rhabarbarum A O 95.6 ananassa Galinsoga ciliata A O 55.3 Ribes nigrum A R 59.3 Galium odoratum A O 88.4 Ribes nigrum A O 81.8 Gaultheria A R 61.6 Ribes Sylvestre A O 98.6 hispidula Gaultheria A O 87.1 Ricinus communis A R 78.5 hispidula Glechoma A O 96.2 Ricinus communis A O 90.2 hederacea Glycine max A R 41.6 Rosa rugosa A R 36.1 Glycine max A O 100.0 Rubus allegheniensis A O 59.3 Glycyrrhiza glabra A R 50.8 Rubus canadensis A O 94.4 Glycyrrhiza glabra A O 90.2 Rubus idaeus A R 58.4 Guizotia A R 23.1 Rubus idaeus A O 97.4 abyssinica Guizotia A O 94.8 Rumex Acetosa A O 83.9 abyssinica Hamamelis A R 91.8 Rumex acetosella A R 46.7 virginiana Hedeoma A O 93.3 Rumex acetosella A O 90.9 pulegioides Helleborus niger A O 82.9 Rumex crispus A R 32.9 Rumex crispus A O 91.8 Allium G O 88.7 schoenoporasum Rumex Scutatus A O 94.9 Allium tuberosum G O 80.3 Ruta graveolens A O 92.5 Aloe vera G R 28.8 Salix purpurea A O 44.8 althaea officinalis G O 94.5 Salix purpurea A R 68.1 Amaranthus G R 35.3 retroflexus Salvia elegans A O 64.2 Amaranthus G O 73.8 retroflexus Melilotus albus A O 98.9 Anethum graveolens G O 52.0 Melissa officinalis A O 89.4 Angelica G R 39.0 archangelica Melissa officinalis A R 93.6 Angelica G O 80.6 archangelica Mentha piperita A O 60.1 Apium graveolens G R 37.7 Senecio vulgaris L. A R 80.9 Apium graveolens G O 83.9 Setaria italica A R 30.0 Aralia nudicaulis G O 86.7 Setaria italica A O 66.2 Aralia nudicaulis G R 89.5 Sium Sisarum A R 30.0 Arctium minus G R 27.1 Sium Sisarum A O 93.3 Arctium minus G O 93.4 Solanum A R 30.1 Arctostaphylos uva- G R 73.3 tuberosum ursi Solanum A O 79.8 Armoracia rusticana G O 53.8 tuberosum Solidago sp A R 43.7 Aronia melanocarpa G R 73.2 Solidago sp A O 72.1 Aronia melanocarpa G O 81.2 Sonchus oleraceus A R 21.6 Artemisia absinthium G R 92.0 Sonchus oleraceus A O 92.4 Artemisia G R 36.0 dracunculus Sorghum dochna A O 60.9 Artemisia G O 72.7 dracunculus Sorghum durra A O 89.3 Asclepias incarnata G R 67.4 Stachys affinis A R 29.3 Asclepias incarnata G O 87.0 Stachys byzantina A R 28.3 Asparagus officinalis G O 98.2 Stellaria graminea A R 49.9 Aster G O 37.4 Stellaria graminea A O 87.6 Aster sp G R 37.3 Stellaria media A R 25.7 Aster sp G O 81.3 Stellaria media A O 26.0 Beckmannia G O 90.0 eruciformis Tanacetum A R 64.6 Beta vulgaris G O 29.0 parthenium Tanacetum A R 36.0 Beta vulgaris G R 71.5 vulgare Tanacetum A O 85.7 Borago officinalis G O 36.4 vulgare Taraxacum A R 36.9 Brassica napus G R 26.6 officinale Taraxacum A O 100.0 Brassica napus G O 98.8 officinale Teucrium A O 92.5 Brassica oleracea G O 97.8 chamaedrys Thymus praecox A O 50.1 Brassica rapa G R 25.3 subsp arcticus Thymus serpyllum A R 27.3 Brassica rapa G O 67.8 Thymus serpyllum A O 88.9 Calamagrostis G R 23.2 arundiflora Thymus vulgaris A R 60.9 Campanula G O 80.2 rapunculus Thymus vulgaris A O 74.3 Canna edulis G R 31.6 Thymus x A O 80.9 Canna edulis G O 44.2 citriodorus Tragopogon A R 43.2 Capsella bursa- G R 63.0 porrifolius pastoris Tragopogon A O 81.9 Capsella bursa- G O 69.5 porrifolius pastoris Tropaeolum majus A R 42.6 Carum carvi G O 32.3 Tropaeolum majus A O 82.6 Chaerophyllum G R 30.7 bulbosum Typha latifolia A O 49.5 Chaerophyllum G O 38.0 bulbosum Typha latifolia A R 65.4 Chelidonium majus G O 91.3 Vaccinium A O 94.5 Cicer arietinum G R 44.7 Corymbosum Vaccinium A O 94.1 Cicer arietinum G O 92.7 macrocarpon Veratrum viride A O 78.4 Cichorium endivia G O 94.9 subsp. Endivia Verbascum A O 96.4 Cichorium intybus G R 25.8 thapsus Vicia sativa A O 98.7 Agropyron repens G O 98.2 Vicia villosa A R 29.0 Alchemilla mollis G O 65.5 Vicia villosa A O 97.6 Alchemilla mollis G R 88.9 Vinca minor A O 74.6 Allium G R 39.0 ampeloprasum Vitis sp. A R 82.1 Allium G O 53.8 ampeloprasum Vitis sp. A O 99.5 Allium cepa G R 35.6 Zea mays A R 24.4 Allium cepa G O 75.1 Zea mays A O 99.2 Allium sativum G O 82.4 Achillea G O 42.8 Daucus carota G O 57.3 millefolium Aconitum napellus G O 37.1 Dirca palustris G R 67.1 Acorus calamus G O 89.0 Dirca palustris G O 97.2 Actinidia arguta G R 35.5 Diyopteris filix-mas G O 52.2 Actinidia arguta G O 45.4 Echinacea purpurea G O 74.4 Adiantum pedatum G O 25.0 Eleusine coracana G R 38.7 Salvia officinalis A O 67.8 Eleusine coracana G O 76.8 Salvia officinalis A R 85.4 Erigeron speciosus G R 26.8 Salvia sclarea A O 61.0 Erysimum G R 59.8 perofskianum Santolina A R 54.1 Erysimum G O 100.2 chamaecyparissus perofskianum Santolina A O 63.1 Fagopyrum G R 37.6 chamaecyparissus esculentum Satureja montana A O 75.6 Fagopyrum G O 27.3 tartaricum Scorzonera A O 62.7 Fagopyrum G R 30.7 hispanica tartaricum Scutellaria A O 82.7 Galinsoga ciliata G O 30.9 lateriflora Galinsoga ciliata G R 51.3 Passiflora caerulae G R 21.1 Galium odoratum G O 96.9 Passiflora caerulae G O 60.6 Gaultheria G R 70.9 Pastinaca sativa G O 72.8 hispidula Gaultheria G O 82.2 Pennisetum G R 30.6 hispidula alopecuroides Gaultheria G O 69.6 Petasites japonicus G O 81.6 procumbens Glechoma G O 94.0 Petroselinum G R 62.9 hederacea crispum Glycine max G R 76.1 Petroselinum G O 76.3 crispum Glycine max G O 100.0 Phalaris canariensis G O 22.0 Glycyrrhiza glabra G R 33.3 Phalaris canariensis G R 36.7 Glycyrrhiza glabra G O 94.5 Phaseolus vulgaris G R 65.5 Guizotia G R 41.5 Phaseolus vulgaris G O 88.2 abyssinica Guizotia G O 95.4 Pimpinella anisum G O 46.2 abyssinica Hamamelis G O 79.7 Pisum sativum G O 52.5 virginiana Hamamelis G R 90.8 Plantago major G R 29.0 virginiana Helianthus G R 31.7 Plantago major G O 96.3 strumosus Helianthus G O 39.4 Plectranthus sp. G R 54.5 strumosus Helianthus G R 31.5 Polygonum aviculare G O 29.6 tuberosus Helianthus G O 70.6 Portulaca oleracera G R 50.9 tuberosus Helichrysum G R 40.4 Potentilla anserina G O 92.5 thianschanicum Helichrysum G O 69.2 Poterium G O 74.2 thianschanicum sanquisorba Helleborus niger G R 43.8 Prunella vulgaris G O 77.1 Helleborus niger G O 90.6 Prunella vulgaris G R 91.8 Hordeum G R 22.6 Pteridium aquilinum G O 87.5 hexastichon Hordeum G O 86.0 Levisticum officinale G R 75.1 hexastichon Hyssopus G R 25.8 Levisticum officinale G O 92.5 officinalis Inula helenium G O 82.2 Lotus corniculatus G R 25.7 Lactuca sativa G R 28.5 Lotus corniculatus G O 98.5 Lactuca sativa G O 95.5 Lupinus polyphyllus G O 94.5 Lathyrus sylvestris G R 22.1 Lupinus polyphyllus G R 99.9 Lathyrus sylvestris G O 79.5 Lycopersicon G R 70.0 esculentum Laurus nobilis G R 49.6 Lycopersicon G O 90.2 esculentum Laurus nobilis G O 72.3 Malus hupehensis G R 44.8 Lavandula G O 57.6 Malus hupehensis G O 82.9 angustifolia Lavandula G R 65.2 Medicago sativa G R 26.2 angustifolia Ledum G R 35.1 Medicago sativa G O 99.2 groenlandicum Ledum G O 97.9 Ruta graveolens G R 46.4 groenlandicum Leonurus cardiaca G O 99.9 Ruta graveolens G O 84.6 Cichorium intybus G O 95.8 Salix purpurea G O 32.4 Circium arvense G O 73.0 Salix purpurea G R 95.3 Circium arvense G R 96.5 Salvia elegans G O 57.0 Coix Lacryma- G O 57.4 Salvia officinalis G O 65.8 Jobi Cornus canadensis G O 62.5 Salvia officinalis G R 94.9 Cornus canadensis G R 68.0 Salvia sclarea G O 58.5 Crataegus G O 58.3 Sambucus ebulus G R 32.1 submollis Crataegus G R 73.2 Sambucus ebulus G O 67.7 submollis Cymbopogon G R 65.5 Santolina G R 49.3 citratus chamaecyparissus Cymbopogon G O 70.9 Saponaria officinalis G R 22.3 citratus Cyperus G O 85.0 Saponaria officinalis G O 88.5 esculentus Daucus carota G R 23.3 Satureja hortensis G O 73.3 Melilotus alba G R 96.9 Satureja montana G O 74.8 Melilotus alba G O 99.0 Scorzonera hispanica G R 43.1 Melissa officinalis G O 33.2 Scorzonera hispanica G O 52.1 Melissa officinalis G R 90.6 Scutellaria G O 92.0 lateriflora Mentha piperita G O 41.8 Secale cereale G R 23.7 Mentha pulegium G O 38.7 Senecio vulgaris G R 29.1 Mentha spicata G R 32.7 Setaria italica G R 21.9 Mentha spicata G O 80.1 Setaria italica G O 83.2 Mentha suaveolens G O 55.7 Silene vulgaris G R 24.1 Nepeta cataria G R 93.1 Stum sisarum G R 37.9 Ocimum basilicum G O 75.6 Sium sisarum G O 100.0 Oenothera biennis G R 42.9 solanum melongena G R 22.7 Oenothera biennis G O 86.1 Solanum tuberosum G R 50.2 Origanum G O 65.8 Solanum tuberosum G O 73.3 majorana Origanum vulgare G O 89.6 Solidago sp G R 32.8 Origanum vulgare G R 92.3 Solidago sp G O 87.3 Oryza Sativa G O 95.6 Sonchus oleraceus G R 37.8 Oxalis Deppei G O 86.3 Sonchus oleraceus G O 48.1 Oxalis Deppei G R 87.8 Sorghum dochna G R 43.1 Oxyria digyna G R 20.8 Sorghum dochna G O 91.3 Oxyria digyna G O 89.3 sorghum durra G R 56.4 Panax G R 52.7 sorghum durra G O 63.2 quinquefolius Panicum G R 31.5 Sorghum sudanense G R 56.1 miliaceum Panicum G O 94.4 Sorghum sudanense G O 89.7 miliaceum Stachys Affinis G R 27.9 Teucrium G R 61.7 chamaedrys Stachys byzantina G R 42.8 Teucrium G O 89.8 chamaedrys Stachys byzantina G O 72.1 Thymus G O 64.0 fragantissimus Stellaria graminea G R 39.7 Thymus G R 85.4 fragantissimus Stellaria media G R 27.9 Thymus praecox G R 28.3 subsp arcticus Stellaria media G O 50.0 Thymus praecox G O 39.1 subsp arcticus Symphytum G O 43.5 Thymus serpyllum G R 28.4 officinale Symphytum G R 74.2 Thymus serpyllum G O 90.3 officinale Tanacetum G O 72.2 Thymus vulgaris G R 69.0 cinerariifolium Rhaphanus sativus G R 24.0 Thymus vulgaris G O 70.6 Rhaphanus sativus G O 85.0 Thymus x citriodorus G O 70.7 Rheum G R 22.9 Asclepias incarnata T R 86.7 rhabarbarum Rheum G O 85.5 Aster T O 34.1 rhabarbarum Ribes nidigrolaria G O 59.7 Aster sp T R 46.8 Ribes nigrum G O 80.4 Aster sp T O 49.7 Ribes nigrum G R 81.5 Atropa belladonna T O 71.7 Ribes Sylvestre G O 91.7 Avena sativa T R 40.4 Ricinus communis G R 27.0 Beta vulgaris T O 30.6 Ricinus communis G O 98.3 Beta vulgaris T R 41.7 Rosmarinus G O 27.5 Borago officinalis T R 59.2 officinalis Rubus idaeus G R 38.7 Borago officinalis T O 76.5 Rubus idaeus G O 51.2 Brassica napus T R 35.8 Rumex crispus G R 37.1 Brassica Napus T O 91.9 Rumex crispus G O 95.0 Brassica nigra T R 24.3 Rumex scutatus G O 88.5 Brassica oleracea T O 83.8 Tiarella cordifolia G O 88.4 Bromus inermis T O 69.6 Tropaelum majus G O 76.8 Bromus inermis T R 91.2 Typha latifolia G O 76.4 Calendula officinalis T R 34.5 Typha latifolia G R 82.9 Canna edulis T R 20.5 Vaccinium G R 72.1 Canna edulis T O 73.5 corymbosum Vaccinium G O 95.4 Capsella bursa- T R 32.1 corymbosum pastoris Vaccinium G O 95.3 Capsella bursa- T O 75.1 macrocarpon pastoris Veratrum viride G O 80.8 Carex morrowii T R 44.0 Verbascum G R 27.3 Carex morrowii T O 94.3 thapsus Verbascum G O 91.3 Carum carvi T R 20.5 thapsus Viburnum G O 68.5 Cerastium T R 36.8 trilobum tomentosum Viburnum G R 72.6 Chaerophyllum T R 23.0 trilobum bulbosum Vicia sativa G R 32.2 Chaerophyllum T O 80.2 bulbosum Vicia sativa G O 96.8 Chelidonium majus T O 94.3 Vicia villosa G R 29.7 Chenopodium quinoa T O 48.2 Vicia villosa G O 98.7 Chenopodium quinoa T R 48.3 Vinca minor G O 35.8 Cicer arietinum T R 25.6 Vitis sp. G R 77.5 Cicer arietinum T O 81.7 Vitis sp. G O 99.8 Cichorium endivia T R 20.8 subsp endivia Zea mays G O 54.2 Cichorium endivia T O 95.5 subsp endivia Zea mays G R 56.0 Cichorium intybus T R 20.4 Perilla frutescens T R 83.5 Cichorium intybus T O 96.0 Achillea T O 89.0 Circium arvense T R 58.3 millefolium Aconitum napellus T O 63.6 Circium arvense T O 79.6 Acorus calamus T O 94.2 Citrullus colocynthis T R 41.2 Actinidia arguta T R 52.4 Citrullus colocynthis T O 84.9 Actinidia arguta T O 84.8 Coriandrum sativum T O 38.4 Adiantum pedatum T O 92.2 Coriandrum sativum T R 48.8 Agrimonia T O 39.2 Cornus canadensis T O 32.1 eupatoria Agropyron rupens T O 97.3 Amaranthus T R 20.7 caudathus Alchemilla mollis T O 85.2 Amaranthus T O 69.3 caudathus Alchemilla mollis T R 96.8 Amaranthus T R 32.4 retroflexus Allium T R 33.5 angelica T R 44.2 ampeloprasum archangelica Allium T O 94.1 angelica T O 55.7 ampeloprasum archangelica Allium cepa T R 54.4 Anthriscus T O 96.1 cerefolium Allium cepa T O 100.0 Apium graveolens T R 30.3 Allium sativum T O 76.5 Aralia nudicaulis T R 68.2 Allium T O 87.0 Aralia nudicaulis T O 97.8 schoenoprasum Allium tuberosum T R 53.6 Arctium minus T O 92.9 Allium tuberosum T O 98.7 Arctostaphylos uva- T O 72.0 ursi Aloe vera T R 43.7 Arctostaphylos uva- T R 79.8 ursi Aloe vera T O 79.9 Armoracia rusticana T O 88.0 Althaea officinalis T O 95.8 Aronia melanocarpa T R 74.9 Tanacetum G R 67.9 Aronia melanocarpa T O 80.0 parthenium Tanacetum G R 49.5 Artemisia T O 41.7 vulgare absinthium Tanacetum G O 97.8 Artemisia T R 96.1 vulgare absinthium Taraxacum G R 45.4 Artemisia T O 96.2 officinale dracunculus taraxacum G O 100.0 Artium lappa T O 21.1 officinale Asclepias T O 81.5 Oxalis Deppei T O 73.4 incarnata Fragaria x T O 44.3 oxyria digyna T R 23.6 ananassa Galinsoga ciliata T R 49.4 oxyria digyna T O 92.5 Galinsoga ciliata T O 56.9 Panax quinquefolius T O 24.8 Galium odoratum T R 59.4 Panax quinquefolius T R 36.6 Galium odoratum T O 95.3 Panicum miliaceum T R 26.9 Gaultheria T R 37.9 Passiflora caerulea T R 55.3 hispidula Gaultheria T O 78.5 Passiflora caerulea T O 77.6 hispidula Gaultheria T O 85.7 Pastinaca sativa T O 49.2 procumbens Glechoma T O 95.9 Pastinaca sativa T O 82.9 hederacea Glycine max T O 96.8 Pennisetum T O 74.9 alopecuroides Glycine max T R 32.8 Petasites Japonicus T R 22.9 Glycine max T O 100.0 Petasites Japonicus T O 79.5 Glycyrrhiza glabra T R 70.2 Petroselinum T O 61.1 crispum Glycyrrhiza glabra T O 90.3 Petroselinum T O 83.7 crispum Guizotia T R 34.4 Petroselinum T R 99.0 abyssinica crispum Guizotia T O 97.9 Phalaris canariensis T R 29.5 abyssinica Hamamelis T R 72.1 Phalaris canariensis T O 67.2 virginiana Hamamelis T O 77.1 Phaseolus vulgaris T O 93.1 virginiana Hedeoma T O 34.7 Physalis pruinosa T O 64.2 pulegioides Helianthus T R 20.6 Pimpinella anisum T R 59.0 strumosus Helianthus T O 57.2 Pimpinella anisum T O 88.5 strumosus Helianthus T O 61.0 Pisum sativum T O 75.4 tuberosa Helianthus T R 46.9 Plantago major T O 99.6 tuberosus Helichrysum T O 23.5 Plectranthus sp. T R 49.4 angustifolium Helichrysum T R 94.5 Podophyllum T O 87.3 angustifolium peltatum Helichrysum T R 98.1 Laurus nobilis T R 51.7 thianschanicum Helleborus niger T O 26.2 Lauras nobilis T O 87.2 Humulus lupulus T R 38.0 Lavandula latifolia T R 75.5 Humulus lupulus T O 93.8 Lavendula T R 81.9 angustifolia Hyoscyamus niger T O 41.5 Ledum T R 45.9 groenlandicum Hyssopus T R 44.6 Ledum T O 99.5 officinalis groenlandicum Inula helenium T O 97.6 Lens culinaris subsp. T R 28.0 Culinaris Juniperus T R 80.0 Lens culinaris subsp. T O 97.6 communis Culinaris Koeleria glauca T O 94.7 Levisticum officinale T R 51.4 Koeleria glauca T R 99.4 Levisticum officinale T O 87.8 Lactuca sativa T O 94.0 Lotus corniculatus T R 53.7 Lathyrus Sativus T R 24.0 Lotus corniculatus T O 97.4 Lathyrus Sativus T O 33.0 Lupinus polyphyllus T O 95.8 Lathyrus sylvestris T O 43.1 Lupinus polyphyllus T R 99.3 Cornus canadensis T R 80.2 Luzula sylvatica T R 29.5 Crataegus sp T R 22.9 Malus hupehensis T R 58.7 Crataegus T O 81.5 Malus hupehensis T O 62.5 submollis Cryptotaenia T R 20.9 Malus spp. T O 25.7 canadensis Cymbopogon T R 40.5 Malva sylvestris T O 73.5 citratus Cymbopogon T O 77.0 Medicago sativa T R 46.2 citratus Cyperus T R 20.9 Medicago sativa T O 94.9 esculentus Cyperus T O 72.0 Melilotus officinalis T O 99.4 esculentus Dirca palustris T R 67.1 Melissa officinalis T R 91.0 Dirca palustris T O 82.2 Mentha piperita T O 86.8 Diyopteris filix- T O 23.9 Ruta graveolens T O 68.5 mas Echinacea T O 92.2 Salix purpurea T R 37.1 purpurea Eleusine coracana T R 30.0 Salix purpurea T O 46.1 Erysimum T R 81.7 Salvia officinalis T O 67.7 perofskianum Erysimum T O 98.8 Salvia officinalis T R 91.1 perofskianum Fagopyrum T O 35.5 Sambucus T R 35.7 esculentum canadensis Fagopyrum T O 40.0 Sambucus T O 99.0 tararicum canadensis Fagopyrum T R 30.1 Sanguisorba minor T O 90.6 tataricum Foeniculum T O 21.0 Santolina T O 62.7 vulgare Fpomoea batatas T O 98.6 Santolina T R 73.4 Menyanthes T O 64.3 Saponaria officinalis T O 93.2 trifoliata Miscanthus T R 36.1 Satureja hortensis T R 43.1 sinensis Andress Miscanthus T O 66.6 Satureja hortensis T O 87.9 sinensis Andress Nepeta cataria T O 23.6 Satureja montana T R 55.1 Ocimum Basilicum T O 81.3 Satureja montana T O 79.2 Oenothera biennis T R 35.7 Satureja repandra T R 49.7 Oenothera biennis T O 75.6 Satureja repandra T O 73.3 Onobrychis T R 44.5 Scorzorera hipanica T O 63.3 viciifolia Onobrychis T O 90.7 Scuttellaria T O 29.3 viciifolia lateriflora Origanum vulgare T R 76.5 Setaria italica T R 20.8 Origanum vulgare T O 82.9 Silene vulgaris T O 96.8 Oryza sativa T O 51.4 Sium sisarum T R 27.4 Oxalis Deppei T R 48.4 Slum sisarum T O 88.8 Solanum T R 21.9 Teucrium T R 40.0 melongens chamaedrys Solidago sp T R 45.9 Thymus T O 93.7 fragantissimus Solidago sp T O 74.0 Thymus T R 97.3 fragantissimus Sonchus oleraceus T R 22.7 Thymus praecox T O 46.0 subsp arcticus Sonchus oleraceus T O 38.1 Thymus T R 74.3 pseudolanuginosus Sorghum T O 57.0 Thymus serpyllum T O 88.6 caffrorum Sorghum T R 74.0 Thymus x citriodorus T R 66.4 caffrorum Sorghum dochna T O 44.3 Thymus x citriodorus T O 97.8 Sorghum dochna T O 65.8 Tiarella cordifolia T O 94.9 Sorghum dochna T R 70.7 Tragopogon T R 45.0 porrifolius Sorghum dochna T R 89.0 Tragopogon T O 72.0 porrifolius Sorghum durra T R 39.6 Triticosecale spp T R 27.8 Polygonum T R 32.8 Triticosecale spp T O 87.8 aviculare Polygonum T O 53.9 aviculare Potentilla anserina T O 94.9 Prunella vulgaris T O 76.4 Prunella vulgaris T R 94.7 Pteridium T O 90.1 aquilinum Raphanus T R 39.5 raphanistrum Raphanus T O 91.0 raphanistrum Raphanus sativus T O 79.1 Ribes nigrum T R 89.6 Rites nigrum T O 95.4 Ribes Sylvestre T R 20.1 Ribes Sylvestre T O 97.4 Ricinus communis T R 26.5 Ricinus communis T O 92.4 Rosa rugosa T O 41.6 Rubus canadensis T O 96.4 Rubus idaeus T R 44.8 Rubus idaeus T O 88.7 Rumes scutatus T O 88.7 Rumex acetosella T R 40.9 Rumex acetosella T O 90.9 Rumex crispus T R 33.4 Rumex crispus T O 89.3 Triticum aestivum T R 26.6 Triticum aestivum T O 42.6 Tropaeolum majus T R 21.4 Tropaeolum majus T O 81.5 Typha latifolia T O 44.8 Typha latifolia T R 72.5 Urtica dioica T R 35.2 Urtica dioica T O 62.9 Vaccinium T R 27.4 angustifolium Vaccinium T R 78.0 macrocarpon Vaccinium T O 87.8 macrocarpon Veratrum viride T O 90.2 Verbascum T O 84.3 thapsus Viburnum trilobum T R 45.2 Viburnum trilobum T O 70.0 Vicia sativa T O 99.0 Vicia villosa T R 44.2 Vicia villosa T O 98.3 Vinca minor T O 21.5 Vitis sp. T O 99.9 Zea mays T R 31.7 Zea mays T O 90.2 Sorghum durra T O 76.5 Sorghum T O 40.5 sudanense Stachys ajfinis T R 67.2 Stachys ajfinis T O 86.6 Stachys byzantina T R 85.7 Stellaria graminea T O 43.3 Stellaria graminea T R 39.2 linne Stellaria media T R 21.1 Stipa capillata T R 24.2 Symphytum T R 64.4 officinale Tanacetum T R 62.2 parthenium Tanacetum T R 42.5 vulgare Tanacetum T O 97.5 vulgare Taraxacum T R 47.5 officinale Taraxacum T O 100.0 officinale

TABLE 10 HLE Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achillea A O 21.9 Cichorium intybus A S 32.1 millefolium Lolium A O 31.0 Achillea A S 24.5 multiflorum millefolium Lolium perenne A O 20.8 Aconitum napellus A O 25.8 Lolium perenne A R 21.7 Adiantum pedatum A R 27.6 Lolium perenne A S 22.1 Agrimonia A V 26.0 Malva sylvestris A S 22.9 eupatoria Matricaria A O 28.5 Agropyron A R 21.0 recutita cristatum Melaleuca A O 21.9 Agropyron repens A S 23.4 alternifolia Agropyron repens A R 28.2 Melissa officinalis A S 23.4 Agropyron repens A S 39.8 Mentha piperita A O 31.6 Agrostis A O 38.9 Mentha piperita A W 33.2 Stofonifera Mentha pulegium A O 42.2 Alchemilla mollis A V 27.9 Mentha pulegium A V 21.5 Alchemilla mollis A O 66.0 Mentha pulegium A S 33.8 Alchemilla mollis A R 100.0 Mentha spicata A O 24.3 Alchemilla mollis A S 23.5 Oenothera biennis A O 25.2 Alkanna tinctoria A S 26.2 Oenothera biennis A R 78.8 Allium Tuberosum A S 57.9 Origanum A V 37.4 Aloe vera A O 20.5 majorana Ambrosia A O 29.1 Oxyria digyna A V 28.2 artemisiifolia Panicum A oO 33.3 Amelanchier A W 96.5 miliaceum sanguinea Peucedanum A R 23.4 Amelanchier A V 52.4 cervaria sanguinea Phalaris A R 22.4 Anethum A O 32.1 arundinacea graveolens Phalaris A O 27.6 Anethum A W 22.8 canariensis graveolens Phaseolus A S 28.3 Angelica A S 39.2 coccineus archangelica Phaseolus mungo A R 37.8 Anthemis nobilis A O 37.6 Phaseolus vulgaris A O 24.3 Anthemis nobilis A S 26.4 Phaseolus A S 74.3 Anthemis tinctoria A O 31.9 Vulgaris Anthemis tinctoria A S 38.4 Phleum pratense A R 27.8 Apium graveolens A S 49.2 Physalis ixocarpa A O 21.5 Arctium minus A O 46.4 Physalis ixocarpa A S 26.5 Arctostaphylos A R 100.0 Physalis Pruinosa A S 60.2 uva-ursi Phytolacca A S 100.0 Aronia A O 21.9 americana melanocarpa Plantago A O 21.1 Aronia A W 78.4 coronopus melanocarpa Plantago A S 25.7 Aronia A V 100.0 coronopus melanocarpa Plantago major A O 26.0 Aronia A R 29.0 Plectranthus sp. A O 23.1 melanocarpa Poa pratensis A O 21.7 Aronia A O 33.6 Polygonum A R 79.7 melanocarpa aviculare Artemisia A W 89.2 Portulaca olevcae A O 34.5 dracunculus Poterium A R 25.8 Ludoviciana A O 33.4 sanguisorba Ludoviciana A S 20.7 Poterium A O 34.6 Aster sp A R 26.2 sanguisorba Beta vulgaris A R 100.0 Poterium A W 31.0 Beta vulgaris spp. A R 92.2 sanguisorba Maritima Pteridium A R 54.4 Borago officinalis A S 22.6 aquilinum Brassica napus A S 68.3 Raphanus sativus A S 66.4 Brassica napus A R 29.5 Raphanus sativus A R 81.8 Brassica nigra A S 32.6 Rheum officinale A S 37.9 Brassica oleracea A O 22.9 Ribes nigrum A W 100.0 Brassica oleracea A V 20.8 Ribes nigrum A S 47.6 Brassica oleracea A R 22.2 Ribes nigrum A V 27.5 Brassica rapa A S 23.2 Ribes rubrum A R 35.4 Brassica rapa A R 26.9 Ribes Sylvestre A W 100.0 Bromus inermis A O 34.1 Rosa rugosa A W 95.1 Bromus inermis A R 21.9 Rosa rugosa A R 24.6 Calamintha A O 35.4 Rosmarinus A R 58.4 nepeta officinalis Canna edulis A O 56.4 Rubus idaeus A W 27.6 Canna edulis A R 21.4 Rubus idaeus A S 33.0 Carum carvi A O 24.2 Lavandula A S 42.2 Chaerophyllum A O 25.5 latifolia bulbosum Leonurus cardiaca A R 100.0 chenopodium A R 24.0 Lepidium sativum A O 100.0 bonus-henricus Saccharum A R 23.8 Chenopodium A S 85.8 officinarum bonus-henricus Salvia elegans A O 100.0 Citrullus lanatus A R 26.3 Salvia officinalis A O 95.7 Coix Lacryma- A S 86.1 Salvia officinalis A W 77.9 Jobi Salvia officinalis A R 83.7 Cosmos A O 33.8 Salvia officinalis A S 20.5 sulphureus Salvia sclarea A O 100.0 Cosmos A S 20.7 Salvia sclarea A V 28.6 sulphureus Santolina A O 27.1 Crataegus sp A O 84.1 chamaecyparissus Crataegus sp A R 23.6 Satureja montana A W 23.2 Crataegus sp A S 21.7 Satureja montana A S 27.7 Crataegus A S 34.0 Scorzonera A R 60.1 submollis hispanica Cryptotaenia A V 22.1 Scutellaria A S 45.9 canadensis lateriflora Cucumis anguria A O 26.2 Artemisia G O 31.5 Cucumis Anguria A R 53.4 absinthium Cucumis melo A S 53.6 Artemisia G V 24.2 Cucumis sativus A R 53.3 absinthium Curcuma zedoaria A O 24.3 Aster G S 29.2 Cymbopogon A S 91.2 Beckmannia G O 22.7 citratus eruciformis Datisca cannabina A S 55.7 Beta vulgaris G R 100.0 Daucus carota A R 100.0 Betula glandulosa G S 26.7 Daucus carota A V 24.7 Borago officinalis G O 25.7 Daucus carota A O 37.9 Brassica Napus G S 50.4 Digitalis purpurea A S 34.0 Brassica napus G R 48.2 Dirca palustris A R 20.3 Brassica nigra G S 23.9 Dirca palustris A S 27.9 Brassica oleracea G R 28.1 Dolichos Lablab A R 21.5 Brassica oleracea G S 22.5 Dryopteris filix- A R 58.8 Brassica rapa G R 56.4 mas Calamintha nepeta G V 24.8 Dryopteris filix- A S 22.0 Calamintha nepeta G O 38.8 mas Canna edulis G O 66.3 Echinacea A O 38.2 Capsella bursa- G R 25.8 purpurea pastoris Echinacea A S 28.1 Carthamus G R 22.2 purpurea tinctorius Eleusine coracana A S 20.7 Chelidonium G O 31.6 Erigeron A O 29.6 majus canadensis Chenopodium G S 21.3 Fagopyrum A S 29.3 album esculentum Cichorium endivia G S 21.4 Fagopyrum A S 24.4 subsp. Endivia tataricum Cicer arietinum G S 50.7 Foeniculum A O 25.1 Cichorium endivia G O 48.5 vulgare subsp. Endivia Fragaria x A O 22.3 Cichorium endivia G S 27.9 ananassa subsp. Endivia Fragaria x A W 100.0 Coix Lacryma- G O 24.5 ananassa Jobi Fragaria x A V 21.4 Cornus canadensis G S 36.1 ananassa Crataegus sp G W 57.8 Fragaria x A S 29.4 Cucurbita Pepo G R 23.1 ananassa Curcuma zedoaria G O 24.0 Fragaria x A V 21.6 Datura metel G O 21.0 ananassa Aconitum napellus G R 97.7 Galinsoga ciliata A R 61.6 Acorus calamus G S 20.0 Galium odoratum A R 21.0 Adiantum pedatum G R 100.0 Gaultheria A O 33.7 Agastache G W 25.3 hispidula foeniculum Gentiana lutea A R 52.1 Ageratum G O 28.5 Glechoma A O 21.8 conyzoides hederacea Agropyron G R 37.3 Glycine Max A S 81.3 cristatum Glycyrrhiza A W 100.0 Agropyron repens R 31.4 glabra Fagopyrum G S 32.9 Glycyrrhiza A S 63.3 esculentum glabra Fagopyrum G S 41.2 Guizotia A R 36.9 tataricum abyssinica Foeniculum G V 25.7 Hamamelis A R 100.0 vulgare virginiana Foeniculum G S 42.5 Helianthus A S 32.1 vulgare Tuberosus Foeniculum G O 24.1 Heliotropium A R 22.8 Vulgare arborescens Galinsoga ciliata G S 25.0 Heliotropium A S 24.9 Galium odoratum G R 89.4 arborescens Gaultheria G O 35.1 Helleborus niger A S 25.6 hispidula Hordeum vulgare A O 58.1 Gaultheria G R 67.2 Hypericum A S 24.8 hispidula perforatum Gaultheria G S 74.7 Hyssopus A O 21.1 procumbens officinalis Glycine max G R 24.6 Hyssopus A S 93.6 Glycyrrhiza G W 56.8 officinalis glabra Lactuca serriola A S 34.3 Glycyrrhiza G V 30.0 Laurus nobilis A W 100.0 glabra Lavandula A W 57.1 Glycyrrhiza G R 92.4 latifolia glabra Lavandula A O 43.7 Glycyrrhiza G S 28.6 latifolia glabra Chenopodium A S 50.4 Hamamelis G R 100.0 quinoa virginiana Chrysanthemum A O 26.0 Hamamelis G S 29.3 coronarium virginiana Cicer arietinum A S 23.3 Hedeoma G O 60.0 Senecio vulgaris A R 34.0 pulegioides Sonchus oleraceus A O 29.1 Helenium hoopesii G O 37.3 Sorghum dochna A O 21.1 Helenium hoopesii G S 34.7 Sorghum dochna A V 24.4 Helianthus G V 21.4 Sorghum durra A O 23.4 tuberosus Sorghum durra A V 23.6 Helichrysum G O 43.0 Spinacia oleracea A S 26.8 thianschanicum Stellaria graminea A O 24.8 Helichrysum G R 39.2 Symphytum A O 91.6 thianschanicum officinale Heliotropium G R 22.8 Tanacetum A R 28.3 arborescens cinerariifolium Heliotropium G S 39.5 Tanacetum A O 46.3 arborescens vulgare Helleborus niger G S 34.2 Tanacetum A S 33.7 Hypericum henryi G S 23.7 vulgare Hypericum G S 23.8 Taraxacum A W 26.4 perforatum officinale Hyssopus G W 45.1 Taraxacum A V 24.0 officinalis officinale Hyssopus G S 24.2 Taraxacum A O 21.0 officinalis officinale Inula helenium G W 96.2 Teucrium A O 37.0 Ipomola batatas G V 21.9 chamaedrys Lactuca sativa G W 35.1 Thymus A W 20.2 Laportea G O 25.1 fragantissimus canadensis Thymus herba- A W 20.8 Laportea G S 26.5 barona canadensis Thymus vulgaris A R 77.9 Ricinus communis G S 46.0 Thymus vulgaris A W 23.6 Rosmarinus G R 60.4 Thymus x A W 21.3 officinalis citriodorus Rubus idaeus G W 28.2 Thymus x A S 21.1 Rubus occidentalis G R 93.6 citriodorus Mentha arvensis G S 65.5 Trichosanthes A O 23.2 Mentha piperita G O 24.2 kirilowii Mentha piperita G S 23.7 Trigonella foenum A S 32.0 Mentha piperita G V 34.2 graecum Mentha pulegium G O 63.3 Triticum durum A S 22.0 Mentha pulegium G V 30.2 Triticum turgidum A O 60.0 Mentha spicata G S 45.9 Triticum spelta A S 47.6 Monarda didyma G S 47.7 Urtica dioica A O 33.3 Nepeta cataria G R 100.0 Vaccinium A W 42.6 Nicotiana tabacum G O 75.8 augustifolium Hordeum vulgare G O 33.4 Vaccinium A W 22.4 subsp. Vulgare Corymbosum Sambucus ebulus G R 48.6 Vaccinium A S 21.6 Sanguisorba G R 100.0 Corymbosum officinalis Vaccinium A W 22.5 Santolina G O 100.0 macrocarpon chamaecyparissus Vaccinium A S 54.8 Serratula tinctoria G S 56.8 macrocarpon Satureja montana G O 34.1 Valerianella A O 49.2 Scolymus G R 37.9 locusta hispanicus Veronica A O 43.7 Scutellaria G S 54.7 officinalis lateriflora Viburnum A W 75.4 Senecio vulgaris G R 35.3 trilobum Marsh. Solidago sp G S 22.6 Vitis A S 33.8 Sonchus oleraceus G O 23.7 Vitis A W 100.0 Sorghum G V 27.1 Vitis A O 21.0 caffrorum Zea Mays A S 95.2 Sorghum dochna G S 40.7 Achillea G O 28.8 Sorghum dochna G O 21.4 millefolium Sorghum G V 23.3 Achillea G S 27.3 sudanense millefolium Sorghum G W 92.9 Aconitum napellus G O 23.1 sudanense Rubus idaeus A R 27.9 Stellaria graminea G O 25.4 Rubus idaeus A O 37.4 Stellaria media G O 30.4 Rumex Acetosa A S 45.2 Stellaria media G R 22.0 Rumex crispus A O 26.1 Tanacetum G O 57.3 Rumex crispus A R 100.0 vulgare Rumex Scutatus A V 43.8 Tanacetum G W 38.4 Ruta graveolens A O 28.7 vulgare Saccharum A O 29.6 Tanacetum G O 38.2 officinarum vulgare Alchemilla mollis G W 20.6 Tanacetum G W 26.3 Alchemilla mollis G O 56.1 vulgare Alchemilla mollis G R 28.1 Taraxacum G V 20.0 Alchemilla mollis G S 25.3 officinale Allium cepa G O 20.2 taraxacum G O 28.0 Allium sativum G O 100.0 officinale Allium tuberosum G O 100.0 Thymus G R 79.9 Althaea officinalis G S 30.8 fragantissimus Amaranthus G S 22.3 Thymus G O 26.2 caudatus fragantissimus Amelanchier G W 88.3 Thymus herba- G W 20.2 sanguinea barona Anethum G O 26.2 Thymus serpyllum G V 22.2 graveolens Triticosecale spp. G S 29.7 Angelica G S 43.2 Triticum durum G S 37.8 archangelica Triticum spelta G O 31.0 Anthemis nobilis G S 21.7 Triticum spelta G S 37.9 Arctostaphylos G O 33.1 Typha latifolia G S 27.5 uva-ursi Urtica dioica G O 60.3 Arctostaphylos G R 100.0 Vaccinium G S 33.2 uva-ursi corymbosum Arctostaphylos G S 23.4 Vaccinium G S 43.7 uva-ursi angustifolium Annoracia G O 22.5 Vaccinium G W 57.8 rusticana macrocarpon Aronia G W 79.0 Vaccinium G S 59.9 melanocarpa macrocarpon Aronia G V 100.0 Valerianella G O 32.1 melanocarpa locusta Aronia G S 22.7 Veratrum viride G O 22.1 melanocarpa Verbascum G S 33.8 Aronia G O 29.6 thapsus melanocarpa Viburnum G V 21.3 Laserpitium G S 22.1 trilobum latifolium Viburnum G W 73.0 Lathyrus sativus G O 29.9 trilobum Lathyrus sativus G W 27.8 Vicia faba G S 21.2 Lathyrus sativus G S 28.1 Vigna unguiculata G R 20.1 Laurus nobilis G W 100.0 Vitis G V 26.0 Lavandula G O 65.7 Vitis G W 66.1 angustifolia Vitis G O 41.7 Ledum G O 100.0 Rubus occidentalis G O 40.0 groenlandicum Rumex acetosella G V 24.3 Leonorus cardiaca G R 61.3 Rumex crispus G R 100.0 Lepidium sativum G O 100.0 Rumex patientia G O 32.0 Levisticum G W 91.4 Rumex scutatus G V 28.6 officinale Ruta graveolens G S 23.4 Lolium perenne G O 37.3 Saccharum G O 30.2 Lotus G S 21.8 officinarum tetragonolobus Salix purpurea G S 24.8 Lupinus G O 42.3 Salvia elegans G O 100.0 polyphyllus Corchorus T O 24.4 Malus hupehensis G S 25.9 olitorius Medicago sativa G S 32.1 Comus canadensis T S 41.3 Melaleuca G O 40.0 Crataegus sp T S 34.0 alternifolia Crataegus T S 39.6 Melissa officinalis G S 23.1 submollis Daucus carota G O 32.3 Curcuma longa T O 55.3 Daucus carrota G R 90.9 Curcuma zedoaria T O 24.4 Dipsacus sativus G O 32.7 Cydonia oblonga T V 35.2 Dirca palustris G S 33.5 Cynara scolymus T O 41.2 Dolichos Lablab G R 32.1 Cynara scolymus T R 36.8 Dryopteris filix- G R 80.9 Dactilis T O 31.9 mas Glomerata Echinacea G S 63.0 Datura T S 25.9 purpurea stramonium Elymus Junceus G R 25.9 Daucus carota T R 92.3 Erigeron G O 43.0 Daucus carota T O 31.0 canadensis Dipsacus sativus T O 100.0 Erigeron G O 22.8 Dirca palustris T S 31.4 speciosus Dolichos lablab T O 23.1 Erigeron G S 24.2 Dryopteris filix- T R 68.2 speciosus mas Erysimum G O 20.8 Echinacea T S 38.2 perofskianum purpurea Ocimum basilicum G O 40.1 Eleusine coracana T O 22.1 Ocimum basilicum G S 27.9 Elymus junceus T R 37.9 Oenothera biennis G O 26.3 Erigeron T O 35.0 Oenothera biennis G R 100.0 speciosus Oenothera biennis G O 49.6 Erysimum T O 22.6 Oenothera biennis G S 54.0 perofskianum Origanum vulgare G W 100.0 Erysimum T S 23.2 Origanum vulgare G O 26.7 perofskianum Origanum vulgare G S 21.3 Fagopyrum T S 24.7 Oryza Sativa G S 34.5 esculentum Oxalis Deppei G O 27.4 Foeniculum T O 31.4 Lodd. vulgare Panicum G O 25.3 Foeniculum T V 69.1 miliaceum vulgare Pastinaca sativa G R 95.0 Foeniculum T S 38.5 Petroselinum G R 44.5 vulgare crispum Fragaria x T O 50.4 Petroselinum G S 26.5 ananassa crispum Fragaria x T V 30.2 Peucedanum G R 25.1 ananassa cervaria Fragaria x T S 28.4 Phaseolus G R 30.9 ananassa coccineus Passiflora spp. T O 30.2 Phaseolus G O 27.5 Passiflora spp. T V 59.4 coccineus Passiflora spp. T S 24.4 Phaseolus mungo G R 24.3 Fucus vesiculosus T O 42.7 Phlox paniculata G S 37.9 Galinsoga ciliata T R 49.3 Physalis pruinosa G S 26.5 Gaultheria T W 36.9 Phytolacca G S 100.0 hispidula americana Gentiana T S 26.1 Pimpinella anisum G S 23.7 macrophylla Plantago G O 25.1 Bromus inermis T O 27.8 coronopus Canna edulis T O 40.3 Plantago major G O 25.0 Capsicum annuum T S 22.6 Plantago major G R 20.5 Carex morrowii T O 26.0 Plantago major G S 23.6 Carex morrowii T R 49.8 Poa compressa G O 28.5 Carya cordiformis T S 28.8 Poa pratensis G O 37.5 Carya cordiformis T O 21.0 Polygonum G R 25.4 Carya cordiformis T W 88.7 aviculare Clematis armandii T O 20.1 Polygonum G O 21.3 Chaerophyllum T O 22.8 pensylvanicum bulbosum Portulaca G O 28.0 Chaerophyllum T S 24.3 oleracea bulbosum Poterium G O 25.6 Agaricus T S 25.4 sanguisorba bisporatus Poterium G V 21.9 Chelidonium T O 39.0 sanguisorba majus Prunella vulgaris G O 23.4 Chenopodium T S 44.3 Pteridium G R 43.1 bonus-henricus aquilinum chrysanthemum T O 33.4 Reseda odorata G O 46.5 coronarium Rhaphanus sativus G S 32.6 chrysanthemum T S 23.9 Rheum x cultorum G S 20.9 coronarium Ribes nidigrolaria G W 29.8 Cichorium endivia T O 44.3 Ribes nidigrolaria G V 53.7 subs. Endivia Ribes nigrum G V 20.3 Cichorium endivia T S 20.5 Ribes Silvestre G W 91.6 subs. Endivia Salvia officinalis G W 52.4 Circium arvense T R 49.7 Salvia officinalis G R 100.0 Citrullus T R 37.0 Salvia officinalis G O 100.0 colocynthis Salvia sclarea G O 100.0 Hibiscus T O 39.9 Salvia sclarea G V 23.0 cannabinus Salvia sclarea G W 31.1 Hibiscus T S 21.1 Sambucus ebulus G O 52.1 cannabinus Alchemilla mollis T S 31.2 Humulus lupulus T S 54.8 Allium T S 42.9 Humulus lupulus T R 50.5 ascalonicum Hydrastis T O 20.5 Allium sativum T O 100.0 canadensis Allium tuberosum T O 100.0 Hypericum henryi T O 32.5 Alpinia T O 21.9 Hypericum T S 27.9 officinarum perforatum Alpinia T S 100.0 Hypericum sp T W 55.9 officinarum Hypomyces T S 42.7 Amaranthus T S 36.0 lactifluorum candatus Iberis amara T S 100.0 Amaranthus T S 66.8 Inula helenium T S 30.1 gangeticus Ipomola batatas T V 27.4 Ananas comosus T O 20.3 Ipomola batatas T S 44.9 Ananas comosus T W 23.8 Juniperus T S 57.8 Anethum T O 35.8 communis graveolens Laportea T S 63.5 angelica T R 53.5 canadensis archangelica Populus x T W 72.0 Anthemis nobilis T O 45.3 petrowskyana Anthemis T S 47.5 Portulaca T O 33.7 tinctorium oleracera Anthriscus T O 20.5 Poterium T W 100.0 cerefolium sanguisorba Arctium minus T O 54.1 Prunus spp. T S 39.6 Arctostaphylos T O 28.1 Prunus persica T O 21.4 uva-ursi Prunus persica T V 26.6 Arctostaphylos T R 100.0 Psidium guajava T V 37.7 uva-ursi Psoralea T S 51.5 Aronia T V 100.0 corylifolia melanocarpa Pteridium T R 76.2 Aronia T W 42.7 aquilinum melanocarpa Pteridium T S 27.9 Aronia prunifolia T W 39.0 aquilinum Artemisia T O 25.6 Punica granatum T W 66.4 absinthium mentha arvensis T R 34.0 Artemisia T O 31.3 Mentha piperita T S 60.1 dracunulus Mentha pulegium T V 24.5 Artemisia T S 22.3 Mentha pulegium T W 24.8 dracunulus Mentha spicata T O 24.4 Aster T S 20.9 Mentha T S 28.9 Avena sativa T S 100.0 suaveolens Averrhoa T O 25.8 Monarda didyma T O 54.7 carambola Musa paradisiaca T O 21.4 Beta vulgaris T R 100.0 Musa paradisiaca T W 32.8 Beta vulgaris T O 59.3 nasturtium T O 100.0 Beta vulgaris T S 41.4 officinale Betula glandulosa T S 61.8 Nepeta cataria T O 60.1 Boesenbergia T O 36.9 Nepeta cataria T S 23.4 rotunda Nigella sativa T S 23.2 Boesenbergia T S 42.5 Agaricus T S 25.8 rotunda bisporatus Boletus edulis T S 43.1 Psidium spp. T S 28.3 Borago officinalis T S 36.3 Pleurotus spp. T S 31.6 Brassica hirta T S 30.2 Citrus reticulata T V 32.7 Brassica juncea T R 41.4 Citrus reticulata T S 29.4 Brassica Napus T S 29.9 Ocimum Basilicum T V 30.7 Brassica napus T R 22.9 Ocimum Basilicum T W 30.9 Brassica oleracea T R 25.6 Ocimum Basilicum T O 39.1 Brassica oleracea T V 27.0 Oenothera biennis T S 29.6 Brassica oleracea T R 26.5 Oenothera biennis T O 24.2 Brassica rapa T R 24.8 Oenothera biennis T R 58.6 Vitis G S 30.7 Rubus occidentalis T R 93.2 Xanthium G O 22.1 Rubus occidentalis T O 42.1 sibiricum Rubus occidentalis T S 20.5 Zea mays G S 20.3 Rumex acetosella T V 44.9 Abies lasiocarpa T S 22.4 Rumex crispus T O 31.3 Achillea T S 21.1 Rumex crispus T R 100.0 millefolium Rumex crispus T S 20.8 Aconitum napellus T O 100.0 Ruta graveolens T O 24.1 Acorus calamus T S 21.0 Serenoa repens T S 28.5 Ageratum T O 20.1 Salvia officinalis T R 66.5 conyzoides Salvia officinalis T O 54.0 Agrimonia T W 59.6 Salvia officinalis T W 47.2 eupatoria Sambucus T S 23.2 Agropyron T R 53.4 canadensis cristatum Sambucus T O 35.0 Agropyron repens T S 22.6 canadensis Agrostis alba T O 25.3 Sambucus T R 32.6 Alchemilla mollis T W 88.7 canadensis Alchemilla mollis T O 42.6 Sambucus T W 54.0 Alchemilla mollis T R 70.4 canadensis Citrullus T S 35.5 Sanguisorba T W 50.0 colocynthis minor Citrus limettoides T O 47.1 Santolina T O 75.8 Citrus limon T S 26.2 chamaecyparissus Citrus limon T O 73.5 Santolina T R 33.3 Citrus sinensis T V 25.2 chamaecyparissus Coix Lacryma- T O 32.7 Serratula tinctoria T S 36.3 Jobi Datura metel T O 36.9 Coix Lacryma- T S 31.4 Datura metel T S 21.4 Jobi Satureja montana T O 100.0 Laurus nobilis T W 73.6 Satureja montana T R 66.8 Laurus nobilis T S 21.2 Satureja repandra T R 87.4 Lavandula T O 22.7 Scorzorera T R 42.3 angustifolia hispanica Lavandula T S 25.1 Scorzorera T S 20.8 angustifolia hispanica Lavandula T O 100.0 Scutellaria T S 36.0 latifolia lateriflora Lavandula T S 28.5 Slum sisarum T O 22.1 latifolia Solanum T O 22.4 Ledum T O 54.3 melongena groenlandicum Solidago sp T S 22.6 Lentinus edodes T S 25.7 Sonchus oleraceus T R 41.8 Leonurus cardiaca T R 24.3 Sorghum T O 23.0 Lepidium sativum T O 100.0 caffrorum Levisticum T R 41.2 Sorghum dochna T O 30.3 officinale Sorghum dochna T O 53.5 Litchi chinensis T S 100.0 Rehmannia T O 83.0 Lolium T O 24.0 glutinosa multiflorum Frangula alnus T S 40.7 Lolium perenne T O 27.8 Thymus T O 100.0 Lonicera T S 20.9 fragantissimus ramosissima Thymus praecox T O 38.7 Lupinus T O 35.1 subsp arcticus polyphyllus Thymus T R 21.5 Lupinus T S 20.5 pseudolanuginosus polyphyllus Thymus vulgaris T W 20.0 Luzula sylvatica T R 22.6 Triticosecale spp. T O 26.0 Majorana T V 20.1 Triticum aestivum T O 20.9 hortensis Triticum turgidum T O 49.4 Malus spp. T V 37.8 Triticum spelta T O 35.0 Malus spp. T S 45.1 Tropaeolum majus T S 23.5 Malus hupehensis T S 24.4 Tsuga diversifolia T S 34.3 Melaleuca T O 26.7 Tsuga mertensiana T S 32.8 altemifolia Typha latifolia T S 36.1 Melissa officinalis T S 20.7 Urtica dioica T O 32.8 Ginkgo biloba T V 27.1 Achillea ptarmica A O 54.3 Glycyrrhiza T W 58.1 Achillea ptarmica G O 64.3 glabra Geranium T R 93.4 Glycyrrhiza T S 50.4 pratense glabra Geranium A R 98.5 Glycyrrhiza T R 25.1 pratense glabra Geranium G R 97.4 Gossypium T O 22.7 pratense herbaceum Thalictrum T O 53.6 Gossypium T S 27.3 aquilegiifolium herbaceum Thalictrum G O 60.4 Guizotia T S 38.5 aquilegiifolium abyssinica Veronica spicata T O 55.9 Hamamelis T O 37.1 Veronica spicata A O 59.2 virginiana Veronica spicata G O 56.2 Hamamelis T R 100.0 Helenium spp. T O 55.7 virginiana Salvia sylvestris T O 77.4 Hedeoma T O 28.5 Salvia sylvestris A O 66.9 pulegioides Salvia sylvestris G O 55.0 Hedeoma T S 28.2 Salvia regeliana T O 62.6 pulegioides Crambe cordifolia G R 56.3 Helenium hoopesii T O 31.7 Crambe cordifolia G O 56.7 Helenium hoopesii T S 56.0 Rudbeckia maxima G O 68.4 Helianthus T V 23.7 Trollius x T R 97.6 tuberosus cultorum Helichrysum T O 38.4 Trollius x A R 93.2 thianschanicum cultorum Helichrysum T R 27.0 Trollius x G R 100.1 thianschanicum cultorum Helleborus niger T S 32.1 Amsonia A R 53.2 Schizonepeta T O 29.1 tabernaemontana tenuifolia Oenothera T R 109.8 Schizonepeta T S 21.1 fruticosa spp. tenuifolia Oenothera T O 61.3 Onobrychis T O 42.6 fruticosa spp. viciifolia Oenothera A R 97.5 Origanum vulgare T S 53.8 fruticosa spp. Oryza sativa T S 33.3 Oenothera G R 105.9 Oxalis Deppei T O 30.8 fruticosa spp. Panicum T S 21.2 Veronica T O 68.6 miliaceum austriaca ssp Pastinaca sativa T S 53.9 teucrium G O 58.1 Pastinaca sativa T R 20.8 Veronica T R 55.6 Pastinaca sativa T O 26.9 austriaca ssp Petroselinum T R 58.2 teucrium G O 70.4 crispum Coreopsis T R 104.8 Phaseolus T S 27.1 verticillata coccineus Coreopsis A R 99.4 Phaseolus T W 37.9 verticillata vulgaris Potentilla G O 56.2 Phaseolus T O 22.2 fruticosa vulgaris Potentilla Phaseolus T S 23.2 fruticosa vulgaris Pteridium Phlox paniculata T S 21.3 aquilinum Physalis pruinosa T S 35.2 Matteuccia T R 67.2 Phytolacca T S 100.0 pensylvanica americana Matteuccia A R 59.0 Plantago T O 21.2 pensylvanica coronopus Ocimum T O 54.8 Plantago T S 48.2 tenuiflorum coronopus Carthamus A R 50.9 Poa pratensis T O 50.7 tinctorius Podophyllum T S 27.9 Carthamus G R 69.0 peltatum tinctorius Polygonum T S 25.0 Ligustrum vulgare T O 87.0 chinense Ligustrum vulgare A O 76.2 Polygonum T O 26.0 Ligustrum vulgare G O 85.7 aviculare Malva verticillata T R 80.1 Polygonum T R 100.0 Malva verticillata A R 82.8 aviculare Malva verticillata G R 82.4 Polygonum T O 42.3 Hamamelis T R 56.1 pensylvanicum virginiana Polygonum T O 28.8 Arctostaphylos T R 74.8 persicaria uva-ursi Populus T S 100.0 Arctostaphylos G R 86.0 incrassata uva-ursi Populus Tremula T S 48.5 Vicia faba T O 84.6 Populus x T S 44.1 Sempervivum T O 57.3 petrowskyana tectorum Populus x T O 100.0 Sempervivum A O 74.8 petrowskyana tectorum Raphanus sativus T R 36.5 Sempervivum G O 52.3 Raphanus sativus T S 22.4 tectorum Reseda luteola T S 23.6 Ajuga reptans T O 55.3 Reseda odorata T O 20.3 Ajuga reptans A O 52.3 Frangula alnus T R 65.3 Ajuga reptans G O 72.1 Rheum officinale T O 100.0 Phlox paniculata T O 66.2 Rheum officinale T S 33.3 Ligularia dentata A O 52.1 Rheum x cultorum T S 34.0 Ligularia dentata G R 50.8 Ricinus communis T S 27.5 Onoclea sensibilis G O 54.7 Ribes Grossularia T W 24.8 Onoclea sensibilis G R 50.1 Ribes nidigrolaria T W 24.4 Pinus cembra A R 83.2 Ribes nigrum T S 50.1 Pinus cembra G R 76.3 Ribes nigrum T V 23.8 Comus sericea T R 104.0 Ribes nigrum T W 64.1 Comus sericea A O 53.4 Ribes Sylvestre T W 32.4 Comus sericea A R 91.8 Rosa rugosa T W 100.0 Comus sericea G O 51.0 Rosmarinus T R 75.8 Comus sericea G R 98.5 officinalis Hydrangea T R 58.1 Rosmarinus T W 46.6 quercifolia officinalis Solidago caesia T R 60.7 Rubus idaeus T O 27.6 Solidago caesia A R 60.5 Rubus idaeus T S 24.3 Comus alba T R 98.9 Rubus idaeus T O 35.5 Comus alba A R 106.7 Vaccinium T S 33.7 Comus alba G R 85.3 angustifolium Carpinus T R 95.4 Vaccinium T V 24.1 caroliniana macrocarpon Carpinus A R 86.2 Vaccinium T W 30.3 caroliniana macrocarpon Carpinus G R 94.5 Vaccinium T S 70.9 caroliniana macrocarpon Astilbe chinensis T R 54.3 Vaccinium T O 57.2 Astilbe chinensis G R 50.3 macrocarpon Symphoricarpos G R 52.0 Valeriana T O 26.0 albus officinalis Euphorbia T R 103.8 Valerianella T O 53.7 amygdaloides locusta Euphorbia A R 75.2 Verbascum T O 22.8 amygdaloides thapsus Euphorbia G R 71.3 Verbascum T S 25.2 amygdaloides thapsus Viburnum A R 61.0 Veronica T O 29.9 plicatum officinalis Viburnum G R 57.9 Vitis T S 39.1 plicatum Vitis T O 40.0 Buxus microphylla T R 58.0 Vitis T W 23.5 Astilboides T R 104.2 Vitis T S 26.4 tabularis Weigela T S 20.1 Astilboides A R 108.1 coraeensis tabularis Weigela hortensis T S 25.3 Astilboides G R 100.3 Xanthium T O 28.4 tabularis sibiricum Staphylea trifolia A R 63.6 Zea mays T S 38.4 Bergenia x T R 100.5 Oenothera biennis A R 80.3 schmidtii Alchemilla mollis T R 96.0 Bergenia x A R 113.7 Alchemilla mollis A R 87.2 schmidtii Symphytum A O 80.2 Bergenia x G R 99.3 officinale schmidtii Fragaria x A R 97.9 Rodgersia T R 68.9 ananassa podophylla Fragaria x G R 93.8 Rodgersia A R 59.4 ananassa podophylla Vaccinium G R 58.6 Rodgersia G R 56.5 corymbosum podophylla Vaccinium A R 71.8 Geranium phaeum T R 92.7 augustifolium Geranium phaeum A R 84.3 Vaccinium G R 53.6 Geranium phaeum G R 101.0 augustifolium Rubus pubescens T R 71.5 Vitis A R 62.5 Rubus pubescens A R 76.2 Vitis G R 79.4 Rubus pubescens G R 82.8 Petasites A R 56.5 Taxus x media T R 60.1 japonicus Taxus x media A R 61.6 Petasites G R 53.0 Taxus x media G R 52.3 japonicus Geranium x T R 106.1 Nicotiana rustica G O 61.1 cantabrigiense Pysalis ixocarpa A R 53.8 Geranium x A R 94.2 Pteridium T O 69.2 cantabrigiense aquilinum Geranium x G R 95.9 Pteridium A R 66.2 cantabrigiense aquilinum Fuchia T R 100.2 Pteridium G R 56.3 magellanica aquilinum Fuchia A R 91.9 Sorghum durra T V 21.6 magellanica Sorghum T V 23.7 Fuchia G R 102.2 sudanense magellanica Stachys byzantina T O 25.3 Microbiata A R 51.5 Stellaria graminea T O 27.6 decussata Stellaria graminea T S 36.7 Microbiata G R 51.9 Stellaria media T O 22.6 decussata Stipa capillata T O 36.7 Rhododendron G R 51.2 Symphytum T O 20.6 spp. officinale Stephanandra T R 102.5 Symphytum T V 25.0 incisa officinale Stephanandra A R 104.6 Tanacetum T R 24.9 incisa cinerariifolium Stephanandra G R 99.1 Tanacetum T O 46.4 incisa vulgare Corylus maxima A R 50.8 Tanacetum T S 32.0 Corylus maxima G R 57.1 vulgare Cyperus G R 58.2 Taraxacum T O 63.1 altemifolius officinale Soleirolia A R 51.2 Thlaspi arvense T O 32.5 soleirolii Thymus T R 36.7 Soleirolia G R 68.0 fragantissimus soleirolii Ligularia dentata G O 52.6 Strelitzia reginae T R 106.5 Achillea ptarmica T O 50.9 Strelitzia reginae A R 94.3 Potentilla G R 98.6 Strelitzia reginae G R 111.7 fruticosa Hedychium T R 53.5 Vemonia gigantea A R 50.4 coronarium Vemonia gigantea A O 62.3 Hedychium A R 86.9 Vemonia gigantea G R 51.2 coronarium Vemonia gigantea G O 50.7 Hedychium G R 74.6 Penstemon T R 64.5 coronarium digitalis Strelitzia reginae T R 78.6 Penstemon A R 63.5 Strelitzia reginae A R 78.0 digitalis Strelitzia reginae G R 107.3 Penstemon A O 57.3 digitalis Penstemon G R 63.4 digitalis Penstemon G O 67.8 digitalis Malus spp. T R 56.1 Malus spp. T O 56.7 Malus spp. A R 50.8 Malus spp. G R 51.2 Hosta sieboldiana G O 50.9 Hamamelis mollis T R 99.1 Hamamelis mollis A R 94.1 Hamamelis mollis G R 89.4 Chaenomeles x T R 56.2 superba Chaenomeles x A R 71.9 superba Chaenomeles x G R 66.6 superba Chaenomeles x G O 52.0 superba Centaurea T R 50.9 dealbata Centaurea A R 74.1 dealbata Paeonia spp. T R 79.8 Paeonia spp. T O 58.6 Paeonia spp. A R 79.6 Paeonia spp. A O 58.5 Paeonia spp. G R 82.0 Paeonia spp. G O 60.0 Lysimachia T R 83.3 clethroides Lysimachia T O 64.3 clethroides Lysimachia G R 85.8 clethroides Lysimachia G O 67.8 clethroides Magnolia x T R 61.4 loebneri Iberis T O 62.4 sempervirens Iberis G O 63.8 sempervirens Filipendula T R 98.3 vulgaris Filipendula A R 94.5 vulgaris Filipendula G R 96.3 vulgaris Geranium T R 89.4 sanguineum Geranium T O 63.3 sanguineum Geranium A R 82.6 sanguineum Geranium A O 53.2 sanguineum Garanium G R 88.8 sanguineum Garanium G O 57.7 sanguineum Philadelphus A O 55.5 coronarius paeonia T R 58.9 suffruticosa paeonia T O 52.1 suffruticosa Paeonia A R 73.8 suffruticosa Paeonia A O 52.2 suffruticosa Paeonia G R 58.7 suffruticosa Paeonia G O 50.4 suffruticosa Dahlia spp. T R 77.4 Begonia T O 69.8 convolvulacea Begonia A O 67.5 convolvulacea Begonia G O 72.6 convolvulacea Begonia eminii T O 72.8 Begonia eminii A O 77.2 Begonia eminii G O 75.4 Begonia glabra T O 82.3 Begonia mannii A O 82.5 Begonia mannii G O 72.8 Begonia T O 79.0 polygonoides Begonia A O 74.8 polygonoides Begonia G O 73.2 polygonoides Fushia spp. T R 76.6 Fushia spp. A R 70.7 Fushia spp. G R 76.9 Butomus A O 58.8 umbellatus Symphoricarpos G R 58.7 orbiculatus Rodgersia spp. A R 59.5 Rodgersia spp. G R 59.0 Lamiastrum T R 91.5 galeobdolon Astilbe x arendsii A R 84.5 Clematis alpina A R 54.4 Stewartia T R 75.5 pseudocamellia Stewartia A R 84.1 pseudocamellia Stewartia G R 81.3 pseudocamellia Pinus mugo T R 58.9 Pinus mugo A R 53.7 Pinus mugo G R 61.7 Rubus thibelanus T R 97.6 Rubus thibelanus A R 97.9 Rubus thibetanus G R 95.4 Rubus arcticus T R 89.3 Rubus arcticus A R 85.5 Rubus arcticus G R 93.2 ribes americanum T R 70.4 Passiflora spp. T O 62.4 Rubus occidentalis T R 70.9 Nicotiana G O 60.9 tabacum Beta vulgaris T O 71.3

TABLE 11 Clostripain Inhibition Inhibition Nom latin Stress extrait (%) Nom latin Stress extrait (%) Achidinia arguta A R 34.1 Campanula G S 24.5 Anthoxanthum A R 35.0 rapunculus odoratum Cirsium arvense G R 30.0 Apocynum A R 47.6 Cissus discolor G O 40.8 cannabinum Coccoloba G R 24.9 Arctium minus A R 34.5 caracasana (Hill) Convallaria majalis G R 28.5 Bemhardi Cucurbita pepo G O 20.9 Beckmannia A O 47.3 Cucurbita pepo G S 42.5 erucaeformis Errhenatherum G S 21.6 Beta vulgaris A O 37.2 elatius Brassica rapa A O 24.6 Filipendula rubra G R 44.3 Buddlej a davidii A R 27.6 Galium odoratum G O 31.2 Bupleurum A O 34.6 Glycyrrhiza glabra G O 27.6 falcatum Hedychium sp. G O 35.6 Capsicum annuum A S 36.8 Houttuynia cordata G O 30.2 Capsicum annuum A R 24.9 Lactuca sativa G O 28.8 Cotinus cossysria A R 21.0 Lactuca sativa G O 21.6 Kolkwitzia A R 27.9 Lotus G S 42.9 amabilis tetragonolobus Laserpitium A R 20.4 Lycopersicon G R 32.3 latifolium esculentum Lindera benzoin A R 38.6 Lysimachia G R 22.7 Lolium perenne A S 34.7 clethroides Miscanthus A O 39.9 Magnolia stellata G R 23.6 sacchariflorus Microlepia G O 21.0 Ophiopogon A R 20.5 platyphylla iaponicus Miscanthus G R 25.6 Phaseolus mungo A S 30.0 sacchariflorus Phaseolus A O 36.4 pastinaca saliva G S 44.7 Vulgaris Phaseolus vulgaris G O 36.7 Phaseolus A R 23.4 Pteridium G O 22.2 Vulgaris aquilinum Plumbago A O 26.5 Solidago sp ? G S 40.8 zeylanica Symphytum G S 22.7 Portulacea A O 22.2 officinale oleracea Tanacetum vulgare G S 31.4 Salixpurpurea F. A R 38.6 Thymus G O 20.1 Gracilis fragantissumus Solanum A S 26.0 Urtica dioica G O 32.6 melanocerasum Zea mays G O 22.4 Stellaria media A O 31.6 Abies balsamea T O 38.6 (linne) Cyrillo Allium T S 30.3 Tanacetum A S 35.3 ampeloprasum vulgare Allium sativum T O 55.5 Tanacetum A O 35.4 Amaranthus T R 75.4 vulgare gangeticus Trifolium A S 22.0 Apium graveolens T R 21.7 incamatum Aralia cordata T S 48.2 Vaccinum A O 34.0 Asclepias tuberosa T O 20.2 augustifolium Asctinidia T O 47.7 Zea Mays A O 21.9 chinensis Aframomum G O 27.9 Baptisla tinctoria T O 50.4 melegueta Betula T R 24.9 Allium sativum G O 35.3 alleghaniensis Anthemis nobilis G O 35.8 Brassica oleracea T R 21.4 Anthurium G O 55.2 Brassica rapa T R 30.5 guildingii Caladium sp. T O 39.8 Astilbe x arendsii G R 25.6 Carica papaya T R 23.8 Beta vulgaris G R 28.0 Chaerophyllum T R 24.3 Vaccinum T O 39.2 bulbosum macrocarpon Chrysanthenum T O 32.7 Verbena T R 46.2 coronarium officinalis Clematis T R 21.6 Zea mays T R 32.5 chiisanensis Myrica G O 22.7 Coccoloba T O 40.1 pensylvanica caracasana N G O 24.4 Cocos nucifera T R 22.5 Nicotiana tabacum G R 22.8 Comus mas T R 34.2 Paeonia G R 31.3 Cucurbita pepo T S 24.9 pastinaca sativa G R 29.2 Cymbopogon T O 20.4 citratus Forsythia x T S 44.0 intermedia Heliotropium T O 27.1 arborescens Lonicera T O 34.9 ramosissima Malus pranifolia T R 23.6 Marrubium vulgare T R 49.3 Miscanthus T R 26.9 sinensis Anchess Nephelium T O 42.6 longana ou Euphoria longana Psoralea corylifolia T S 54.0 Raphanus sativus T O 21.4 Ribes Nigrum T R 40.9 Rubus thibetanus T R 24.2 Rumex acetosella T O 35.2 linne Sechium edule T R 25.6 Stachys macrantha T O 25.9 Tepary T R 34.9 Thymus vulgaris T O 25.3 “Argenteus” Trifolium pratense T R 31.3 Trollius x cultorum T R 26.5 Uvularia perfoliata T R 38.3

TABLE 12 Subtilisin Inhibition Nom latin Stress extrait (%) Actaea racemosa A O 20.6 Alchemilla mollis A S 23.5 Borago officinalis A S 20.5 Capsicum annuum A S 24.7 Cornus A S 22.6 canadensis L. Genista A R 21.3 multibracteata Glycine max A S 26.0 Lolium perenne A S 75.9 Matricaria A S 23.2 recutita Phaseolus A O 34.7 Vulgaris Prunus Tomentosa A R 20.4 Scuttellaria A O 33.5 lateriflora Solidago A O 42.0 canadensis Spinacia oleracea A S 100.0 Tanacetum A S 42.4 vulgare Tanacetum A O 26.7 vulgare Typha latifolia L. A O 24.9 Zea mays A S 20.9 Zea Mays A O 34.7 Adiantum pedatum G S 22.4 Cichorium endivia G S 26.7 Cucurbita pepo G O 20.8 Echinacea G O 27.6 purpurea Lactuca sativa G O 36.4 pastinaca sativa G S 52.1 Pastinaca sativa G S 20.1 Ribes nigrum G O 41.2 Symphytum G O 30.0 officinale Urtica dioica G O 38.2 Vitis sp. G S 22.3 Alchemilla mollis T S 22.6 Althacea T O 33.5 officinalis Althaea officinalis T S 53.5 Aralia cordata T S 21.0 Asctinidia T O 38.6 chinensis Astilboides T O 41.0 tabularis Averrhoa T S 20.9 carambola Baptisia tinctoria T O 25.5 Beta vulgaris T S 24.2 Convallaria T O 48.2 majalis Datura T O 27.3 stramonium Dioscorea batatas T S 36.4 Eleusine coracana T S 26.2 Fragaria x T O 39.5 ananassa Ginkgo biloba T O 98.8 Heliotropium T O 35.2 arborescens Hibiscus T S 25.2 cannabinus Hypericum T O 30.3 perforatum Ipomea batalas T S 22.1 Lathyrus sylvestris T S 21.8 Lonicera T O 29.6 ramosissima Lonicera T S 39.9 ramosissima Lonicera T R 31.1 syringantha Madia sativa T O 27.5 Monarda T O 28.2 Ocimum T S 27.2 Basilicum Peucedanum T S 29.2 oreaselinum Psoralea T S 20.9 corylifolia Rahmnus frangula T O 26.4 Raphanus sativus T S 25.5 Rheum T S 21.6 rhabarbarum Ribes Nigrum T R 28.9 Rubus occidentalis T S 22.8 Rumes scutatus T S 21.4 Solidago Hybrida T O 34.5 Tanacetum T O 33.9 balsamila Vaccinum T O 81.2 macrocarpon Xanthium T S 31.7 sibiricum Zea mays T S 28.3 

The invention claimed is:
 1. A method of inhibiting a cathepsin, comprising: contacting said cathepsin with a plant extract that is capable of inhibiting activity of said cathepsin, wherein said plant extract is prepared by extraction of plant material from Polygonum aviculare with a solvent mixture of 85% ethanol:15% methanol.
 2. The method of claim 1, wherein said inhibition of cathepsin is greater than about 20%.
 3. The method of claim 1, wherein said cathepsin is cathepsin G. 